C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN74_LEIMU

TriTrypDb:

LmxM.10.0640

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN74

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.559
CLV_NRD_NRD_1	19	21	PF00675	0.692
CLV_PCSK_KEX2_1	176	178	PF00082	0.559
CLV_PCSK_KEX2_1	18	20	PF00082	0.746
CLV_PCSK_SKI1_1	239	243	PF00082	0.623
DEG_SPOP_SBC_1	138	142	PF00917	0.692
DOC_CKS1_1	213	218	PF01111	0.631
DOC_USP7_MATH_1	137	141	PF00917	0.666
DOC_USP7_MATH_1	151	155	PF00917	0.513
DOC_USP7_MATH_1	189	193	PF00917	0.695
DOC_USP7_MATH_1	204	208	PF00917	0.576
DOC_WW_Pin1_4	154	159	PF00397	0.623
DOC_WW_Pin1_4	212	217	PF00397	0.639
DOC_WW_Pin1_4	30	35	PF00397	0.583
DOC_WW_Pin1_4	49	54	PF00397	0.403
DOC_WW_Pin1_4	67	72	PF00397	0.453
LIG_14-3-3_CterR_2	239	243	PF00244	0.694
LIG_Actin_WH2_2	53	70	PF00022	0.638
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	192	196	PF00533	0.454
LIG_FHA_1	196	202	PF00498	0.719
LIG_FHA_2	100	106	PF00498	0.755
LIG_LIR_Gen_1	54	62	PF02991	0.617
LIG_LIR_Nem_3	3	9	PF02991	0.451
LIG_LIR_Nem_3	54	60	PF02991	0.601
LIG_LIR_Nem_3	80	84	PF02991	0.481
LIG_LIR_Nem_3	86	91	PF02991	0.558
LIG_NRBOX	126	132	PF00104	0.779
LIG_PTB_Apo_2	181	188	PF02174	0.636
LIG_PTB_Phospho_1	181	187	PF10480	0.632
LIG_SH2_CRK	48	52	PF00017	0.558
LIG_SH2_NCK_1	57	61	PF00017	0.619
LIG_SH2_STAT5	27	30	PF00017	0.572
LIG_SH2_STAT5	48	51	PF00017	0.588
LIG_SH3_3	147	153	PF00018	0.660
LIG_SH3_3	155	161	PF00018	0.573
LIG_SH3_3	7	13	PF00018	0.740
LIG_WW_2	150	153	PF00397	0.675
MOD_CK1_1	123	129	PF00069	0.771
MOD_CK1_1	141	147	PF00069	0.673
MOD_CK1_1	154	160	PF00069	0.474
MOD_CK2_1	99	105	PF00069	0.749
MOD_GlcNHglycan	118	121	PF01048	0.595
MOD_GlcNHglycan	122	125	PF01048	0.656
MOD_GlcNHglycan	131	134	PF01048	0.530
MOD_GlcNHglycan	135	138	PF01048	0.492
MOD_GlcNHglycan	143	146	PF01048	0.469
MOD_GlcNHglycan	206	209	PF01048	0.611
MOD_GSK3_1	114	121	PF00069	0.723
MOD_GSK3_1	125	132	PF00069	0.711
MOD_GSK3_1	133	140	PF00069	0.674
MOD_GSK3_1	63	70	PF00069	0.631
MOD_N-GLC_1	190	195	PF02516	0.665
MOD_N-GLC_1	30	35	PF02516	0.656
MOD_NEK2_1	114	119	PF00069	0.627
MOD_NEK2_1	131	136	PF00069	0.771
MOD_NEK2_1	196	201	PF00069	0.450
MOD_NEK2_1	203	208	PF00069	0.372
MOD_Plk_1	182	188	PF00069	0.690
MOD_Plk_1	63	69	PF00069	0.661
MOD_Plk_4	126	132	PF00069	0.789
MOD_Plk_4	182	188	PF00069	0.687
MOD_ProDKin_1	154	160	PF00069	0.617
MOD_ProDKin_1	212	218	PF00069	0.632
MOD_ProDKin_1	30	36	PF00069	0.575
MOD_ProDKin_1	49	55	PF00069	0.402
MOD_ProDKin_1	67	73	PF00069	0.446
TRG_ENDOCYTIC_2	48	51	PF00928	0.546
TRG_ENDOCYTIC_2	57	60	PF00928	0.533
TRG_ENDOCYTIC_2	6	9	PF00928	0.452
TRG_ENDOCYTIC_2	88	91	PF00928	0.555
TRG_ER_diArg_1	175	177	PF00400	0.556
TRG_ER_diArg_1	18	20	PF00400	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD67	Leptomonas seymouri	63%	99%
A0A0S4J8D0	Bodo saltans	27%	100%
A0A3S7WR77	Leishmania donovani	94%	100%
A4H656	Leishmania braziliensis	85%	100%
A4HUH6	Leishmania infantum	94%	100%
C9ZVJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QHF1	Leishmania major	93%	100%