Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN75_LEIMU

TriTrypDb:

LmxM.10.0650

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.681
CLV_NRD_NRD_1	112	114	PF00675	0.560
CLV_NRD_NRD_1	117	119	PF00675	0.607
CLV_NRD_NRD_1	169	171	PF00675	0.567
CLV_NRD_NRD_1	181	183	PF00675	0.567
CLV_NRD_NRD_1	191	193	PF00675	0.551
CLV_NRD_NRD_1	308	310	PF00675	0.647
CLV_NRD_NRD_1	78	80	PF00675	0.621
CLV_NRD_NRD_1	81	83	PF00675	0.572
CLV_NRD_NRD_1	84	86	PF00675	0.569
CLV_PCSK_FUR_1	115	119	PF00082	0.614
CLV_PCSK_FUR_1	76	80	PF00082	0.678
CLV_PCSK_FUR_1	82	86	PF00082	0.620
CLV_PCSK_KEX2_1	112	114	PF00082	0.562
CLV_PCSK_KEX2_1	117	119	PF00082	0.608
CLV_PCSK_KEX2_1	181	183	PF00082	0.627
CLV_PCSK_KEX2_1	191	193	PF00082	0.557
CLV_PCSK_KEX2_1	308	310	PF00082	0.633
CLV_PCSK_KEX2_1	5	7	PF00082	0.797
CLV_PCSK_KEX2_1	78	80	PF00082	0.621
CLV_PCSK_KEX2_1	81	83	PF00082	0.572
CLV_PCSK_KEX2_1	84	86	PF00082	0.569
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.616
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.797
CLV_PCSK_PC7_1	113	119	PF00082	0.606
CLV_PCSK_SKI1_1	171	175	PF00082	0.649
CLV_PCSK_SKI1_1	182	186	PF00082	0.478
CLV_PCSK_SKI1_1	19	23	PF00082	0.693
CLV_PCSK_SKI1_1	232	236	PF00082	0.797
CLV_PCSK_SKI1_1	35	39	PF00082	0.515
CLV_PCSK_SKI1_1	64	68	PF00082	0.621
DEG_APCC_DBOX_1	180	188	PF00400	0.555
DEG_Kelch_Keap1_1	207	212	PF01344	0.764
DEG_Nend_Nbox_1	1	3	PF02207	0.799
DOC_CYCLIN_yCln2_LP_2	374	377	PF00134	0.642
DOC_MAPK_gen_1	115	125	PF00069	0.494
DOC_MAPK_gen_1	178	187	PF00069	0.648
DOC_MAPK_MEF2A_6	118	127	PF00069	0.518
DOC_MAPK_RevD_3	65	79	PF00069	0.705
DOC_PP1_RVXF_1	256	263	PF00149	0.515
DOC_PP1_RVXF_1	333	339	PF00149	0.674
DOC_PP2B_LxvP_1	123	126	PF13499	0.689
DOC_PP2B_LxvP_1	203	206	PF13499	0.626
DOC_PP2B_LxvP_1	21	24	PF13499	0.694
DOC_PP2B_LxvP_1	354	357	PF13499	0.598
DOC_PP2B_LxvP_1	374	377	PF13499	0.642
DOC_PP4_FxxP_1	15	18	PF00568	0.767
DOC_WW_Pin1_4	204	209	PF00397	0.653
DOC_WW_Pin1_4	251	256	PF00397	0.650
DOC_WW_Pin1_4	52	57	PF00397	0.530
LIG_APCC_ABBA_1	361	366	PF00400	0.668
LIG_CaM_IQ_9	185	200	PF13499	0.637
LIG_deltaCOP1_diTrp_1	366	372	PF00928	0.672
LIG_FHA_1	103	109	PF00498	0.606
LIG_FHA_1	157	163	PF00498	0.631
LIG_FHA_1	208	214	PF00498	0.669
LIG_FHA_1	252	258	PF00498	0.717
LIG_FHA_1	70	76	PF00498	0.548
LIG_FHA_2	178	184	PF00498	0.370
LIG_FHA_2	318	324	PF00498	0.723
LIG_GBD_Chelix_1	341	349	PF00786	0.688
LIG_LIR_Apic_2	12	18	PF02991	0.770
LIG_LIR_Gen_1	337	345	PF02991	0.673
LIG_LIR_Gen_1	346	355	PF02991	0.566
LIG_LIR_Nem_3	259	265	PF02991	0.517
LIG_LIR_Nem_3	337	341	PF02991	0.586
LIG_LIR_Nem_3	344	350	PF02991	0.507
LIG_LIR_Nem_3	351	356	PF02991	0.467
LIG_LIR_Nem_3	370	375	PF02991	0.597
LIG_MYND_1	14	18	PF01753	0.765
LIG_NRBOX	183	189	PF00104	0.660
LIG_PTB_Apo_2	307	314	PF02174	0.717
LIG_PTB_Phospho_1	307	313	PF10480	0.711
LIG_SH2_CRK	221	225	PF00017	0.633
LIG_SH2_NCK_1	347	351	PF00017	0.659
LIG_SH2_STAT3	303	306	PF00017	0.679
LIG_SH2_STAT5	300	303	PF00017	0.547
LIG_SH2_STAT5	353	356	PF00017	0.552
LIG_SH3_3	143	149	PF00018	0.627
LIG_SH3_3	21	27	PF00018	0.504
LIG_SH3_3	284	290	PF00018	0.573
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.664
LIG_SUMO_SIM_par_1	201	207	PF11976	0.629
LIG_SUMO_SIM_par_1	64	70	PF11976	0.560
LIG_TRFH_1	372	376	PF08558	0.702
LIG_TYR_ITIM	345	350	PF00017	0.609
LIG_UBA3_1	162	171	PF00899	0.654
LIG_UBA3_1	184	193	PF00899	0.680
MOD_CDK_SPxxK_3	251	258	PF00069	0.671
MOD_CK1_1	150	156	PF00069	0.664
MOD_CK1_1	164	170	PF00069	0.542
MOD_CK1_1	207	213	PF00069	0.661
MOD_CK1_1	315	321	PF00069	0.638
MOD_CK2_1	177	183	PF00069	0.369
MOD_GlcNHglycan	127	130	PF01048	0.681
MOD_GlcNHglycan	143	146	PF01048	0.581
MOD_GlcNHglycan	149	152	PF01048	0.718
MOD_GlcNHglycan	282	285	PF01048	0.618
MOD_GlcNHglycan	35	38	PF01048	0.601
MOD_GSK3_1	107	114	PF00069	0.444
MOD_GSK3_1	121	128	PF00069	0.654
MOD_GSK3_1	157	164	PF00069	0.468
MOD_GSK3_1	239	246	PF00069	0.689
MOD_NEK2_1	102	107	PF00069	0.622
MOD_NEK2_1	111	116	PF00069	0.522
MOD_NEK2_1	177	182	PF00069	0.446
MOD_NEK2_1	69	74	PF00069	0.605
MOD_PIKK_1	267	273	PF00454	0.532
MOD_PK_1	121	127	PF00069	0.535
MOD_PKA_2	111	117	PF00069	0.397
MOD_PKA_2	138	144	PF00069	0.704
MOD_PKA_2	239	245	PF00069	0.832
MOD_Plk_1	121	127	PF00069	0.535
MOD_Plk_1	322	328	PF00069	0.739
MOD_Plk_2-3	322	328	PF00069	0.679
MOD_ProDKin_1	204	210	PF00069	0.654
MOD_ProDKin_1	251	257	PF00069	0.647
MOD_ProDKin_1	52	58	PF00069	0.525
TRG_DiLeu_BaEn_1	12	17	PF01217	0.772
TRG_DiLeu_BaEn_1	183	188	PF01217	0.646
TRG_ENDOCYTIC_2	221	224	PF00928	0.641
TRG_ENDOCYTIC_2	347	350	PF00928	0.553
TRG_ENDOCYTIC_2	353	356	PF00928	0.520
TRG_ER_diArg_1	111	113	PF00400	0.574
TRG_ER_diArg_1	115	118	PF00400	0.603
TRG_ER_diArg_1	75	78	PF00400	0.673
TRG_ER_diArg_1	79	82	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X7	Leptomonas seymouri	36%	96%
A0A3S7WR94	Leishmania donovani	88%	100%
A4H657	Leishmania braziliensis	74%	100%
A4HUH7	Leishmania infantum	89%	100%
Q4QHF0	Leishmania major	86%	100%