DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN69_LEIMU

TriTrypDb:

LmxM.10.0590

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.632
CLV_PCSK_SKI1_1	143	147	PF00082	0.461
CLV_PCSK_SKI1_1	232	236	PF00082	0.634
DEG_APCC_DBOX_1	138	146	PF00400	0.407
DOC_CKS1_1	4	9	PF01111	0.485
DOC_CYCLIN_RxL_1	139	148	PF00134	0.411
DOC_CYCLIN_RxL_1	86	100	PF00134	0.355
DOC_MAPK_gen_1	139	147	PF00069	0.420
DOC_MAPK_gen_1	78	87	PF00069	0.490
DOC_MAPK_MEF2A_6	141	149	PF00069	0.403
DOC_PP1_RVXF_1	78	85	PF00149	0.644
DOC_PP2B_LxvP_1	40	43	PF13499	0.473
DOC_USP7_MATH_1	111	115	PF00917	0.640
DOC_USP7_MATH_1	5	9	PF00917	0.691
DOC_USP7_MATH_1	69	73	PF00917	0.609
DOC_USP7_UBL2_3	10	14	PF12436	0.618
DOC_USP7_UBL2_3	15	19	PF12436	0.573
DOC_WW_Pin1_4	119	124	PF00397	0.494
DOC_WW_Pin1_4	3	8	PF00397	0.569
LIG_14-3-3_CanoR_1	172	177	PF00244	0.439
LIG_14-3-3_CanoR_1	80	85	PF00244	0.486
LIG_FHA_1	105	111	PF00498	0.478
LIG_FHA_1	142	148	PF00498	0.391
LIG_FHA_1	150	156	PF00498	0.380
LIG_FHA_1	207	213	PF00498	0.401
LIG_FHA_1	224	230	PF00498	0.629
LIG_FHA_1	37	43	PF00498	0.581
LIG_FHA_2	133	139	PF00498	0.432
LIG_FHA_2	179	185	PF00498	0.495
LIG_FHA_2	233	239	PF00498	0.508
LIG_LIR_Gen_1	100	111	PF02991	0.305
LIG_LIR_Gen_1	187	195	PF02991	0.421
LIG_LIR_Gen_1	83	91	PF02991	0.414
LIG_LIR_Nem_3	100	106	PF02991	0.359
LIG_LIR_Nem_3	187	192	PF02991	0.408
LIG_LIR_Nem_3	241	246	PF02991	0.428
LIG_LIR_Nem_3	83	87	PF02991	0.492
LIG_LIR_Nem_3	89	94	PF02991	0.443
LIG_NRBOX	141	147	PF00104	0.496
LIG_NRBOX	216	222	PF00104	0.499
LIG_Pex14_2	189	193	PF04695	0.375
LIG_Pex14_2	259	263	PF04695	0.498
LIG_SH2_STAT3	157	160	PF00017	0.562
LIG_SH2_STAT3	32	35	PF00017	0.533
LIG_SH2_STAT5	243	246	PF00017	0.494
LIG_SH2_STAT5	32	35	PF00017	0.476
LIG_SH2_STAT5	41	44	PF00017	0.478
LIG_SH3_2	167	172	PF14604	0.579
LIG_SH3_3	164	170	PF00018	0.513
LIG_SH3_3	174	180	PF00018	0.325
LIG_SH3_3	22	28	PF00018	0.673
LIG_SUMO_SIM_par_1	143	148	PF11976	0.394
MOD_CDK_SPxxK_3	3	10	PF00069	0.571
MOD_CK1_1	118	124	PF00069	0.492
MOD_CK1_1	3	9	PF00069	0.485
MOD_CK2_1	232	238	PF00069	0.558
MOD_Cter_Amidation	12	15	PF01082	0.670
MOD_Cter_Amidation	17	20	PF01082	0.661
MOD_GSK3_1	111	118	PF00069	0.659
MOD_GSK3_1	200	207	PF00069	0.595
MOD_GSK3_1	228	235	PF00069	0.632
MOD_GSK3_1	63	70	PF00069	0.482
MOD_GSK3_1	86	93	PF00069	0.434
MOD_NEK2_1	149	154	PF00069	0.492
MOD_NEK2_1	36	41	PF00069	0.586
MOD_PIKK_1	111	117	PF00454	0.676
MOD_PIKK_1	5	11	PF00454	0.655
MOD_PIKK_1	69	75	PF00454	0.560
MOD_PK_1	172	178	PF00069	0.505
MOD_PK_1	86	92	PF00069	0.349
MOD_PKA_2	171	177	PF00069	0.539
MOD_PKA_2	178	184	PF00069	0.500
MOD_PKB_1	78	86	PF00069	0.501
MOD_Plk_1	36	42	PF00069	0.563
MOD_Plk_4	172	178	PF00069	0.445
MOD_Plk_4	36	42	PF00069	0.651
MOD_Plk_4	86	92	PF00069	0.496
MOD_ProDKin_1	119	125	PF00069	0.495
MOD_ProDKin_1	3	9	PF00069	0.569
TRG_ENDOCYTIC_2	243	246	PF00928	0.494
TRG_NLS_MonoExtN_4	12	18	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR2	Leptomonas seymouri	46%	100%
A0A1X0NQJ4	Trypanosomatidae	30%	72%
A0A3Q8I8T9	Leishmania donovani	88%	100%
A0A3R7KUI1	Trypanosoma rangeli	27%	87%
A4H651	Leishmania braziliensis	67%	100%
A4HUH1	Leishmania infantum	87%	100%
E9AI41	Leishmania braziliensis	72%	100%
Q4QHF6	Leishmania major	86%	100%
V5B6H6	Trypanosoma cruzi	25%	86%