Putative pteridine transporter ft6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter ft6, putative

Species:

Leishmania mexicana

UniProt:

E9AN45_LEIMU

TriTrypDb:

LmxM.10.0360

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AN45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN45

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.645
CLV_NRD_NRD_1	232	234	PF00675	0.391
CLV_NRD_NRD_1	240	242	PF00675	0.369
CLV_NRD_NRD_1	614	616	PF00675	0.327
CLV_NRD_NRD_1	9	11	PF00675	0.495
CLV_PCSK_FUR_1	238	242	PF00082	0.284
CLV_PCSK_KEX2_1	240	242	PF00082	0.330
CLV_PCSK_KEX2_1	457	459	PF00082	0.262
CLV_PCSK_KEX2_1	483	485	PF00082	0.575
CLV_PCSK_KEX2_1	651	653	PF00082	0.511
CLV_PCSK_KEX2_1	9	11	PF00082	0.528
CLV_PCSK_KEX2_1	94	96	PF00082	0.346
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.262
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.575
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.535
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.346
CLV_PCSK_PC7_1	236	242	PF00082	0.230
CLV_PCSK_SKI1_1	42	46	PF00082	0.419
CLV_PCSK_SKI1_1	77	81	PF00082	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_AGCK_PIF_1	424	429	PF00069	0.242
DOC_CDC14_PxL_1	8	16	PF14671	0.594
DOC_CYCLIN_yCln2_LP_2	590	596	PF00134	0.425
DOC_MAPK_gen_1	218	228	PF00069	0.602
DOC_MAPK_gen_1	457	464	PF00069	0.495
DOC_MAPK_gen_1	483	491	PF00069	0.377
DOC_MAPK_gen_1	600	609	PF00069	0.639
DOC_MAPK_gen_1	94	100	PF00069	0.554
DOC_MAPK_MEF2A_6	188	195	PF00069	0.382
DOC_MAPK_MEF2A_6	483	491	PF00069	0.410
DOC_MAPK_RevD_3	443	458	PF00069	0.398
DOC_PP1_RVXF_1	459	465	PF00149	0.559
DOC_PP2B_LxvP_1	590	593	PF13499	0.411
DOC_PP2B_LxvP_1	596	599	PF13499	0.380
DOC_PP2B_PxIxI_1	188	194	PF00149	0.338
DOC_PP4_FxxP_1	239	242	PF00568	0.439
DOC_USP7_MATH_1	160	164	PF00917	0.378
DOC_USP7_MATH_1	264	268	PF00917	0.613
DOC_USP7_MATH_1	446	450	PF00917	0.432
DOC_USP7_MATH_1	502	506	PF00917	0.370
DOC_USP7_MATH_1	525	529	PF00917	0.539
DOC_USP7_MATH_1	629	633	PF00917	0.863
DOC_USP7_UBL2_3	612	616	PF12436	0.496
DOC_WW_Pin1_4	260	265	PF00397	0.641
DOC_WW_Pin1_4	405	410	PF00397	0.387
DOC_WW_Pin1_4	584	589	PF00397	0.469
DOC_WW_Pin1_4	630	635	PF00397	0.694
LIG_14-3-3_CanoR_1	218	228	PF00244	0.637
LIG_14-3-3_CanoR_1	266	273	PF00244	0.651
LIG_14-3-3_CanoR_1	461	465	PF00244	0.545
LIG_14-3-3_CanoR_1	544	553	PF00244	0.528
LIG_14-3-3_CanoR_1	65	72	PF00244	0.545
LIG_BRCT_BRCA1_1	427	431	PF00533	0.371
LIG_Clathr_ClatBox_1	226	230	PF01394	0.497
LIG_deltaCOP1_diTrp_1	336	341	PF00928	0.490
LIG_FHA_1	30	36	PF00498	0.612
LIG_FHA_1	329	335	PF00498	0.642
LIG_FHA_1	346	352	PF00498	0.405
LIG_FHA_1	361	367	PF00498	0.308
LIG_FHA_1	410	416	PF00498	0.433
LIG_FHA_1	461	467	PF00498	0.540
LIG_FHA_1	475	481	PF00498	0.404
LIG_FHA_1	593	599	PF00498	0.471
LIG_FHA_1	78	84	PF00498	0.622
LIG_FHA_2	230	236	PF00498	0.609
LIG_FHA_2	633	639	PF00498	0.757
LIG_HP1_1	515	519	PF01393	0.454
LIG_LIR_Apic_2	237	242	PF02991	0.439
LIG_LIR_Apic_2	380	386	PF02991	0.456
LIG_LIR_Apic_2	556	560	PF02991	0.356
LIG_LIR_Gen_1	144	155	PF02991	0.572
LIG_LIR_Gen_1	163	171	PF02991	0.551
LIG_LIR_Gen_1	430	439	PF02991	0.377
LIG_LIR_Gen_1	449	455	PF02991	0.436
LIG_LIR_Gen_1	467	476	PF02991	0.345
LIG_LIR_Gen_1	48	56	PF02991	0.592
LIG_LIR_Gen_1	530	539	PF02991	0.565
LIG_LIR_Gen_1	85	92	PF02991	0.574
LIG_LIR_Nem_3	144	150	PF02991	0.578
LIG_LIR_Nem_3	163	169	PF02991	0.347
LIG_LIR_Nem_3	203	209	PF02991	0.392
LIG_LIR_Nem_3	336	341	PF02991	0.548
LIG_LIR_Nem_3	380	385	PF02991	0.422
LIG_LIR_Nem_3	421	427	PF02991	0.345
LIG_LIR_Nem_3	428	432	PF02991	0.350
LIG_LIR_Nem_3	449	454	PF02991	0.397
LIG_LIR_Nem_3	467	472	PF02991	0.375
LIG_LIR_Nem_3	85	90	PF02991	0.548
LIG_LIR_Nem_3	93	99	PF02991	0.548
LIG_NRBOX	575	581	PF00104	0.276
LIG_PDZ_Class_3	650	655	PF00595	0.657
LIG_Pex14_2	130	134	PF04695	0.421
LIG_Pex14_2	427	431	PF04695	0.360
LIG_Pex14_2	451	455	PF04695	0.420
LIG_PTB_Apo_2	423	430	PF02174	0.425
LIG_PTB_Phospho_1	423	429	PF10480	0.457
LIG_SH2_CRK	112	116	PF00017	0.377
LIG_SH2_CRK	147	151	PF00017	0.568
LIG_SH2_CRK	315	319	PF00017	0.669
LIG_SH2_CRK	343	347	PF00017	0.401
LIG_SH2_CRK	432	436	PF00017	0.352
LIG_SH2_CRK	557	561	PF00017	0.379
LIG_SH2_CRK	63	67	PF00017	0.566
LIG_SH2_CRK	97	101	PF00017	0.423
LIG_SH2_GRB2like	403	406	PF00017	0.460
LIG_SH2_GRB2like	414	417	PF00017	0.410
LIG_SH2_NCK_1	432	436	PF00017	0.354
LIG_SH2_PTP2	403	406	PF00017	0.405
LIG_SH2_PTP2	488	491	PF00017	0.451
LIG_SH2_SRC	297	300	PF00017	0.490
LIG_SH2_SRC	403	406	PF00017	0.534
LIG_SH2_SRC	414	417	PF00017	0.398
LIG_SH2_STAP1	147	151	PF00017	0.540
LIG_SH2_STAP1	343	347	PF00017	0.449
LIG_SH2_STAP1	49	53	PF00017	0.590
LIG_SH2_STAP1	533	537	PF00017	0.395
LIG_SH2_STAP1	92	96	PF00017	0.555
LIG_SH2_STAT3	397	400	PF00017	0.258
LIG_SH2_STAT5	207	210	PF00017	0.494
LIG_SH2_STAT5	397	400	PF00017	0.406
LIG_SH2_STAT5	403	406	PF00017	0.395
LIG_SH2_STAT5	414	417	PF00017	0.333
LIG_SH2_STAT5	453	456	PF00017	0.504
LIG_SH2_STAT5	488	491	PF00017	0.356
LIG_SH2_STAT5	497	500	PF00017	0.348
LIG_SH2_STAT5	92	95	PF00017	0.552
LIG_SH3_1	315	321	PF00018	0.637
LIG_SH3_3	283	289	PF00018	0.472
LIG_SH3_3	290	296	PF00018	0.472
LIG_SH3_3	315	321	PF00018	0.648
LIG_SH3_3	582	588	PF00018	0.395
LIG_SH3_3	628	634	PF00018	0.786
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.369
LIG_SUMO_SIM_par_1	515	521	PF11976	0.384
LIG_TRFH_1	112	116	PF08558	0.417
LIG_TYR_ITIM	110	115	PF00017	0.433
LIG_UBA3_1	110	118	PF00899	0.409
LIG_UBA3_1	226	234	PF00899	0.572
LIG_Vh1_VBS_1	341	359	PF01044	0.463
LIG_WRC_WIRS_1	410	415	PF05994	0.391
LIG_WRC_WIRS_1	466	471	PF05994	0.361
MOD_CDC14_SPxK_1	263	266	PF00782	0.283
MOD_CDK_SPxK_1	260	266	PF00069	0.283
MOD_CK1_1	456	462	PF00069	0.407
MOD_CK1_1	632	638	PF00069	0.692
MOD_CK1_1	67	73	PF00069	0.408
MOD_CK2_1	229	235	PF00069	0.468
MOD_CK2_1	632	638	PF00069	0.774
MOD_Cter_Amidation	259	262	PF01082	0.523
MOD_GlcNHglycan	119	123	PF01048	0.407
MOD_GlcNHglycan	195	198	PF01048	0.427
MOD_GlcNHglycan	448	451	PF01048	0.384
MOD_GlcNHglycan	546	549	PF01048	0.447
MOD_GlcNHglycan	635	638	PF01048	0.758
MOD_GSK3_1	189	196	PF00069	0.496
MOD_GSK3_1	260	267	PF00069	0.476
MOD_GSK3_1	341	348	PF00069	0.415
MOD_GSK3_1	405	412	PF00069	0.290
MOD_GSK3_1	427	434	PF00069	0.425
MOD_GSK3_1	456	463	PF00069	0.419
MOD_GSK3_1	538	545	PF00069	0.431
MOD_GSK3_1	629	636	PF00069	0.724
MOD_GSK3_1	64	71	PF00069	0.462
MOD_N-GLC_1	425	430	PF02516	0.410
MOD_N-GLC_1	640	645	PF02516	0.779
MOD_N-GLC_2	584	586	PF02516	0.540
MOD_NEK2_1	130	135	PF00069	0.400
MOD_NEK2_1	229	234	PF00069	0.465
MOD_NEK2_1	29	34	PF00069	0.484
MOD_NEK2_1	341	346	PF00069	0.421
MOD_NEK2_1	360	365	PF00069	0.352
MOD_NEK2_1	371	376	PF00069	0.369
MOD_NEK2_1	427	432	PF00069	0.411
MOD_NEK2_1	464	469	PF00069	0.418
MOD_NEK2_1	542	547	PF00069	0.409
MOD_NEK2_1	72	77	PF00069	0.432
MOD_NEK2_1	90	95	PF00069	0.338
MOD_NEK2_1	98	103	PF00069	0.394
MOD_NEK2_2	189	194	PF00069	0.522
MOD_NEK2_2	409	414	PF00069	0.393
MOD_PK_1	65	71	PF00069	0.506
MOD_PKA_2	460	466	PF00069	0.405
MOD_PKA_2	525	531	PF00069	0.390
MOD_PKA_2	543	549	PF00069	0.390
MOD_PKA_2	64	70	PF00069	0.432
MOD_Plk_1	425	431	PF00069	0.429
MOD_Plk_4	160	166	PF00069	0.394
MOD_Plk_4	174	180	PF00069	0.381
MOD_Plk_4	341	347	PF00069	0.407
MOD_Plk_4	378	384	PF00069	0.446
MOD_Plk_4	409	415	PF00069	0.394
MOD_Plk_4	427	433	PF00069	0.492
MOD_Plk_4	527	533	PF00069	0.426
MOD_Plk_4	592	598	PF00069	0.424
MOD_ProDKin_1	260	266	PF00069	0.527
MOD_ProDKin_1	405	411	PF00069	0.387
MOD_ProDKin_1	584	590	PF00069	0.469
MOD_ProDKin_1	630	636	PF00069	0.603
MOD_SUMO_for_1	650	653	PF00179	0.518
MOD_SUMO_rev_2	605	614	PF00179	0.463
TRG_DiLeu_BaEn_2	222	228	PF01217	0.365
TRG_ENDOCYTIC_2	112	115	PF00928	0.392
TRG_ENDOCYTIC_2	147	150	PF00928	0.393
TRG_ENDOCYTIC_2	343	346	PF00928	0.403
TRG_ENDOCYTIC_2	403	406	PF00928	0.407
TRG_ENDOCYTIC_2	432	435	PF00928	0.407
TRG_ENDOCYTIC_2	488	491	PF00928	0.534
TRG_ENDOCYTIC_2	49	52	PF00928	0.406
TRG_ENDOCYTIC_2	513	516	PF00928	0.360
TRG_ENDOCYTIC_2	533	536	PF00928	0.396
TRG_ENDOCYTIC_2	63	66	PF00928	0.376
TRG_ENDOCYTIC_2	97	100	PF00928	0.401
TRG_ER_diArg_1	239	241	PF00400	0.375
TRG_ER_diArg_1	8	10	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	93%
A0A0N1HY49	Leptomonas seymouri	47%	97%
A0A0N1HZ06	Leptomonas seymouri	35%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	92%
A0A0N1PAY4	Leptomonas seymouri	47%	74%
A0A0N1PB77	Leptomonas seymouri	35%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	97%
A0A0N1PCC1	Leptomonas seymouri	42%	98%
A0A0S4INN8	Bodo saltans	28%	100%
A0A381MBI0	Leishmania infantum	44%	99%
A0A3Q8I8X7	Leishmania donovani	44%	99%
A0A3Q8IAZ0	Leishmania donovani	73%	94%
A0A3Q8IH50	Leishmania donovani	58%	91%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	43%	97%
A0A3S5H5V2	Leishmania donovani	42%	100%
A0A3S5H6F6	Leishmania donovani	74%	94%
A0A3S5H763	Leishmania donovani	52%	97%
A0A3S7WR10	Leishmania donovani	44%	88%
A0A3S7WR14	Leishmania donovani	75%	95%
A0A3S7WR15	Leishmania donovani	91%	77%
A0A3S7WR24	Leishmania donovani	73%	93%
A4H4T8	Leishmania braziliensis	41%	100%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	70%	100%
A4H618	Leishmania braziliensis	69%	100%
A4H619	Leishmania braziliensis	70%	100%
A4H620	Leishmania braziliensis	61%	100%
A4H6C3	Leishmania braziliensis	45%	100%
A4HNH7	Leishmania braziliensis	35%	99%
A4HSS2	Leishmania infantum	44%	97%
A4HUE4	Leishmania infantum	43%	88%
A4HUE5	Leishmania infantum	91%	95%
A4HUE6	Leishmania infantum	74%	95%
A4HUE7	Leishmania infantum	74%	94%
A4HUE8	Leishmania infantum	74%	93%
A4HUF4	Leishmania infantum	74%	94%
A4HUF5	Leishmania infantum	58%	100%
A4HYA9	Leishmania infantum	52%	97%
A4IC33	Leishmania infantum	36%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AG72	Leishmania infantum	41%	100%
E9AI40	Leishmania braziliensis	78%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	92%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	97%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	58%	100%
Q4QHH8	Leishmania major	72%	100%
Q4QHH9	Leishmania major	72%	100%
Q4QHI0	Leishmania major	72%	100%
Q4QHI1	Leishmania major	73%	99%
Q4QHI2	Leishmania major	84%	100%
Q4QIU9	Leishmania major	41%	100%
Q4QJ48	Leishmania major	42%	100%
Q7KIP2	Leishmania major	36%	100%