Kinetoplastid kinetochore protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 4, putative

Species:

Leishmania mexicana

UniProt:

E9AN40_LEIMU

TriTrypDb:

LmxM.10.0300

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN40

PDB structure(s): 6zpj_A , 6zpj_B

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.824
CLV_NRD_NRD_1	193	195	PF00675	0.569
CLV_NRD_NRD_1	246	248	PF00675	0.567
CLV_NRD_NRD_1	411	413	PF00675	0.838
CLV_NRD_NRD_1	449	451	PF00675	0.706
CLV_NRD_NRD_1	452	454	PF00675	0.666
CLV_NRD_NRD_1	602	604	PF00675	0.486
CLV_NRD_NRD_1	65	67	PF00675	0.635
CLV_NRD_NRD_1	82	84	PF00675	0.807
CLV_PCSK_FUR_1	450	454	PF00082	0.736
CLV_PCSK_KEX2_1	160	162	PF00082	0.751
CLV_PCSK_KEX2_1	193	195	PF00082	0.569
CLV_PCSK_KEX2_1	352	354	PF00082	0.722
CLV_PCSK_KEX2_1	391	393	PF00082	0.749
CLV_PCSK_KEX2_1	411	413	PF00082	0.838
CLV_PCSK_KEX2_1	451	453	PF00082	0.697
CLV_PCSK_KEX2_1	595	597	PF00082	0.544
CLV_PCSK_KEX2_1	602	604	PF00082	0.486
CLV_PCSK_KEX2_1	65	67	PF00082	0.594
CLV_PCSK_KEX2_1	734	736	PF00082	0.686
CLV_PCSK_KEX2_1	82	84	PF00082	0.703
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.722
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.749
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.844
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.544
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.686
CLV_PCSK_PC7_1	156	162	PF00082	0.749
CLV_PCSK_SKI1_1	10	14	PF00082	0.620
CLV_PCSK_SKI1_1	229	233	PF00082	0.559
CLV_PCSK_SKI1_1	257	261	PF00082	0.503
CLV_PCSK_SKI1_1	504	508	PF00082	0.733
CLV_PCSK_SKI1_1	603	607	PF00082	0.428
CLV_PCSK_SKI1_1	653	657	PF00082	0.478
CLV_PCSK_SKI1_1	702	706	PF00082	0.479
CLV_PCSK_SKI1_1	758	762	PF00082	0.503
CLV_Separin_Metazoa	7	11	PF03568	0.723
DEG_APCC_DBOX_1	712	720	PF00400	0.480
DEG_APCC_KENBOX_2	287	291	PF00400	0.667
DEG_SCF_FBW7_1	455	461	PF00400	0.717
DEG_SCF_FBW7_1	492	497	PF00400	0.700
DEG_SPOP_SBC_1	482	486	PF00917	0.749
DEG_SPOP_SBC_1	639	643	PF00917	0.540
DOC_CKS1_1	426	431	PF01111	0.817
DOC_CKS1_1	455	460	PF01111	0.720
DOC_CYCLIN_RxL_1	254	262	PF00134	0.564
DOC_CYCLIN_RxL_1	699	708	PF00134	0.594
DOC_MAPK_gen_1	699	707	PF00069	0.588
DOC_PP4_FxxP_1	694	697	PF00568	0.497
DOC_USP7_MATH_1	135	139	PF00917	0.697
DOC_USP7_MATH_1	159	163	PF00917	0.693
DOC_USP7_MATH_1	331	335	PF00917	0.795
DOC_USP7_MATH_1	494	498	PF00917	0.698
DOC_USP7_MATH_1	502	506	PF00917	0.689
DOC_USP7_MATH_1	564	568	PF00917	0.700
DOC_USP7_MATH_1	630	634	PF00917	0.669
DOC_USP7_MATH_1	729	733	PF00917	0.630
DOC_WW_Pin1_4	131	136	PF00397	0.721
DOC_WW_Pin1_4	164	169	PF00397	0.713
DOC_WW_Pin1_4	297	302	PF00397	0.590
DOC_WW_Pin1_4	419	424	PF00397	0.699
DOC_WW_Pin1_4	425	430	PF00397	0.694
DOC_WW_Pin1_4	451	456	PF00397	0.718
DOC_WW_Pin1_4	488	493	PF00397	0.713
DOC_WW_Pin1_4	508	513	PF00397	0.721
DOC_WW_Pin1_4	585	590	PF00397	0.630
DOC_WW_Pin1_4	648	653	PF00397	0.529
DOC_WW_Pin1_4	666	671	PF00397	0.457
LIG_14-3-3_CanoR_1	10	19	PF00244	0.614
LIG_14-3-3_CanoR_1	119	123	PF00244	0.838
LIG_14-3-3_CanoR_1	160	165	PF00244	0.773
LIG_14-3-3_CanoR_1	172	177	PF00244	0.646
LIG_14-3-3_CanoR_1	204	212	PF00244	0.499
LIG_14-3-3_CanoR_1	332	338	PF00244	0.706
LIG_14-3-3_CanoR_1	392	396	PF00244	0.678
LIG_14-3-3_CanoR_1	474	482	PF00244	0.741
LIG_14-3-3_CanoR_1	616	624	PF00244	0.535
LIG_14-3-3_CanoR_1	702	708	PF00244	0.486
LIG_14-3-3_CanoR_1	758	765	PF00244	0.492
LIG_Actin_WH2_2	743	760	PF00022	0.510
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BIR_III_4	296	300	PF00653	0.524
LIG_Clathr_ClatBox_1	704	708	PF01394	0.492
LIG_EVH1_1	556	560	PF00568	0.737
LIG_FHA_1	204	210	PF00498	0.622
LIG_FHA_1	395	401	PF00498	0.732
LIG_FHA_1	435	441	PF00498	0.797
LIG_FHA_1	482	488	PF00498	0.717
LIG_FHA_1	491	497	PF00498	0.640
LIG_FHA_1	575	581	PF00498	0.704
LIG_FHA_1	641	647	PF00498	0.531
LIG_FHA_2	119	125	PF00498	0.593
LIG_FHA_2	173	179	PF00498	0.702
LIG_FHA_2	290	296	PF00498	0.718
LIG_FHA_2	391	397	PF00498	0.721
LIG_FHA_2	415	421	PF00498	0.823
LIG_FHA_2	459	465	PF00498	0.710
LIG_FHA_2	519	525	PF00498	0.743
LIG_FHA_2	749	755	PF00498	0.486
LIG_LRP6_Inhibitor_1	470	476	PF00058	0.537
LIG_MYND_1	320	324	PF01753	0.760
LIG_NRBOX	255	261	PF00104	0.656
LIG_PDZ_Class_3	760	765	PF00595	0.662
LIG_RPA_C_Fungi	266	278	PF08784	0.373
LIG_RPA_C_Fungi	407	419	PF08784	0.751
LIG_RPA_C_Fungi	469	481	PF08784	0.654
LIG_SH2_CRK	241	245	PF00017	0.560
LIG_SH2_STAP1	272	276	PF00017	0.543
LIG_SH2_STAP1	347	351	PF00017	0.609
LIG_SH2_STAT3	533	536	PF00017	0.530
LIG_SH2_STAT3	674	677	PF00017	0.574
LIG_SH2_STAT3	759	762	PF00017	0.603
LIG_SH2_STAT5	425	428	PF00017	0.829
LIG_SH2_STAT5	672	675	PF00017	0.455
LIG_SH3_1	452	458	PF00018	0.724
LIG_SH3_2	455	460	PF14604	0.744
LIG_SH3_2	557	562	PF14604	0.744
LIG_SH3_2	591	596	PF14604	0.605
LIG_SH3_3	452	458	PF00018	0.724
LIG_SH3_3	554	560	PF00018	0.748
LIG_SH3_3	58	64	PF00018	0.707
LIG_SH3_3	588	594	PF00018	0.637
LIG_SH3_3	704	710	PF00018	0.601
LIG_SUMO_SIM_anti_2	746	752	PF11976	0.500
LIG_SUMO_SIM_par_1	703	708	PF11976	0.484
LIG_SUMO_SIM_par_1	746	752	PF11976	0.500
LIG_UBA3_1	605	610	PF00899	0.614
LIG_WW_3	32	36	PF00397	0.710
LIG_WW_3	62	66	PF00397	0.723
MOD_CDK_SPK_2	297	302	PF00069	0.521
MOD_CDK_SPK_2	451	456	PF00069	0.730
MOD_CDK_SPK_2	648	653	PF00069	0.529
MOD_CDK_SPxK_1	454	460	PF00069	0.705
MOD_CDK_SPxxK_3	427	434	PF00069	0.695
MOD_CK1_1	133	139	PF00069	0.811
MOD_CK1_1	141	147	PF00069	0.719
MOD_CK1_1	325	331	PF00069	0.713
MOD_CK1_1	341	347	PF00069	0.751
MOD_CK1_1	575	581	PF00069	0.672
MOD_CK1_1	641	647	PF00069	0.544
MOD_CK1_1	676	682	PF00069	0.488
MOD_CK1_1	88	94	PF00069	0.744
MOD_CK1_1	99	105	PF00069	0.704
MOD_CK2_1	164	170	PF00069	0.731
MOD_CK2_1	414	420	PF00069	0.727
MOD_CK2_1	458	464	PF00069	0.733
MOD_CK2_1	466	472	PF00069	0.649
MOD_CK2_1	518	524	PF00069	0.749
MOD_Cter_Amidation	409	412	PF01082	0.838
MOD_DYRK1A_RPxSP_1	587	591	PF00069	0.663
MOD_GlcNHglycan	267	270	PF01048	0.527
MOD_GlcNHglycan	309	312	PF01048	0.650
MOD_GlcNHglycan	340	343	PF01048	0.733
MOD_GlcNHglycan	348	351	PF01048	0.690
MOD_GlcNHglycan	36	39	PF01048	0.700
MOD_GlcNHglycan	402	405	PF01048	0.753
MOD_GlcNHglycan	447	450	PF01048	0.811
MOD_GlcNHglycan	515	518	PF01048	0.698
MOD_GlcNHglycan	574	577	PF01048	0.678
MOD_GlcNHglycan	581	584	PF01048	0.650
MOD_GlcNHglycan	618	621	PF01048	0.609
MOD_GlcNHglycan	662	665	PF01048	0.496
MOD_GlcNHglycan	678	681	PF01048	0.374
MOD_GlcNHglycan	729	732	PF01048	0.629
MOD_GlcNHglycan	751	754	PF01048	0.314
MOD_GlcNHglycan	93	96	PF01048	0.848
MOD_GlcNHglycan	98	101	PF01048	0.712
MOD_GSK3_1	126	133	PF00069	0.773
MOD_GSK3_1	135	142	PF00069	0.690
MOD_GSK3_1	160	167	PF00069	0.755
MOD_GSK3_1	341	348	PF00069	0.626
MOD_GSK3_1	390	397	PF00069	0.741
MOD_GSK3_1	414	421	PF00069	0.705
MOD_GSK3_1	439	446	PF00069	0.692
MOD_GSK3_1	454	461	PF00069	0.810
MOD_GSK3_1	490	497	PF00069	0.656
MOD_GSK3_1	498	505	PF00069	0.654
MOD_GSK3_1	508	515	PF00069	0.720
MOD_GSK3_1	520	527	PF00069	0.594
MOD_GSK3_1	560	567	PF00069	0.656
MOD_GSK3_1	570	577	PF00069	0.682
MOD_GSK3_1	579	586	PF00069	0.747
MOD_GSK3_1	84	91	PF00069	0.694
MOD_GSK3_1	94	101	PF00069	0.698
MOD_N-GLC_1	125	130	PF02516	0.581
MOD_N-GLC_1	289	294	PF02516	0.699
MOD_NEK2_1	139	144	PF00069	0.848
MOD_NEK2_1	181	186	PF00069	0.567
MOD_NEK2_1	202	207	PF00069	0.519
MOD_NEK2_1	234	239	PF00069	0.515
MOD_NEK2_1	259	264	PF00069	0.548
MOD_NEK2_1	265	270	PF00069	0.533
MOD_NEK2_1	395	400	PF00069	0.707
MOD_NEK2_1	439	444	PF00069	0.621
MOD_NEK2_1	506	511	PF00069	0.735
MOD_NEK2_1	604	609	PF00069	0.497
MOD_NEK2_1	98	103	PF00069	0.822
MOD_NEK2_2	483	488	PF00069	0.730
MOD_PIKK_1	101	107	PF00454	0.817
MOD_PIKK_1	203	209	PF00454	0.553
MOD_PIKK_1	322	328	PF00454	0.762
MOD_PIKK_1	441	447	PF00454	0.725
MOD_PIKK_1	474	480	PF00454	0.755
MOD_PIKK_1	673	679	PF00454	0.582
MOD_PIKK_1	758	764	PF00454	0.634
MOD_PKA_1	160	166	PF00069	0.757
MOD_PKA_1	391	397	PF00069	0.728
MOD_PKA_2	118	124	PF00069	0.838
MOD_PKA_2	159	165	PF00069	0.752
MOD_PKA_2	171	177	PF00069	0.567
MOD_PKA_2	203	209	PF00069	0.498
MOD_PKA_2	315	321	PF00069	0.583
MOD_PKA_2	331	337	PF00069	0.709
MOD_PKA_2	34	40	PF00069	0.740
MOD_PKA_2	391	397	PF00069	0.716
MOD_PKA_2	85	91	PF00069	0.618
MOD_Plk_1	395	401	PF00069	0.760
MOD_Plk_1	502	508	PF00069	0.835
MOD_Plk_4	106	112	PF00069	0.819
MOD_Plk_4	135	141	PF00069	0.657
MOD_Plk_4	160	166	PF00069	0.757
MOD_ProDKin_1	131	137	PF00069	0.719
MOD_ProDKin_1	164	170	PF00069	0.712
MOD_ProDKin_1	297	303	PF00069	0.592
MOD_ProDKin_1	419	425	PF00069	0.703
MOD_ProDKin_1	427	433	PF00069	0.657
MOD_ProDKin_1	451	457	PF00069	0.717
MOD_ProDKin_1	488	494	PF00069	0.709
MOD_ProDKin_1	508	514	PF00069	0.719
MOD_ProDKin_1	585	591	PF00069	0.629
MOD_ProDKin_1	648	654	PF00069	0.524
MOD_ProDKin_1	666	672	PF00069	0.454
MOD_SUMO_for_1	487	490	PF00179	0.829
TRG_DiLeu_BaEn_1	613	618	PF01217	0.447
TRG_ENDOCYTIC_2	241	244	PF00928	0.563
TRG_ENDOCYTIC_2	272	275	PF00928	0.647
TRG_ER_diArg_1	159	161	PF00400	0.748
TRG_ER_diArg_1	193	195	PF00400	0.522
TRG_ER_diArg_1	450	453	PF00400	0.687
TRG_ER_diArg_1	601	603	PF00400	0.508
TRG_ER_diArg_1	64	66	PF00400	0.573
TRG_NLS_Bipartite_1	65	87	PF00514	0.547
TRG_NLS_MonoCore_2	449	454	PF00514	0.836
TRG_NLS_MonoExtC_3	450	455	PF00514	0.835
TRG_NLS_MonoExtN_4	450	455	PF00514	0.791
TRG_NLS_MonoExtN_4	82	87	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R5	Leptomonas seymouri	52%	100%
A0A3S7WR22	Leishmania donovani	90%	100%
A4H613	Leishmania braziliensis	77%	100%
A4HUE0	Leishmania infantum	90%	100%
Q4QHI6	Leishmania major	90%	100%