Multiple RNA-binding domain-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AN80_LEIMU

TriTrypDb:

LmxM.10.0700

Length:

819

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN80

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.716
CLV_C14_Caspase3-7	188	192	PF00656	0.584
CLV_C14_Caspase3-7	460	464	PF00656	0.446
CLV_C14_Caspase3-7	558	562	PF00656	0.618
CLV_C14_Caspase3-7	56	60	PF00656	0.662
CLV_MEL_PAP_1	470	476	PF00089	0.401
CLV_NRD_NRD_1	115	117	PF00675	0.674
CLV_NRD_NRD_1	123	125	PF00675	0.664
CLV_NRD_NRD_1	178	180	PF00675	0.671
CLV_NRD_NRD_1	3	5	PF00675	0.660
CLV_NRD_NRD_1	35	37	PF00675	0.749
CLV_NRD_NRD_1	361	363	PF00675	0.528
CLV_NRD_NRD_1	63	65	PF00675	0.516
CLV_NRD_NRD_1	676	678	PF00675	0.606
CLV_NRD_NRD_1	702	704	PF00675	0.581
CLV_NRD_NRD_1	765	767	PF00675	0.223
CLV_PCSK_KEX2_1	115	117	PF00082	0.710
CLV_PCSK_KEX2_1	123	125	PF00082	0.655
CLV_PCSK_KEX2_1	178	180	PF00082	0.689
CLV_PCSK_KEX2_1	320	322	PF00082	0.518
CLV_PCSK_KEX2_1	361	363	PF00082	0.537
CLV_PCSK_KEX2_1	37	39	PF00082	0.693
CLV_PCSK_KEX2_1	609	611	PF00082	0.266
CLV_PCSK_KEX2_1	63	65	PF00082	0.537
CLV_PCSK_KEX2_1	676	678	PF00082	0.606
CLV_PCSK_KEX2_1	701	703	PF00082	0.577
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.518
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.693
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.266
CLV_PCSK_PC7_1	357	363	PF00082	0.638
CLV_PCSK_SKI1_1	141	145	PF00082	0.538
CLV_PCSK_SKI1_1	500	504	PF00082	0.328
CLV_PCSK_SKI1_1	509	513	PF00082	0.345
CLV_PCSK_SKI1_1	610	614	PF00082	0.242
CLV_PCSK_SKI1_1	619	623	PF00082	0.246
CLV_PCSK_SKI1_1	750	754	PF00082	0.212
DEG_APCC_DBOX_1	236	244	PF00400	0.283
DEG_SPOP_SBC_1	89	93	PF00917	0.465
DOC_ANK_TNKS_1	122	129	PF00023	0.585
DOC_CYCLIN_RxL_1	451	460	PF00134	0.497
DOC_CYCLIN_RxL_1	606	616	PF00134	0.432
DOC_CYCLIN_RxL_1	734	746	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.422
DOC_MAPK_gen_1	275	285	PF00069	0.412
DOC_MAPK_gen_1	444	453	PF00069	0.355
DOC_MAPK_gen_1	509	518	PF00069	0.362
DOC_MAPK_gen_1	63	71	PF00069	0.633
DOC_PP1_RVXF_1	498	504	PF00149	0.331
DOC_PP2B_LxvP_1	86	89	PF13499	0.691
DOC_SPAK_OSR1_1	473	477	PF12202	0.472
DOC_USP7_MATH_1	102	106	PF00917	0.676
DOC_USP7_MATH_1	18	22	PF00917	0.729
DOC_USP7_MATH_1	205	209	PF00917	0.589
DOC_USP7_MATH_1	232	236	PF00917	0.568
DOC_USP7_MATH_1	262	266	PF00917	0.476
DOC_USP7_MATH_1	328	332	PF00917	0.565
DOC_USP7_MATH_1	348	352	PF00917	0.494
DOC_USP7_MATH_1	39	43	PF00917	0.731
DOC_USP7_MATH_1	481	485	PF00917	0.374
DOC_USP7_MATH_1	625	629	PF00917	0.498
DOC_USP7_MATH_1	721	725	PF00917	0.732
DOC_USP7_MATH_1	765	769	PF00917	0.445
DOC_USP7_MATH_1	770	774	PF00917	0.452
DOC_USP7_MATH_1	89	93	PF00917	0.644
DOC_USP7_UBL2_3	5	9	PF12436	0.665
DOC_USP7_UBL2_3	636	640	PF12436	0.485
DOC_USP7_UBL2_3	734	738	PF12436	0.249
DOC_WW_Pin1_4	108	113	PF00397	0.578
DOC_WW_Pin1_4	705	710	PF00397	0.444
LIG_14-3-3_CanoR_1	233	240	PF00244	0.434
LIG_14-3-3_CanoR_1	284	292	PF00244	0.513
LIG_14-3-3_CanoR_1	309	317	PF00244	0.463
LIG_14-3-3_CanoR_1	446	453	PF00244	0.350
LIG_14-3-3_CanoR_1	492	496	PF00244	0.466
LIG_14-3-3_CanoR_1	505	509	PF00244	0.377
LIG_14-3-3_CanoR_1	619	625	PF00244	0.429
LIG_14-3-3_CanoR_1	72	81	PF00244	0.519
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BIR_III_2	595	599	PF00653	0.479
LIG_BIR_III_4	682	686	PF00653	0.456
LIG_BRCT_BRCA1_1	349	353	PF00533	0.580
LIG_BRCT_BRCA1_1	767	771	PF00533	0.423
LIG_BRCT_BRCA1_2	349	355	PF00533	0.624
LIG_FHA_1	416	422	PF00498	0.326
LIG_FHA_1	447	453	PF00498	0.344
LIG_FHA_1	485	491	PF00498	0.375
LIG_FHA_1	511	517	PF00498	0.442
LIG_FHA_1	572	578	PF00498	0.256
LIG_FHA_1	653	659	PF00498	0.454
LIG_FHA_1	694	700	PF00498	0.666
LIG_FHA_1	759	765	PF00498	0.514
LIG_FHA_2	129	135	PF00498	0.577
LIG_FHA_2	26	32	PF00498	0.660
LIG_FHA_2	54	60	PF00498	0.676
LIG_FHA_2	582	588	PF00498	0.425
LIG_FHA_2	621	627	PF00498	0.423
LIG_FHA_2	743	749	PF00498	0.412
LIG_LIR_Gen_1	372	378	PF02991	0.513
LIG_LIR_Gen_1	468	477	PF02991	0.419
LIG_LIR_Gen_1	487	496	PF02991	0.234
LIG_LIR_Gen_1	67	75	PF02991	0.642
LIG_LIR_Gen_1	751	759	PF02991	0.412
LIG_LIR_Nem_3	468	474	PF02991	0.329
LIG_LIR_Nem_3	487	491	PF02991	0.309
LIG_LIR_Nem_3	507	511	PF02991	0.349
LIG_LIR_Nem_3	519	523	PF02991	0.349
LIG_LIR_Nem_3	67	71	PF02991	0.630
LIG_LIR_Nem_3	751	756	PF02991	0.412
LIG_Pex14_1	373	377	PF04695	0.417
LIG_PTB_Apo_2	239	246	PF02174	0.264
LIG_PTB_Apo_2	576	583	PF02174	0.412
LIG_PTB_Apo_2	736	743	PF02174	0.412
LIG_PTB_Phospho_1	239	245	PF10480	0.309
LIG_SH2_GRB2like	377	380	PF00017	0.420
LIG_SH2_NCK_1	493	497	PF00017	0.448
LIG_SH2_STAP1	573	577	PF00017	0.389
LIG_SH2_STAT5	245	248	PF00017	0.455
LIG_SH2_STAT5	416	419	PF00017	0.367
LIG_SH2_STAT5	493	496	PF00017	0.319
LIG_SH2_STAT5	573	576	PF00017	0.401
LIG_SH2_STAT5	632	635	PF00017	0.412
LIG_SH3_3	263	269	PF00018	0.412
LIG_SH3_3	543	549	PF00018	0.424
LIG_SH3_3	759	765	PF00018	0.429
LIG_Sin3_3	563	570	PF02671	0.358
LIG_TRAF2_1	137	140	PF00917	0.553
LIG_TRAF2_1	227	230	PF00917	0.480
LIG_TRAF2_1	247	250	PF00917	0.320
LIG_TRAF2_1	312	315	PF00917	0.549
LIG_TRAF2_1	42	45	PF00917	0.685
LIG_TYR_ITIM	812	817	PF00017	0.354
MOD_CDK_SPxxK_3	108	115	PF00069	0.487
MOD_CK1_1	21	27	PF00069	0.563
MOD_CK1_1	447	453	PF00069	0.347
MOD_CK1_1	484	490	PF00069	0.439
MOD_CK1_1	652	658	PF00069	0.435
MOD_CK1_1	73	79	PF00069	0.569
MOD_CK1_1	754	760	PF00069	0.283
MOD_CK2_1	25	31	PF00069	0.774
MOD_CK2_1	283	289	PF00069	0.375
MOD_CK2_1	308	314	PF00069	0.418
MOD_CK2_1	39	45	PF00069	0.579
MOD_CK2_1	582	588	PF00069	0.270
MOD_CK2_1	770	776	PF00069	0.295
MOD_CK2_1	786	792	PF00069	0.255
MOD_Cter_Amidation	2	5	PF01082	0.467
MOD_Cter_Amidation	211	214	PF01082	0.530
MOD_GlcNHglycan	1	4	PF01048	0.709
MOD_GlcNHglycan	104	107	PF01048	0.734
MOD_GlcNHglycan	168	171	PF01048	0.562
MOD_GlcNHglycan	20	23	PF01048	0.625
MOD_GlcNHglycan	286	289	PF01048	0.412
MOD_GlcNHglycan	310	313	PF01048	0.397
MOD_GlcNHglycan	478	482	PF01048	0.391
MOD_GlcNHglycan	483	486	PF01048	0.365
MOD_GlcNHglycan	533	536	PF01048	0.628
MOD_GlcNHglycan	549	552	PF01048	0.647
MOD_GlcNHglycan	561	564	PF01048	0.539
MOD_GlcNHglycan	713	716	PF01048	0.732
MOD_GlcNHglycan	719	722	PF01048	0.745
MOD_GlcNHglycan	753	756	PF01048	0.322
MOD_GSK3_1	18	25	PF00069	0.753
MOD_GSK3_1	185	192	PF00069	0.762
MOD_GSK3_1	3	10	PF00069	0.710
MOD_GSK3_1	343	350	PF00069	0.579
MOD_GSK3_1	442	449	PF00069	0.515
MOD_GSK3_1	477	484	PF00069	0.351
MOD_GSK3_1	571	578	PF00069	0.313
MOD_GSK3_1	645	652	PF00069	0.417
MOD_GSK3_1	711	718	PF00069	0.702
MOD_GSK3_1	73	80	PF00069	0.518
MOD_GSK3_1	754	761	PF00069	0.282
MOD_GSK3_1	765	772	PF00069	0.156
MOD_GSK3_1	796	803	PF00069	0.283
MOD_N-GLC_1	206	211	PF02516	0.684
MOD_N-GLC_1	447	452	PF02516	0.345
MOD_NEK2_1	142	147	PF00069	0.479
MOD_NEK2_1	166	171	PF00069	0.530
MOD_NEK2_1	23	28	PF00069	0.658
MOD_NEK2_1	255	260	PF00069	0.249
MOD_NEK2_1	283	288	PF00069	0.162
MOD_NEK2_1	308	313	PF00069	0.388
MOD_NEK2_1	329	334	PF00069	0.569
MOD_NEK2_1	347	352	PF00069	0.660
MOD_NEK2_1	442	447	PF00069	0.509
MOD_NEK2_1	477	482	PF00069	0.351
MOD_NEK2_1	491	496	PF00069	0.402
MOD_NEK2_1	510	515	PF00069	0.404
MOD_NEK2_1	571	576	PF00069	0.333
MOD_NEK2_1	800	805	PF00069	0.274
MOD_NEK2_2	262	267	PF00069	0.222
MOD_NEK2_2	796	801	PF00069	0.283
MOD_PIKK_1	221	227	PF00454	0.533
MOD_PIKK_1	348	354	PF00454	0.608
MOD_PIKK_1	436	442	PF00454	0.573
MOD_PKA_2	114	120	PF00069	0.598
MOD_PKA_2	189	195	PF00069	0.465
MOD_PKA_2	232	238	PF00069	0.422
MOD_PKA_2	283	289	PF00069	0.325
MOD_PKA_2	3	9	PF00069	0.542
MOD_PKA_2	308	314	PF00069	0.373
MOD_PKA_2	39	45	PF00069	0.512
MOD_PKA_2	491	497	PF00069	0.376
MOD_PKA_2	504	510	PF00069	0.385
MOD_PKA_2	765	771	PF00069	0.264
MOD_Plk_1	447	453	PF00069	0.360
MOD_Plk_1	477	483	PF00069	0.329
MOD_Plk_1	625	631	PF00069	0.249
MOD_Plk_2-3	786	792	PF00069	0.249
MOD_Plk_4	255	261	PF00069	0.313
MOD_Plk_4	372	378	PF00069	0.435
MOD_Plk_4	447	453	PF00069	0.327
MOD_Plk_4	571	577	PF00069	0.367
MOD_Plk_4	603	609	PF00069	0.281
MOD_ProDKin_1	108	114	PF00069	0.576
MOD_ProDKin_1	705	711	PF00069	0.444
MOD_SUMO_rev_2	169	176	PF00179	0.669
MOD_SUMO_rev_2	99	105	PF00179	0.658
TRG_AP2beta_CARGO_1	751	760	PF09066	0.283
TRG_DiLeu_BaEn_2	587	593	PF01217	0.343
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.251
TRG_ENDOCYTIC_2	508	511	PF00928	0.337
TRG_ENDOCYTIC_2	573	576	PF00928	0.434
TRG_ENDOCYTIC_2	814	817	PF00928	0.345
TRG_ER_diArg_1	115	118	PF00400	0.713
TRG_ER_diArg_1	237	240	PF00400	0.332
TRG_ER_diArg_1	63	66	PF00400	0.544
TRG_ER_diArg_1	676	678	PF00400	0.473
TRG_ER_diArg_1	701	703	PF00400	0.705
TRG_NES_CRM1_1	466	478	PF08389	0.405
TRG_NLS_MonoExtC_3	35	40	PF00514	0.740
TRG_NLS_MonoExtN_4	34	40	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	808	813	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY42	Leptomonas seymouri	67%	87%
A0A0S4J8G6	Bodo saltans	42%	91%
A0A1X0NQT4	Trypanosomatidae	50%	94%
A0A3Q8I7R0	Leishmania donovani	91%	86%
A0A3R7NQE9	Trypanosoma rangeli	50%	96%
A4H661	Leishmania braziliensis	79%	100%
A4HUI2	Leishmania infantum	91%	86%
C9ZVK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	96%
P0CR16	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	29%	100%
P0CR17	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	29%	100%
Q06106	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	92%
Q4QHE5	Leishmania major	90%	100%
Q4WJT7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	99%
Q5BGA9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q8R3C6	Mus musculus	28%	86%
V5B419	Trypanosoma cruzi	50%	100%