Flagellar glycoprotein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum adhesion protein 1

Species:

Leishmania mexicana

UniProt:

E9AN73_LEIMU

TriTrypDb:

LmxM.10.0630

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0016020	membrane	2	6
GO:0031514	motile cilium	5	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

E9AN73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.383
CLV_C14_Caspase3-7	73	77	PF00656	0.444
CLV_NRD_NRD_1	10	12	PF00675	0.804
CLV_NRD_NRD_1	126	128	PF00675	0.688
CLV_PCSK_KEX2_1	10	12	PF00082	0.772
CLV_PCSK_KEX2_1	128	130	PF00082	0.569
CLV_PCSK_KEX2_1	516	518	PF00082	0.674
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.569
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.674
CLV_PCSK_SKI1_1	519	523	PF00082	0.550
CLV_PCSK_SKI1_1	545	549	PF00082	0.734
DEG_APCC_DBOX_1	518	526	PF00400	0.370
DOC_CKS1_1	190	195	PF01111	0.437
DOC_CKS1_1	276	281	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	457	460	PF00134	0.442
DOC_MAPK_MEF2A_6	115	122	PF00069	0.281
DOC_MAPK_MEF2A_6	18	26	PF00069	0.608
DOC_MAPK_MEF2A_6	191	200	PF00069	0.318
DOC_PP1_RVXF_1	499	506	PF00149	0.302
DOC_PP2B_LxvP_1	218	221	PF13499	0.450
DOC_PP2B_LxvP_1	457	460	PF13499	0.442
DOC_PP4_FxxP_1	456	459	PF00568	0.500
DOC_PP4_FxxP_1	495	498	PF00568	0.453
DOC_USP7_MATH_1	312	316	PF00917	0.344
DOC_USP7_MATH_1	318	322	PF00917	0.314
DOC_USP7_MATH_1	368	372	PF00917	0.587
DOC_USP7_MATH_1	482	486	PF00917	0.531
DOC_USP7_MATH_1	567	571	PF00917	0.456
DOC_USP7_MATH_2	368	374	PF00917	0.550
DOC_WW_Pin1_4	18	23	PF00397	0.675
DOC_WW_Pin1_4	189	194	PF00397	0.406
DOC_WW_Pin1_4	222	227	PF00397	0.489
DOC_WW_Pin1_4	275	280	PF00397	0.490
DOC_WW_Pin1_4	316	321	PF00397	0.464
DOC_WW_Pin1_4	361	366	PF00397	0.414
DOC_WW_Pin1_4	38	43	PF00397	0.538
DOC_WW_Pin1_4	45	50	PF00397	0.555
DOC_WW_Pin1_4	510	515	PF00397	0.396
DOC_WW_Pin1_4	585	590	PF00397	0.534
DOC_WW_Pin1_4	9	14	PF00397	0.750
LIG_14-3-3_CanoR_1	150	155	PF00244	0.447
LIG_14-3-3_CanoR_1	191	197	PF00244	0.404
LIG_14-3-3_CanoR_1	204	208	PF00244	0.306
LIG_14-3-3_CanoR_1	345	353	PF00244	0.410
LIG_14-3-3_CanoR_1	541	547	PF00244	0.409
LIG_APCC_ABBA_1	339	344	PF00400	0.371
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	249	253	PF00533	0.390
LIG_BRCT_BRCA1_1	589	593	PF00533	0.675
LIG_deltaCOP1_diTrp_1	512	521	PF00928	0.296
LIG_EVH1_2	22	26	PF00568	0.447
LIG_FHA_1	179	185	PF00498	0.449
LIG_FHA_1	26	32	PF00498	0.650
LIG_FHA_1	276	282	PF00498	0.429
LIG_FHA_1	293	299	PF00498	0.375
LIG_FHA_1	336	342	PF00498	0.459
LIG_FHA_1	354	360	PF00498	0.383
LIG_FHA_1	462	468	PF00498	0.604
LIG_FHA_1	487	493	PF00498	0.409
LIG_FHA_1	592	598	PF00498	0.776
LIG_FHA_2	164	170	PF00498	0.316
LIG_FHA_2	463	469	PF00498	0.482
LIG_GBD_Chelix_1	163	171	PF00786	0.581
LIG_HOMEOBOX	436	439	PF00046	0.302
LIG_LIR_Apic_2	265	269	PF02991	0.476
LIG_LIR_Apic_2	455	459	PF02991	0.546
LIG_LIR_Gen_1	28	37	PF02991	0.467
LIG_LIR_Gen_1	355	366	PF02991	0.450
LIG_LIR_Gen_1	433	444	PF02991	0.451
LIG_LIR_Gen_1	58	69	PF02991	0.445
LIG_LIR_Gen_1	590	601	PF02991	0.704
LIG_LIR_Nem_3	138	144	PF02991	0.480
LIG_LIR_Nem_3	28	33	PF02991	0.464
LIG_LIR_Nem_3	283	287	PF02991	0.469
LIG_LIR_Nem_3	347	353	PF02991	0.371
LIG_LIR_Nem_3	355	361	PF02991	0.368
LIG_LIR_Nem_3	437	441	PF02991	0.362
LIG_LIR_Nem_3	58	64	PF02991	0.416
LIG_LIR_Nem_3	590	596	PF02991	0.694
LIG_MYND_1	320	324	PF01753	0.446
LIG_Pex14_2	26	30	PF04695	0.505
LIG_Pex14_2	452	456	PF04695	0.395
LIG_PTB_Apo_2	155	162	PF02174	0.430
LIG_REV1ctd_RIR_1	340	349	PF16727	0.439
LIG_SH2_CRK	61	65	PF00017	0.424
LIG_SH2_CRK	84	88	PF00017	0.472
LIG_SH2_PTP2	266	269	PF00017	0.442
LIG_SH2_STAT5	162	165	PF00017	0.341
LIG_SH2_STAT5	219	222	PF00017	0.469
LIG_SH2_STAT5	262	265	PF00017	0.420
LIG_SH2_STAT5	266	269	PF00017	0.472
LIG_SH2_STAT5	299	302	PF00017	0.426
LIG_SH2_STAT5	351	354	PF00017	0.380
LIG_SH3_3	17	23	PF00018	0.488
LIG_SH3_3	273	279	PF00018	0.460
LIG_SH3_3	362	368	PF00018	0.506
LIG_SH3_3	547	553	PF00018	0.524
LIG_SH3_3	594	600	PF00018	0.768
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.467
LIG_SUMO_SIM_par_1	305	311	PF11976	0.328
LIG_SUMO_SIM_par_1	326	331	PF11976	0.427
LIG_SUMO_SIM_par_1	582	588	PF11976	0.475
LIG_TYR_ITSM	56	63	PF00017	0.402
MOD_CDC14_SPxK_1	513	516	PF00782	0.418
MOD_CDK_SPxK_1	510	516	PF00069	0.422
MOD_CDK_SPxxK_3	510	517	PF00069	0.367
MOD_CK1_1	136	142	PF00069	0.434
MOD_CK1_1	146	152	PF00069	0.366
MOD_CK1_1	199	205	PF00069	0.465
MOD_CK1_1	231	237	PF00069	0.517
MOD_CK1_1	247	253	PF00069	0.383
MOD_CK1_1	316	322	PF00069	0.438
MOD_CK1_1	371	377	PF00069	0.614
MOD_CK1_1	379	385	PF00069	0.553
MOD_CK1_1	386	392	PF00069	0.496
MOD_CK1_1	393	399	PF00069	0.475
MOD_CK1_1	400	406	PF00069	0.440
MOD_CK1_1	48	54	PF00069	0.439
MOD_CK1_1	524	530	PF00069	0.504
MOD_CK2_1	400	406	PF00069	0.625
MOD_CK2_1	462	468	PF00069	0.415
MOD_CK2_1	47	53	PF00069	0.382
MOD_GlcNHglycan	105	108	PF01048	0.634
MOD_GlcNHglycan	115	118	PF01048	0.575
MOD_GlcNHglycan	145	148	PF01048	0.734
MOD_GlcNHglycan	201	204	PF01048	0.732
MOD_GlcNHglycan	315	318	PF01048	0.618
MOD_GlcNHglycan	361	364	PF01048	0.658
MOD_GlcNHglycan	373	376	PF01048	0.667
MOD_GlcNHglycan	409	412	PF01048	0.712
MOD_GlcNHglycan	527	530	PF01048	0.679
MOD_GlcNHglycan	557	560	PF01048	0.758
MOD_GlcNHglycan	575	578	PF01048	0.319
MOD_GlcNHglycan	66	69	PF01048	0.685
MOD_GlcNHglycan	78	81	PF01048	0.628
MOD_GSK3_1	146	153	PF00069	0.493
MOD_GSK3_1	171	178	PF00069	0.466
MOD_GSK3_1	180	187	PF00069	0.441
MOD_GSK3_1	192	199	PF00069	0.459
MOD_GSK3_1	203	210	PF00069	0.479
MOD_GSK3_1	270	277	PF00069	0.468
MOD_GSK3_1	288	295	PF00069	0.323
MOD_GSK3_1	298	305	PF00069	0.403
MOD_GSK3_1	306	313	PF00069	0.313
MOD_GSK3_1	369	376	PF00069	0.568
MOD_GSK3_1	377	384	PF00069	0.611
MOD_GSK3_1	385	392	PF00069	0.520
MOD_GSK3_1	393	400	PF00069	0.535
MOD_GSK3_1	426	433	PF00069	0.468
MOD_GSK3_1	458	465	PF00069	0.571
MOD_GSK3_1	478	485	PF00069	0.493
MOD_GSK3_1	5	12	PF00069	0.642
MOD_GSK3_1	521	528	PF00069	0.440
MOD_GSK3_1	539	546	PF00069	0.477
MOD_GSK3_1	587	594	PF00069	0.578
MOD_N-GLC_1	174	179	PF02516	0.670
MOD_N-GLC_1	255	260	PF02516	0.605
MOD_N-GLC_1	302	307	PF02516	0.682
MOD_N-GLC_1	426	431	PF02516	0.720
MOD_N-GLC_1	461	466	PF02516	0.735
MOD_N-GLC_1	471	476	PF02516	0.643
MOD_N-GLC_1	478	483	PF02516	0.643
MOD_N-GLC_1	525	530	PF02516	0.647
MOD_NEK2_1	103	108	PF00069	0.465
MOD_NEK2_1	163	168	PF00069	0.346
MOD_NEK2_1	171	176	PF00069	0.344
MOD_NEK2_1	196	201	PF00069	0.455
MOD_NEK2_1	25	30	PF00069	0.627
MOD_NEK2_1	298	303	PF00069	0.469
MOD_NEK2_1	310	315	PF00069	0.353
MOD_NEK2_1	353	358	PF00069	0.428
MOD_NEK2_1	359	364	PF00069	0.292
MOD_NEK2_1	503	508	PF00069	0.419
MOD_NEK2_1	521	526	PF00069	0.386
MOD_NEK2_2	203	208	PF00069	0.331
MOD_NEK2_2	540	545	PF00069	0.399
MOD_PIKK_1	268	274	PF00454	0.366
MOD_PIKK_1	353	359	PF00454	0.381
MOD_PIKK_1	430	436	PF00454	0.449
MOD_PIKK_1	503	509	PF00454	0.462
MOD_PKA_2	171	177	PF00069	0.349
MOD_PKA_2	203	209	PF00069	0.340
MOD_PKA_2	344	350	PF00069	0.432
MOD_PKA_2	540	546	PF00069	0.404
MOD_Plk_1	255	261	PF00069	0.387
MOD_Plk_1	426	432	PF00069	0.512
MOD_Plk_1	461	467	PF00069	0.520
MOD_Plk_1	471	477	PF00069	0.441
MOD_Plk_2-3	133	139	PF00069	0.357
MOD_Plk_4	136	142	PF00069	0.402
MOD_Plk_4	180	186	PF00069	0.400
MOD_Plk_4	196	202	PF00069	0.333
MOD_Plk_4	203	209	PF00069	0.429
MOD_Plk_4	213	219	PF00069	0.379
MOD_Plk_4	303	309	PF00069	0.491
MOD_Plk_4	318	324	PF00069	0.514
MOD_Plk_4	330	336	PF00069	0.363
MOD_Plk_4	346	352	PF00069	0.289
MOD_Plk_4	462	468	PF00069	0.627
MOD_Plk_4	486	492	PF00069	0.456
MOD_Plk_4	55	61	PF00069	0.453
MOD_Plk_4	568	574	PF00069	0.366
MOD_ProDKin_1	18	24	PF00069	0.673
MOD_ProDKin_1	189	195	PF00069	0.404
MOD_ProDKin_1	222	228	PF00069	0.487
MOD_ProDKin_1	275	281	PF00069	0.495
MOD_ProDKin_1	316	322	PF00069	0.461
MOD_ProDKin_1	361	367	PF00069	0.424
MOD_ProDKin_1	38	44	PF00069	0.540
MOD_ProDKin_1	45	51	PF00069	0.547
MOD_ProDKin_1	510	516	PF00069	0.399
MOD_ProDKin_1	585	591	PF00069	0.536
MOD_ProDKin_1	9	15	PF00069	0.752
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.471
TRG_ENDOCYTIC_2	436	439	PF00928	0.443
TRG_ENDOCYTIC_2	60	63	PF00928	0.386
TRG_ENDOCYTIC_2	84	87	PF00928	0.476
TRG_ER_diArg_1	126	129	PF00400	0.316
TRG_ER_diArg_1	498	501	PF00400	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRY9	Trypanosomatidae	29%	100%
A0A3S7WR66	Leishmania donovani	83%	100%
A0A422NWX8	Trypanosoma rangeli	29%	100%
A4H655	Leishmania braziliensis	68%	96%
A4HUH5	Leishmania infantum	83%	100%
C9ZVK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QHF2	Leishmania major	77%	95%
V5BP43	Trypanosoma cruzi	28%	100%