Isocitrate dehydrogenase [NADP]

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

isocitrate dehydrogenase [NADP]

Species:

Leishmania mexicana

UniProt:

E9AN39_LEIMU

TriTrypDb:

LmxM.10.0290

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN39

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	12
GO:0006082	organic acid metabolic process	3	12
GO:0006099	tricarboxylic acid cycle	3	12
GO:0006102	isocitrate metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0072350	tricarboxylic acid metabolic process	6	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1902652	secondary alcohol metabolic process	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006739	NADP metabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004448	isocitrate dehydrogenase [NAD(P)+] activity	5	12
GO:0004450	isocitrate dehydrogenase (NADP+) activity	6	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051287	NAD binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.552
CLV_C14_Caspase3-7	73	77	PF00656	0.505
CLV_NRD_NRD_1	226	228	PF00675	0.306
CLV_NRD_NRD_1	3	5	PF00675	0.563
CLV_PCSK_KEX2_1	28	30	PF00082	0.506
CLV_PCSK_KEX2_1	3	5	PF00082	0.563
CLV_PCSK_KEX2_1	411	413	PF00082	0.355
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.520
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.355
CLV_PCSK_SKI1_1	126	130	PF00082	0.305
CLV_PCSK_SKI1_1	158	162	PF00082	0.290
CLV_PCSK_SKI1_1	28	32	PF00082	0.548
CLV_PCSK_SKI1_1	3	7	PF00082	0.559
CLV_PCSK_SKI1_1	55	59	PF00082	0.294
CLV_PCSK_SKI1_1	75	79	PF00082	0.163
CLV_PCSK_SKI1_1	98	102	PF00082	0.294
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CKS1_1	180	185	PF01111	0.494
DOC_MAPK_DCC_7	53	63	PF00069	0.494
DOC_MAPK_gen_1	227	233	PF00069	0.494
DOC_MAPK_gen_1	91	97	PF00069	0.571
DOC_MAPK_JIP1_4	173	179	PF00069	0.599
DOC_MAPK_MEF2A_6	198	206	PF00069	0.502
DOC_MAPK_MEF2A_6	55	63	PF00069	0.494
DOC_PP1_RVXF_1	44	50	PF00149	0.494
DOC_PP2B_LxvP_1	56	59	PF13499	0.494
DOC_PP4_FxxP_1	134	137	PF00568	0.494
DOC_USP7_MATH_1	15	19	PF00917	0.731
DOC_USP7_MATH_1	184	188	PF00917	0.551
DOC_USP7_MATH_1	8	12	PF00917	0.643
DOC_USP7_UBL2_3	115	119	PF12436	0.494
DOC_WW_Pin1_4	100	105	PF00397	0.490
DOC_WW_Pin1_4	117	122	PF00397	0.494
DOC_WW_Pin1_4	179	184	PF00397	0.486
LIG_14-3-3_CanoR_1	166	174	PF00244	0.472
LIG_14-3-3_CanoR_1	17	26	PF00244	0.592
LIG_14-3-3_CanoR_1	46	52	PF00244	0.555
LIG_APCC_ABBA_1	57	62	PF00400	0.505
LIG_FHA_1	166	172	PF00498	0.505
LIG_FHA_1	189	195	PF00498	0.599
LIG_FHA_1	314	320	PF00498	0.494
LIG_FHA_1	349	355	PF00498	0.488
LIG_FHA_1	359	365	PF00498	0.492
LIG_FHA_1	395	401	PF00498	0.502
LIG_FHA_1	43	49	PF00498	0.500
LIG_FHA_2	101	107	PF00498	0.494
LIG_FHA_2	180	186	PF00498	0.540
LIG_FHA_2	188	194	PF00498	0.467
LIG_FHA_2	71	77	PF00498	0.505
LIG_LIR_Apic_2	132	137	PF02991	0.494
LIG_LIR_Gen_1	250	259	PF02991	0.496
LIG_LYPXL_yS_3	229	232	PF13949	0.505
LIG_MAD2	145	153	PF02301	0.494
LIG_Pex14_2	247	251	PF04695	0.494
LIG_SH2_PTP2	60	63	PF00017	0.519
LIG_SH2_SRC	60	63	PF00017	0.519
LIG_SH2_STAP1	255	259	PF00017	0.494
LIG_SH2_STAT3	255	258	PF00017	0.519
LIG_SH2_STAT5	60	63	PF00017	0.510
LIG_SH2_STAT5	67	70	PF00017	0.499
LIG_SH3_3	168	174	PF00018	0.503
LIG_SH3_3	177	183	PF00018	0.468
LIG_SH3_3	58	64	PF00018	0.494
LIG_SUMO_SIM_par_1	136	141	PF11976	0.580
LIG_SUMO_SIM_par_1	190	196	PF11976	0.535
LIG_SUMO_SIM_par_1	229	235	PF11976	0.494
LIG_TYR_ITIM	58	63	PF00017	0.502
LIG_TYR_ITIM	65	70	PF00017	0.483
LIG_WRC_WIRS_1	248	253	PF05994	0.494
LIG_WRC_WIRS_1	48	53	PF05994	0.543
MOD_CK1_1	18	24	PF00069	0.633
MOD_CK1_1	187	193	PF00069	0.580
MOD_CK1_1	350	356	PF00069	0.491
MOD_CK1_1	9	15	PF00069	0.709
MOD_CK2_1	100	106	PF00069	0.494
MOD_GlcNHglycan	185	189	PF01048	0.380
MOD_GlcNHglycan	407	410	PF01048	0.380
MOD_GlcNHglycan	8	11	PF01048	0.643
MOD_GSK3_1	117	124	PF00069	0.480
MOD_GSK3_1	15	22	PF00069	0.670
MOD_GSK3_1	184	191	PF00069	0.595
MOD_GSK3_1	231	238	PF00069	0.494
MOD_GSK3_1	346	353	PF00069	0.490
MOD_N-GLC_1	121	126	PF02516	0.294
MOD_N-GLC_2	23	25	PF02516	0.600
MOD_NEK2_1	129	134	PF00069	0.500
MOD_NEK2_1	19	24	PF00069	0.562
MOD_NEK2_1	216	221	PF00069	0.501
MOD_NEK2_1	231	236	PF00069	0.462
MOD_NEK2_1	247	252	PF00069	0.494
MOD_NEK2_1	314	319	PF00069	0.494
MOD_NEK2_1	68	73	PF00069	0.489
MOD_NEK2_2	121	126	PF00069	0.494
MOD_PKA_1	3	9	PF00069	0.618
MOD_PKA_2	165	171	PF00069	0.472
MOD_PKA_2	3	9	PF00069	0.618
MOD_Plk_1	42	48	PF00069	0.494
MOD_Plk_1	68	74	PF00069	0.505
MOD_Plk_2-3	323	329	PF00069	0.505
MOD_Plk_4	129	135	PF00069	0.494
MOD_Plk_4	235	241	PF00069	0.494
MOD_Plk_4	314	320	PF00069	0.494
MOD_Plk_4	353	359	PF00069	0.494
MOD_Plk_4	9	15	PF00069	0.709
MOD_ProDKin_1	100	106	PF00069	0.490
MOD_ProDKin_1	117	123	PF00069	0.494
MOD_ProDKin_1	179	185	PF00069	0.486
MOD_SUMO_for_1	283	286	PF00179	0.580
MOD_SUMO_for_1	32	35	PF00179	0.580
MOD_SUMO_for_1	410	413	PF00179	0.580
MOD_SUMO_rev_2	317	327	PF00179	0.505
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.494
TRG_ENDOCYTIC_2	223	226	PF00928	0.504
TRG_ENDOCYTIC_2	229	232	PF00928	0.481
TRG_ENDOCYTIC_2	243	246	PF00928	0.453
TRG_ENDOCYTIC_2	60	63	PF00928	0.502
TRG_ENDOCYTIC_2	67	70	PF00928	0.483
TRG_ER_diArg_1	2	4	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A096P8D3	Ostreococcus tauri	32%	93%
A0A0N1I742	Leptomonas seymouri	88%	100%
A0A0S4IN25	Bodo saltans	65%	100%
A0A0S4JT83	Bodo saltans	72%	100%
A0A1X0NQ73	Trypanosomatidae	72%	96%
A0A1X0P451	Trypanosomatidae	66%	100%
A0A3Q8IC24	Leishmania donovani	98%	100%
A0A3R7NV25	Trypanosoma rangeli	74%	100%
A0A422NTJ0	Trypanosoma rangeli	65%	100%
A4H612	Leishmania braziliensis	91%	100%
A4HUD9	Leishmania infantum	98%	100%
C9ZVF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A5M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
O13285	Candida tropicalis	64%	100%
O13294	Candida tropicalis	63%	100%
O14254	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	99%
O75874	Homo sapiens	65%	100%
O88844	Mus musculus	64%	100%
P21954	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	64%	100%
P33198	Sus scrofa	66%	100%
P41562	Rattus norvegicus	65%	100%
P41939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	63%	100%
P48735	Homo sapiens	67%	96%
P50215	Sphingobium yanoikuyae	62%	100%
P50217	Solanum tuberosum	65%	100%
P50218	Nicotiana tabacum	64%	100%
P53982	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	100%
P54071	Mus musculus	68%	96%
P56574	Rattus norvegicus	68%	96%
P65098	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	63%	100%
P79089	Aspergillus niger	62%	87%
P9WKL0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	63%	100%
P9WKL1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	63%	100%
Q04467	Bos taurus	68%	96%
Q06197	Glycine max	65%	100%
Q40345	Medicago sativa	64%	100%
Q4QHI7	Leishmania major	97%	100%
Q4R502	Macaca fascicularis	67%	96%
Q5R9C5	Pongo abelii	65%	100%
Q6XUZ5	Ovis aries	65%	100%
Q75JR2	Dictyostelium discoideum	62%	100%
Q75JR3	Dictyostelium discoideum	61%	100%
Q8LPJ5	Arabidopsis thaliana	65%	90%
Q9SLK0	Arabidopsis thaliana	64%	100%
Q9SRZ6	Arabidopsis thaliana	64%	100%
Q9XSG3	Bos taurus	64%	100%
Q9Z2K8	Microtus ochrogaster	65%	100%
Q9Z2K9	Microtus mexicanus	65%	100%
V5B9G3	Trypanosoma cruzi	75%	100%