Zinc-binding dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-binding dehydrogenase-like protein

Species:

Leishmania mexicana

UniProt:

E9AN67_LEIMU

TriTrypDb:

LmxM.10.0570

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AN67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.341
CLV_NRD_NRD_1	112	114	PF00675	0.351
CLV_NRD_NRD_1	355	357	PF00675	0.334
CLV_NRD_NRD_1	439	441	PF00675	0.491
CLV_PCSK_FUR_1	436	440	PF00082	0.577
CLV_PCSK_KEX2_1	112	114	PF00082	0.266
CLV_PCSK_KEX2_1	355	357	PF00082	0.357
CLV_PCSK_KEX2_1	438	440	PF00082	0.483
CLV_PCSK_SKI1_1	116	120	PF00082	0.163
CLV_PCSK_SKI1_1	169	173	PF00082	0.313
CLV_PCSK_SKI1_1	247	251	PF00082	0.348
CLV_PCSK_SKI1_1	303	307	PF00082	0.364
CLV_PCSK_SKI1_1	42	46	PF00082	0.529
CLV_PCSK_SKI1_1	421	425	PF00082	0.355
DEG_APCC_DBOX_1	374	382	PF00400	0.429
DEG_SPOP_SBC_1	105	109	PF00917	0.163
DOC_CYCLIN_yCln2_LP_2	345	348	PF00134	0.231
DOC_MAPK_FxFP_2	122	125	PF00069	0.275
DOC_MAPK_gen_1	162	172	PF00069	0.402
DOC_MAPK_gen_1	436	444	PF00069	0.569
DOC_MAPK_JIP1_4	30	36	PF00069	0.510
DOC_PP1_RVXF_1	167	173	PF00149	0.313
DOC_PP1_RVXF_1	214	221	PF00149	0.432
DOC_PP2B_LxvP_1	345	348	PF13499	0.221
DOC_PP4_FxxP_1	122	125	PF00568	0.275
DOC_USP7_MATH_1	100	104	PF00917	0.323
DOC_USP7_MATH_1	143	147	PF00917	0.306
DOC_USP7_MATH_1	205	209	PF00917	0.459
DOC_USP7_MATH_1	25	29	PF00917	0.580
DOC_USP7_MATH_1	275	279	PF00917	0.283
DOC_USP7_MATH_1	321	325	PF00917	0.364
DOC_USP7_MATH_1	74	78	PF00917	0.372
DOC_USP7_UBL2_3	119	123	PF12436	0.163
DOC_WW_Pin1_4	12	17	PF00397	0.503
DOC_WW_Pin1_4	203	208	PF00397	0.419
DOC_WW_Pin1_4	276	281	PF00397	0.389
DOC_WW_Pin1_4	56	61	PF00397	0.360
DOC_WW_Pin1_4	63	68	PF00397	0.363
LIG_14-3-3_CanoR_1	156	164	PF00244	0.163
LIG_14-3-3_CanoR_1	355	361	PF00244	0.332
LIG_14-3-3_CanoR_1	95	99	PF00244	0.173
LIG_Actin_WH2_2	14	32	PF00022	0.533
LIG_BRCT_BRCA1_1	14	18	PF00533	0.386
LIG_eIF4E_1	312	318	PF01652	0.391
LIG_FHA_1	207	213	PF00498	0.587
LIG_FHA_1	246	252	PF00498	0.390
LIG_FHA_1	277	283	PF00498	0.242
LIG_FHA_1	94	100	PF00498	0.377
LIG_FHA_2	295	301	PF00498	0.300
LIG_LIR_Apic_2	193	199	PF02991	0.391
LIG_LIR_Gen_1	295	302	PF02991	0.221
LIG_LIR_Gen_1	359	367	PF02991	0.313
LIG_LIR_Nem_3	15	21	PF02991	0.379
LIG_LIR_Nem_3	183	187	PF02991	0.260
LIG_LIR_Nem_3	295	299	PF02991	0.221
LIG_LIR_Nem_3	359	365	PF02991	0.313
LIG_MYND_1	27	31	PF01753	0.611
LIG_Pex14_2	172	176	PF04695	0.402
LIG_SH2_CRK	65	69	PF00017	0.284
LIG_SH2_NCK_1	187	191	PF00017	0.391
LIG_SH2_NCK_1	296	300	PF00017	0.371
LIG_SH2_NCK_1	445	449	PF00017	0.571
LIG_SH2_PTP2	19	22	PF00017	0.539
LIG_SH2_PTP2	234	237	PF00017	0.325
LIG_SH2_PTP2	362	365	PF00017	0.313
LIG_SH2_SRC	272	275	PF00017	0.313
LIG_SH2_SRC	284	287	PF00017	0.211
LIG_SH2_STAP1	308	312	PF00017	0.313
LIG_SH2_STAT5	126	129	PF00017	0.332
LIG_SH2_STAT5	19	22	PF00017	0.621
LIG_SH2_STAT5	234	237	PF00017	0.325
LIG_SH2_STAT5	268	271	PF00017	0.328
LIG_SH2_STAT5	272	275	PF00017	0.323
LIG_SH2_STAT5	284	287	PF00017	0.279
LIG_SH2_STAT5	292	295	PF00017	0.332
LIG_SH2_STAT5	296	299	PF00017	0.332
LIG_SH2_STAT5	308	311	PF00017	0.322
LIG_SH2_STAT5	316	319	PF00017	0.291
LIG_SH2_STAT5	362	365	PF00017	0.313
LIG_SH2_STAT5	389	392	PF00017	0.532
LIG_SH3_1	19	25	PF00018	0.543
LIG_SH3_3	10	16	PF00018	0.675
LIG_SH3_3	19	25	PF00018	0.572
LIG_SH3_3	199	205	PF00018	0.586
LIG_SH3_3	61	67	PF00018	0.416
LIG_SH3_4	119	126	PF00018	0.163
LIG_SUMO_SIM_anti_2	297	304	PF11976	0.221
LIG_TYR_ITIM	294	299	PF00017	0.163
LIG_TYR_ITIM	360	365	PF00017	0.332
LIG_TYR_ITIM	63	68	PF00017	0.281
LIG_WW_1	16	19	PF00397	0.520
LIG_WW_3	346	350	PF00397	0.163
MOD_CDK_SPK_2	276	281	PF00069	0.163
MOD_CDK_SPxxK_3	276	283	PF00069	0.313
MOD_CK1_1	108	114	PF00069	0.397
MOD_CK1_1	152	158	PF00069	0.231
MOD_CK1_1	180	186	PF00069	0.432
MOD_CK1_1	206	212	PF00069	0.398
MOD_CK1_1	225	231	PF00069	0.157
MOD_CK1_1	252	258	PF00069	0.305
MOD_CK1_1	276	282	PF00069	0.275
MOD_CK1_1	37	43	PF00069	0.480
MOD_CK1_1	56	62	PF00069	0.361
MOD_CK1_1	8	14	PF00069	0.593
MOD_CK2_1	321	327	PF00069	0.364
MOD_GlcNHglycan	145	148	PF01048	0.307
MOD_GlcNHglycan	157	160	PF01048	0.217
MOD_GlcNHglycan	179	182	PF01048	0.340
MOD_GlcNHglycan	251	254	PF01048	0.348
MOD_GlcNHglycan	39	42	PF01048	0.524
MOD_GlcNHglycan	414	417	PF01048	0.485
MOD_GSK3_1	100	107	PF00069	0.277
MOD_GSK3_1	108	115	PF00069	0.254
MOD_GSK3_1	245	252	PF00069	0.273
MOD_GSK3_1	25	32	PF00069	0.622
MOD_GSK3_1	3	10	PF00069	0.663
MOD_GSK3_1	467	474	PF00069	0.611
MOD_N-GLC_1	54	59	PF02516	0.385
MOD_NEK2_1	34	39	PF00069	0.507
MOD_NEK2_1	454	459	PF00069	0.538
MOD_NMyristoyl	1	7	PF02799	0.492
MOD_PIKK_1	174	180	PF00454	0.364
MOD_PIKK_1	242	248	PF00454	0.383
MOD_PIKK_1	34	40	PF00454	0.391
MOD_PIKK_1	454	460	PF00454	0.444
MOD_PIKK_1	74	80	PF00454	0.382
MOD_PK_1	356	362	PF00069	0.357
MOD_PKA_1	112	118	PF00069	0.318
MOD_PKA_2	112	118	PF00069	0.355
MOD_PKA_2	155	161	PF00069	0.163
MOD_PKA_2	94	100	PF00069	0.173
MOD_Plk_1	294	300	PF00069	0.330
MOD_Plk_1	454	460	PF00069	0.501
MOD_Plk_1	54	60	PF00069	0.531
MOD_Plk_2-3	304	310	PF00069	0.273
MOD_Plk_4	94	100	PF00069	0.256
MOD_ProDKin_1	12	18	PF00069	0.493
MOD_ProDKin_1	203	209	PF00069	0.423
MOD_ProDKin_1	276	282	PF00069	0.389
MOD_ProDKin_1	56	62	PF00069	0.353
MOD_ProDKin_1	63	69	PF00069	0.358
TRG_DiLeu_BaEn_2	398	404	PF01217	0.459
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.516
TRG_ENDOCYTIC_2	187	190	PF00928	0.332
TRG_ENDOCYTIC_2	234	237	PF00928	0.325
TRG_ENDOCYTIC_2	268	271	PF00928	0.275
TRG_ENDOCYTIC_2	296	299	PF00928	0.221
TRG_ENDOCYTIC_2	362	365	PF00928	0.313
TRG_ENDOCYTIC_2	65	68	PF00928	0.294
TRG_ER_diArg_1	354	356	PF00400	0.357
TRG_ER_diArg_1	436	439	PF00400	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I8	Leptomonas seymouri	43%	100%
A0A0N1I4X2	Leptomonas seymouri	68%	100%
A0A0S4ILS9	Bodo saltans	27%	100%
A0A0S4JMB1	Bodo saltans	24%	100%
A0A1X0NRR2	Trypanosomatidae	46%	98%
A0A3Q8IRG0	Leishmania donovani	26%	100%
A0A3S7WR50	Leishmania donovani	42%	100%
A0A3S7WR58	Leishmania donovani	87%	100%
A4H648	Leishmania braziliensis	42%	98%
A4H649	Leishmania braziliensis	82%	100%
A4HUG8	Leishmania infantum	42%	100%
A4HUG9	Leishmania infantum	86%	100%
A4IE56	Leishmania infantum	26%	100%
C9ZVI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AN66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	98%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
K4BW79	Solanum lycopersicum	27%	100%
O23939	Fragaria vesca	24%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
O57380	Pelophylax perezi	25%	100%
P42328	Geobacillus stearothermophilus	24%	100%
Q0VC50	Bos taurus	26%	100%
Q24K16	Bos taurus	25%	100%
Q4Q0Z7	Leishmania major	25%	100%
Q4QHF8	Leishmania major	86%	100%
Q4QHF9	Leishmania major	42%	98%
Q4W4Z2	Caenorhabditis elegans	26%	100%
Q67N85	Symbiobacterium thermophilum (strain T / IAM 14863)	26%	100%
Q7T3C7	Danio rerio	26%	100%
Q84V25	Fragaria ananassa	25%	100%
Q8BGC4	Mus musculus	23%	100%
Q8H0M1	Spinacia oleracea	26%	100%
Q8JFV8	Danio rerio	25%	99%
Q8N4Q0	Homo sapiens	24%	100%
Q8WWV3	Homo sapiens	27%	100%
Q924D0	Mus musculus	27%	100%
Q99536	Homo sapiens	28%	100%
Q9AYU1	Triphysaria versicolor	24%	100%
Q9SV68	Arabidopsis thaliana	23%	100%
Q9ZUC1	Arabidopsis thaliana	27%	100%
V5ALK9	Trypanosoma cruzi	46%	100%
V5B1P3	Trypanosoma cruzi	27%	100%