Putative pteridine transporter ft5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter ft5, putative

Species:

Leishmania mexicana

UniProt:

E9AN47_LEIMU

TriTrypDb:

LmxM.10.0400

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AN47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN47

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.422
CLV_PCSK_KEX2_1	143	145	PF00082	0.296
CLV_PCSK_KEX2_1	543	545	PF00082	0.525
CLV_PCSK_KEX2_1	58	60	PF00082	0.455
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.296
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.525
CLV_PCSK_SKI1_1	11	15	PF00082	0.404
CLV_PCSK_SKI1_1	126	130	PF00082	0.357
CLV_PCSK_SKI1_1	25	29	PF00082	0.557
CLV_PCSK_SKI1_1	285	289	PF00082	0.269
CLV_PCSK_SKI1_1	345	349	PF00082	0.359
CLV_PCSK_SKI1_1	668	672	PF00082	0.252
DEG_APCC_DBOX_1	284	292	PF00400	0.425
DEG_COP1_1	332	340	PF00400	0.390
DEG_Nend_UBRbox_3	1	3	PF02207	0.603
DOC_CDC14_PxL_1	629	637	PF14671	0.335
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.375
DOC_MAPK_gen_1	143	149	PF00069	0.504
DOC_MAPK_gen_1	283	290	PF00069	0.542
DOC_MAPK_gen_1	543	551	PF00069	0.327
DOC_MAPK_gen_1	656	665	PF00069	0.589
DOC_MAPK_HePTP_8	232	244	PF00069	0.222
DOC_MAPK_MEF2A_6	235	244	PF00069	0.324
DOC_MAPK_MEF2A_6	283	290	PF00069	0.404
DOC_MAPK_MEF2A_6	543	551	PF00069	0.360
DOC_MAPK_MEF2A_6	73	80	PF00069	0.537
DOC_MAPK_NFAT4_5	73	81	PF00069	0.607
DOC_PP1_RVXF_1	519	525	PF00149	0.509
DOC_PP2B_LxvP_1	464	467	PF13499	0.380
DOC_PP2B_LxvP_1	646	649	PF13499	0.361
DOC_PP2B_LxvP_1	652	655	PF13499	0.330
DOC_PP4_FxxP_1	42	45	PF00568	0.574
DOC_SPAK_OSR1_1	104	108	PF12202	0.415
DOC_USP7_MATH_1	209	213	PF00917	0.328
DOC_USP7_MATH_1	293	297	PF00917	0.525
DOC_USP7_MATH_1	469	473	PF00917	0.331
DOC_USP7_MATH_1	585	589	PF00917	0.489
DOC_USP7_MATH_1	669	673	PF00917	0.555
DOC_USP7_MATH_1	685	689	PF00917	0.807
DOC_WW_Pin1_4	18	23	PF00397	0.772
DOC_WW_Pin1_4	31	36	PF00397	0.779
DOC_WW_Pin1_4	6	11	PF00397	0.659
DOC_WW_Pin1_4	621	626	PF00397	0.352
LIG_14-3-3_CanoR_1	297	307	PF00244	0.437
LIG_14-3-3_CanoR_1	521	525	PF00244	0.495
LIG_APCC_ABBAyCdc20_2	322	328	PF00400	0.387
LIG_BRCT_BRCA1_1	487	491	PF00533	0.321
LIG_CSL_BTD_1	572	575	PF09270	0.403
LIG_EH1_1	523	531	PF00400	0.346
LIG_EVH1_2	625	629	PF00568	0.363
LIG_FHA_1	127	133	PF00498	0.572
LIG_FHA_1	406	412	PF00498	0.355
LIG_FHA_1	421	427	PF00498	0.258
LIG_FHA_1	459	465	PF00498	0.427
LIG_FHA_1	521	527	PF00498	0.490
LIG_FHA_1	649	655	PF00498	0.421
LIG_FHA_1	690	696	PF00498	0.595
LIG_FHA_1	700	706	PF00498	0.545
LIG_LIR_Apic_2	440	446	PF02991	0.406
LIG_LIR_Gen_1	110	118	PF02991	0.505
LIG_LIR_Gen_1	134	141	PF02991	0.524
LIG_LIR_Gen_1	193	204	PF02991	0.522
LIG_LIR_Gen_1	212	223	PF02991	0.501
LIG_LIR_Gen_1	408	414	PF02991	0.295
LIG_LIR_Gen_1	461	470	PF02991	0.350
LIG_LIR_Gen_1	490	499	PF02991	0.327
LIG_LIR_Gen_1	509	515	PF02991	0.386
LIG_LIR_Gen_1	535	542	PF02991	0.340
LIG_LIR_Gen_1	590	599	PF02991	0.515
LIG_LIR_Gen_1	628	637	PF02991	0.268
LIG_LIR_Nem_3	110	115	PF02991	0.450
LIG_LIR_Nem_3	134	139	PF02991	0.498
LIG_LIR_Nem_3	142	148	PF02991	0.498
LIG_LIR_Nem_3	193	199	PF02991	0.528
LIG_LIR_Nem_3	212	218	PF02991	0.297
LIG_LIR_Nem_3	252	258	PF02991	0.342
LIG_LIR_Nem_3	369	374	PF02991	0.562
LIG_LIR_Nem_3	408	412	PF02991	0.323
LIG_LIR_Nem_3	440	445	PF02991	0.372
LIG_LIR_Nem_3	461	466	PF02991	0.395
LIG_LIR_Nem_3	488	492	PF02991	0.300
LIG_LIR_Nem_3	49	54	PF02991	0.610
LIG_LIR_Nem_3	509	514	PF02991	0.347
LIG_LIR_Nem_3	535	540	PF02991	0.340
LIG_LIR_Nem_3	628	632	PF02991	0.263
LIG_LYPXL_yS_3	54	57	PF13949	0.450
LIG_Pex14_1	213	217	PF04695	0.380
LIG_Pex14_2	101	105	PF04695	0.408
LIG_Pex14_2	487	491	PF04695	0.310
LIG_Pex14_2	511	515	PF04695	0.370
LIG_Rb_pABgroove_1	531	539	PF01858	0.339
LIG_SH2_CRK	112	116	PF00017	0.516
LIG_SH2_CRK	146	150	PF00017	0.373
LIG_SH2_CRK	161	165	PF00017	0.327
LIG_SH2_CRK	196	200	PF00017	0.518
LIG_SH2_CRK	403	407	PF00017	0.351
LIG_SH2_CRK	492	496	PF00017	0.302
LIG_SH2_NCK_1	278	282	PF00017	0.380
LIG_SH2_NCK_1	492	496	PF00017	0.304
LIG_SH2_SRC	278	281	PF00017	0.406
LIG_SH2_STAP1	141	145	PF00017	0.505
LIG_SH2_STAP1	196	200	PF00017	0.490
LIG_SH2_STAP1	403	407	PF00017	0.399
LIG_SH2_STAP1	593	597	PF00017	0.345
LIG_SH2_STAT3	95	98	PF00017	0.416
LIG_SH2_STAT5	141	144	PF00017	0.502
LIG_SH2_STAT5	256	259	PF00017	0.444
LIG_SH2_STAT5	371	374	PF00017	0.583
LIG_SH2_STAT5	457	460	PF00017	0.356
LIG_SH2_STAT5	463	466	PF00017	0.345
LIG_SH2_STAT5	474	477	PF00017	0.283
LIG_SH2_STAT5	489	492	PF00017	0.265
LIG_SH2_STAT5	513	516	PF00017	0.454
LIG_SH2_STAT5	557	560	PF00017	0.298
LIG_SH2_STAT5	82	85	PF00017	0.521
LIG_SH3_3	162	168	PF00018	0.305
LIG_SH3_3	373	379	PF00018	0.599
LIG_SH3_3	479	485	PF00018	0.284
LIG_SH3_3	49	55	PF00018	0.551
LIG_SUMO_SIM_anti_2	301	311	PF11976	0.389
LIG_SUMO_SIM_par_1	575	581	PF11976	0.334
LIG_TRAF2_1	332	335	PF00917	0.390
LIG_TRFH_1	161	165	PF08558	0.367
LIG_TYR_ITIM	159	164	PF00017	0.383
LIG_TYR_ITIM	276	281	PF00017	0.196
LIG_TYR_ITIM	52	57	PF00017	0.484
LIG_TYR_ITSM	488	495	PF00017	0.409
LIG_UBA3_1	159	167	PF00899	0.359
LIG_UBA3_1	383	391	PF00899	0.391
LIG_UBA3_1	536	543	PF00899	0.329
LIG_Vh1_VBS_1	412	430	PF01044	0.451
LIG_Vh1_VBS_1	491	509	PF01044	0.392
LIG_WRC_WIRS_1	406	411	PF05994	0.252
LIG_WRC_WIRS_1	470	475	PF05994	0.341
MOD_CDK_SPK_2	6	11	PF00069	0.500
MOD_CDK_SPxxK_3	18	25	PF00069	0.757
MOD_CK1_1	516	522	PF00069	0.357
MOD_CK1_1	620	626	PF00069	0.303
MOD_CK1_1	672	678	PF00069	0.533
MOD_CK2_1	329	335	PF00069	0.323
MOD_CK2_1	690	696	PF00069	0.493
MOD_GlcNHglycan	169	172	PF01048	0.354
MOD_GlcNHglycan	244	247	PF01048	0.377
MOD_GlcNHglycan	314	317	PF01048	0.262
MOD_GlcNHglycan	6	9	PF01048	0.704
MOD_GlcNHglycan	671	674	PF01048	0.448
MOD_GSK3_1	117	124	PF00069	0.402
MOD_GSK3_1	329	336	PF00069	0.416
MOD_GSK3_1	401	408	PF00069	0.365
MOD_GSK3_1	487	494	PF00069	0.375
MOD_GSK3_1	516	523	PF00069	0.369
MOD_GSK3_1	602	609	PF00069	0.380
MOD_GSK3_1	617	624	PF00069	0.350
MOD_GSK3_1	685	692	PF00069	0.662
MOD_N-GLC_1	690	695	PF02516	0.486
MOD_NEK2_1	100	105	PF00069	0.297
MOD_NEK2_1	121	126	PF00069	0.382
MOD_NEK2_1	139	144	PF00069	0.288
MOD_NEK2_1	147	152	PF00069	0.344
MOD_NEK2_1	179	184	PF00069	0.350
MOD_NEK2_1	401	406	PF00069	0.371
MOD_NEK2_1	420	425	PF00069	0.302
MOD_NEK2_1	458	463	PF00069	0.473
MOD_NEK2_1	487	492	PF00069	0.361
MOD_NEK2_1	524	529	PF00069	0.368
MOD_NEK2_1	602	607	PF00069	0.359
MOD_NEK2_2	469	474	PF00069	0.343
MOD_PKA_2	520	526	PF00069	0.355
MOD_PKA_2	585	591	PF00069	0.340
MOD_Plk_1	333	339	PF00069	0.256
MOD_Plk_1	690	696	PF00069	0.659
MOD_Plk_2-3	333	339	PF00069	0.181
MOD_Plk_4	209	215	PF00069	0.344
MOD_Plk_4	305	311	PF00069	0.470
MOD_Plk_4	401	407	PF00069	0.357
MOD_Plk_4	415	421	PF00069	0.309
MOD_Plk_4	438	444	PF00069	0.396
MOD_Plk_4	458	464	PF00069	0.359
MOD_Plk_4	46	52	PF00069	0.516
MOD_Plk_4	469	475	PF00069	0.344
MOD_Plk_4	487	493	PF00069	0.442
MOD_Plk_4	525	531	PF00069	0.316
MOD_Plk_4	532	538	PF00069	0.326
MOD_Plk_4	587	593	PF00069	0.376
MOD_Plk_4	648	654	PF00069	0.374
MOD_ProDKin_1	18	24	PF00069	0.731
MOD_ProDKin_1	31	37	PF00069	0.739
MOD_ProDKin_1	6	12	PF00069	0.572
MOD_ProDKin_1	621	627	PF00069	0.422
MOD_SUMO_rev_2	3	7	PF00179	0.485
MOD_SUMO_rev_2	34	40	PF00179	0.551
MOD_SUMO_rev_2	661	670	PF00179	0.413
MOD_SUMO_rev_2	704	712	PF00179	0.437
TRG_DiLeu_BaEn_2	37	43	PF01217	0.414
TRG_DiLeu_BaEn_4	362	368	PF01217	0.202
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.326
TRG_ENDOCYTIC_2	112	115	PF00928	0.326
TRG_ENDOCYTIC_2	146	149	PF00928	0.351
TRG_ENDOCYTIC_2	161	164	PF00928	0.342
TRG_ENDOCYTIC_2	196	199	PF00928	0.343
TRG_ENDOCYTIC_2	278	281	PF00928	0.452
TRG_ENDOCYTIC_2	403	406	PF00928	0.353
TRG_ENDOCYTIC_2	457	460	PF00928	0.358
TRG_ENDOCYTIC_2	463	466	PF00928	0.357
TRG_ENDOCYTIC_2	492	495	PF00928	0.357
TRG_ENDOCYTIC_2	54	57	PF00928	0.490
TRG_ENDOCYTIC_2	593	596	PF00928	0.346
TRG_ER_diArg_1	57	59	PF00400	0.582
TRG_ER_diLys_1	709	712	PF00400	0.431
TRG_NES_CRM1_1	465	479	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	50%	100%
A0A0N1HY49	Leptomonas seymouri	52%	100%
A0A0N1HZ06	Leptomonas seymouri	40%	100%
A0A0N1IHL1	Leptomonas seymouri	44%	100%
A0A0N1PAY4	Leptomonas seymouri	51%	81%
A0A0N1PB77	Leptomonas seymouri	39%	100%
A0A0N1PBZ2	Leptomonas seymouri	60%	100%
A0A0N1PCC1	Leptomonas seymouri	45%	100%
A0A0S4INN8	Bodo saltans	32%	100%
A0A381MBI0	Leishmania infantum	48%	100%
A0A3Q8I8X7	Leishmania donovani	47%	100%
A0A3Q8IAZ0	Leishmania donovani	60%	100%
A0A3Q8IH50	Leishmania donovani	88%	99%
A0A3Q8IVN0	Leishmania donovani	39%	100%
A0A3R7M4J1	Trypanosoma rangeli	46%	100%
A0A3S5H5P4	Leishmania donovani	51%	100%
A0A3S5H5V2	Leishmania donovani	43%	100%
A0A3S5H6F6	Leishmania donovani	58%	100%
A0A3S5H763	Leishmania donovani	60%	100%
A0A3S7WR10	Leishmania donovani	50%	96%
A0A3S7WR14	Leishmania donovani	61%	100%
A0A3S7WR15	Leishmania donovani	58%	84%
A0A3S7WR24	Leishmania donovani	59%	100%
A4H4T8	Leishmania braziliensis	43%	98%
A4H5Y4	Leishmania braziliensis	48%	99%
A4H617	Leishmania braziliensis	56%	100%
A4H618	Leishmania braziliensis	56%	100%
A4H619	Leishmania braziliensis	56%	100%
A4H620	Leishmania braziliensis	81%	100%
A4H6C3	Leishmania braziliensis	48%	99%
A4HNH7	Leishmania braziliensis	38%	95%
A4HSS2	Leishmania infantum	51%	100%
A4HUE4	Leishmania infantum	51%	96%
A4HUE5	Leishmania infantum	58%	100%
A4HUE6	Leishmania infantum	61%	100%
A4HUE7	Leishmania infantum	60%	100%
A4HUE8	Leishmania infantum	59%	100%
A4HUF4	Leishmania infantum	58%	100%
A4HUF5	Leishmania infantum	90%	100%
A4HYA9	Leishmania infantum	60%	100%
A4IC33	Leishmania infantum	39%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9AG72	Leishmania infantum	43%	100%
E9AI40	Leishmania braziliensis	57%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QDC4	Leishmania major	58%	100%
Q4QH81	Leishmania major	49%	100%
Q4QHH7	Leishmania major	87%	100%
Q4QHH8	Leishmania major	57%	100%
Q4QHH9	Leishmania major	56%	100%
Q4QHI0	Leishmania major	60%	100%
Q4QHI1	Leishmania major	60%	97%
Q4QHI2	Leishmania major	60%	99%
Q4QIU9	Leishmania major	46%	100%
Q4QJ48	Leishmania major	49%	100%
Q7KIP2	Leishmania major	39%	96%