Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN87_LEIMU

TriTrypDb:

LmxM.10.0770

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.509
CLV_C14_Caspase3-7	59	63	PF00656	0.453
CLV_NRD_NRD_1	292	294	PF00675	0.639
CLV_NRD_NRD_1	332	334	PF00675	0.600
CLV_NRD_NRD_1	460	462	PF00675	0.587
CLV_NRD_NRD_1	504	506	PF00675	0.583
CLV_NRD_NRD_1	559	561	PF00675	0.367
CLV_NRD_NRD_1	75	77	PF00675	0.545
CLV_PCSK_FUR_1	460	464	PF00082	0.570
CLV_PCSK_KEX2_1	242	244	PF00082	0.754
CLV_PCSK_KEX2_1	292	294	PF00082	0.639
CLV_PCSK_KEX2_1	332	334	PF00082	0.600
CLV_PCSK_KEX2_1	460	462	PF00082	0.557
CLV_PCSK_KEX2_1	504	506	PF00082	0.583
CLV_PCSK_KEX2_1	559	561	PF00082	0.367
CLV_PCSK_KEX2_1	75	77	PF00082	0.545
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.736
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.586
CLV_PCSK_SKI1_1	229	233	PF00082	0.473
CLV_PCSK_SKI1_1	317	321	PF00082	0.491
CLV_PCSK_SKI1_1	354	358	PF00082	0.470
CLV_PCSK_SKI1_1	75	79	PF00082	0.452
DEG_APCC_DBOX_1	532	540	PF00400	0.459
DEG_Kelch_actinfilin_1	342	346	PF01344	0.452
DOC_CKS1_1	268	273	PF01111	0.512
DOC_CYCLIN_RxL_1	311	322	PF00134	0.461
DOC_MAPK_gen_1	312	320	PF00069	0.327
DOC_MAPK_MEF2A_6	152	160	PF00069	0.460
DOC_MAPK_MEF2A_6	16	23	PF00069	0.457
DOC_MAPK_MEF2A_6	266	275	PF00069	0.515
DOC_PP1_RVXF_1	203	210	PF00149	0.447
DOC_USP7_MATH_1	174	178	PF00917	0.548
DOC_USP7_MATH_1	188	192	PF00917	0.732
DOC_USP7_MATH_1	34	38	PF00917	0.661
DOC_USP7_MATH_2	239	245	PF00917	0.481
DOC_WW_Pin1_4	111	116	PF00397	0.604
DOC_WW_Pin1_4	179	184	PF00397	0.526
DOC_WW_Pin1_4	267	272	PF00397	0.524
DOC_WW_Pin1_4	319	324	PF00397	0.513
DOC_WW_Pin1_4	399	404	PF00397	0.635
DOC_WW_Pin1_4	42	47	PF00397	0.727
DOC_WW_Pin1_4	54	59	PF00397	0.460
DOC_WW_Pin1_4	81	86	PF00397	0.543
LIG_14-3-3_CanoR_1	152	160	PF00244	0.460
LIG_14-3-3_CanoR_1	16	22	PF00244	0.506
LIG_14-3-3_CanoR_1	203	208	PF00244	0.419
LIG_14-3-3_CanoR_1	243	249	PF00244	0.714
LIG_14-3-3_CanoR_1	266	271	PF00244	0.491
LIG_14-3-3_CanoR_1	292	301	PF00244	0.600
LIG_14-3-3_CanoR_1	504	514	PF00244	0.385
LIG_APCC_ABBA_1	537	542	PF00400	0.481
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BRCT_BRCA1_1	205	209	PF00533	0.473
LIG_DLG_GKlike_1	203	210	PF00625	0.447
LIG_FHA_1	18	24	PF00498	0.481
LIG_FHA_1	223	229	PF00498	0.516
LIG_FHA_1	268	274	PF00498	0.453
LIG_FHA_1	33	39	PF00498	0.628
LIG_FHA_1	345	351	PF00498	0.459
LIG_FHA_1	355	361	PF00498	0.440
LIG_FHA_1	426	432	PF00498	0.471
LIG_FHA_1	483	489	PF00498	0.513
LIG_FHA_1	517	523	PF00498	0.415
LIG_FHA_2	123	129	PF00498	0.480
LIG_FHA_2	133	139	PF00498	0.510
LIG_FHA_2	144	150	PF00498	0.530
LIG_FHA_2	350	356	PF00498	0.376
LIG_FHA_2	475	481	PF00498	0.433
LIG_Integrin_RGD_1	81	83	PF01839	0.495
LIG_LIR_Apic_2	177	183	PF02991	0.546
LIG_LIR_Gen_1	355	363	PF02991	0.422
LIG_LIR_Gen_1	424	434	PF02991	0.428
LIG_LIR_Nem_3	355	359	PF02991	0.425
LIG_LIR_Nem_3	424	430	PF02991	0.425
LIG_LIR_Nem_3	449	454	PF02991	0.426
LIG_Pex14_2	11	15	PF04695	0.488
LIG_Pex14_2	209	213	PF04695	0.456
LIG_SH2_CRK	180	184	PF00017	0.550
LIG_SH2_CRK	427	431	PF00017	0.434
LIG_SH2_NCK_1	180	184	PF00017	0.550
LIG_SH2_SRC	301	304	PF00017	0.418
LIG_SH2_STAP1	427	431	PF00017	0.419
LIG_SH2_STAP1	443	447	PF00017	0.300
LIG_SH2_STAT3	555	558	PF00017	0.422
LIG_SH2_STAT5	427	430	PF00017	0.419
LIG_SH3_3	270	276	PF00018	0.485
LIG_SH3_3	397	403	PF00018	0.604
LIG_SH3_3	407	413	PF00018	0.522
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.549
LIG_SUMO_SIM_anti_2	517	525	PF11976	0.481
LIG_SUMO_SIM_par_1	19	26	PF11976	0.492
LIG_SUMO_SIM_par_1	342	347	PF11976	0.449
LIG_SUMO_SIM_par_1	484	491	PF11976	0.534
LIG_TYR_ITIM	425	430	PF00017	0.428
LIG_UBA3_1	421	429	PF00899	0.422
LIG_UBA3_1	536	543	PF00899	0.477
MOD_CK1_1	147	153	PF00069	0.448
MOD_CK1_1	191	197	PF00069	0.694
MOD_CK1_1	244	250	PF00069	0.549
MOD_CK1_1	255	261	PF00069	0.642
MOD_CK1_1	297	303	PF00069	0.341
MOD_CK1_1	402	408	PF00069	0.492
MOD_CK1_1	479	485	PF00069	0.579
MOD_CK1_1	93	99	PF00069	0.793
MOD_CK2_1	122	128	PF00069	0.482
MOD_CK2_1	151	157	PF00069	0.551
MOD_CK2_1	296	302	PF00069	0.340
MOD_CK2_1	30	36	PF00069	0.650
MOD_CK2_1	319	325	PF00069	0.518
MOD_CK2_1	349	355	PF00069	0.440
MOD_CK2_1	42	48	PF00069	0.591
MOD_Cter_Amidation	73	76	PF01082	0.434
MOD_GlcNHglycan	101	104	PF01048	0.791
MOD_GlcNHglycan	176	179	PF01048	0.655
MOD_GlcNHglycan	254	257	PF01048	0.728
MOD_GlcNHglycan	259	264	PF01048	0.645
MOD_GlcNHglycan	32	35	PF01048	0.638
MOD_GlcNHglycan	432	435	PF01048	0.483
MOD_GlcNHglycan	448	451	PF01048	0.526
MOD_GlcNHglycan	480	484	PF01048	0.694
MOD_GSK3_1	143	150	PF00069	0.529
MOD_GSK3_1	169	176	PF00069	0.592
MOD_GSK3_1	191	198	PF00069	0.692
MOD_GSK3_1	241	248	PF00069	0.600
MOD_GSK3_1	255	262	PF00069	0.528
MOD_GSK3_1	293	300	PF00069	0.378
MOD_GSK3_1	30	37	PF00069	0.707
MOD_GSK3_1	344	351	PF00069	0.589
MOD_GSK3_1	38	45	PF00069	0.751
MOD_GSK3_1	421	428	PF00069	0.422
MOD_GSK3_1	442	449	PF00069	0.487
MOD_GSK3_1	482	489	PF00069	0.547
MOD_GSK3_1	505	512	PF00069	0.398
MOD_GSK3_1	90	97	PF00069	0.546
MOD_N-GLC_1	23	28	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	169	174	PF00069	0.465
MOD_NEK2_1	281	286	PF00069	0.418
MOD_NEK2_1	294	299	PF00069	0.514
MOD_NEK2_1	349	354	PF00069	0.419
MOD_NEK2_1	421	426	PF00069	0.426
MOD_PIKK_1	1	7	PF00454	0.531
MOD_PIKK_1	344	350	PF00454	0.460
MOD_PKA_1	242	248	PF00069	0.550
MOD_PKA_1	332	338	PF00069	0.476
MOD_PKA_1	559	565	PF00069	0.407
MOD_PKA_2	151	157	PF00069	0.579
MOD_PKA_2	242	248	PF00069	0.550
MOD_PKA_2	332	338	PF00069	0.501
MOD_PKA_2	509	515	PF00069	0.404
MOD_PKA_2	559	565	PF00069	0.407
MOD_PKB_1	264	272	PF00069	0.478
MOD_Plk_1	169	175	PF00069	0.650
MOD_Plk_1	195	201	PF00069	0.705
MOD_Plk_1	23	29	PF00069	0.504
MOD_Plk_1	245	251	PF00069	0.555
MOD_Plk_1	468	474	PF00069	0.542
MOD_Plk_4	104	110	PF00069	0.504
MOD_Plk_4	188	194	PF00069	0.738
MOD_Plk_4	396	402	PF00069	0.572
MOD_Plk_4	468	474	PF00069	0.542
MOD_Plk_4	510	516	PF00069	0.331
MOD_ProDKin_1	111	117	PF00069	0.597
MOD_ProDKin_1	179	185	PF00069	0.528
MOD_ProDKin_1	267	273	PF00069	0.516
MOD_ProDKin_1	319	325	PF00069	0.518
MOD_ProDKin_1	399	405	PF00069	0.624
MOD_ProDKin_1	42	48	PF00069	0.724
MOD_ProDKin_1	54	60	PF00069	0.452
MOD_ProDKin_1	81	87	PF00069	0.556
MOD_SUMO_rev_2	138	147	PF00179	0.427
TRG_DiLeu_BaEn_1	518	523	PF01217	0.400
TRG_DiLeu_BaEn_2	354	360	PF01217	0.298
TRG_DiLeu_BaEn_4	111	117	PF01217	0.501
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.426
TRG_ENDOCYTIC_2	427	430	PF00928	0.434
TRG_ER_diArg_1	202	205	PF00400	0.349
TRG_ER_diArg_1	291	293	PF00400	0.634
TRG_ER_diArg_1	331	333	PF00400	0.608
TRG_ER_diArg_1	459	461	PF00400	0.551
TRG_ER_diArg_1	503	505	PF00400	0.401
TRG_ER_diArg_1	75	77	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	36%	82%
A0A0N1PDV8	Leptomonas seymouri	29%	97%
A0A3S5H6G6	Leishmania donovani	84%	100%
A0A3S7WR70	Leishmania donovani	30%	88%
A4H664	Leishmania braziliensis	30%	87%
A4HUI8	Leishmania infantum	30%	88%
A4HUI9	Leishmania infantum	84%	86%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QHD7	Leishmania major	84%	100%
Q4QHD8	Leishmania major	28%	100%