Chromatin assembly factor 1 subunit A

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit A, putative

Species:

Leishmania mexicana

UniProt:

E9AN68_LEIMU

TriTrypDb:

LmxM.10.0580

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AN68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.439
CLV_C14_Caspase3-7	448	452	PF00656	0.458
CLV_C14_Caspase3-7	456	460	PF00656	0.666
CLV_C14_Caspase3-7	470	474	PF00656	0.615
CLV_C14_Caspase3-7	722	726	PF00656	0.579
CLV_C14_Caspase3-7	795	799	PF00656	0.643
CLV_MEL_PAP_1	656	662	PF00089	0.540
CLV_NRD_NRD_1	143	145	PF00675	0.552
CLV_NRD_NRD_1	155	157	PF00675	0.476
CLV_NRD_NRD_1	171	173	PF00675	0.515
CLV_NRD_NRD_1	183	185	PF00675	0.464
CLV_NRD_NRD_1	193	195	PF00675	0.461
CLV_NRD_NRD_1	292	294	PF00675	0.702
CLV_NRD_NRD_1	416	418	PF00675	0.286
CLV_NRD_NRD_1	481	483	PF00675	0.528
CLV_NRD_NRD_1	490	492	PF00675	0.555
CLV_NRD_NRD_1	583	585	PF00675	0.536
CLV_NRD_NRD_1	632	634	PF00675	0.431
CLV_NRD_NRD_1	637	639	PF00675	0.451
CLV_NRD_NRD_1	644	646	PF00675	0.450
CLV_PCSK_FUR_1	488	492	PF00082	0.498
CLV_PCSK_KEX2_1	143	145	PF00082	0.625
CLV_PCSK_KEX2_1	154	156	PF00082	0.653
CLV_PCSK_KEX2_1	183	185	PF00082	0.600
CLV_PCSK_KEX2_1	253	255	PF00082	0.565
CLV_PCSK_KEX2_1	292	294	PF00082	0.716
CLV_PCSK_KEX2_1	35	37	PF00082	0.366
CLV_PCSK_KEX2_1	416	418	PF00082	0.286
CLV_PCSK_KEX2_1	490	492	PF00082	0.539
CLV_PCSK_KEX2_1	570	572	PF00082	0.567
CLV_PCSK_KEX2_1	583	585	PF00082	0.469
CLV_PCSK_KEX2_1	632	634	PF00082	0.436
CLV_PCSK_KEX2_1	637	639	PF00082	0.469
CLV_PCSK_KEX2_1	644	646	PF00082	0.444
CLV_PCSK_KEX2_1	785	787	PF00082	0.716
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.565
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.332
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.546
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.716
CLV_PCSK_PC7_1	412	418	PF00082	0.286
CLV_PCSK_PC7_1	633	639	PF00082	0.531
CLV_PCSK_PC7_1	640	646	PF00082	0.527
CLV_PCSK_SKI1_1	155	159	PF00082	0.532
CLV_PCSK_SKI1_1	183	187	PF00082	0.518
CLV_PCSK_SKI1_1	213	217	PF00082	0.600
CLV_PCSK_SKI1_1	346	350	PF00082	0.604
CLV_PCSK_SKI1_1	584	588	PF00082	0.529
CLV_PCSK_SKI1_1	607	611	PF00082	0.497
CLV_PCSK_SKI1_1	782	786	PF00082	0.709
DEG_Nend_Nbox_1	1	3	PF02207	0.420
DEG_SCF_FBW7_1	731	737	PF00400	0.630
DEG_SCF_TRCP1_1	455	460	PF00400	0.464
DEG_SPOP_SBC_1	445	449	PF00917	0.379
DEG_SPOP_SBC_1	80	84	PF00917	0.667
DOC_CKS1_1	731	736	PF01111	0.628
DOC_MAPK_MEF2A_6	614	622	PF00069	0.555
DOC_PP2B_LxvP_1	216	219	PF13499	0.601
DOC_PP2B_LxvP_1	310	313	PF13499	0.656
DOC_USP7_MATH_1	123	127	PF00917	0.648
DOC_USP7_MATH_1	358	362	PF00917	0.640
DOC_USP7_MATH_1	363	367	PF00917	0.567
DOC_USP7_MATH_1	383	387	PF00917	0.408
DOC_USP7_MATH_1	445	449	PF00917	0.288
DOC_USP7_MATH_1	599	603	PF00917	0.577
DOC_USP7_MATH_1	658	662	PF00917	0.618
DOC_USP7_MATH_1	718	722	PF00917	0.708
DOC_USP7_MATH_1	748	752	PF00917	0.758
DOC_USP7_MATH_1	75	79	PF00917	0.692
DOC_USP7_MATH_1	773	777	PF00917	0.660
DOC_USP7_MATH_1	81	85	PF00917	0.699
DOC_USP7_MATH_1	88	92	PF00917	0.563
DOC_USP7_MATH_2	773	779	PF00917	0.561
DOC_USP7_UBL2_3	213	217	PF12436	0.560
DOC_USP7_UBL2_3	603	607	PF12436	0.389
DOC_USP7_UBL2_3	770	774	PF12436	0.621
DOC_WW_Pin1_4	129	134	PF00397	0.596
DOC_WW_Pin1_4	244	249	PF00397	0.566
DOC_WW_Pin1_4	647	652	PF00397	0.503
DOC_WW_Pin1_4	730	735	PF00397	0.640
DOC_WW_Pin1_4	744	749	PF00397	0.575
DOC_WW_Pin1_4	89	94	PF00397	0.638
LIG_14-3-3_CanoR_1	637	643	PF00244	0.551
LIG_14-3-3_CanoR_1	659	668	PF00244	0.635
LIG_Actin_WH2_2	34	51	PF00022	0.382
LIG_Actin_WH2_2	403	418	PF00022	0.349
LIG_AP2alpha_1	25	29	PF02296	0.342
LIG_BRCT_BRCA1_1	505	509	PF00533	0.507
LIG_CSL_BTD_1	648	651	PF09270	0.485
LIG_CSL_BTD_1	758	761	PF09270	0.492
LIG_FHA_1	106	112	PF00498	0.605
LIG_FHA_1	275	281	PF00498	0.726
LIG_FHA_1	4	10	PF00498	0.368
LIG_FHA_1	43	49	PF00498	0.507
LIG_FHA_1	604	610	PF00498	0.546
LIG_FHA_1	672	678	PF00498	0.743
LIG_FHA_1	767	773	PF00498	0.668
LIG_FHA_1	95	101	PF00498	0.554
LIG_FHA_2	187	193	PF00498	0.556
LIG_FHA_2	41	47	PF00498	0.417
LIG_FHA_2	585	591	PF00498	0.556
LIG_FHA_2	694	700	PF00498	0.672
LIG_FHA_2	731	737	PF00498	0.675
LIG_LIR_Apic_2	504	508	PF02991	0.615
LIG_LIR_Gen_1	27	38	PF02991	0.325
LIG_LIR_Gen_1	330	337	PF02991	0.537
LIG_LIR_Gen_1	361	372	PF02991	0.634
LIG_LIR_Gen_1	393	402	PF02991	0.406
LIG_LIR_Gen_1	433	442	PF02991	0.286
LIG_LIR_Nem_3	227	232	PF02991	0.621
LIG_LIR_Nem_3	27	33	PF02991	0.326
LIG_LIR_Nem_3	361	367	PF02991	0.544
LIG_LIR_Nem_3	370	376	PF02991	0.505
LIG_LIR_Nem_3	393	397	PF02991	0.409
LIG_LIR_Nem_3	506	512	PF02991	0.551
LIG_LIR_Nem_3	526	531	PF02991	0.366
LIG_LIR_Nem_3	654	660	PF02991	0.566
LIG_MYND_1	744	748	PF01753	0.519
LIG_NRBOX	126	132	PF00104	0.471
LIG_Pex14_2	25	29	PF04695	0.342
LIG_Pex14_2	373	377	PF04695	0.621
LIG_PTB_Apo_2	421	428	PF02174	0.286
LIG_PTB_Phospho_1	421	427	PF10480	0.286
LIG_RPA_C_Fungi	633	645	PF08784	0.538
LIG_SH2_CRK	30	34	PF00017	0.317
LIG_SH2_CRK	505	509	PF00017	0.600
LIG_SH2_STAT5	23	26	PF00017	0.385
LIG_SH2_STAT5	30	33	PF00017	0.320
LIG_SH2_STAT5	315	318	PF00017	0.587
LIG_SH2_STAT5	390	393	PF00017	0.331
LIG_SH2_STAT5	535	538	PF00017	0.574
LIG_SH3_1	755	761	PF00018	0.498
LIG_SH3_3	357	363	PF00018	0.637
LIG_SH3_3	507	513	PF00018	0.553
LIG_SH3_3	663	669	PF00018	0.720
LIG_SH3_3	69	75	PF00018	0.596
LIG_SH3_3	728	734	PF00018	0.633
LIG_SH3_3	755	761	PF00018	0.534
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.535
LIG_TRAF2_1	116	119	PF00917	0.453
LIG_TRAF2_1	563	566	PF00917	0.533
LIG_TRAF2_1	737	740	PF00917	0.687
LIG_UBA3_1	228	237	PF00899	0.616
LIG_UBA3_1	62	68	PF00899	0.660
LIG_WRC_WIRS_1	364	369	PF05994	0.612
LIG_WRC_WIRS_1	544	549	PF05994	0.399
LIG_WW_1	312	315	PF00397	0.594
MOD_CDK_SPxxK_3	129	136	PF00069	0.572
MOD_CK1_1	447	453	PF00069	0.292
MOD_CK1_1	460	466	PF00069	0.533
MOD_CK1_1	545	551	PF00069	0.434
MOD_CK1_1	602	608	PF00069	0.516
MOD_CK1_1	721	727	PF00069	0.513
MOD_CK1_1	747	753	PF00069	0.677
MOD_CK1_1	776	782	PF00069	0.553
MOD_CK1_1	83	89	PF00069	0.536
MOD_CK2_1	186	192	PF00069	0.359
MOD_CK2_1	268	274	PF00069	0.629
MOD_CK2_1	40	46	PF00069	0.392
MOD_CK2_1	461	467	PF00069	0.692
MOD_CK2_1	473	479	PF00069	0.456
MOD_CK2_1	554	560	PF00069	0.629
MOD_CK2_1	584	590	PF00069	0.570
MOD_CK2_1	730	736	PF00069	0.703
MOD_CK2_1	747	753	PF00069	0.557
MOD_CK2_1	81	87	PF00069	0.709
MOD_GlcNHglycan	430	433	PF01048	0.286
MOD_GlcNHglycan	455	458	PF01048	0.502
MOD_GlcNHglycan	505	508	PF01048	0.515
MOD_GlcNHglycan	548	551	PF01048	0.601
MOD_GlcNHglycan	562	565	PF01048	0.529
MOD_GlcNHglycan	714	719	PF01048	0.729
MOD_GlcNHglycan	750	753	PF01048	0.803
MOD_GlcNHglycan	775	778	PF01048	0.660
MOD_GSK3_1	105	112	PF00069	0.670
MOD_GSK3_1	445	452	PF00069	0.288
MOD_GSK3_1	453	460	PF00069	0.574
MOD_GSK3_1	469	476	PF00069	0.544
MOD_GSK3_1	542	549	PF00069	0.432
MOD_GSK3_1	593	600	PF00069	0.535
MOD_GSK3_1	714	721	PF00069	0.661
MOD_GSK3_1	730	737	PF00069	0.648
MOD_GSK3_1	744	751	PF00069	0.771
MOD_GSK3_1	75	82	PF00069	0.515
MOD_GSK3_1	773	780	PF00069	0.554
MOD_GSK3_1	798	805	PF00069	0.639
MOD_N-GLC_1	280	285	PF02516	0.661
MOD_N-GLC_1	496	501	PF02516	0.553
MOD_N-GLC_1	761	766	PF02516	0.490
MOD_NEK2_1	111	116	PF00069	0.597
MOD_NEK2_1	231	236	PF00069	0.587
MOD_NEK2_1	29	34	PF00069	0.353
MOD_NEK2_1	62	67	PF00069	0.556
MOD_NEK2_2	777	782	PF00069	0.509
MOD_PIKK_1	477	483	PF00454	0.538
MOD_PIKK_1	94	100	PF00454	0.529
MOD_PKA_2	420	426	PF00069	0.379
MOD_PKA_2	658	664	PF00069	0.573
MOD_PKB_1	494	502	PF00069	0.540
MOD_Plk_1	266	272	PF00069	0.724
MOD_Plk_1	274	280	PF00069	0.743
MOD_Plk_1	304	310	PF00069	0.588
MOD_Plk_1	542	548	PF00069	0.431
MOD_Plk_1	627	633	PF00069	0.470
MOD_Plk_1	702	708	PF00069	0.790
MOD_Plk_1	761	767	PF00069	0.491
MOD_Plk_2-3	471	477	PF00069	0.560
MOD_Plk_2-3	693	699	PF00069	0.670
MOD_Plk_4	224	230	PF00069	0.560
MOD_Plk_4	275	281	PF00069	0.680
MOD_Plk_4	305	311	PF00069	0.586
MOD_Plk_4	593	599	PF00069	0.526
MOD_ProDKin_1	129	135	PF00069	0.588
MOD_ProDKin_1	244	250	PF00069	0.565
MOD_ProDKin_1	647	653	PF00069	0.497
MOD_ProDKin_1	730	736	PF00069	0.642
MOD_ProDKin_1	744	750	PF00069	0.575
MOD_ProDKin_1	89	95	PF00069	0.630
MOD_SUMO_for_1	157	160	PF00179	0.484
MOD_SUMO_for_1	165	168	PF00179	0.403
MOD_SUMO_for_1	236	239	PF00179	0.619
MOD_SUMO_for_1	754	757	PF00179	0.707
MOD_SUMO_rev_2	177	182	PF00179	0.566
MOD_SUMO_rev_2	585	594	PF00179	0.574
MOD_SUMO_rev_2	747	756	PF00179	0.678
TRG_DiLeu_BaEn_1	160	165	PF01217	0.505
TRG_DiLeu_BaEn_1	305	310	PF01217	0.575
TRG_DiLeu_BaEn_1	58	63	PF01217	0.512
TRG_DiLeu_BaEn_2	523	529	PF01217	0.451
TRG_DiLeu_BaEn_4	305	311	PF01217	0.635
TRG_ENDOCYTIC_2	30	33	PF00928	0.352
TRG_ENDOCYTIC_2	364	367	PF00928	0.627
TRG_ENDOCYTIC_2	394	397	PF00928	0.414
TRG_ER_diArg_1	154	156	PF00400	0.528
TRG_ER_diArg_1	183	185	PF00400	0.517
TRG_ER_diArg_1	323	326	PF00400	0.478
TRG_ER_diArg_1	415	417	PF00400	0.286
TRG_ER_diArg_1	488	491	PF00400	0.541
TRG_ER_diArg_1	631	633	PF00400	0.459
TRG_ER_diArg_1	637	640	PF00400	0.510
TRG_ER_diArg_1	643	645	PF00400	0.443
TRG_NLS_MonoCore_2	663	668	PF00514	0.597
TRG_NLS_MonoExtC_3	135	140	PF00514	0.660
TRG_NLS_MonoExtN_4	133	140	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	573	577	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G0	Leptomonas seymouri	56%	100%
A0A1X0NRX9	Trypanosomatidae	40%	99%
A0A3S5H6G3	Leishmania donovani	90%	100%
A4H650	Leishmania braziliensis	78%	100%
A4HUH0	Leishmania infantum	90%	100%
Q4QHF7	Leishmania major	88%	99%
V5D2A3	Trypanosoma cruzi	42%	100%