Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AN46_LEIMU

TriTrypDb:

LmxM.10.0370

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AN46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN46

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.635
CLV_C14_Caspase3-7	576	580	PF00656	0.820
CLV_MEL_PAP_1	349	355	PF00089	0.301
CLV_NRD_NRD_1	182	184	PF00675	0.389
CLV_PCSK_KEX2_1	430	432	PF00082	0.573
CLV_PCSK_KEX2_1	44	46	PF00082	0.348
CLV_PCSK_KEX2_1	510	512	PF00082	0.434
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.573
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.348
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.434
CLV_PCSK_SKI1_1	227	231	PF00082	0.400
CLV_PCSK_SKI1_1	27	31	PF00082	0.405
DEG_SPOP_SBC_1	574	578	PF00917	0.652
DOC_CDC14_PxL_1	520	528	PF14671	0.382
DOC_CKS1_1	532	537	PF01111	0.483
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.429
DOC_MAPK_gen_1	168	178	PF00069	0.600
DOC_MAPK_gen_1	430	438	PF00069	0.374
DOC_MAPK_gen_1	44	50	PF00069	0.557
DOC_MAPK_gen_1	548	557	PF00069	0.638
DOC_MAPK_MEF2A_6	138	145	PF00069	0.380
DOC_MAPK_MEF2A_6	430	438	PF00069	0.408
DOC_PP1_RVXF_1	406	412	PF00149	0.570
DOC_PP2B_LxvP_1	537	540	PF13499	0.415
DOC_PP2B_PxIxI_1	138	144	PF00149	0.339
DOC_USP7_MATH_1	110	114	PF00917	0.373
DOC_USP7_MATH_1	18	22	PF00917	0.643
DOC_USP7_MATH_1	213	217	PF00917	0.611
DOC_USP7_MATH_1	403	407	PF00917	0.575
DOC_USP7_MATH_1	472	476	PF00917	0.537
DOC_USP7_MATH_1	574	578	PF00917	0.690
DOC_WW_Pin1_4	14	19	PF00397	0.464
DOC_WW_Pin1_4	209	214	PF00397	0.640
DOC_WW_Pin1_4	531	536	PF00397	0.465
LIG_14-3-3_CanoR_1	168	178	PF00244	0.637
LIG_14-3-3_CanoR_1	215	222	PF00244	0.651
LIG_14-3-3_CanoR_1	408	412	PF00244	0.542
LIG_BIR_III_4	249	253	PF00653	0.573
LIG_Clathr_ClatBox_1	176	180	PF01394	0.498
LIG_EH1_1	410	418	PF00400	0.392
LIG_eIF4E_1	520	526	PF01652	0.282
LIG_FHA_1	119	125	PF00498	0.388
LIG_FHA_1	276	282	PF00498	0.642
LIG_FHA_1	28	34	PF00498	0.621
LIG_FHA_1	293	299	PF00498	0.407
LIG_FHA_1	308	314	PF00498	0.310
LIG_FHA_1	408	414	PF00498	0.543
LIG_FHA_1	490	496	PF00498	0.240
LIG_FHA_1	532	538	PF00498	0.469
LIG_FHA_2	180	186	PF00498	0.622
LIG_GBD_Chelix_1	393	401	PF00786	0.570
LIG_GBD_Chelix_1	412	420	PF00786	0.525
LIG_HP1_1	462	466	PF01393	0.450
LIG_LIR_Apic_2	259	265	PF02991	0.581
LIG_LIR_Apic_2	327	333	PF02991	0.469
LIG_LIR_Apic_2	364	368	PF02991	0.383
LIG_LIR_Apic_2	503	507	PF02991	0.353
LIG_LIR_Gen_1	113	120	PF02991	0.555
LIG_LIR_Gen_1	35	42	PF02991	0.571
LIG_LIR_Gen_1	377	386	PF02991	0.381
LIG_LIR_Gen_1	396	403	PF02991	0.445
LIG_LIR_Gen_1	477	487	PF02991	0.567
LIG_LIR_Nem_3	113	119	PF02991	0.343
LIG_LIR_Nem_3	153	159	PF02991	0.395
LIG_LIR_Nem_3	282	288	PF02991	0.550
LIG_LIR_Nem_3	327	332	PF02991	0.432
LIG_LIR_Nem_3	35	40	PF02991	0.546
LIG_LIR_Nem_3	375	379	PF02991	0.351
LIG_LIR_Nem_3	396	401	PF02991	0.393
LIG_LIR_Nem_3	43	49	PF02991	0.546
LIG_Pex14_2	374	378	PF04695	0.362
LIG_Pex14_2	398	402	PF04695	0.423
LIG_Pex14_2	80	84	PF04695	0.416
LIG_PTB_Apo_2	370	377	PF02174	0.423
LIG_PTB_Apo_2	396	403	PF02174	0.491
LIG_PTB_Phospho_1	370	376	PF10480	0.457
LIG_Rb_pABgroove_1	418	426	PF01858	0.385
LIG_SH2_CRK	13	17	PF00017	0.563
LIG_SH2_CRK	262	266	PF00017	0.670
LIG_SH2_CRK	290	294	PF00017	0.397
LIG_SH2_CRK	365	369	PF00017	0.379
LIG_SH2_CRK	379	383	PF00017	0.354
LIG_SH2_CRK	448	452	PF00017	0.411
LIG_SH2_CRK	47	51	PF00017	0.426
LIG_SH2_CRK	504	508	PF00017	0.376
LIG_SH2_CRK	62	66	PF00017	0.378
LIG_SH2_CRK	97	101	PF00017	0.566
LIG_SH2_GRB2like	361	364	PF00017	0.408
LIG_SH2_GRB2like	520	523	PF00017	0.402
LIG_SH2_NCK_1	245	249	PF00017	0.488
LIG_SH2_NCK_1	365	369	PF00017	0.367
LIG_SH2_NCK_1	379	383	PF00017	0.352
LIG_SH2_NCK_1	448	452	PF00017	0.316
LIG_SH2_SRC	245	248	PF00017	0.491
LIG_SH2_STAP1	290	294	PF00017	0.445
LIG_SH2_STAP1	42	46	PF00017	0.552
LIG_SH2_STAP1	480	484	PF00017	0.390
LIG_SH2_STAP1	97	101	PF00017	0.541
LIG_SH2_STAT5	157	160	PF00017	0.491
LIG_SH2_STAT5	344	347	PF00017	0.406
LIG_SH2_STAT5	361	364	PF00017	0.338
LIG_SH2_STAT5	376	379	PF00017	0.314
LIG_SH2_STAT5	42	45	PF00017	0.553
LIG_SH2_STAT5	444	447	PF00017	0.345
LIG_SH2_STAT5	448	451	PF00017	0.388
LIG_SH3_1	262	268	PF00018	0.637
LIG_SH3_3	262	268	PF00018	0.647
LIG_SH3_3	350	356	PF00018	0.411
LIG_SUMO_SIM_par_1	391	396	PF11976	0.287
LIG_SUMO_SIM_par_1	462	468	PF11976	0.380
LIG_TRFH_1	62	66	PF08558	0.413
LIG_TYR_ITIM	60	65	PF00017	0.432
LIG_TYR_ITSM	375	382	PF00017	0.455
LIG_UBA3_1	176	184	PF00899	0.573
LIG_UBA3_1	397	404	PF00899	0.467
LIG_UBA3_1	423	430	PF00899	0.374
LIG_UBA3_1	543	548	PF00899	0.287
LIG_UBA3_1	60	68	PF00899	0.410
LIG_Vh1_VBS_1	288	306	PF01044	0.459
MOD_CDC14_SPxK_1	212	215	PF00782	0.284
MOD_CDK_SPxK_1	209	215	PF00069	0.284
MOD_CK1_1	17	23	PF00069	0.414
MOD_CK1_1	531	537	PF00069	0.297
MOD_CK1_1	577	583	PF00069	0.671
MOD_CK2_1	179	185	PF00069	0.483
MOD_Cter_Amidation	208	211	PF01082	0.521
MOD_GlcNHglycan	145	148	PF01048	0.423
MOD_GlcNHglycan	290	293	PF01048	0.255
MOD_GlcNHglycan	353	356	PF01048	0.485
MOD_GlcNHglycan	387	390	PF01048	0.415
MOD_GlcNHglycan	69	73	PF01048	0.411
MOD_GSK3_1	120	127	PF00069	0.371
MOD_GSK3_1	139	146	PF00069	0.493
MOD_GSK3_1	14	21	PF00069	0.458
MOD_GSK3_1	209	216	PF00069	0.472
MOD_GSK3_1	275	282	PF00069	0.532
MOD_GSK3_1	288	295	PF00069	0.426
MOD_GSK3_1	347	354	PF00069	0.300
MOD_GSK3_1	374	381	PF00069	0.430
MOD_GSK3_1	403	410	PF00069	0.415
MOD_GSK3_1	485	492	PF00069	0.427
MOD_GSK3_1	573	580	PF00069	0.686
MOD_N-GLC_1	230	235	PF02516	0.236
MOD_N-GLC_1	372	377	PF02516	0.407
MOD_NEK2_1	120	125	PF00069	0.377
MOD_NEK2_1	179	184	PF00069	0.461
MOD_NEK2_1	22	27	PF00069	0.427
MOD_NEK2_1	230	235	PF00069	0.388
MOD_NEK2_1	288	293	PF00069	0.423
MOD_NEK2_1	307	312	PF00069	0.349
MOD_NEK2_1	374	379	PF00069	0.414
MOD_NEK2_1	40	45	PF00069	0.334
MOD_NEK2_1	411	416	PF00069	0.418
MOD_NEK2_1	48	53	PF00069	0.389
MOD_NEK2_1	489	494	PF00069	0.406
MOD_NEK2_1	528	533	PF00069	0.500
MOD_NEK2_1	80	85	PF00069	0.396
MOD_NEK2_2	139	144	PF00069	0.520
MOD_PIKK_1	230	236	PF00454	0.236
MOD_PIKK_1	90	96	PF00454	0.378
MOD_PK_1	347	353	PF00069	0.439
MOD_PKA_2	351	357	PF00069	0.511
MOD_PKA_2	407	413	PF00069	0.401
MOD_PKA_2	472	478	PF00069	0.386
MOD_PKB_1	186	194	PF00069	0.266
MOD_Plk_1	372	378	PF00069	0.424
MOD_Plk_4	110	116	PF00069	0.396
MOD_Plk_4	120	126	PF00069	0.388
MOD_Plk_4	325	331	PF00069	0.445
MOD_Plk_4	374	380	PF00069	0.515
MOD_Plk_4	393	399	PF00069	0.258
MOD_Plk_4	407	413	PF00069	0.397
MOD_Plk_4	446	452	PF00069	0.397
MOD_Plk_4	474	480	PF00069	0.433
MOD_Plk_4	539	545	PF00069	0.432
MOD_Plk_4	579	585	PF00069	0.700
MOD_ProDKin_1	14	20	PF00069	0.278
MOD_ProDKin_1	209	215	PF00069	0.525
MOD_ProDKin_1	531	537	PF00069	0.465
MOD_SUMO_rev_2	553	562	PF00179	0.459
TRG_DiLeu_BaEn_2	172	178	PF01217	0.366
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.372
TRG_DiLeu_LyEn_5	521	526	PF01217	0.236
TRG_ENDOCYTIC_2	13	16	PF00928	0.376
TRG_ENDOCYTIC_2	290	293	PF00928	0.398
TRG_ENDOCYTIC_2	379	382	PF00928	0.407
TRG_ENDOCYTIC_2	448	451	PF00928	0.430
TRG_ENDOCYTIC_2	47	50	PF00928	0.404
TRG_ENDOCYTIC_2	480	483	PF00928	0.391
TRG_ENDOCYTIC_2	520	523	PF00928	0.476
TRG_ENDOCYTIC_2	62	65	PF00928	0.392
TRG_ENDOCYTIC_2	97	100	PF00928	0.396
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	86%
A0A0N1HY49	Leptomonas seymouri	46%	89%
A0A0N1HZ06	Leptomonas seymouri	36%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	84%
A0A0N1PAY4	Leptomonas seymouri	46%	68%
A0A0N1PB77	Leptomonas seymouri	37%	93%
A0A0N1PBZ2	Leptomonas seymouri	67%	89%
A0A0N1PCC1	Leptomonas seymouri	43%	90%
A0A381MBI0	Leishmania infantum	45%	91%
A0A3Q8I8X7	Leishmania donovani	45%	91%
A0A3Q8IAZ0	Leishmania donovani	89%	86%
A0A3Q8IH50	Leishmania donovani	60%	83%
A0A3Q8IVN0	Leishmania donovani	37%	96%
A0A3R7M4J1	Trypanosoma rangeli	43%	94%
A0A3S5H5P4	Leishmania donovani	45%	89%
A0A3S5H5V2	Leishmania donovani	44%	92%
A0A3S5H6F6	Leishmania donovani	91%	86%
A0A3S5H763	Leishmania donovani	52%	89%
A0A3S7WR10	Leishmania donovani	44%	81%
A0A3S7WR14	Leishmania donovani	82%	88%
A0A3S7WR15	Leishmania donovani	71%	71%
A0A3S7WR24	Leishmania donovani	89%	86%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	81%	100%
A4H618	Leishmania braziliensis	81%	100%
A4H619	Leishmania braziliensis	81%	100%
A4H620	Leishmania braziliensis	58%	100%
A4H6C3	Leishmania braziliensis	45%	100%
A4HNH7	Leishmania braziliensis	37%	100%
A4HSS2	Leishmania infantum	45%	89%
A4HUE4	Leishmania infantum	43%	81%
A4HUE5	Leishmania infantum	72%	87%
A4HUE6	Leishmania infantum	82%	88%
A4HUE7	Leishmania infantum	88%	86%
A4HUE8	Leishmania infantum	89%	86%
A4HUF4	Leishmania infantum	90%	86%
A4HUF5	Leishmania infantum	59%	91%
A4HYA9	Leishmania infantum	52%	89%
A4IC33	Leishmania infantum	36%	95%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AG72	Leishmania infantum	44%	92%
E9AI40	Leishmania braziliensis	74%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	85%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	90%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	95%
Q4QDC4	Leishmania major	53%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	89%	100%
Q4QHH9	Leishmania major	88%	100%
Q4QHI0	Leishmania major	88%	100%
Q4QHI1	Leishmania major	80%	100%
Q4QHI2	Leishmania major	76%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	44%	100%
Q7KIP2	Leishmania major	36%	100%