Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN78_LEIMU

TriTrypDb:

LmxM.10.0680

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.585
CLV_NRD_NRD_1	122	124	PF00675	0.586
CLV_NRD_NRD_1	175	177	PF00675	0.701
CLV_NRD_NRD_1	325	327	PF00675	0.866
CLV_NRD_NRD_1	391	393	PF00675	0.527
CLV_NRD_NRD_1	474	476	PF00675	0.689
CLV_PCSK_KEX2_1	122	124	PF00082	0.586
CLV_PCSK_KEX2_1	175	177	PF00082	0.751
CLV_PCSK_KEX2_1	325	327	PF00082	0.866
CLV_PCSK_KEX2_1	474	476	PF00082	0.682
CLV_PCSK_KEX2_1	54	56	PF00082	0.654
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.732
CLV_PCSK_SKI1_1	168	172	PF00082	0.718
CLV_PCSK_SKI1_1	218	222	PF00082	0.676
CLV_PCSK_SKI1_1	383	387	PF00082	0.548
CLV_PCSK_SKI1_1	68	72	PF00082	0.718
DEG_APCC_DBOX_1	35	43	PF00400	0.643
DEG_APCC_DBOX_1	67	75	PF00400	0.456
DEG_Nend_UBRbox_4	1	3	PF02207	0.537
DEG_SPOP_SBC_1	346	350	PF00917	0.817
DOC_CKS1_1	365	370	PF01111	0.724
DOC_CKS1_1	418	423	PF01111	0.738
DOC_CYCLIN_RxL_1	215	224	PF00134	0.672
DOC_MAPK_gen_1	162	172	PF00069	0.718
DOC_MAPK_gen_1	65	74	PF00069	0.713
DOC_MAPK_MEF2A_6	3	10	PF00069	0.524
DOC_MAPK_MEF2A_6	32	39	PF00069	0.660
DOC_PP2B_LxvP_1	28	31	PF13499	0.585
DOC_PP2B_LxvP_1	8	11	PF13499	0.685
DOC_PP4_FxxP_1	377	380	PF00568	0.550
DOC_USP7_MATH_1	103	107	PF00917	0.835
DOC_USP7_MATH_1	111	115	PF00917	0.717
DOC_USP7_MATH_1	141	145	PF00917	0.777
DOC_USP7_MATH_1	174	178	PF00917	0.698
DOC_USP7_MATH_1	279	283	PF00917	0.806
DOC_USP7_MATH_1	317	321	PF00917	0.702
DOC_USP7_MATH_1	329	333	PF00917	0.790
DOC_USP7_MATH_1	347	351	PF00917	0.513
DOC_USP7_MATH_1	440	444	PF00917	0.723
DOC_USP7_MATH_1	9	13	PF00917	0.640
DOC_WW_Pin1_4	107	112	PF00397	0.652
DOC_WW_Pin1_4	219	224	PF00397	0.525
DOC_WW_Pin1_4	358	363	PF00397	0.849
DOC_WW_Pin1_4	364	369	PF00397	0.749
DOC_WW_Pin1_4	417	422	PF00397	0.736
DOC_WW_Pin1_4	96	101	PF00397	0.826
LIG_14-3-3_CanoR_1	122	129	PF00244	0.725
LIG_14-3-3_CanoR_1	188	193	PF00244	0.606
LIG_14-3-3_CanoR_1	269	278	PF00244	0.648
LIG_14-3-3_CanoR_1	325	329	PF00244	0.654
LIG_14-3-3_CanoR_1	331	339	PF00244	0.659
LIG_14-3-3_CanoR_1	352	360	PF00244	0.824
LIG_14-3-3_CanoR_1	36	40	PF00244	0.670
LIG_14-3-3_CanoR_1	48	57	PF00244	0.524
LIG_14-3-3_CanoR_1	485	493	PF00244	0.710
LIG_14-3-3_CanoR_1	87	96	PF00244	0.828
LIG_Actin_WH2_2	394	411	PF00022	0.634
LIG_APCC_ABBA_1	496	501	PF00400	0.712
LIG_BIR_III_2	126	130	PF00653	0.716
LIG_Clathr_ClatBox_1	74	78	PF01394	0.490
LIG_EH_1	424	428	PF12763	0.585
LIG_EVH1_1	30	34	PF00568	0.778
LIG_FHA_1	380	386	PF00498	0.548
LIG_FHA_1	91	97	PF00498	0.545
LIG_FHA_2	193	199	PF00498	0.813
LIG_FHA_2	222	228	PF00498	0.515
LIG_FHA_2	428	434	PF00498	0.737
LIG_LIR_Apic_2	147	151	PF02991	0.737
LIG_LIR_LC3C_4	169	173	PF02991	0.600
LIG_NRBOX	254	260	PF00104	0.720
LIG_NRBOX	70	76	PF00104	0.466
LIG_SH2_SRC	21	24	PF00017	0.701
LIG_SH2_STAT5	270	273	PF00017	0.521
LIG_SH2_STAT5	468	471	PF00017	0.794
LIG_SH3_2	223	228	PF14604	0.513
LIG_SH3_2	31	36	PF14604	0.777
LIG_SH3_3	220	226	PF00018	0.673
LIG_SH3_3	28	34	PF00018	0.782
LIG_SH3_3	297	303	PF00018	0.581
LIG_SH3_3	354	360	PF00018	0.851
LIG_SH3_3	362	368	PF00018	0.714
LIG_SH3_3	420	426	PF00018	0.738
LIG_SH3_3	79	85	PF00018	0.791
LIG_SH3_CIN85_PxpxPR_1	31	36	PF14604	0.777
LIG_SUMO_SIM_par_1	6	12	PF11976	0.524
LIG_TRAF2_1	240	243	PF00917	0.736
LIG_WW_3	33	37	PF00397	0.771
MOD_CDK_SPK_2	364	369	PF00069	0.721
MOD_CK1_1	106	112	PF00069	0.773
MOD_CK1_1	144	150	PF00069	0.742
MOD_CK1_1	179	185	PF00069	0.773
MOD_CK1_1	327	333	PF00069	0.759
MOD_CK1_1	351	357	PF00069	0.727
MOD_CK1_1	358	364	PF00069	0.734
MOD_CK1_1	494	500	PF00069	0.690
MOD_CK2_1	110	116	PF00069	0.845
MOD_CK2_1	179	185	PF00069	0.692
MOD_CK2_1	192	198	PF00069	0.679
MOD_CK2_1	201	207	PF00069	0.679
MOD_CK2_1	440	446	PF00069	0.724
MOD_GlcNHglycan	105	108	PF01048	0.744
MOD_GlcNHglycan	11	14	PF01048	0.644
MOD_GlcNHglycan	283	286	PF01048	0.643
MOD_GlcNHglycan	334	337	PF01048	0.701
MOD_GlcNHglycan	357	360	PF01048	0.850
MOD_GlcNHglycan	372	375	PF01048	0.617
MOD_GlcNHglycan	440	443	PF01048	0.723
MOD_GlcNHglycan	452	455	PF01048	0.587
MOD_GlcNHglycan	489	492	PF01048	0.709
MOD_GSK3_1	103	110	PF00069	0.697
MOD_GSK3_1	140	147	PF00069	0.588
MOD_GSK3_1	176	183	PF00069	0.768
MOD_GSK3_1	188	195	PF00069	0.595
MOD_GSK3_1	301	308	PF00069	0.714
MOD_GSK3_1	309	316	PF00069	0.621
MOD_GSK3_1	347	354	PF00069	0.837
MOD_GSK3_1	375	382	PF00069	0.704
MOD_GSK3_1	440	447	PF00069	0.720
MOD_GSK3_1	481	488	PF00069	0.768
MOD_GSK3_1	497	504	PF00069	0.523
MOD_GSK3_1	87	94	PF00069	0.677
MOD_N-GLC_1	141	146	PF02516	0.497
MOD_N-GLC_1	305	310	PF02516	0.715
MOD_N-GLC_1	427	432	PF02516	0.737
MOD_N-GLC_1	481	486	PF02516	0.668
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	192	197	PF00069	0.653
MOD_NEK2_1	241	246	PF00069	0.706
MOD_NEK2_1	259	264	PF00069	0.673
MOD_NEK2_1	408	413	PF00069	0.710
MOD_NEK2_1	427	432	PF00069	0.755
MOD_NEK2_1	444	449	PF00069	0.620
MOD_NEK2_1	77	82	PF00069	0.776
MOD_NEK2_2	440	445	PF00069	0.725
MOD_PIKK_1	141	147	PF00454	0.771
MOD_PIKK_1	21	27	PF00454	0.800
MOD_PIKK_1	221	227	PF00454	0.521
MOD_PIKK_1	247	253	PF00454	0.711
MOD_PIKK_1	410	416	PF00454	0.681
MOD_PIKK_1	446	452	PF00454	0.708
MOD_PKA_2	121	127	PF00069	0.733
MOD_PKA_2	174	180	PF00069	0.750
MOD_PKA_2	193	199	PF00069	0.505
MOD_PKA_2	268	274	PF00069	0.635
MOD_PKA_2	301	307	PF00069	0.579
MOD_PKA_2	324	330	PF00069	0.581
MOD_PKA_2	35	41	PF00069	0.672
MOD_PKA_2	351	357	PF00069	0.820
MOD_PKA_2	408	414	PF00069	0.658
MOD_PKA_2	444	450	PF00069	0.713
MOD_Plk_1	305	311	PF00069	0.852
MOD_Plk_1	464	470	PF00069	0.551
MOD_Plk_4	144	150	PF00069	0.742
MOD_Plk_4	188	194	PF00069	0.788
MOD_Plk_4	234	240	PF00069	0.621
MOD_Plk_4	259	265	PF00069	0.733
MOD_Plk_4	305	311	PF00069	0.852
MOD_Plk_4	464	470	PF00069	0.554
MOD_ProDKin_1	107	113	PF00069	0.655
MOD_ProDKin_1	219	225	PF00069	0.524
MOD_ProDKin_1	358	364	PF00069	0.848
MOD_ProDKin_1	417	423	PF00069	0.737
MOD_ProDKin_1	96	102	PF00069	0.828
MOD_SUMO_for_1	156	159	PF00179	0.447
MOD_SUMO_rev_2	51	56	PF00179	0.555
TRG_ENDOCYTIC_2	190	193	PF00928	0.521
TRG_ER_diArg_1	324	326	PF00400	0.712
TRG_ER_diArg_1	86	89	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC56	Leishmania donovani	79%	100%
A4HUI0	Leishmania infantum	79%	100%
Q4QHE7	Leishmania major	77%	100%