Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease G, putative

Species:

Leishmania mexicana

UniProt:

E9AN71_LEIMU

TriTrypDb:

LmxM.10.0610

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AN71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN71

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.421
CLV_NRD_NRD_1	128	130	PF00675	0.206
CLV_NRD_NRD_1	140	142	PF00675	0.206
CLV_NRD_NRD_1	147	149	PF00675	0.206
CLV_NRD_NRD_1	257	259	PF00675	0.234
CLV_NRD_NRD_1	280	282	PF00675	0.240
CLV_NRD_NRD_1	464	466	PF00675	0.305
CLV_PCSK_FUR_1	277	281	PF00082	0.135
CLV_PCSK_KEX2_1	128	130	PF00082	0.215
CLV_PCSK_KEX2_1	147	149	PF00082	0.215
CLV_PCSK_KEX2_1	279	281	PF00082	0.231
CLV_PCSK_KEX2_1	33	35	PF00082	0.408
CLV_PCSK_KEX2_1	490	492	PF00082	0.268
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.443
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.190
CLV_PCSK_SKI1_1	372	376	PF00082	0.239
DEG_APCC_DBOX_1	298	306	PF00400	0.335
DEG_APCC_DBOX_1	359	367	PF00400	0.374
DOC_CKS1_1	82	87	PF01111	0.522
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.591
DOC_MAPK_gen_1	258	266	PF00069	0.479
DOC_MAPK_gen_1	33	39	PF00069	0.656
DOC_MAPK_gen_1	411	420	PF00069	0.436
DOC_MAPK_MEF2A_6	341	350	PF00069	0.452
DOC_PP4_FxxP_1	389	392	PF00568	0.406
DOC_USP7_MATH_1	329	333	PF00917	0.519
DOC_USP7_MATH_1	339	343	PF00917	0.319
DOC_USP7_MATH_1	365	369	PF00917	0.561
DOC_USP7_MATH_1	41	45	PF00917	0.691
DOC_USP7_MATH_1	440	444	PF00917	0.620
DOC_USP7_MATH_1	457	461	PF00917	0.440
DOC_USP7_MATH_1	51	55	PF00917	0.724
DOC_USP7_MATH_1	87	91	PF00917	0.638
DOC_WW_Pin1_4	148	153	PF00397	0.499
DOC_WW_Pin1_4	281	286	PF00397	0.532
DOC_WW_Pin1_4	49	54	PF00397	0.708
DOC_WW_Pin1_4	81	86	PF00397	0.559
LIG_14-3-3_CanoR_1	382	387	PF00244	0.482
LIG_14-3-3_CanoR_1	43	53	PF00244	0.625
LIG_14-3-3_CanoR_1	465	469	PF00244	0.498
LIG_BIR_III_2	439	443	PF00653	0.610
LIG_BRCT_BRCA1_1	367	371	PF00533	0.452
LIG_BRCT_BRCA1_1	442	446	PF00533	0.596
LIG_Clathr_ClatBox_1	314	318	PF01394	0.497
LIG_FHA_1	109	115	PF00498	0.519
LIG_FHA_1	11	17	PF00498	0.310
LIG_FHA_1	255	261	PF00498	0.417
LIG_FHA_1	33	39	PF00498	0.660
LIG_FHA_1	349	355	PF00498	0.493
LIG_FHA_1	50	56	PF00498	0.711
LIG_FHA_2	289	295	PF00498	0.374
LIG_Integrin_RGD_1	281	283	PF01839	0.213
LIG_LIR_Apic_2	403	408	PF02991	0.431
LIG_LIR_Gen_1	249	256	PF02991	0.417
LIG_LIR_Gen_1	467	476	PF02991	0.576
LIG_LIR_LC3C_4	35	39	PF02991	0.564
LIG_LIR_Nem_3	139	143	PF02991	0.452
LIG_LIR_Nem_3	22	27	PF02991	0.357
LIG_LIR_Nem_3	249	253	PF02991	0.412
LIG_LIR_Nem_3	368	374	PF02991	0.415
LIG_LIR_Nem_3	443	449	PF02991	0.514
LIG_LIR_Nem_3	467	471	PF02991	0.565
LIG_LIR_Nem_3	73	79	PF02991	0.483
LIG_PCNA_yPIPBox_3	489	502	PF02747	0.421
LIG_SH2_CRK	140	144	PF00017	0.452
LIG_SH2_CRK	405	409	PF00017	0.417
LIG_SH2_CRK	449	453	PF00017	0.495
LIG_SH2_CRK	468	472	PF00017	0.456
LIG_SH2_STAP1	126	130	PF00017	0.417
LIG_SH2_STAP1	27	31	PF00017	0.691
LIG_SH2_STAT3	27	30	PF00017	0.627
LIG_SH2_STAT5	120	123	PF00017	0.473
LIG_SH2_STAT5	205	208	PF00017	0.439
LIG_SH2_STAT5	303	306	PF00017	0.476
LIG_SH3_3	146	152	PF00018	0.532
LIG_SH3_3	302	308	PF00018	0.412
LIG_SH3_3	323	329	PF00018	0.443
LIG_SH3_3	35	41	PF00018	0.580
LIG_SH3_3	361	367	PF00018	0.417
LIG_SH3_3	389	395	PF00018	0.406
LIG_SH3_3	75	81	PF00018	0.574
LIG_SUMO_SIM_par_1	362	368	PF11976	0.523
LIG_TYR_ITIM	138	143	PF00017	0.452
MOD_CK1_1	204	210	PF00069	0.496
MOD_CK1_1	32	38	PF00069	0.660
MOD_CK1_1	44	50	PF00069	0.667
MOD_CK1_1	60	66	PF00069	0.578
MOD_CK1_1	90	96	PF00069	0.525
MOD_CK2_1	107	113	PF00069	0.505
MOD_CK2_1	221	227	PF00069	0.406
MOD_CK2_1	288	294	PF00069	0.374
MOD_Cter_Amidation	145	148	PF01082	0.221
MOD_Cter_Amidation	277	280	PF01082	0.187
MOD_DYRK1A_RPxSP_1	148	152	PF00069	0.452
MOD_GlcNHglycan	144	147	PF01048	0.302
MOD_GlcNHglycan	3	6	PF01048	0.423
MOD_GlcNHglycan	331	334	PF01048	0.287
MOD_GlcNHglycan	335	338	PF01048	0.279
MOD_GlcNHglycan	341	344	PF01048	0.234
MOD_GlcNHglycan	442	445	PF01048	0.321
MOD_GSK3_1	116	123	PF00069	0.335
MOD_GSK3_1	179	186	PF00069	0.461
MOD_GSK3_1	19	26	PF00069	0.308
MOD_GSK3_1	204	211	PF00069	0.445
MOD_GSK3_1	254	261	PF00069	0.473
MOD_GSK3_1	329	336	PF00069	0.429
MOD_GSK3_1	348	355	PF00069	0.526
MOD_GSK3_1	41	48	PF00069	0.641
MOD_GSK3_1	57	64	PF00069	0.652
MOD_N-GLC_1	172	177	PF02516	0.281
MOD_N-GLC_1	183	188	PF02516	0.330
MOD_N-GLC_1	288	293	PF02516	0.174
MOD_N-GLC_1	41	46	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.434
MOD_NEK2_1	10	15	PF00069	0.248
MOD_NEK2_1	19	24	PF00069	0.311
MOD_NEK2_1	228	233	PF00069	0.414
MOD_NEK2_1	424	429	PF00069	0.587
MOD_NEK2_1	432	437	PF00069	0.506
MOD_NEK2_1	45	50	PF00069	0.654
MOD_NEK2_1	464	469	PF00069	0.583
MOD_NEK2_1	471	476	PF00069	0.619
MOD_PIKK_1	221	227	PF00454	0.475
MOD_PIKK_1	26	32	PF00454	0.655
MOD_PIKK_1	61	67	PF00454	0.666
MOD_PK_1	262	268	PF00069	0.452
MOD_PK_1	382	388	PF00069	0.469
MOD_PKA_1	147	153	PF00069	0.452
MOD_PKA_1	258	264	PF00069	0.473
MOD_PKA_2	147	153	PF00069	0.452
MOD_PKA_2	359	365	PF00069	0.374
MOD_PKA_2	413	419	PF00069	0.440
MOD_PKA_2	440	446	PF00069	0.569
MOD_PKA_2	464	470	PF00069	0.564
MOD_Plk_1	190	196	PF00069	0.426
MOD_Plk_1	228	234	PF00069	0.445
MOD_Plk_1	241	247	PF00069	0.367
MOD_Plk_1	262	268	PF00069	0.510
MOD_Plk_1	41	47	PF00069	0.566
MOD_Plk_1	424	430	PF00069	0.601
MOD_Plk_1	70	76	PF00069	0.666
MOD_Plk_4	116	122	PF00069	0.335
MOD_Plk_4	359	365	PF00069	0.461
MOD_ProDKin_1	148	154	PF00069	0.499
MOD_ProDKin_1	281	287	PF00069	0.532
MOD_ProDKin_1	49	55	PF00069	0.709
MOD_ProDKin_1	81	87	PF00069	0.563
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.261
TRG_ENDOCYTIC_2	140	143	PF00928	0.452
TRG_ENDOCYTIC_2	449	452	PF00928	0.474
TRG_ENDOCYTIC_2	468	471	PF00928	0.559
TRG_ER_diArg_1	128	130	PF00400	0.417
TRG_ER_diArg_1	147	149	PF00400	0.406
TRG_ER_diArg_1	277	280	PF00400	0.505
TRG_NES_CRM1_1	254	270	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK94	Leptomonas seymouri	61%	100%
A0A0S4JFH6	Bodo saltans	37%	100%
A0A1X0NQR8	Trypanosomatidae	38%	100%
A0A3Q8I8T5	Leishmania donovani	91%	100%
A0A422NX36	Trypanosoma rangeli	36%	100%
A4H653	Leishmania braziliensis	79%	99%
A4HUH3	Leishmania infantum	91%	100%
C9ZVJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q0IH72	Xenopus laevis	26%	100%
Q4QHF4	Leishmania major	89%	100%
Q502K1	Danio rerio	28%	100%
Q8C163	Mus musculus	26%	100%
Q9Y2C4	Homo sapiens	26%	100%
V5BJI6	Trypanosoma cruzi	39%	100%