Uroporphyrinogen_deCOase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN86_LEIMU

TriTrypDb:

LmxM.10.0760

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.573
CLV_C14_Caspase3-7	309	313	PF00656	0.509
CLV_NRD_NRD_1	352	354	PF00675	0.505
CLV_NRD_NRD_1	384	386	PF00675	0.504
CLV_NRD_NRD_1	403	405	PF00675	0.324
CLV_NRD_NRD_1	537	539	PF00675	0.320
CLV_PCSK_KEX2_1	352	354	PF00082	0.508
CLV_PCSK_KEX2_1	384	386	PF00082	0.504
CLV_PCSK_KEX2_1	403	405	PF00082	0.324
CLV_PCSK_KEX2_1	537	539	PF00082	0.316
CLV_PCSK_SKI1_1	409	413	PF00082	0.431
CLV_PCSK_SKI1_1	456	460	PF00082	0.408
CLV_PCSK_SKI1_1	467	471	PF00082	0.546
CLV_PCSK_SKI1_1	537	541	PF00082	0.296
DEG_COP1_1	233	242	PF00400	0.510
DEG_COP1_1	312	322	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.419
DEG_SCF_FBW7_2	55	62	PF00400	0.400
DEG_SPOP_SBC_1	322	326	PF00917	0.530
DOC_CDC14_PxL_1	506	514	PF14671	0.379
DOC_CKS1_1	2	7	PF01111	0.347
DOC_CKS1_1	387	392	PF01111	0.375
DOC_CYCLIN_RxL_1	6	17	PF00134	0.312
DOC_MAPK_gen_1	206	215	PF00069	0.468
DOC_MAPK_gen_1	593	602	PF00069	0.332
DOC_MAPK_MEF2A_6	523	530	PF00069	0.394
DOC_MAPK_MEF2A_6	580	588	PF00069	0.331
DOC_MAPK_NFAT4_5	523	531	PF00069	0.400
DOC_PP2B_LxvP_1	412	415	PF13499	0.467
DOC_PP2B_LxvP_1	512	515	PF13499	0.383
DOC_PP4_FxxP_1	411	414	PF00568	0.412
DOC_USP7_MATH_1	235	239	PF00917	0.626
DOC_USP7_MATH_1	318	322	PF00917	0.664
DOC_USP7_MATH_1	458	462	PF00917	0.523
DOC_USP7_MATH_1	498	502	PF00917	0.530
DOC_USP7_MATH_1	95	99	PF00917	0.534
DOC_WW_Pin1_4	1	6	PF00397	0.486
DOC_WW_Pin1_4	238	243	PF00397	0.655
DOC_WW_Pin1_4	323	328	PF00397	0.505
DOC_WW_Pin1_4	386	391	PF00397	0.360
DOC_WW_Pin1_4	500	505	PF00397	0.569
DOC_WW_Pin1_4	55	60	PF00397	0.650
DOC_WW_Pin1_4	81	86	PF00397	0.457
LIG_14-3-3_CanoR_1	167	174	PF00244	0.501
LIG_14-3-3_CanoR_1	192	197	PF00244	0.461
LIG_14-3-3_CanoR_1	384	390	PF00244	0.550
LIG_14-3-3_CanoR_1	403	407	PF00244	0.311
LIG_14-3-3_CanoR_1	41	46	PF00244	0.384
LIG_14-3-3_CanoR_1	460	464	PF00244	0.440
LIG_14-3-3_CanoR_1	484	489	PF00244	0.513
LIG_14-3-3_CanoR_1	523	527	PF00244	0.327
LIG_14-3-3_CanoR_1	555	563	PF00244	0.410
LIG_14-3-3_CanoR_1	595	602	PF00244	0.377
LIG_Actin_WH2_2	336	354	PF00022	0.418
LIG_Actin_WH2_2	445	462	PF00022	0.342
LIG_BIR_III_4	611	615	PF00653	0.356
LIG_BRCT_BRCA1_1	332	336	PF00533	0.439
LIG_BRCT_BRCA1_1	43	47	PF00533	0.369
LIG_BRCT_BRCA1_1	532	536	PF00533	0.370
LIG_BRCT_BRCA1_1	83	87	PF00533	0.476
LIG_eIF4E_2	392	398	PF01652	0.405
LIG_FHA_1	15	21	PF00498	0.324
LIG_FHA_1	169	175	PF00498	0.797
LIG_FHA_1	180	186	PF00498	0.486
LIG_FHA_1	2	8	PF00498	0.478
LIG_FHA_1	437	443	PF00498	0.384
LIG_FHA_1	523	529	PF00498	0.405
LIG_FHA_1	583	589	PF00498	0.380
LIG_FHA_2	355	361	PF00498	0.425
LIG_FHA_2	403	409	PF00498	0.384
LIG_FHA_2	547	553	PF00498	0.313
LIG_FHA_2	92	98	PF00498	0.567
LIG_IBAR_NPY_1	247	249	PF08397	0.489
LIG_Integrin_RGD_1	216	218	PF01839	0.501
LIG_LIR_Apic_2	389	395	PF02991	0.398
LIG_LIR_Apic_2	408	414	PF02991	0.306
LIG_LIR_Gen_1	374	383	PF02991	0.328
LIG_LIR_Gen_1	44	55	PF02991	0.425
LIG_LIR_Gen_1	446	455	PF02991	0.360
LIG_LIR_LC3C_4	503	508	PF02991	0.360
LIG_LIR_Nem_3	257	261	PF02991	0.321
LIG_LIR_Nem_3	374	380	PF02991	0.349
LIG_LIR_Nem_3	44	50	PF02991	0.391
LIG_LIR_Nem_3	446	452	PF02991	0.369
LIG_LIR_Nem_3	81	86	PF02991	0.406
LIG_MLH1_MIPbox_1	83	87	PF16413	0.476
LIG_PTAP_UEV_1	531	536	PF05743	0.331
LIG_SH2_CRK	45	49	PF00017	0.363
LIG_SH2_NCK_1	597	601	PF00017	0.356
LIG_SH2_SRC	566	569	PF00017	0.373
LIG_SH2_STAP1	45	49	PF00017	0.336
LIG_SH2_STAT3	113	116	PF00017	0.388
LIG_SH2_STAT3	222	225	PF00017	0.541
LIG_SH2_STAT5	113	116	PF00017	0.408
LIG_SH2_STAT5	222	225	PF00017	0.561
LIG_SH2_STAT5	249	252	PF00017	0.476
LIG_SH2_STAT5	451	454	PF00017	0.392
LIG_SH2_STAT5	566	569	PF00017	0.291
LIG_SH2_STAT5	597	600	PF00017	0.357
LIG_SH2_STAT5	86	89	PF00017	0.465
LIG_SH3_1	529	535	PF00018	0.393
LIG_SH3_2	532	537	PF14604	0.305
LIG_SH3_3	13	19	PF00018	0.382
LIG_SH3_3	236	242	PF00018	0.743
LIG_SH3_3	358	364	PF00018	0.507
LIG_SH3_3	45	51	PF00018	0.415
LIG_SH3_3	504	510	PF00018	0.468
LIG_SH3_3	529	535	PF00018	0.393
LIG_SH3_3	626	632	PF00018	0.486
LIG_SH3_3	69	75	PF00018	0.443
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.444
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.446
LIG_SUMO_SIM_par_1	124	129	PF11976	0.413
LIG_TRAF2_1	306	309	PF00917	0.480
LIG_TYR_ITIM	43	48	PF00017	0.259
MOD_CK1_1	139	145	PF00069	0.647
MOD_CK1_1	159	165	PF00069	0.571
MOD_CK1_1	238	244	PF00069	0.680
MOD_CK1_1	321	327	PF00069	0.669
MOD_CK1_1	365	371	PF00069	0.399
MOD_CK1_1	502	508	PF00069	0.433
MOD_CK1_1	556	562	PF00069	0.483
MOD_CK2_1	365	371	PF00069	0.439
MOD_CK2_1	441	447	PF00069	0.370
MOD_CK2_1	546	552	PF00069	0.408
MOD_CK2_1	91	97	PF00069	0.611
MOD_GlcNHglycan	103	107	PF01048	0.471
MOD_GlcNHglycan	235	238	PF01048	0.794
MOD_GlcNHglycan	281	284	PF01048	0.601
MOD_GlcNHglycan	320	323	PF01048	0.569
MOD_GlcNHglycan	430	433	PF01048	0.532
MOD_GlcNHglycan	443	446	PF01048	0.268
MOD_GlcNHglycan	456	459	PF01048	0.374
MOD_GlcNHglycan	461	464	PF01048	0.470
MOD_GlcNHglycan	496	499	PF01048	0.546
MOD_GlcNHglycan	532	535	PF01048	0.429
MOD_GlcNHglycan	602	605	PF01048	0.346
MOD_GlcNHglycan	88	91	PF01048	0.668
MOD_GlcNHglycan	96	100	PF01048	0.587
MOD_GSK3_1	124	131	PF00069	0.480
MOD_GSK3_1	136	143	PF00069	0.729
MOD_GSK3_1	155	162	PF00069	0.666
MOD_GSK3_1	166	173	PF00069	0.561
MOD_GSK3_1	175	182	PF00069	0.443
MOD_GSK3_1	192	199	PF00069	0.496
MOD_GSK3_1	238	245	PF00069	0.699
MOD_GSK3_1	261	268	PF00069	0.400
MOD_GSK3_1	318	325	PF00069	0.687
MOD_GSK3_1	436	443	PF00069	0.476
MOD_GSK3_1	454	461	PF00069	0.348
MOD_GSK3_1	490	497	PF00069	0.570
MOD_GSK3_1	498	505	PF00069	0.494
MOD_GSK3_1	546	553	PF00069	0.439
MOD_GSK3_1	60	67	PF00069	0.337
MOD_GSK3_1	81	88	PF00069	0.458
MOD_GSK3_1	91	98	PF00069	0.563
MOD_LATS_1	153	159	PF00433	0.630
MOD_N-GLC_1	24	29	PF02516	0.495
MOD_N-GLC_1	600	605	PF02516	0.372
MOD_N-GLC_1	99	104	PF02516	0.464
MOD_NEK2_1	124	129	PF00069	0.416
MOD_NEK2_1	261	266	PF00069	0.461
MOD_NEK2_1	441	446	PF00069	0.352
MOD_NEK2_1	459	464	PF00069	0.589
MOD_NEK2_1	521	526	PF00069	0.379
MOD_NEK2_2	550	555	PF00069	0.394
MOD_PIKK_1	104	110	PF00454	0.444
MOD_PIKK_1	140	146	PF00454	0.669
MOD_PIKK_1	147	153	PF00454	0.651
MOD_PIKK_1	436	442	PF00454	0.386
MOD_PK_1	484	490	PF00069	0.514
MOD_PKA_2	131	137	PF00069	0.578
MOD_PKA_2	147	153	PF00069	0.677
MOD_PKA_2	166	172	PF00069	0.501
MOD_PKA_2	191	197	PF00069	0.454
MOD_PKA_2	402	408	PF00069	0.448
MOD_PKA_2	459	465	PF00069	0.443
MOD_PKA_2	522	528	PF00069	0.324
MOD_PKB_1	593	601	PF00069	0.335
MOD_Plk_1	24	30	PF00069	0.444
MOD_Plk_1	600	606	PF00069	0.531
MOD_Plk_4	109	115	PF00069	0.386
MOD_Plk_4	339	345	PF00069	0.455
MOD_Plk_4	388	394	PF00069	0.431
MOD_Plk_4	43	49	PF00069	0.392
MOD_Plk_4	502	508	PF00069	0.430
MOD_Plk_4	64	70	PF00069	0.363
MOD_Plk_4	73	79	PF00069	0.403
MOD_ProDKin_1	1	7	PF00069	0.470
MOD_ProDKin_1	238	244	PF00069	0.651
MOD_ProDKin_1	323	329	PF00069	0.498
MOD_ProDKin_1	386	392	PF00069	0.366
MOD_ProDKin_1	500	506	PF00069	0.552
MOD_ProDKin_1	55	61	PF00069	0.641
MOD_ProDKin_1	81	87	PF00069	0.461
TRG_AP2beta_CARGO_1	374	384	PF09066	0.331
TRG_ENDOCYTIC_2	249	252	PF00928	0.497
TRG_ENDOCYTIC_2	45	48	PF00928	0.363
TRG_ENDOCYTIC_2	597	600	PF00928	0.385
TRG_ER_diArg_1	224	227	PF00400	0.557
TRG_ER_diArg_1	266	269	PF00400	0.438
TRG_ER_diArg_1	351	353	PF00400	0.449
TRG_ER_diArg_1	383	385	PF00400	0.498
TRG_ER_diArg_1	536	538	PF00400	0.316
TRG_ER_diArg_1	592	595	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	27%	92%
A0A0N1PDV8	Leptomonas seymouri	44%	100%
A0A3S5H6G6	Leishmania donovani	31%	100%
A0A3S7WR70	Leishmania donovani	86%	99%
A4H664	Leishmania braziliensis	66%	97%
A4H665	Leishmania braziliensis	29%	73%
A4HUI8	Leishmania infantum	85%	99%
A4HUI9	Leishmania infantum	31%	96%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QHD7	Leishmania major	30%	100%
Q4QHD8	Leishmania major	84%	99%