Fibronectin type-III domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FLA1-binding protein

Species:

Leishmania mexicana

UniProt:

E9AN72_LEIMU

TriTrypDb:

LmxM.10.0620

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 3
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AN72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.189
CLV_C14_Caspase3-7	409	413	PF00656	0.237
CLV_C14_Caspase3-7	613	617	PF00656	0.437
CLV_C14_Caspase3-7	739	743	PF00656	0.619
CLV_NRD_NRD_1	6	8	PF00675	0.702
CLV_NRD_NRD_1	687	689	PF00675	0.705
CLV_NRD_NRD_1	721	723	PF00675	0.428
CLV_PCSK_KEX2_1	6	8	PF00082	0.712
CLV_PCSK_KEX2_1	719	721	PF00082	0.382
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.382
CLV_PCSK_SKI1_1	350	354	PF00082	0.407
CLV_PCSK_SKI1_1	486	490	PF00082	0.508
CLV_PCSK_SKI1_1	547	551	PF00082	0.508
CLV_PCSK_SKI1_1	722	726	PF00082	0.519
DEG_APCC_DBOX_1	719	727	PF00400	0.596
DEG_SPOP_SBC_1	281	285	PF00917	0.411
DEG_SPOP_SBC_1	435	439	PF00917	0.241
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	515	521	PF00134	0.305
DOC_MAPK_RevD_3	706	720	PF00069	0.171
DOC_PP2B_LxvP_1	515	518	PF13499	0.262
DOC_PP4_FxxP_1	460	463	PF00568	0.361
DOC_USP7_MATH_1	129	133	PF00917	0.437
DOC_USP7_MATH_1	282	286	PF00917	0.361
DOC_USP7_MATH_1	435	439	PF00917	0.399
DOC_USP7_MATH_1	54	58	PF00917	0.341
DOC_USP7_MATH_1	699	703	PF00917	0.417
DOC_WW_Pin1_4	208	213	PF00397	0.279
DOC_WW_Pin1_4	319	324	PF00397	0.459
DOC_WW_Pin1_4	363	368	PF00397	0.391
DOC_WW_Pin1_4	404	409	PF00397	0.420
DOC_WW_Pin1_4	436	441	PF00397	0.381
DOC_WW_Pin1_4	533	538	PF00397	0.423
DOC_WW_Pin1_4	601	606	PF00397	0.469
LIG_14-3-3_CanoR_1	426	436	PF00244	0.437
LIG_14-3-3_CanoR_1	6	15	PF00244	0.499
LIG_14-3-3_CanoR_1	721	727	PF00244	0.712
LIG_14-3-3_CanoR_1	92	97	PF00244	0.343
LIG_BRCT_BRCA1_1	210	214	PF00533	0.298
LIG_BRCT_BRCA1_1	220	224	PF00533	0.265
LIG_BRCT_BRCA1_1	247	251	PF00533	0.390
LIG_BRCT_BRCA1_1	321	325	PF00533	0.307
LIG_BRCT_BRCA1_1	423	427	PF00533	0.338
LIG_BRCT_BRCA1_1	437	441	PF00533	0.234
LIG_BRCT_BRCA1_1	527	531	PF00533	0.511
LIG_BRCT_BRCA1_1	84	88	PF00533	0.335
LIG_Clathr_ClatBox_1	242	246	PF01394	0.234
LIG_deltaCOP1_diTrp_1	241	251	PF00928	0.271
LIG_deltaCOP1_diTrp_1	412	419	PF00928	0.344
LIG_EH_1	60	64	PF12763	0.306
LIG_FHA_1	135	141	PF00498	0.439
LIG_FHA_1	237	243	PF00498	0.359
LIG_FHA_1	282	288	PF00498	0.335
LIG_FHA_1	296	302	PF00498	0.336
LIG_FHA_1	334	340	PF00498	0.342
LIG_FHA_1	405	411	PF00498	0.346
LIG_FHA_1	453	459	PF00498	0.390
LIG_FHA_1	54	60	PF00498	0.338
LIG_FHA_1	648	654	PF00498	0.270
LIG_FHA_1	658	664	PF00498	0.305
LIG_FHA_1	674	680	PF00498	0.376
LIG_FHA_1	69	75	PF00498	0.481
LIG_FHA_1	690	696	PF00498	0.215
LIG_FHA_1	76	82	PF00498	0.406
LIG_FHA_2	158	164	PF00498	0.222
LIG_FHA_2	257	263	PF00498	0.312
LIG_FHA_2	265	271	PF00498	0.414
LIG_FHA_2	356	362	PF00498	0.458
LIG_FHA_2	742	748	PF00498	0.601
LIG_LIR_Gen_1	211	220	PF02991	0.407
LIG_LIR_Gen_1	296	306	PF02991	0.446
LIG_LIR_Gen_1	560	571	PF02991	0.374
LIG_LIR_Gen_1	670	679	PF02991	0.346
LIG_LIR_Nem_3	119	125	PF02991	0.408
LIG_LIR_Nem_3	211	217	PF02991	0.326
LIG_LIR_Nem_3	221	227	PF02991	0.260
LIG_LIR_Nem_3	241	247	PF02991	0.344
LIG_LIR_Nem_3	296	302	PF02991	0.430
LIG_LIR_Nem_3	322	328	PF02991	0.373
LIG_LIR_Nem_3	366	371	PF02991	0.430
LIG_LIR_Nem_3	395	401	PF02991	0.411
LIG_LIR_Nem_3	560	566	PF02991	0.335
LIG_LIR_Nem_3	670	675	PF02991	0.291
LIG_LIR_Nem_3	85	90	PF02991	0.308
LIG_LIR_Nem_3	94	99	PF02991	0.328
LIG_LYPXL_yS_3	491	494	PF13949	0.383
LIG_MLH1_MIPbox_1	527	531	PF16413	0.400
LIG_MLH1_MIPbox_1	84	88	PF16413	0.303
LIG_NRBOX	511	517	PF00104	0.374
LIG_Pex14_1	415	419	PF04695	0.273
LIG_Pex14_2	368	372	PF04695	0.315
LIG_PTB_Apo_2	142	149	PF02174	0.305
LIG_PTB_Apo_2	173	180	PF02174	0.206
LIG_PTB_Apo_2	422	429	PF02174	0.337
LIG_PTB_Apo_2	539	546	PF02174	0.352
LIG_PTB_Phospho_1	173	179	PF10480	0.209
LIG_SH2_CRK	299	303	PF00017	0.344
LIG_SH2_CRK	563	567	PF00017	0.326
LIG_SH2_CRK	590	594	PF00017	0.326
LIG_SH2_GRB2like	451	454	PF00017	0.375
LIG_SH2_GRB2like	644	647	PF00017	0.455
LIG_SH2_NCK_1	288	292	PF00017	0.237
LIG_SH2_NCK_1	299	303	PF00017	0.334
LIG_SH2_NCK_1	33	37	PF00017	0.341
LIG_SH2_NCK_1	388	392	PF00017	0.348
LIG_SH2_NCK_1	563	567	PF00017	0.326
LIG_SH2_PTP2	400	403	PF00017	0.413
LIG_SH2_SRC	33	36	PF00017	0.350
LIG_SH2_STAP1	388	392	PF00017	0.231
LIG_SH2_STAP1	495	499	PF00017	0.320
LIG_SH2_STAP1	563	567	PF00017	0.326
LIG_SH2_STAP1	659	663	PF00017	0.249
LIG_SH2_STAP1	93	97	PF00017	0.310
LIG_SH2_STAT3	141	144	PF00017	0.350
LIG_SH2_STAT3	158	161	PF00017	0.383
LIG_SH2_STAT5	142	145	PF00017	0.286
LIG_SH2_STAT5	158	161	PF00017	0.298
LIG_SH2_STAT5	179	182	PF00017	0.247
LIG_SH2_STAT5	288	291	PF00017	0.329
LIG_SH2_STAT5	299	302	PF00017	0.425
LIG_SH2_STAT5	371	374	PF00017	0.406
LIG_SH2_STAT5	400	403	PF00017	0.391
LIG_SH2_STAT5	493	496	PF00017	0.372
LIG_SH2_STAT5	659	662	PF00017	0.355
LIG_SH2_STAT5	678	681	PF00017	0.363
LIG_SH2_STAT5	86	89	PF00017	0.360
LIG_SH2_STAT5	96	99	PF00017	0.379
LIG_SH3_3	232	238	PF00018	0.330
LIG_SH3_3	602	608	PF00018	0.325
LIG_SH3_3	637	643	PF00018	0.420
LIG_SH3_3	648	654	PF00018	0.238
LIG_SH3_3	723	729	PF00018	0.603
LIG_SUMO_SIM_par_1	216	223	PF11976	0.453
LIG_SUMO_SIM_par_1	379	384	PF11976	0.336
LIG_SUMO_SIM_par_1	712	718	PF11976	0.177
LIG_TRAF2_1	303	306	PF00917	0.230
LIG_TRAF2_1	592	595	PF00917	0.392
LIG_TRAF2_1	744	747	PF00917	0.737
LIG_TYR_ITIM	297	302	PF00017	0.342
LIG_TYR_ITIM	489	494	PF00017	0.389
LIG_TYR_ITIM	588	593	PF00017	0.322
MOD_CK1_1	164	170	PF00069	0.320
MOD_CK1_1	201	207	PF00069	0.420
MOD_CK1_1	293	299	PF00069	0.392
MOD_CK1_1	319	325	PF00069	0.399
MOD_CK1_1	429	435	PF00069	0.347
MOD_CK1_1	610	616	PF00069	0.479
MOD_CK1_1	632	638	PF00069	0.361
MOD_CK2_1	157	163	PF00069	0.244
MOD_CK2_1	300	306	PF00069	0.438
MOD_CK2_1	403	409	PF00069	0.305
MOD_CK2_1	741	747	PF00069	0.639
MOD_GlcNHglycan	109	112	PF01048	0.556
MOD_GlcNHglycan	163	166	PF01048	0.515
MOD_GlcNHglycan	181	184	PF01048	0.572
MOD_GlcNHglycan	200	203	PF01048	0.534
MOD_GlcNHglycan	229	232	PF01048	0.561
MOD_GlcNHglycan	246	250	PF01048	0.415
MOD_GlcNHglycan	254	257	PF01048	0.492
MOD_GlcNHglycan	284	287	PF01048	0.559
MOD_GlcNHglycan	292	295	PF01048	0.595
MOD_GlcNHglycan	302	305	PF01048	0.461
MOD_GlcNHglycan	432	435	PF01048	0.580
MOD_GlcNHglycan	527	530	PF01048	0.694
MOD_GlcNHglycan	701	704	PF01048	0.400
MOD_GlcNHglycan	8	11	PF01048	0.610
MOD_GSK3_1	157	164	PF00069	0.213
MOD_GSK3_1	252	259	PF00069	0.357
MOD_GSK3_1	264	271	PF00069	0.343
MOD_GSK3_1	282	289	PF00069	0.299
MOD_GSK3_1	293	300	PF00069	0.338
MOD_GSK3_1	340	347	PF00069	0.279
MOD_GSK3_1	355	362	PF00069	0.316
MOD_GSK3_1	410	417	PF00069	0.316
MOD_GSK3_1	426	433	PF00069	0.301
MOD_GSK3_1	50	57	PF00069	0.273
MOD_GSK3_1	603	610	PF00069	0.462
MOD_GSK3_1	653	660	PF00069	0.273
MOD_GSK3_1	680	687	PF00069	0.402
MOD_GSK3_1	737	744	PF00069	0.747
MOD_GSK3_1	82	89	PF00069	0.308
MOD_N-GLC_1	174	179	PF02516	0.459
MOD_N-GLC_1	355	360	PF02516	0.587
MOD_N-GLC_1	374	379	PF02516	0.440
MOD_N-GLC_1	403	408	PF02516	0.564
MOD_N-GLC_1	452	457	PF02516	0.543
MOD_N-GLC_1	469	474	PF02516	0.450
MOD_N-GLC_1	500	505	PF02516	0.578
MOD_N-GLC_1	508	513	PF02516	0.503
MOD_N-GLC_1	525	530	PF02516	0.594
MOD_N-GLC_1	532	537	PF02516	0.518
MOD_N-GLC_1	545	550	PF02516	0.426
MOD_N-GLC_1	632	637	PF02516	0.555
MOD_N-GLC_1	647	652	PF02516	0.471
MOD_N-GLC_1	673	678	PF02516	0.518
MOD_N-GLC_1	680	685	PF02516	0.576
MOD_NEK2_1	169	174	PF00069	0.318
MOD_NEK2_1	227	232	PF00069	0.297
MOD_NEK2_1	245	250	PF00069	0.371
MOD_NEK2_1	280	285	PF00069	0.249
MOD_NEK2_1	373	378	PF00069	0.443
MOD_NEK2_1	427	432	PF00069	0.381
MOD_NEK2_1	441	446	PF00069	0.276
MOD_NEK2_1	50	55	PF00069	0.327
MOD_NEK2_1	525	530	PF00069	0.446
MOD_NEK2_1	531	536	PF00069	0.403
MOD_NEK2_1	545	550	PF00069	0.229
MOD_NEK2_1	647	652	PF00069	0.326
MOD_NEK2_1	657	662	PF00069	0.374
MOD_NEK2_2	123	128	PF00069	0.363
MOD_NEK2_2	174	179	PF00069	0.193
MOD_NEK2_2	355	360	PF00069	0.339
MOD_PIKK_1	157	163	PF00454	0.413
MOD_PIKK_1	201	207	PF00454	0.301
MOD_PIKK_1	614	620	PF00454	0.342
MOD_PKA_1	6	12	PF00069	0.553
MOD_PKA_2	116	122	PF00069	0.363
MOD_PKA_2	268	274	PF00069	0.415
MOD_PKA_2	359	365	PF00069	0.353
MOD_PKA_2	6	12	PF00069	0.597
MOD_PKA_2	91	97	PF00069	0.301
MOD_PKB_1	720	728	PF00069	0.710
MOD_Plk_1	169	175	PF00069	0.320
MOD_Plk_1	355	361	PF00069	0.383
MOD_Plk_1	373	379	PF00069	0.348
MOD_Plk_1	411	417	PF00069	0.344
MOD_Plk_1	500	506	PF00069	0.385
MOD_Plk_1	508	514	PF00069	0.295
MOD_Plk_1	545	551	PF00069	0.364
MOD_Plk_1	647	653	PF00069	0.360
MOD_Plk_1	680	686	PF00069	0.296
MOD_Plk_1	74	80	PF00069	0.424
MOD_Plk_2-3	742	748	PF00069	0.681
MOD_Plk_4	135	141	PF00069	0.336
MOD_Plk_4	152	158	PF00069	0.263
MOD_Plk_4	169	175	PF00069	0.307
MOD_Plk_4	256	262	PF00069	0.323
MOD_Plk_4	297	303	PF00069	0.310
MOD_Plk_4	344	350	PF00069	0.317
MOD_Plk_4	374	380	PF00069	0.357
MOD_Plk_4	508	514	PF00069	0.434
MOD_Plk_4	545	551	PF00069	0.362
MOD_Plk_4	562	568	PF00069	0.250
MOD_Plk_4	722	728	PF00069	0.703
MOD_Plk_4	75	81	PF00069	0.324
MOD_Plk_4	82	88	PF00069	0.322
MOD_Plk_4	92	98	PF00069	0.245
MOD_ProDKin_1	208	214	PF00069	0.274
MOD_ProDKin_1	319	325	PF00069	0.452
MOD_ProDKin_1	363	369	PF00069	0.388
MOD_ProDKin_1	404	410	PF00069	0.415
MOD_ProDKin_1	436	442	PF00069	0.385
MOD_ProDKin_1	533	539	PF00069	0.420
MOD_ProDKin_1	601	607	PF00069	0.478
TRG_DiLeu_BaEn_1	75	80	PF01217	0.385
TRG_ENDOCYTIC_2	299	302	PF00928	0.456
TRG_ENDOCYTIC_2	388	391	PF00928	0.407
TRG_ENDOCYTIC_2	400	403	PF00928	0.403
TRG_ENDOCYTIC_2	491	494	PF00928	0.333
TRG_ENDOCYTIC_2	563	566	PF00928	0.421
TRG_ENDOCYTIC_2	590	593	PF00928	0.324
TRG_ENDOCYTIC_2	644	647	PF00928	0.272
TRG_ENDOCYTIC_2	96	99	PF00928	0.314
TRG_ER_diArg_1	5	7	PF00400	0.530
TRG_ER_diArg_1	720	722	PF00400	0.588
TRG_NLS_MonoCore_2	718	723	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL9	Leptomonas seymouri	40%	100%
A0A1X0NRS2	Trypanosomatidae	29%	100%
A0A3Q8I8Q8	Leishmania donovani	85%	100%
A0A422NWY1	Trypanosoma rangeli	30%	100%
A4H654	Leishmania braziliensis	74%	100%
A4HUH4	Leishmania infantum	86%	100%
C9ZQ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
C9ZVJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZVJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QHF3	Leishmania major	86%	100%
V5B409	Trypanosoma cruzi	27%	100%