Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9AN37_LEIMU

TriTrypDb:

LmxM.10.0270

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN37

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.534
CLV_C14_Caspase3-7	585	589	PF00656	0.534
CLV_C14_Caspase3-7	624	628	PF00656	0.721
CLV_MEL_PAP_1	65	71	PF00089	0.730
CLV_NRD_NRD_1	256	258	PF00675	0.743
CLV_NRD_NRD_1	28	30	PF00675	0.759
CLV_NRD_NRD_1	576	578	PF00675	0.315
CLV_NRD_NRD_1	707	709	PF00675	0.565
CLV_NRD_NRD_1	805	807	PF00675	0.627
CLV_NRD_NRD_1	812	814	PF00675	0.488
CLV_PCSK_KEX2_1	256	258	PF00082	0.735
CLV_PCSK_KEX2_1	27	29	PF00082	0.755
CLV_PCSK_KEX2_1	576	578	PF00082	0.314
CLV_PCSK_KEX2_1	805	807	PF00082	0.627
CLV_PCSK_KEX2_1	812	814	PF00082	0.488
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.755
CLV_PCSK_PC7_1	572	578	PF00082	0.313
CLV_PCSK_SKI1_1	112	116	PF00082	0.615
CLV_PCSK_SKI1_1	23	27	PF00082	0.592
CLV_PCSK_SKI1_1	359	363	PF00082	0.485
CLV_PCSK_SKI1_1	563	567	PF00082	0.346
CLV_PCSK_SKI1_1	812	816	PF00082	0.584
CLV_PCSK_SKI1_1	85	89	PF00082	0.701
DEG_APCC_DBOX_1	464	472	PF00400	0.482
DEG_APCC_DBOX_1	811	819	PF00400	0.582
DEG_MDM2_SWIB_1	744	751	PF02201	0.628
DEG_SPOP_SBC_1	263	267	PF00917	0.793
DEG_SPOP_SBC_1	505	509	PF00917	0.562
DEG_SPOP_SBC_1	685	689	PF00917	0.739
DOC_CKS1_1	765	770	PF01111	0.615
DOC_CKS1_1	8	13	PF01111	0.776
DOC_CYCLIN_yClb1_LxF_4	563	569	PF00134	0.513
DOC_MAPK_gen_1	119	128	PF00069	0.584
DOC_MAPK_gen_1	609	617	PF00069	0.575
DOC_MAPK_gen_1	691	700	PF00069	0.494
DOC_MAPK_MEF2A_6	121	130	PF00069	0.589
DOC_MAPK_MEF2A_6	472	480	PF00069	0.441
DOC_MAPK_MEF2A_6	68	76	PF00069	0.742
DOC_PP1_RVXF_1	110	116	PF00149	0.654
DOC_PP1_RVXF_1	244	251	PF00149	0.651
DOC_PP1_RVXF_1	443	450	PF00149	0.330
DOC_PP2B_LxvP_1	235	238	PF13499	0.721
DOC_PP2B_LxvP_1	367	370	PF13499	0.561
DOC_PP2B_LxvP_1	660	663	PF13499	0.709
DOC_PP4_FxxP_1	425	428	PF00568	0.587
DOC_PP4_FxxP_1	554	557	PF00568	0.482
DOC_USP7_MATH_1	164	168	PF00917	0.635
DOC_USP7_MATH_1	178	182	PF00917	0.629
DOC_USP7_MATH_1	258	262	PF00917	0.785
DOC_USP7_MATH_1	263	267	PF00917	0.778
DOC_USP7_MATH_1	315	319	PF00917	0.757
DOC_USP7_MATH_1	331	335	PF00917	0.577
DOC_USP7_MATH_1	386	390	PF00917	0.744
DOC_USP7_MATH_1	395	399	PF00917	0.723
DOC_USP7_MATH_1	426	430	PF00917	0.622
DOC_USP7_MATH_1	589	593	PF00917	0.482
DOC_USP7_MATH_1	610	614	PF00917	0.571
DOC_USP7_MATH_1	621	625	PF00917	0.599
DOC_USP7_MATH_1	674	678	PF00917	0.772
DOC_USP7_MATH_1	685	689	PF00917	0.735
DOC_USP7_MATH_1	766	770	PF00917	0.771
DOC_USP7_MATH_1	83	87	PF00917	0.720
DOC_USP7_MATH_1	880	884	PF00917	0.750
DOC_USP7_MATH_1	888	892	PF00917	0.749
DOC_USP7_MATH_1	895	899	PF00917	0.659
DOC_USP7_UBL2_3	117	121	PF12436	0.571
DOC_USP7_UBL2_3	23	27	PF12436	0.760
DOC_WW_Pin1_4	107	112	PF00397	0.731
DOC_WW_Pin1_4	160	165	PF00397	0.771
DOC_WW_Pin1_4	206	211	PF00397	0.554
DOC_WW_Pin1_4	291	296	PF00397	0.759
DOC_WW_Pin1_4	3	8	PF00397	0.745
DOC_WW_Pin1_4	327	332	PF00397	0.722
DOC_WW_Pin1_4	338	343	PF00397	0.587
DOC_WW_Pin1_4	438	443	PF00397	0.658
DOC_WW_Pin1_4	764	769	PF00397	0.789
DOC_WW_Pin1_4	916	921	PF00397	0.599
LIG_14-3-3_CanoR_1	123	127	PF00244	0.667
LIG_14-3-3_CanoR_1	465	469	PF00244	0.486
LIG_14-3-3_CanoR_1	485	495	PF00244	0.350
LIG_14-3-3_CanoR_1	609	615	PF00244	0.591
LIG_14-3-3_CanoR_1	68	76	PF00244	0.743
LIG_14-3-3_CanoR_1	741	747	PF00244	0.692
LIG_14-3-3_CanoR_1	82	90	PF00244	0.631
LIG_Actin_WH2_2	584	601	PF00022	0.533
LIG_Actin_WH2_2	800	818	PF00022	0.643
LIG_APCC_ABBA_1	647	652	PF00400	0.565
LIG_BIR_III_2	696	700	PF00653	0.773
LIG_BIR_III_4	299	303	PF00653	0.631
LIG_BRCT_BRCA1_1	345	349	PF00533	0.646
LIG_CaM_NSCaTE_8	199	206	PF13499	0.670
LIG_CtBP_PxDLS_1	864	868	PF00389	0.670
LIG_deltaCOP1_diTrp_1	420	425	PF00928	0.518
LIG_deltaCOP1_diTrp_1	549	554	PF00928	0.555
LIG_EVH1_1	660	664	PF00568	0.458
LIG_FHA_1	123	129	PF00498	0.637
LIG_FHA_1	20	26	PF00498	0.744
LIG_FHA_1	37	43	PF00498	0.579
LIG_FHA_1	439	445	PF00498	0.607
LIG_FHA_1	471	477	PF00498	0.528
LIG_FHA_1	523	529	PF00498	0.551
LIG_FHA_1	548	554	PF00498	0.496
LIG_FHA_1	8	14	PF00498	0.748
LIG_FHA_1	823	829	PF00498	0.601
LIG_FHA_1	895	901	PF00498	0.672
LIG_FHA_1	911	917	PF00498	0.554
LIG_FHA_2	187	193	PF00498	0.584
LIG_FHA_2	238	244	PF00498	0.720
LIG_FHA_2	465	471	PF00498	0.482
LIG_FHA_2	507	513	PF00498	0.482
LIG_FHA_2	670	676	PF00498	0.572
LIG_FHA_2	730	736	PF00498	0.663
LIG_LIR_Apic_2	424	428	PF02991	0.582
LIG_LIR_Apic_2	549	555	PF02991	0.533
LIG_LIR_Gen_1	134	143	PF02991	0.658
LIG_LIR_Gen_1	420	428	PF02991	0.543
LIG_LIR_Gen_1	743	751	PF02991	0.555
LIG_LIR_Gen_1	849	859	PF02991	0.697
LIG_LIR_Nem_3	420	425	PF02991	0.498
LIG_LIR_Nem_3	493	498	PF02991	0.482
LIG_LIR_Nem_3	743	747	PF02991	0.540
LIG_LIR_Nem_3	849	854	PF02991	0.694
LIG_LYPXL_SIV_4	561	569	PF13949	0.562
LIG_Pex14_2	744	748	PF04695	0.629
LIG_REV1ctd_RIR_1	112	121	PF16727	0.618
LIG_SH2_CRK	232	236	PF00017	0.736
LIG_SH2_GRB2like	129	132	PF00017	0.590
LIG_SH2_NCK_1	666	670	PF00017	0.687
LIG_SH2_SRC	129	132	PF00017	0.590
LIG_SH2_STAP1	135	139	PF00017	0.650
LIG_SH2_STAP1	365	369	PF00017	0.432
LIG_SH2_STAT5	129	132	PF00017	0.579
LIG_SH2_STAT5	232	235	PF00017	0.771
LIG_SH2_STAT5	546	549	PF00017	0.501
LIG_SH2_STAT5	573	576	PF00017	0.489
LIG_SH3_3	140	146	PF00018	0.704
LIG_SH3_3	252	258	PF00018	0.667
LIG_SH3_3	380	386	PF00018	0.514
LIG_SH3_3	41	47	PF00018	0.795
LIG_SH3_3	5	11	PF00018	0.734
LIG_SH3_3	658	664	PF00018	0.562
LIG_SH3_3	755	761	PF00018	0.784
LIG_SH3_3	762	768	PF00018	0.762
LIG_SUMO_SIM_anti_2	823	831	PF11976	0.505
LIG_SUMO_SIM_par_1	452	457	PF11976	0.508
LIG_SUMO_SIM_par_1	467	473	PF11976	0.514
LIG_SUMO_SIM_par_1	823	831	PF11976	0.591
LIG_TRAF2_1	33	36	PF00917	0.611
LIG_TRAF2_1	385	388	PF00917	0.691
LIG_TRAF2_1	630	633	PF00917	0.698
LIG_TRAF2_1	773	776	PF00917	0.803
LIG_TYR_ITIM	230	235	PF00017	0.737
LIG_UBA3_1	113	121	PF00899	0.657
LIG_WW_1	663	666	PF00397	0.485
MOD_CDC14_SPxK_1	209	212	PF00782	0.563
MOD_CDK_SPK_2	107	112	PF00069	0.731
MOD_CDK_SPK_2	327	332	PF00069	0.757
MOD_CDK_SPxK_1	206	212	PF00069	0.557
MOD_CDK_SPxxK_3	291	298	PF00069	0.785
MOD_CDK_SPxxK_3	438	445	PF00069	0.518
MOD_CK1_1	167	173	PF00069	0.685
MOD_CK1_1	262	268	PF00069	0.768
MOD_CK1_1	582	588	PF00069	0.483
MOD_CK1_1	677	683	PF00069	0.802
MOD_CK1_1	689	695	PF00069	0.710
MOD_CK1_1	792	798	PF00069	0.764
MOD_CK1_1	874	880	PF00069	0.688
MOD_CK2_1	131	137	PF00069	0.563
MOD_CK2_1	237	243	PF00069	0.655
MOD_CK2_1	395	401	PF00069	0.795
MOD_CK2_1	627	633	PF00069	0.628
MOD_CK2_1	669	675	PF00069	0.571
MOD_CK2_1	67	73	PF00069	0.671
MOD_CK2_1	729	735	PF00069	0.597
MOD_GlcNHglycan	166	169	PF01048	0.807
MOD_GlcNHglycan	17	20	PF01048	0.707
MOD_GlcNHglycan	180	183	PF01048	0.795
MOD_GlcNHglycan	204	207	PF01048	0.658
MOD_GlcNHglycan	261	264	PF01048	0.820
MOD_GlcNHglycan	266	269	PF01048	0.817
MOD_GlcNHglycan	317	320	PF01048	0.731
MOD_GlcNHglycan	325	328	PF01048	0.772
MOD_GlcNHglycan	398	401	PF01048	0.768
MOD_GlcNHglycan	460	463	PF01048	0.284
MOD_GlcNHglycan	495	498	PF01048	0.282
MOD_GlcNHglycan	584	587	PF01048	0.279
MOD_GlcNHglycan	591	594	PF01048	0.283
MOD_GlcNHglycan	623	626	PF01048	0.662
MOD_GlcNHglycan	629	632	PF01048	0.743
MOD_GlcNHglycan	669	672	PF01048	0.728
MOD_GlcNHglycan	675	679	PF01048	0.729
MOD_GlcNHglycan	682	685	PF01048	0.682
MOD_GlcNHglycan	688	691	PF01048	0.531
MOD_GlcNHglycan	768	771	PF01048	0.779
MOD_GlcNHglycan	796	799	PF01048	0.753
MOD_GlcNHglycan	85	88	PF01048	0.706
MOD_GlcNHglycan	856	860	PF01048	0.668
MOD_GlcNHglycan	876	879	PF01048	0.404
MOD_GlcNHglycan	882	885	PF01048	0.661
MOD_GlcNHglycan	896	900	PF01048	0.647
MOD_GSK3_1	15	22	PF00069	0.782
MOD_GSK3_1	160	167	PF00069	0.762
MOD_GSK3_1	198	205	PF00069	0.607
MOD_GSK3_1	258	265	PF00069	0.769
MOD_GSK3_1	3	10	PF00069	0.737
MOD_GSK3_1	323	330	PF00069	0.745
MOD_GSK3_1	426	433	PF00069	0.709
MOD_GSK3_1	434	441	PF00069	0.677
MOD_GSK3_1	486	493	PF00069	0.574
MOD_GSK3_1	56	63	PF00069	0.725
MOD_GSK3_1	589	596	PF00069	0.593
MOD_GSK3_1	623	630	PF00069	0.529
MOD_GSK3_1	680	687	PF00069	0.811
MOD_GSK3_1	729	736	PF00069	0.707
MOD_GSK3_1	868	875	PF00069	0.640
MOD_GSK3_1	97	104	PF00069	0.434
MOD_N-GLC_1	117	122	PF02516	0.613
MOD_N-GLC_1	186	191	PF02516	0.564
MOD_N-GLC_1	274	279	PF02516	0.782
MOD_N-GLC_1	357	362	PF02516	0.430
MOD_N-GLC_1	729	734	PF02516	0.656
MOD_NEK2_1	138	143	PF00069	0.605
MOD_NEK2_1	290	295	PF00069	0.732
MOD_NEK2_1	379	384	PF00069	0.598
MOD_NEK2_1	548	553	PF00069	0.529
MOD_NEK2_2	302	307	PF00069	0.670
MOD_NEK2_2	742	747	PF00069	0.681
MOD_NEK2_2	846	851	PF00069	0.706
MOD_PIKK_1	520	526	PF00454	0.511
MOD_PIKK_1	593	599	PF00454	0.611
MOD_PIKK_1	669	675	PF00454	0.740
MOD_PIKK_1	716	722	PF00454	0.671
MOD_PIKK_1	749	755	PF00454	0.510
MOD_PK_1	332	338	PF00069	0.517
MOD_PKA_2	122	128	PF00069	0.658
MOD_PKA_2	464	470	PF00069	0.486
MOD_PKA_2	486	492	PF00069	0.516
MOD_PKA_2	493	499	PF00069	0.455
MOD_PKA_2	610	616	PF00069	0.593
MOD_PKA_2	67	73	PF00069	0.704
MOD_PKA_2	716	722	PF00069	0.671
MOD_PKA_2	740	746	PF00069	0.650
MOD_PKA_2	792	798	PF00069	0.767
MOD_PKA_2	880	886	PF00069	0.778
MOD_PKA_2	910	916	PF00069	0.714
MOD_Plk_1	357	363	PF00069	0.534
MOD_Plk_1	37	43	PF00069	0.520
MOD_Plk_1	370	376	PF00069	0.379
MOD_Plk_1	548	554	PF00069	0.585
MOD_Plk_1	822	828	PF00069	0.605
MOD_Plk_1	871	877	PF00069	0.530
MOD_Plk_1	895	901	PF00069	0.655
MOD_Plk_2-3	499	505	PF00069	0.408
MOD_Plk_4	122	128	PF00069	0.638
MOD_Plk_4	302	308	PF00069	0.697
MOD_Plk_4	464	470	PF00069	0.501
MOD_Plk_4	522	528	PF00069	0.496
MOD_Plk_4	548	554	PF00069	0.541
MOD_Plk_4	60	66	PF00069	0.668
MOD_Plk_4	610	616	PF00069	0.570
MOD_Plk_4	655	661	PF00069	0.726
MOD_Plk_4	822	828	PF00069	0.494
MOD_ProDKin_1	107	113	PF00069	0.729
MOD_ProDKin_1	160	166	PF00069	0.766
MOD_ProDKin_1	206	212	PF00069	0.557
MOD_ProDKin_1	291	297	PF00069	0.757
MOD_ProDKin_1	3	9	PF00069	0.745
MOD_ProDKin_1	327	333	PF00069	0.720
MOD_ProDKin_1	338	344	PF00069	0.586
MOD_ProDKin_1	438	444	PF00069	0.635
MOD_ProDKin_1	764	770	PF00069	0.790
MOD_ProDKin_1	916	922	PF00069	0.602
MOD_SUMO_rev_2	398	407	PF00179	0.806
MOD_SUMO_rev_2	531	538	PF00179	0.533
TRG_DiLeu_BaEn_1	357	362	PF01217	0.307
TRG_DiLeu_BaEn_4	37	43	PF01217	0.520
TRG_DiLeu_BaEn_4	865	871	PF01217	0.663
TRG_ENDOCYTIC_2	135	138	PF00928	0.643
TRG_ENDOCYTIC_2	232	235	PF00928	0.739
TRG_ER_diArg_1	146	149	PF00400	0.673
TRG_ER_diArg_1	255	257	PF00400	0.770
TRG_ER_diArg_1	484	487	PF00400	0.559
TRG_ER_diArg_1	491	494	PF00400	0.528
TRG_ER_diArg_1	576	578	PF00400	0.515
TRG_ER_diArg_1	608	611	PF00400	0.578
TRG_ER_diArg_1	804	806	PF00400	0.638
TRG_ER_diArg_1	812	814	PF00400	0.481
TRG_NLS_MonoCore_2	25	30	PF00514	0.752
TRG_NLS_MonoExtC_3	26	31	PF00514	0.749
TRG_NLS_MonoExtN_4	23	30	PF00514	0.768
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK4	Leptomonas seymouri	54%	94%
A0A1X0NQ48	Trypanosomatidae	36%	100%
A0A3Q8I8M2	Leishmania donovani	86%	100%
A0A422NRV3	Trypanosoma rangeli	39%	100%
A4H610	Leishmania braziliensis	73%	100%
A4HUD7	Leishmania infantum	87%	100%
C9ZVF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QHI9	Leishmania major	87%	100%
V5DA05	Trypanosoma cruzi	37%	100%