Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 51 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 41, no: 8 |
| NetGPI | no | yes: 0, no: 49 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 50 |
| GO:0110165 | cellular anatomical entity | 1 | 50 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0018995 | host cellular component | 2 | 4 |
| GO:0033643 | host cell part | 3 | 4 |
| GO:0033646 | host intracellular part | 4 | 4 |
| GO:0033647 | host intracellular organelle | 5 | 4 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
| GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: E9AN53
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 50 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 50 |
| GO:0007155 | cell adhesion | 2 | 50 |
| GO:0008152 | metabolic process | 1 | 50 |
| GO:0009987 | cellular process | 1 | 50 |
| GO:0019538 | protein metabolic process | 3 | 50 |
| GO:0043170 | macromolecule metabolic process | 3 | 50 |
| GO:0044238 | primary metabolic process | 2 | 50 |
| GO:0071704 | organic substance metabolic process | 2 | 50 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 50 |
| GO:0009966 | regulation of signal transduction | 4 | 4 |
| GO:0010646 | regulation of cell communication | 4 | 4 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
| GO:0023051 | regulation of signaling | 3 | 4 |
| GO:0035821 | modulation of process of another organism | 2 | 4 |
| GO:0044003 | modulation by symbiont of host process | 3 | 4 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
| GO:0048583 | regulation of response to stimulus | 3 | 4 |
| GO:0050789 | regulation of biological process | 2 | 4 |
| GO:0050794 | regulation of cellular process | 3 | 4 |
| GO:0051701 | biological process involved in interaction with host | 3 | 4 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
| GO:0065007 | biological regulation | 1 | 4 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 50 |
| GO:0004175 | endopeptidase activity | 4 | 50 |
| GO:0004222 | metalloendopeptidase activity | 5 | 50 |
| GO:0005488 | binding | 1 | 50 |
| GO:0008233 | peptidase activity | 3 | 50 |
| GO:0008237 | metallopeptidase activity | 4 | 50 |
| GO:0016787 | hydrolase activity | 2 | 50 |
| GO:0043167 | ion binding | 2 | 50 |
| GO:0043169 | cation binding | 3 | 50 |
| GO:0046872 | metal ion binding | 4 | 50 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 50 |
| GO:0008047 | enzyme activator activity | 3 | 4 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
| GO:0019208 | phosphatase regulator activity | 3 | 4 |
| GO:0019211 | phosphatase activator activity | 4 | 4 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
| GO:0030234 | enzyme regulator activity | 2 | 4 |
| GO:0072542 | protein phosphatase activator activity | 5 | 4 |
| GO:0098772 | molecular function regulator activity | 1 | 4 |
| GO:0140677 | molecular function activator activity | 2 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 503 | 507 | PF00656 | 0.242 |
| CLV_C14_Caspase3-7 | 548 | 552 | PF00656 | 0.271 |
| CLV_C14_Caspase3-7 | 93 | 97 | PF00656 | 0.238 |
| CLV_PCSK_KEX2_1 | 154 | 156 | PF00082 | 0.623 |
| CLV_PCSK_PC1ET2_1 | 154 | 156 | PF00082 | 0.611 |
| CLV_PCSK_SKI1_1 | 262 | 266 | PF00082 | 0.602 |
| CLV_PCSK_SKI1_1 | 398 | 402 | PF00082 | 0.515 |
| CLV_PCSK_SKI1_1 | 573 | 577 | PF00082 | 0.499 |
| CLV_PCSK_SKI1_1 | 628 | 632 | PF00082 | 0.243 |
| DEG_APCC_DBOX_1 | 542 | 550 | PF00400 | 0.372 |
| DEG_SPOP_SBC_1 | 3 | 7 | PF00917 | 0.673 |
| DEG_SPOP_SBC_1 | 300 | 304 | PF00917 | 0.240 |
| DOC_ANK_TNKS_1 | 501 | 508 | PF00023 | 0.242 |
| DOC_CYCLIN_RxL_1 | 625 | 634 | PF00134 | 0.243 |
| DOC_CYCLIN_yCln2_LP_2 | 120 | 126 | PF00134 | 0.332 |
| DOC_MAPK_gen_1 | 292 | 300 | PF00069 | 0.383 |
| DOC_PP2B_LxvP_1 | 346 | 349 | PF13499 | 0.427 |
| DOC_PP4_FxxP_1 | 196 | 199 | PF00568 | 0.448 |
| DOC_USP7_MATH_1 | 2 | 6 | PF00917 | 0.577 |
| DOC_USP7_MATH_1 | 349 | 353 | PF00917 | 0.253 |
| DOC_USP7_MATH_1 | 646 | 650 | PF00917 | 0.609 |
| DOC_USP7_MATH_1 | 77 | 81 | PF00917 | 0.420 |
| DOC_USP7_MATH_2 | 83 | 89 | PF00917 | 0.234 |
| DOC_USP7_UBL2_3 | 394 | 398 | PF12436 | 0.262 |
| DOC_WW_Pin1_4 | 449 | 454 | PF00397 | 0.273 |
| DOC_WW_Pin1_4 | 495 | 500 | PF00397 | 0.284 |
| DOC_WW_Pin1_4 | 536 | 541 | PF00397 | 0.452 |
| DOC_WW_Pin1_4 | 631 | 636 | PF00397 | 0.427 |
| DOC_WW_Pin1_4 | 96 | 101 | PF00397 | 0.331 |
| LIG_14-3-3_CanoR_1 | 112 | 120 | PF00244 | 0.433 |
| LIG_14-3-3_CanoR_1 | 421 | 425 | PF00244 | 0.433 |
| LIG_14-3-3_CanoR_1 | 523 | 528 | PF00244 | 0.434 |
| LIG_14-3-3_CanoR_1 | 543 | 553 | PF00244 | 0.228 |
| LIG_14-3-3_CanoR_1 | 56 | 62 | PF00244 | 0.374 |
| LIG_14-3-3_CanoR_1 | 599 | 607 | PF00244 | 0.453 |
| LIG_14-3-3_CanoR_1 | 628 | 636 | PF00244 | 0.414 |
| LIG_AP2alpha_1 | 274 | 278 | PF02296 | 0.257 |
| LIG_APCC_ABBA_1 | 167 | 172 | PF00400 | 0.452 |
| LIG_APCC_ABBA_1 | 361 | 366 | PF00400 | 0.425 |
| LIG_APCC_ABBA_1 | 483 | 488 | PF00400 | 0.452 |
| LIG_BRCT_BRCA1_1 | 274 | 278 | PF00533 | 0.376 |
| LIG_BRCT_BRCA1_1 | 549 | 553 | PF00533 | 0.452 |
| LIG_BRCT_BRCA1_2 | 549 | 555 | PF00533 | 0.250 |
| LIG_FHA_1 | 202 | 208 | PF00498 | 0.335 |
| LIG_FHA_1 | 229 | 235 | PF00498 | 0.345 |
| LIG_FHA_1 | 259 | 265 | PF00498 | 0.398 |
| LIG_FHA_1 | 27 | 33 | PF00498 | 0.523 |
| LIG_FHA_1 | 358 | 364 | PF00498 | 0.353 |
| LIG_FHA_1 | 417 | 423 | PF00498 | 0.448 |
| LIG_FHA_1 | 424 | 430 | PF00498 | 0.365 |
| LIG_FHA_1 | 522 | 528 | PF00498 | 0.433 |
| LIG_FHA_1 | 537 | 543 | PF00498 | 0.281 |
| LIG_FHA_1 | 609 | 615 | PF00498 | 0.342 |
| LIG_FHA_1 | 621 | 627 | PF00498 | 0.264 |
| LIG_FHA_2 | 143 | 149 | PF00498 | 0.376 |
| LIG_FHA_2 | 206 | 212 | PF00498 | 0.234 |
| LIG_FHA_2 | 275 | 281 | PF00498 | 0.312 |
| LIG_FHA_2 | 473 | 479 | PF00498 | 0.260 |
| LIG_FHA_2 | 501 | 507 | PF00498 | 0.249 |
| LIG_GBD_Chelix_1 | 621 | 629 | PF00786 | 0.316 |
| LIG_LIR_Gen_1 | 254 | 264 | PF02991 | 0.400 |
| LIG_LIR_Gen_1 | 276 | 285 | PF02991 | 0.303 |
| LIG_LIR_Gen_1 | 318 | 326 | PF02991 | 0.344 |
| LIG_LIR_Gen_1 | 438 | 448 | PF02991 | 0.302 |
| LIG_LIR_LC3C_4 | 623 | 627 | PF02991 | 0.242 |
| LIG_LIR_Nem_3 | 210 | 215 | PF02991 | 0.337 |
| LIG_LIR_Nem_3 | 254 | 259 | PF02991 | 0.400 |
| LIG_LIR_Nem_3 | 276 | 282 | PF02991 | 0.303 |
| LIG_LIR_Nem_3 | 318 | 324 | PF02991 | 0.332 |
| LIG_LIR_Nem_3 | 438 | 443 | PF02991 | 0.373 |
| LIG_LIR_Nem_3 | 452 | 457 | PF02991 | 0.419 |
| LIG_LIR_Nem_3 | 506 | 512 | PF02991 | 0.367 |
| LIG_NRBOX | 620 | 626 | PF00104 | 0.243 |
| LIG_Pex14_1 | 403 | 407 | PF04695 | 0.440 |
| LIG_Pex14_2 | 274 | 278 | PF04695 | 0.339 |
| LIG_PTB_Apo_2 | 206 | 213 | PF02174 | 0.437 |
| LIG_SH2_CRK | 256 | 260 | PF00017 | 0.397 |
| LIG_SH2_CRK | 356 | 360 | PF00017 | 0.452 |
| LIG_SH2_CRK | 509 | 513 | PF00017 | 0.413 |
| LIG_SH2_GRB2like | 535 | 538 | PF00017 | 0.336 |
| LIG_SH2_PTP2 | 564 | 567 | PF00017 | 0.448 |
| LIG_SH2_PTP2 | 78 | 81 | PF00017 | 0.339 |
| LIG_SH2_SRC | 321 | 324 | PF00017 | 0.337 |
| LIG_SH2_SRC | 564 | 567 | PF00017 | 0.448 |
| LIG_SH2_STAP1 | 256 | 260 | PF00017 | 0.404 |
| LIG_SH2_STAP1 | 525 | 529 | PF00017 | 0.452 |
| LIG_SH2_STAT3 | 525 | 528 | PF00017 | 0.437 |
| LIG_SH2_STAT5 | 195 | 198 | PF00017 | 0.249 |
| LIG_SH2_STAT5 | 215 | 218 | PF00017 | 0.339 |
| LIG_SH2_STAT5 | 321 | 324 | PF00017 | 0.340 |
| LIG_SH2_STAT5 | 356 | 359 | PF00017 | 0.440 |
| LIG_SH2_STAT5 | 442 | 445 | PF00017 | 0.350 |
| LIG_SH2_STAT5 | 457 | 460 | PF00017 | 0.395 |
| LIG_SH2_STAT5 | 535 | 538 | PF00017 | 0.383 |
| LIG_SH2_STAT5 | 558 | 561 | PF00017 | 0.366 |
| LIG_SH2_STAT5 | 564 | 567 | PF00017 | 0.322 |
| LIG_SH2_STAT5 | 78 | 81 | PF00017 | 0.421 |
| LIG_SH3_3 | 556 | 562 | PF00018 | 0.246 |
| LIG_SH3_3 | 71 | 77 | PF00018 | 0.336 |
| LIG_SH3_5 | 453 | 457 | PF00018 | 0.263 |
| LIG_SUMO_SIM_anti_2 | 620 | 626 | PF11976 | 0.237 |
| LIG_SUMO_SIM_par_1 | 28 | 34 | PF11976 | 0.518 |
| LIG_SUMO_SIM_par_1 | 617 | 623 | PF11976 | 0.237 |
| LIG_TRAF2_1 | 220 | 223 | PF00917 | 0.320 |
| LIG_TYR_ITIM | 319 | 324 | PF00017 | 0.366 |
| LIG_TYR_ITIM | 76 | 81 | PF00017 | 0.384 |
| MOD_CDK_SPK_2 | 495 | 500 | PF00069 | 0.306 |
| MOD_CDK_SPxxK_3 | 495 | 502 | PF00069 | 0.254 |
| MOD_CDK_SPxxK_3 | 536 | 543 | PF00069 | 0.462 |
| MOD_CK1_1 | 218 | 224 | PF00069 | 0.529 |
| MOD_CK1_1 | 299 | 305 | PF00069 | 0.272 |
| MOD_CK1_1 | 332 | 338 | PF00069 | 0.471 |
| MOD_CK1_1 | 411 | 417 | PF00069 | 0.283 |
| MOD_CK1_1 | 423 | 429 | PF00069 | 0.334 |
| MOD_CK1_1 | 435 | 441 | PF00069 | 0.261 |
| MOD_CK1_1 | 5 | 11 | PF00069 | 0.680 |
| MOD_CK1_1 | 547 | 553 | PF00069 | 0.411 |
| MOD_CK1_1 | 584 | 590 | PF00069 | 0.500 |
| MOD_CK1_1 | 620 | 626 | PF00069 | 0.244 |
| MOD_CK1_1 | 69 | 75 | PF00069 | 0.275 |
| MOD_CK1_1 | 95 | 101 | PF00069 | 0.352 |
| MOD_CK2_1 | 274 | 280 | PF00069 | 0.293 |
| MOD_CK2_1 | 372 | 378 | PF00069 | 0.542 |
| MOD_GlcNHglycan | 115 | 118 | PF01048 | 0.303 |
| MOD_GlcNHglycan | 331 | 334 | PF01048 | 0.466 |
| MOD_GlcNHglycan | 351 | 354 | PF01048 | 0.371 |
| MOD_GlcNHglycan | 410 | 413 | PF01048 | 0.253 |
| MOD_GlcNHglycan | 586 | 589 | PF01048 | 0.496 |
| MOD_GlcNHglycan | 68 | 71 | PF01048 | 0.408 |
| MOD_GSK3_1 | 201 | 208 | PF00069 | 0.532 |
| MOD_GSK3_1 | 258 | 265 | PF00069 | 0.429 |
| MOD_GSK3_1 | 296 | 303 | PF00069 | 0.273 |
| MOD_GSK3_1 | 416 | 423 | PF00069 | 0.435 |
| MOD_GSK3_1 | 427 | 434 | PF00069 | 0.294 |
| MOD_GSK3_1 | 517 | 524 | PF00069 | 0.387 |
| MOD_GSK3_1 | 579 | 586 | PF00069 | 0.462 |
| MOD_GSK3_1 | 86 | 93 | PF00069 | 0.327 |
| MOD_N-GLC_1 | 296 | 301 | PF02516 | 0.367 |
| MOD_N-GLC_1 | 398 | 403 | PF02516 | 0.435 |
| MOD_N-GLC_1 | 408 | 413 | PF02516 | 0.306 |
| MOD_N-GLC_1 | 432 | 437 | PF02516 | 0.308 |
| MOD_N-GLC_1 | 444 | 449 | PF02516 | 0.273 |
| MOD_N-GLC_1 | 465 | 470 | PF02516 | 0.253 |
| MOD_N-GLC_1 | 500 | 505 | PF02516 | 0.270 |
| MOD_N-GLC_1 | 536 | 541 | PF02516 | 0.383 |
| MOD_N-GLC_1 | 85 | 90 | PF02516 | 0.237 |
| MOD_NEK2_1 | 274 | 279 | PF00069 | 0.440 |
| MOD_NEK2_1 | 296 | 301 | PF00069 | 0.252 |
| MOD_NEK2_1 | 486 | 491 | PF00069 | 0.279 |
| MOD_NEK2_1 | 617 | 622 | PF00069 | 0.253 |
| MOD_NEK2_1 | 629 | 634 | PF00069 | 0.438 |
| MOD_NEK2_1 | 90 | 95 | PF00069 | 0.286 |
| MOD_PK_1 | 523 | 529 | PF00069 | 0.419 |
| MOD_PK_1 | 545 | 551 | PF00069 | 0.243 |
| MOD_PKA_1 | 154 | 160 | PF00069 | 0.296 |
| MOD_PKA_2 | 154 | 160 | PF00069 | 0.296 |
| MOD_PKA_2 | 420 | 426 | PF00069 | 0.515 |
| MOD_PKA_2 | 529 | 535 | PF00069 | 0.358 |
| MOD_PKA_2 | 598 | 604 | PF00069 | 0.506 |
| MOD_Plk_1 | 221 | 227 | PF00069 | 0.253 |
| MOD_Plk_1 | 296 | 302 | PF00069 | 0.280 |
| MOD_Plk_1 | 432 | 438 | PF00069 | 0.456 |
| MOD_Plk_1 | 444 | 450 | PF00069 | 0.288 |
| MOD_Plk_1 | 85 | 91 | PF00069 | 0.237 |
| MOD_Plk_2-3 | 148 | 154 | PF00069 | 0.443 |
| MOD_Plk_4 | 154 | 160 | PF00069 | 0.346 |
| MOD_Plk_4 | 221 | 227 | PF00069 | 0.253 |
| MOD_Plk_4 | 274 | 280 | PF00069 | 0.419 |
| MOD_Plk_4 | 296 | 302 | PF00069 | 0.277 |
| MOD_Plk_4 | 435 | 441 | PF00069 | 0.416 |
| MOD_Plk_4 | 457 | 463 | PF00069 | 0.265 |
| MOD_Plk_4 | 609 | 615 | PF00069 | 0.260 |
| MOD_Plk_4 | 617 | 623 | PF00069 | 0.253 |
| MOD_Plk_4 | 77 | 83 | PF00069 | 0.251 |
| MOD_ProDKin_1 | 449 | 455 | PF00069 | 0.292 |
| MOD_ProDKin_1 | 495 | 501 | PF00069 | 0.307 |
| MOD_ProDKin_1 | 536 | 542 | PF00069 | 0.542 |
| MOD_ProDKin_1 | 631 | 637 | PF00069 | 0.433 |
| MOD_ProDKin_1 | 96 | 102 | PF00069 | 0.373 |
| TRG_DiLeu_BaLyEn_6 | 625 | 630 | PF01217 | 0.243 |
| TRG_ENDOCYTIC_2 | 195 | 198 | PF00928 | 0.253 |
| TRG_ENDOCYTIC_2 | 256 | 259 | PF00928 | 0.481 |
| TRG_ENDOCYTIC_2 | 321 | 324 | PF00928 | 0.384 |
| TRG_ENDOCYTIC_2 | 356 | 359 | PF00928 | 0.542 |
| TRG_ENDOCYTIC_2 | 451 | 454 | PF00928 | 0.542 |
| TRG_ENDOCYTIC_2 | 509 | 512 | PF00928 | 0.473 |
| TRG_ENDOCYTIC_2 | 564 | 567 | PF00928 | 0.391 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.384 |
| TRG_Pf-PMV_PEXEL_1 | 47 | 51 | PF00026 | 0.355 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 36% | 100% |
| A0A0S4IN60 | Bodo saltans | 30% | 73% |
| A0A0S4IYM3 | Bodo saltans | 32% | 90% |
| A0A1X0NDG7 | Trypanosomatidae | 30% | 100% |
| A0A1X0NDJ3 | Trypanosomatidae | 28% | 91% |
| A0A1X0NDK7 | Trypanosomatidae | 28% | 92% |
| A0A1X0NDK9 | Trypanosomatidae | 29% | 100% |
| A0A1X0NDU8 | Trypanosomatidae | 29% | 98% |
| A0A1X0NE71 | Trypanosomatidae | 28% | 100% |
| A0A1X0NEE9 | Trypanosomatidae | 29% | 71% |
| A0A1X0NER9 | Trypanosomatidae | 32% | 100% |
| A0A1X0NET7 | Trypanosomatidae | 35% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 32% | 100% |
| A0A1X0NEZ6 | Trypanosomatidae | 29% | 100% |
| A0A1X0NF32 | Trypanosomatidae | 31% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 30% | 100% |
| A0A1X0NFJ0 | Trypanosomatidae | 29% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 29% | 98% |
| A0A1X0NFL1 | Trypanosomatidae | 29% | 69% |
| A0A1X0NFS0 | Trypanosomatidae | 31% | 75% |
| A0A1X0NFT1 | Trypanosomatidae | 28% | 72% |
| A0A1X0NFU4 | Trypanosomatidae | 27% | 80% |
| A0A1X0NG20 | Trypanosomatidae | 32% | 100% |
| A0A1X0NGP3 | Trypanosomatidae | 30% | 77% |
| A0A1X0NGY3 | Trypanosomatidae | 29% | 85% |
| A0A1X0NGZ3 | Trypanosomatidae | 29% | 100% |
| A0A1X0NHP6 | Trypanosomatidae | 30% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NI38 | Trypanosomatidae | 27% | 75% |
| A0A1X0NI74 | Trypanosomatidae | 28% | 87% |
| A0A1X0NII4 | Trypanosomatidae | 28% | 78% |
| A0A1X0NIZ3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 30% | 100% |
| A0A1X0NJU4 | Trypanosomatidae | 31% | 76% |
| A0A1X0NK29 | Trypanosomatidae | 29% | 71% |
| A0A1X0NK66 | Trypanosomatidae | 31% | 99% |
| A0A1X0NKJ8 | Trypanosomatidae | 28% | 88% |
| A0A1X0NKW9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 30% | 100% |
| A0A1X0NMK3 | Trypanosomatidae | 27% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 35% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 30% | 89% |
| A0A1X0NN43 | Trypanosomatidae | 30% | 91% |
| A0A1X0NNK8 | Trypanosomatidae | 30% | 99% |
| A0A1X0NP64 | Trypanosomatidae | 28% | 74% |
| A0A1X0NPW0 | Trypanosomatidae | 29% | 100% |
| A0A1X0NQM4 | Trypanosomatidae | 33% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 36% | 100% |
| A0A1X0NQW6 | Trypanosomatidae | 33% | 100% |
| A0A1X0NRY8 | Trypanosomatidae | 37% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 35% | 100% |
| A0A1X0NUR2 | Trypanosomatidae | 31% | 89% |
| A0A1X0NV28 | Trypanosomatidae | 34% | 100% |
| A0A1X0NVC3 | Trypanosomatidae | 33% | 96% |
| A0A1X0NVE0 | Trypanosomatidae | 29% | 84% |
| A0A1X0NW07 | Trypanosomatidae | 27% | 100% |
| A0A1X0NX94 | Trypanosomatidae | 29% | 100% |
| A0A1X0NX98 | Trypanosomatidae | 30% | 82% |
| A0A1X0NXB6 | Trypanosomatidae | 30% | 93% |
| A0A1X0NXH6 | Trypanosomatidae | 32% | 90% |
| A0A1X0NXQ4 | Trypanosomatidae | 28% | 97% |
| A0A1X0NXR7 | Trypanosomatidae | 32% | 87% |
| A0A1X0NYE3 | Trypanosomatidae | 29% | 100% |
| A0A1X0NYE7 | Trypanosomatidae | 31% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 34% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 26% | 92% |
| A0A1X0NYS5 | Trypanosomatidae | 33% | 100% |
| A0A1X0NYZ2 | Trypanosomatidae | 39% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 26% | 100% |
| A0A1X0NZ63 | Trypanosomatidae | 28% | 100% |
| A0A1X0NZN6 | Trypanosomatidae | 29% | 100% |
| A0A1X0P055 | Trypanosomatidae | 35% | 100% |
| A0A1X0P154 | Trypanosomatidae | 28% | 100% |
| A0A1X0P331 | Trypanosomatidae | 33% | 100% |
| A0A1X0P3K0 | Trypanosomatidae | 28% | 90% |
| A0A1X0P3S2 | Trypanosomatidae | 29% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 32% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 28% | 100% |
| A0A1X0P5J0 | Trypanosomatidae | 32% | 95% |
| A0A1X0P6H3 | Trypanosomatidae | 32% | 67% |
| A0A1X0P7K5 | Trypanosomatidae | 30% | 74% |
| A0A1X0P7R3 | Trypanosomatidae | 34% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 32% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 31% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 32% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 75% | 100% |
| A0A3Q8I8P8 | Leishmania donovani | 76% | 100% |
| A0A3Q8I8S6 | Leishmania donovani | 79% | 100% |
| A0A3Q8I8S9 | Leishmania donovani | 76% | 100% |
| A0A3Q8IAZ8 | Leishmania donovani | 75% | 100% |
| A0A3Q8IC35 | Leishmania donovani | 75% | 100% |
| A0A3Q8IC44 | Leishmania donovani | 74% | 100% |
| A0A3Q8IH61 | Leishmania donovani | 75% | 100% |
| A0A3Q8IIN4 | Leishmania donovani | 37% | 100% |
| A0A3R7JT49 | Trypanosoma rangeli | 36% | 78% |
| A0A3R7JTB6 | Trypanosoma rangeli | 33% | 93% |
| A0A3R7K7T9 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7K9S1 | Trypanosoma rangeli | 32% | 100% |
| A0A3R7KB14 | Trypanosoma rangeli | 34% | 75% |
| A0A3R7KLR6 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7KMY2 | Trypanosoma rangeli | 34% | 98% |
| A0A3R7LFC4 | Trypanosoma rangeli | 34% | 97% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7M574 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M7N6 | Trypanosoma rangeli | 36% | 95% |
| A0A3R7MTS2 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7N1W7 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7N289 | Trypanosoma rangeli | 35% | 90% |
| A0A3R7NTI8 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7R2J4 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7R5R1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7R818 | Trypanosoma rangeli | 32% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 75% | 100% |
| A0A3S5IQY2 | Trypanosoma rangeli | 36% | 100% |
| A0A3S7WR43 | Leishmania donovani | 75% | 100% |
| A0A3S7WR46 | Leishmania donovani | 75% | 100% |
| A0A3S7WR60 | Leishmania donovani | 76% | 100% |
| A0A3S7X192 | Leishmania donovani | 38% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 35% | 87% |
| A0A422MU95 | Trypanosoma rangeli | 34% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 33% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 33% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 31% | 88% |
| A0A422MZ47 | Trypanosoma rangeli | 37% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 34% | 100% |
| A0A422N361 | Trypanosoma rangeli | 32% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 34% | 100% |
| A0A422NDS2 | Trypanosoma rangeli | 32% | 100% |
| A0A422NDT3 | Trypanosoma rangeli | 31% | 100% |
| A0A422NP82 | Trypanosoma rangeli | 36% | 100% |
| A4H626 | Leishmania braziliensis | 61% | 100% |
| A4H627 | Leishmania braziliensis | 60% | 100% |
| A4H630 | Leishmania braziliensis | 65% | 100% |
| A4H631 | Leishmania braziliensis | 61% | 100% |
| A4H632 | Leishmania braziliensis | 64% | 100% |
| A4H633 | Leishmania braziliensis | 61% | 100% |
| A4H634 | Leishmania braziliensis | 65% | 100% |
| A4H635 | Leishmania braziliensis | 66% | 100% |
| A4H636 | Leishmania braziliensis | 60% | 100% |
| A4H637 | Leishmania braziliensis | 65% | 100% |
| A4H638 | Leishmania braziliensis | 68% | 100% |
| A4H639 | Leishmania braziliensis | 66% | 99% |
| A4H640 | Leishmania braziliensis | 66% | 100% |
| A4H6D3 | Leishmania braziliensis | 62% | 100% |
| A4H6D5 | Leishmania braziliensis | 62% | 100% |
| A4H6D7 | Leishmania braziliensis | 60% | 100% |
| A4H6D8 | Leishmania braziliensis | 61% | 100% |
| A4H6D9 | Leishmania braziliensis | 61% | 100% |
| A4H6E0 | Leishmania braziliensis | 62% | 100% |
| A4H6E1 | Leishmania braziliensis | 62% | 100% |
| A4H6E2 | Leishmania braziliensis | 62% | 100% |
| A4H6E3 | Leishmania braziliensis | 64% | 100% |
| A4H6E5 | Leishmania braziliensis | 68% | 100% |
| A4HJI2 | Leishmania braziliensis | 37% | 100% |
| A4HUF6 | Leishmania infantum | 75% | 100% |
| A4HUF8 | Leishmania infantum | 76% | 100% |
| A4HUF9 | Leishmania infantum | 79% | 100% |
| A4HUG0 | Leishmania infantum | 75% | 86% |
| A4I6X5 | Leishmania infantum | 37% | 100% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 100% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 32% | 97% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 100% |
| E9AHH5 | Leishmania infantum | 35% | 100% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 97% | 100% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 81% | 100% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 38% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| O62446 | Caenorhabditis elegans | 24% | 99% |
| P08148 | Leishmania major | 77% | 100% |
| P15706 | Leishmania chagasi | 76% | 100% |
| P23223 | Leishmania donovani | 74% | 100% |
| P43150 | Leishmania mexicana | 95% | 100% |
| Q00689 | Leishmania guyanensis | 67% | 100% |
| Q06031 | Crithidia fasciculata | 53% | 100% |
| Q27673 | Leishmania amazonensis | 80% | 100% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 23% | 96% |
| Q4Q662 | Leishmania major | 37% | 100% |
| Q4Q8L3 | Leishmania major | 40% | 100% |
| Q4QHG9 | Leishmania major | 76% | 100% |
| Q4QHH0 | Leishmania major | 76% | 100% |
| Q4QHH1 | Leishmania major | 77% | 100% |
| Q4QHH2 | Leishmania major | 77% | 100% |
| Q61YG1 | Caenorhabditis briggsae | 24% | 99% |
| Q6LA77 | Leishmania infantum | 76% | 100% |
| Q8MNZ1 | Leishmania tropica | 80% | 100% |
| Q9VH19 | Drosophila melanogaster | 23% | 96% |
| V5A359 | Trypanosoma cruzi | 40% | 100% |
| V5A488 | Trypanosoma cruzi | 33% | 81% |
| V5AII7 | Trypanosoma cruzi | 40% | 100% |
| V5APQ4 | Trypanosoma cruzi | 34% | 82% |
| V5AX72 | Trypanosoma cruzi | 34% | 89% |
| V5B5M0 | Trypanosoma cruzi | 34% | 89% |
| V5B9W5 | Trypanosoma cruzi | 30% | 97% |
| V5BAN1 | Trypanosoma cruzi | 35% | 83% |
| V5BLT3 | Trypanosoma cruzi | 31% | 100% |
| V5D358 | Trypanosoma cruzi | 35% | 77% |