Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AN93_LEIMU

TriTrypDb:

LmxM.10.0830

Length:

1705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1019	1023	PF00656	0.459
CLV_C14_Caspase3-7	1438	1442	PF00656	0.340
CLV_C14_Caspase3-7	1459	1463	PF00656	0.340
CLV_C14_Caspase3-7	1540	1544	PF00656	0.388
CLV_C14_Caspase3-7	161	165	PF00656	0.517
CLV_C14_Caspase3-7	212	216	PF00656	0.625
CLV_C14_Caspase3-7	225	229	PF00656	0.486
CLV_C14_Caspase3-7	230	234	PF00656	0.559
CLV_C14_Caspase3-7	239	243	PF00656	0.570
CLV_C14_Caspase3-7	432	436	PF00656	0.711

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V0	Leptomonas seymouri	46%	100%
A0A3Q8I8R7	Leishmania donovani	83%	97%
A4H671	Leishmania braziliensis	65%	96%
A4HUJ5	Leishmania infantum	83%	97%
Q4QHD1	Leishmania major	87%	100%

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