LeishMANIAdb
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Leishmanolysin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leishmanolysin
Gene product:
GP63, leishmanolysin
Species:
Leishmania mexicana
UniProt:
E9AN54_LEIMU
TriTrypDb:
LmxM.10.0390
Length:
602

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 51
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 41, no: 9
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0016020 membrane 2 51
GO:0110165 cellular anatomical entity 1 51
GO:0005737 cytoplasm 2 4
GO:0018995 host cellular component 2 4
GO:0033643 host cell part 3 4
GO:0033646 host intracellular part 4 4
GO:0033647 host intracellular organelle 5 4
GO:0033648 host intracellular membrane-bounded organelle 6 4
GO:0042025 host cell nucleus 7 4

Expansion

Sequence features

E9AN54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN54

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 51
GO:0006807 nitrogen compound metabolic process 2 51
GO:0007155 cell adhesion 2 51
GO:0008152 metabolic process 1 51
GO:0009987 cellular process 1 51
GO:0019538 protein metabolic process 3 51
GO:0043170 macromolecule metabolic process 3 51
GO:0044238 primary metabolic process 2 51
GO:0071704 organic substance metabolic process 2 51
GO:1901564 organonitrogen compound metabolic process 3 51
GO:0009966 regulation of signal transduction 4 4
GO:0010646 regulation of cell communication 4 4
GO:0010749 regulation of nitric oxide mediated signal transduction 6 4
GO:0023051 regulation of signaling 3 4
GO:0035821 modulation of process of another organism 2 4
GO:0044003 modulation by symbiont of host process 3 4
GO:0044068 modulation by symbiont of host cellular process 4 4
GO:0044081 modulation by symbiont of host nitric oxide-mediated signal transduction 5 4
GO:0044403 biological process involved in symbiotic interaction 2 4
GO:0044419 biological process involved in interspecies interaction between organisms 1 4
GO:0044501 modulation of signal transduction in another organism 3 4
GO:0048583 regulation of response to stimulus 3 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051701 biological process involved in interaction with host 3 4
GO:0052027 modulation by symbiont of host signal transduction pathway 4 4
GO:0065007 biological regulation 1 4
GO:0075130 modulation by symbiont of host protein kinase-mediated signal transduction 5 4
GO:1902531 regulation of intracellular signal transduction 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 51
GO:0004175 endopeptidase activity 4 51
GO:0004222 metalloendopeptidase activity 5 51
GO:0005488 binding 1 51
GO:0008233 peptidase activity 3 51
GO:0008237 metallopeptidase activity 4 51
GO:0016787 hydrolase activity 2 51
GO:0043167 ion binding 2 51
GO:0043169 cation binding 3 51
GO:0046872 metal ion binding 4 51
GO:0140096 catalytic activity, acting on a protein 2 51
GO:0008047 enzyme activator activity 3 4
GO:0008160 protein tyrosine phosphatase activator activity 6 4
GO:0019208 phosphatase regulator activity 3 4
GO:0019211 phosphatase activator activity 4 4
GO:0019888 protein phosphatase regulator activity 4 4
GO:0030234 enzyme regulator activity 2 4
GO:0072542 protein phosphatase activator activity 5 4
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 324 328 PF00656 0.238
CLV_C14_Caspase3-7 408 412 PF00656 0.238
CLV_C14_Caspase3-7 471 475 PF00656 0.245
CLV_C14_Caspase3-7 545 549 PF00656 0.270
CLV_MEL_PAP_1 132 138 PF00089 0.456
CLV_NRD_NRD_1 582 584 PF00675 0.633
CLV_PCSK_KEX2_1 152 154 PF00082 0.620
CLV_PCSK_KEX2_1 582 584 PF00082 0.633
CLV_PCSK_PC1ET2_1 152 154 PF00082 0.609
CLV_PCSK_SKI1_1 153 157 PF00082 0.597
CLV_PCSK_SKI1_1 260 264 PF00082 0.605
DEG_APCC_DBOX_1 539 547 PF00400 0.370
DEG_SPOP_SBC_1 3 7 PF00917 0.665
DOC_CYCLIN_yCln2_LP_2 118 124 PF00134 0.330
DOC_MAPK_gen_1 290 299 PF00069 0.381
DOC_PP4_FxxP_1 194 197 PF00568 0.449
DOC_PP4_FxxP_1 440 443 PF00568 0.314
DOC_USP7_MATH_1 347 351 PF00917 0.254
DOC_USP7_MATH_1 446 450 PF00917 0.241
DOC_USP7_MATH_1 90 94 PF00917 0.273
DOC_WW_Pin1_4 533 538 PF00397 0.452
DOC_WW_Pin1_4 93 98 PF00397 0.326
LIG_14-3-3_CanoR_1 110 118 PF00244 0.430
LIG_14-3-3_CanoR_1 419 423 PF00244 0.353
LIG_14-3-3_CanoR_1 495 503 PF00244 0.335
LIG_14-3-3_CanoR_1 520 525 PF00244 0.434
LIG_14-3-3_CanoR_1 56 62 PF00244 0.420
LIG_14-3-3_CanoR_1 586 594 PF00244 0.578
LIG_AP2alpha_1 440 444 PF02296 0.255
LIG_AP2alpha_2 442 444 PF02296 0.234
LIG_APCC_ABBA_1 165 170 PF00400 0.449
LIG_APCC_ABBA_1 359 364 PF00400 0.426
LIG_APCC_ABBA_1 458 463 PF00400 0.320
LIG_APCC_ABBA_1 480 485 PF00400 0.452
LIG_BIR_II_1 1 5 PF00653 0.727
LIG_BIR_III_4 278 282 PF00653 0.231
LIG_BRCT_BRCA1_1 272 276 PF00533 0.373
LIG_BRCT_BRCA1_1 447 451 PF00533 0.254
LIG_BRCT_BRCA1_1 546 550 PF00533 0.452
LIG_BRCT_BRCA1_2 546 552 PF00533 0.249
LIG_FHA_1 200 206 PF00498 0.336
LIG_FHA_1 227 233 PF00498 0.344
LIG_FHA_1 257 263 PF00498 0.399
LIG_FHA_1 27 33 PF00498 0.549
LIG_FHA_1 356 362 PF00498 0.443
LIG_FHA_1 415 421 PF00498 0.421
LIG_FHA_1 497 503 PF00498 0.274
LIG_FHA_1 519 525 PF00498 0.434
LIG_FHA_1 534 540 PF00498 0.281
LIG_FHA_1 588 594 PF00498 0.599
LIG_FHA_2 141 147 PF00498 0.373
LIG_FHA_2 273 279 PF00498 0.300
LIG_FHA_2 543 549 PF00498 0.297
LIG_GBD_Chelix_1 594 602 PF00786 0.593
LIG_LIR_Apic_2 192 197 PF02991 0.430
LIG_LIR_Gen_1 275 283 PF02991 0.309
LIG_LIR_Gen_1 316 324 PF02991 0.447
LIG_LIR_Gen_1 428 437 PF02991 0.302
LIG_LIR_Gen_1 505 513 PF02991 0.259
LIG_LIR_LC3C_4 590 594 PF02991 0.485
LIG_LIR_Nem_3 192 196 PF02991 0.294
LIG_LIR_Nem_3 208 213 PF02991 0.426
LIG_LIR_Nem_3 275 280 PF02991 0.310
LIG_LIR_Nem_3 428 433 PF02991 0.318
LIG_LIR_Nem_3 448 454 PF02991 0.329
LIG_LIR_Nem_3 474 480 PF02991 0.320
LIG_LIR_Nem_3 505 509 PF02991 0.359
LIG_PDZ_Class_2 597 602 PF00595 0.580
LIG_Pex14_1 401 405 PF04695 0.441
LIG_Pex14_2 272 276 PF04695 0.387
LIG_Pex14_2 440 444 PF04695 0.273
LIG_PTB_Apo_2 204 211 PF02174 0.437
LIG_SH2_CRK 254 258 PF00017 0.398
LIG_SH2_CRK 354 358 PF00017 0.452
LIG_SH2_CRK 430 434 PF00017 0.281
LIG_SH2_CRK 506 510 PF00017 0.414
LIG_SH2_GRB2like 532 535 PF00017 0.334
LIG_SH2_PTP2 561 564 PF00017 0.449
LIG_SH2_SRC 561 564 PF00017 0.449
LIG_SH2_STAP1 254 258 PF00017 0.405
LIG_SH2_STAP1 522 526 PF00017 0.452
LIG_SH2_STAT3 522 525 PF00017 0.437
LIG_SH2_STAT5 193 196 PF00017 0.249
LIG_SH2_STAT5 213 216 PF00017 0.430
LIG_SH2_STAT5 294 297 PF00017 0.248
LIG_SH2_STAT5 319 322 PF00017 0.409
LIG_SH2_STAT5 354 357 PF00017 0.375
LIG_SH2_STAT5 436 439 PF00017 0.436
LIG_SH2_STAT5 454 457 PF00017 0.265
LIG_SH2_STAT5 555 558 PF00017 0.449
LIG_SH2_STAT5 561 564 PF00017 0.382
LIG_SH3_3 553 559 PF00018 0.246
LIG_SH3_3 71 77 PF00018 0.334
LIG_Sin3_3 589 596 PF02671 0.589
LIG_SUMO_SIM_par_1 28 34 PF11976 0.546
LIG_TRAF2_1 218 221 PF00917 0.319
MOD_CDK_SPK_2 93 98 PF00069 0.243
MOD_CDK_SPxxK_3 533 540 PF00069 0.458
MOD_CK1_1 2 8 PF00069 0.696
MOD_CK1_1 216 222 PF00069 0.529
MOD_CK1_1 330 336 PF00069 0.468
MOD_CK1_1 418 424 PF00069 0.353
MOD_CK1_1 544 550 PF00069 0.408
MOD_CK1_1 69 75 PF00069 0.295
MOD_CK1_1 93 99 PF00069 0.390
MOD_CK2_1 370 376 PF00069 0.543
MOD_CK2_1 466 472 PF00069 0.296
MOD_Cter_Amidation 580 583 PF01082 0.636
MOD_GlcNHglycan 113 116 PF01048 0.308
MOD_GlcNHglycan 272 275 PF01048 0.290
MOD_GlcNHglycan 329 332 PF01048 0.468
MOD_GlcNHglycan 347 350 PF01048 0.272
MOD_GlcNHglycan 408 411 PF01048 0.253
MOD_GlcNHglycan 448 451 PF01048 0.398
MOD_GlcNHglycan 468 471 PF01048 0.238
MOD_GlcNHglycan 529 532 PF01048 0.475
MOD_GlcNHglycan 68 71 PF01048 0.469
MOD_GSK3_1 199 206 PF00069 0.532
MOD_GSK3_1 256 263 PF00069 0.426
MOD_GSK3_1 414 421 PF00069 0.393
MOD_GSK3_1 514 521 PF00069 0.385
MOD_N-GLC_1 299 304 PF02516 0.365
MOD_N-GLC_1 406 411 PF02516 0.381
MOD_N-GLC_1 533 538 PF02516 0.380
MOD_N-GLC_2 11 13 PF02516 0.516
MOD_NEK2_1 270 275 PF00069 0.469
MOD_NEK2_1 298 303 PF00069 0.246
MOD_NEK2_1 345 350 PF00069 0.253
MOD_NEK2_1 445 450 PF00069 0.330
MOD_NEK2_1 502 507 PF00069 0.245
MOD_NEK2_1 541 546 PF00069 0.274
MOD_PK_1 520 526 PF00069 0.416
MOD_PKA_2 418 424 PF00069 0.403
MOD_PKA_2 526 532 PF00069 0.356
MOD_PKA_2 57 63 PF00069 0.377
MOD_Plk_1 219 225 PF00069 0.253
MOD_Plk_1 425 431 PF00069 0.266
MOD_Plk_1 541 547 PF00069 0.390
MOD_Plk_2-3 146 152 PF00069 0.440
MOD_Plk_2-3 542 548 PF00069 0.237
MOD_Plk_4 189 195 PF00069 0.248
MOD_Plk_4 219 225 PF00069 0.253
MOD_Plk_4 272 278 PF00069 0.380
MOD_ProDKin_1 533 539 PF00069 0.543
MOD_ProDKin_1 93 99 PF00069 0.365
TRG_ENDOCYTIC_2 193 196 PF00928 0.253
TRG_ENDOCYTIC_2 254 257 PF00928 0.482
TRG_ENDOCYTIC_2 294 297 PF00928 0.275
TRG_ENDOCYTIC_2 319 322 PF00928 0.481
TRG_ENDOCYTIC_2 354 357 PF00928 0.543
TRG_ENDOCYTIC_2 430 433 PF00928 0.255
TRG_ENDOCYTIC_2 506 509 PF00928 0.518
TRG_ENDOCYTIC_2 561 564 PF00928 0.537
TRG_Pf-PMV_PEXEL_1 47 51 PF00026 0.353

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL11 Leptomonas seymouri 34% 92%
A0A0S4IN60 Bodo saltans 32% 67%
A0A0S4IUT6 Bodo saltans 31% 73%
A0A0S4IYM3 Bodo saltans 31% 83%
A0A1X0NDG7 Trypanosomatidae 31% 92%
A0A1X0NDJ3 Trypanosomatidae 29% 83%
A0A1X0NDK2 Trypanosomatidae 32% 100%
A0A1X0NDK7 Trypanosomatidae 29% 84%
A0A1X0NDU8 Trypanosomatidae 28% 90%
A0A1X0NE71 Trypanosomatidae 29% 100%
A0A1X0NER9 Trypanosomatidae 32% 94%
A0A1X0NET7 Trypanosomatidae 32% 100%
A0A1X0NEX7 Trypanosomatidae 31% 92%
A0A1X0NEZ6 Trypanosomatidae 30% 92%
A0A1X0NF32 Trypanosomatidae 31% 100%
A0A1X0NF41 Trypanosomatidae 28% 98%
A0A1X0NFJ0 Trypanosomatidae 31% 100%
A0A1X0NFK3 Trypanosomatidae 28% 90%
A0A1X0NFS0 Trypanosomatidae 28% 69%
A0A1X0NFU4 Trypanosomatidae 28% 74%
A0A1X0NFZ9 Trypanosomatidae 31% 100%
A0A1X0NG20 Trypanosomatidae 31% 97%
A0A1X0NGP3 Trypanosomatidae 30% 70%
A0A1X0NGY3 Trypanosomatidae 30% 78%
A0A1X0NGZ3 Trypanosomatidae 30% 100%
A0A1X0NH86 Trypanosomatidae 31% 68%
A0A1X0NHP6 Trypanosomatidae 29% 100%
A0A1X0NHQ6 Trypanosomatidae 30% 100%
A0A1X0NI38 Trypanosomatidae 26% 68%
A0A1X0NI74 Trypanosomatidae 29% 80%
A0A1X0NII4 Trypanosomatidae 30% 71%
A0A1X0NIZ3 Trypanosomatidae 33% 100%
A0A1X0NJS3 Trypanosomatidae 29% 92%
A0A1X0NJU4 Trypanosomatidae 30% 70%
A0A1X0NK66 Trypanosomatidae 30% 91%
A0A1X0NKJ8 Trypanosomatidae 29% 81%
A0A1X0NKW9 Trypanosomatidae 31% 100%
A0A1X0NME2 Trypanosomatidae 31% 96%
A0A1X0NMK3 Trypanosomatidae 26% 100%
A0A1X0NMK7 Trypanosomatidae 36% 100%
A0A1X0NMV0 Trypanosomatidae 31% 82%
A0A1X0NN43 Trypanosomatidae 29% 84%
A0A1X0NNK8 Trypanosomatidae 29% 91%
A0A1X0NP64 Trypanosomatidae 28% 68%
A0A1X0NPW0 Trypanosomatidae 29% 94%
A0A1X0NQM4 Trypanosomatidae 33% 100%
A0A1X0NQN3 Trypanosomatidae 35% 100%
A0A1X0NQU4 Trypanosomatidae 34% 93%
A0A1X0NQW6 Trypanosomatidae 32% 100%
A0A1X0NRF3 Trypanosomatidae 30% 90%
A0A1X0NRY8 Trypanosomatidae 35% 100%
A0A1X0NU16 Trypanosomatidae 36% 100%
A0A1X0NUR2 Trypanosomatidae 33% 82%
A0A1X0NV28 Trypanosomatidae 37% 100%
A0A1X0NVC3 Trypanosomatidae 32% 88%
A0A1X0NVE0 Trypanosomatidae 28% 77%
A0A1X0NW07 Trypanosomatidae 26% 96%
A0A1X0NX94 Trypanosomatidae 31% 93%
A0A1X0NX98 Trypanosomatidae 30% 75%
A0A1X0NXB6 Trypanosomatidae 29% 85%
A0A1X0NXH6 Trypanosomatidae 32% 82%
A0A1X0NXQ4 Trypanosomatidae 27% 89%
A0A1X0NXR7 Trypanosomatidae 32% 80%
A0A1X0NYE3 Trypanosomatidae 29% 96%
A0A1X0NYE7 Trypanosomatidae 30% 100%
A0A1X0NYN2 Trypanosomatidae 33% 100%
A0A1X0NYN4 Trypanosomatidae 25% 85%
A0A1X0NYS5 Trypanosomatidae 32% 100%
A0A1X0NYZ2 Trypanosomatidae 38% 100%
A0A1X0NZ46 Trypanosomatidae 26% 100%
A0A1X0NZ63 Trypanosomatidae 28% 94%
A0A1X0NZN6 Trypanosomatidae 27% 92%
A0A1X0P055 Trypanosomatidae 33% 100%
A0A1X0P154 Trypanosomatidae 27% 100%
A0A1X0P331 Trypanosomatidae 34% 100%
A0A1X0P3K0 Trypanosomatidae 28% 83%
A0A1X0P3S2 Trypanosomatidae 27% 100%
A0A1X0P4L8 Trypanosomatidae 31% 100%
A0A1X0P4Y5 Trypanosomatidae 27% 94%
A0A1X0P544 Trypanosomatidae 29% 94%
A0A1X0P5J0 Trypanosomatidae 31% 88%
A0A1X0P7K5 Trypanosomatidae 29% 68%
A0A1X0P7R3 Trypanosomatidae 37% 100%
A0A1X0P8B4 Trypanosomatidae 32% 100%
A0A1X0P9Z4 Trypanosomatidae 30% 100%
A0A1X0PB04 Trypanosomatidae 30% 100%
A0A3Q8I8N3 Leishmania donovani 80% 100%
A0A3Q8I8P8 Leishmania donovani 81% 100%
A0A3Q8I8S6 Leishmania donovani 76% 94%
A0A3Q8I8S9 Leishmania donovani 81% 100%
A0A3Q8IAZ8 Leishmania donovani 80% 100%
A0A3Q8IC35 Leishmania donovani 80% 100%
A0A3Q8IC44 Leishmania donovani 78% 100%
A0A3Q8IH61 Leishmania donovani 80% 100%
A0A3Q8IIN4 Leishmania donovani 37% 95%
A0A3R7JT49 Trypanosoma rangeli 36% 71%
A0A3R7JTB6 Trypanosoma rangeli 32% 86%
A0A3R7JV87 Trypanosoma rangeli 33% 100%
A0A3R7K7T9 Trypanosoma rangeli 33% 100%
A0A3R7K9S1 Trypanosoma rangeli 33% 100%
A0A3R7KB14 Trypanosoma rangeli 34% 69%
A0A3R7KLR6 Trypanosoma rangeli 32% 94%
A0A3R7KMY2 Trypanosoma rangeli 35% 90%
A0A3R7LFC4 Trypanosoma rangeli 34% 89%
A0A3R7LFZ4 Trypanosoma rangeli 37% 100%
A0A3R7LWG1 Trypanosoma rangeli 33% 100%
A0A3R7LX11 Trypanosoma rangeli 34% 100%
A0A3R7M1R8 Trypanosoma rangeli 35% 100%
A0A3R7M574 Trypanosoma rangeli 35% 94%
A0A3R7M5K4 Trypanosoma rangeli 35% 100%
A0A3R7M7N6 Trypanosoma rangeli 36% 88%
A0A3R7MTS2 Trypanosoma rangeli 36% 100%
A0A3R7MW36 Trypanosoma rangeli 34% 100%
A0A3R7MXF4 Trypanosoma rangeli 36% 98%
A0A3R7N1W7 Trypanosoma rangeli 34% 100%
A0A3R7N289 Trypanosoma rangeli 33% 83%
A0A3R7N7I3 Trypanosoma rangeli 38% 100%
A0A3R7NTI8 Trypanosoma rangeli 35% 100%
A0A3R7R2J4 Trypanosoma rangeli 34% 93%
A0A3R7R5R1 Trypanosoma rangeli 34% 100%
A0A3R7R818 Trypanosoma rangeli 31% 100%
A0A3S5H6G0 Leishmania donovani 81% 100%
A0A3S5IQY2 Trypanosoma rangeli 38% 100%
A0A3S7WR43 Leishmania donovani 81% 100%
A0A3S7WR46 Leishmania donovani 81% 100%
A0A3S7WR60 Leishmania donovani 80% 100%
A0A3S7X192 Leishmania donovani 35% 100%
A0A422MRQ6 Trypanosoma rangeli 36% 80%
A0A422MU95 Trypanosoma rangeli 34% 100%
A0A422MVF5 Trypanosoma rangeli 32% 100%
A0A422MVS3 Trypanosoma rangeli 35% 100%
A0A422MW99 Trypanosoma rangeli 31% 81%
A0A422MZ47 Trypanosoma rangeli 37% 100%
A0A422MZG4 Trypanosoma rangeli 34% 100%
A0A422N361 Trypanosoma rangeli 32% 100%
A0A422N7Q6 Trypanosoma rangeli 32% 93%
A0A422NDS2 Trypanosoma rangeli 31% 100%
A0A422NDT3 Trypanosoma rangeli 31% 100%
A0A422NP82 Trypanosoma rangeli 37% 100%
A4H626 Leishmania braziliensis 58% 100%
A4H627 Leishmania braziliensis 57% 100%
A4H630 Leishmania braziliensis 64% 100%
A4H631 Leishmania braziliensis 57% 100%
A4H632 Leishmania braziliensis 62% 100%
A4H633 Leishmania braziliensis 58% 100%
A4H634 Leishmania braziliensis 62% 100%
A4H635 Leishmania braziliensis 63% 100%
A4H636 Leishmania braziliensis 61% 100%
A4H637 Leishmania braziliensis 63% 100%
A4H638 Leishmania braziliensis 70% 100%
A4H639 Leishmania braziliensis 66% 100%
A4H640 Leishmania braziliensis 62% 100%
A4H6D3 Leishmania braziliensis 57% 100%
A4H6D5 Leishmania braziliensis 58% 100%
A4H6D7 Leishmania braziliensis 57% 100%
A4H6D8 Leishmania braziliensis 56% 100%
A4H6D9 Leishmania braziliensis 56% 100%
A4H6E0 Leishmania braziliensis 57% 100%
A4H6E1 Leishmania braziliensis 56% 100%
A4H6E2 Leishmania braziliensis 58% 100%
A4H6E3 Leishmania braziliensis 59% 100%
A4H6E4 Leishmania braziliensis 58% 100%
A4H6E5 Leishmania braziliensis 68% 100%
A4HJI2 Leishmania braziliensis 37% 100%
A4HUF6 Leishmania infantum 80% 100%
A4HUF8 Leishmania infantum 81% 100%
A4HUF9 Leishmania infantum 76% 94%
A4HUG0 Leishmania infantum 79% 79%
A4I6X5 Leishmania infantum 37% 95%
C9ZUT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A1R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A7S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 89%
D0A855 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 98%
E9AHH5 Leishmania infantum 35% 100%
E9AN53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AN55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 93%
E9AN56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 93%
E9AN57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AZL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B1Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 95%
O62446 Caenorhabditis elegans 26% 91%
P08148 Leishmania major 80% 100%
P15706 Leishmania chagasi 81% 100%
P23223 Leishmania donovani 78% 100%
P43150 Leishmania mexicana 79% 93%
Q00689 Leishmania guyanensis 64% 97%
Q06031 Crithidia fasciculata 52% 92%
Q27673 Leishmania amazonensis 92% 100%
Q29AK2 Drosophila pseudoobscura pseudoobscura 23% 88%
Q4Q662 Leishmania major 37% 100%
Q4Q8L3 Leishmania major 40% 100%
Q4QHG9 Leishmania major 80% 100%
Q4QHH0 Leishmania major 78% 100%
Q4QHH1 Leishmania major 80% 100%
Q4QHH2 Leishmania major 80% 100%
Q61YG1 Caenorhabditis briggsae 26% 91%
Q6LA77 Leishmania infantum 81% 100%
Q8BMN4 Mus musculus 24% 88%
Q8MNZ1 Leishmania tropica 76% 92%
Q9VH19 Drosophila melanogaster 23% 88%
V5A303 Trypanosoma cruzi 37% 100%
V5A359 Trypanosoma cruzi 39% 100%
V5A488 Trypanosoma cruzi 33% 75%
V5AII7 Trypanosoma cruzi 36% 100%
V5AN34 Trypanosoma cruzi 37% 100%
V5APQ4 Trypanosoma cruzi 34% 76%
V5AX72 Trypanosoma cruzi 35% 82%
V5B5M0 Trypanosoma cruzi 34% 82%
V5B9W5 Trypanosoma cruzi 30% 89%
V5BAN1 Trypanosoma cruzi 34% 77%
V5BD39 Trypanosoma cruzi 39% 100%
V5BLT3 Trypanosoma cruzi 31% 96%
V5CI97 Trypanosoma cruzi 32% 94%
V5D358 Trypanosoma cruzi 34% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS