RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AN50_LEIMU

TriTrypDb:

LmxM.10.0430

Length:

161

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AN50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	148	154	PF00089	0.292
CLV_NRD_NRD_1	103	105	PF00675	0.324
CLV_NRD_NRD_1	150	152	PF00675	0.418
CLV_NRD_NRD_1	81	83	PF00675	0.504
CLV_PCSK_KEX2_1	103	105	PF00082	0.328
CLV_PCSK_KEX2_1	150	152	PF00082	0.378
CLV_PCSK_KEX2_1	81	83	PF00082	0.495
CLV_PCSK_SKI1_1	106	110	PF00082	0.304
DOC_MAPK_gen_1	103	110	PF00069	0.488
DOC_MAPK_gen_1	150	158	PF00069	0.608
DOC_PP1_RVXF_1	71	77	PF00149	0.579
DOC_PP2B_LxvP_1	51	54	PF13499	0.645
DOC_PP4_FxxP_1	138	141	PF00568	0.610
DOC_USP7_MATH_1	85	89	PF00917	0.586
LIG_14-3-3_CanoR_1	150	155	PF00244	0.556
LIG_eIF4E_1	129	135	PF01652	0.598
LIG_FHA_1	130	136	PF00498	0.505
LIG_FHA_2	126	132	PF00498	0.551
LIG_IRF3_LxIS_1	9	16	PF10401	0.365
LIG_LIR_Apic_2	137	141	PF02991	0.516
LIG_LIR_Apic_2	46	52	PF02991	0.672
LIG_LIR_Nem_3	26	32	PF02991	0.695
LIG_LIR_Nem_3	45	51	PF02991	0.590
LIG_Pex14_2	27	31	PF04695	0.532
LIG_SH2_CRK	49	53	PF00017	0.727
LIG_SH2_STAP1	129	133	PF00017	0.590
LIG_SH2_STAT5	154	157	PF00017	0.639
LIG_SH2_STAT5	32	35	PF00017	0.738
LIG_SH3_3	139	145	PF00018	0.670
LIG_SUMO_SIM_par_1	130	137	PF11976	0.503
LIG_TRAF2_1	128	131	PF00917	0.551
LIG_TRAF2_1	64	67	PF00917	0.604
LIG_TRFH_1	49	53	PF08558	0.742
LIG_WRC_WIRS_1	135	140	PF05994	0.520
MOD_CK1_1	16	22	PF00069	0.365
MOD_CK2_1	125	131	PF00069	0.562
MOD_GlcNHglycan	6	9	PF01048	0.689
MOD_GlcNHglycan	87	90	PF01048	0.471
MOD_GSK3_1	125	132	PF00069	0.560
MOD_GSK3_1	85	92	PF00069	0.673
MOD_NEK2_1	13	18	PF00069	0.514
MOD_NEK2_1	23	28	PF00069	0.329
MOD_PIKK_1	30	36	PF00454	0.716
MOD_PKA_1	150	156	PF00069	0.542
MOD_PKA_2	150	156	PF00069	0.456
MOD_PKA_2	89	95	PF00069	0.619
MOD_Plk_1	129	135	PF00069	0.559
MOD_Plk_4	129	135	PF00069	0.598
MOD_Plk_4	150	156	PF00069	0.533
MOD_Plk_4	16	22	PF00069	0.341
MOD_Plk_4	23	29	PF00069	0.417
TRG_DiLeu_BaEn_1	130	135	PF01217	0.495
TRG_DiLeu_BaEn_4	130	136	PF01217	0.499
TRG_ENDOCYTIC_2	48	51	PF00928	0.665
TRG_ER_diArg_1	103	106	PF00400	0.519
TRG_ER_diArg_1	150	152	PF00400	0.506
TRG_ER_diArg_1	80	82	PF00400	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT25	Leptomonas seymouri	36%	99%
A0A3Q8I8R6	Leishmania donovani	42%	98%
A0A3S7WR53	Leishmania donovani	87%	100%
A4H623	Leishmania braziliensis	73%	99%
A4HUF1	Leishmania infantum	88%	100%
A4HUF2	Leishmania infantum	43%	98%
E9AN51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
Q4QHH4	Leishmania major	44%	96%
Q4QHH5	Leishmania major	86%	100%