4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pterin 4 alpha carbinolamine dehydratase, putative

Species:

Leishmania mexicana

UniProt:

E9AN35_LEIMU

TriTrypDb:

LmxM.10.0250

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN35

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006729	tetrahydrobiopterin biosynthetic process	6	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019751	polyol metabolic process	4	11
GO:0034311	diol metabolic process	5	11
GO:0034312	diol biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042558	pteridine-containing compound metabolic process	4	11
GO:0042559	pteridine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046146	tetrahydrobiopterin metabolic process	5	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	5	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0016836	hydro-lyase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.566
CLV_C14_Caspase3-7	239	243	PF00656	0.578
CLV_C14_Caspase3-7	74	78	PF00656	0.646
CLV_NRD_NRD_1	181	183	PF00675	0.460
CLV_NRD_NRD_1	189	191	PF00675	0.534
CLV_NRD_NRD_1	196	198	PF00675	0.554
CLV_NRD_NRD_1	51	53	PF00675	0.429
CLV_PCSK_KEX2_1	165	167	PF00082	0.297
CLV_PCSK_KEX2_1	189	191	PF00082	0.500
CLV_PCSK_KEX2_1	51	53	PF00082	0.429
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.297
CLV_PCSK_PC7_1	161	167	PF00082	0.297
CLV_PCSK_SKI1_1	63	67	PF00082	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.462
DEG_SPOP_SBC_1	84	88	PF00917	0.713
DOC_ANK_TNKS_1	188	195	PF00023	0.512
DOC_PP4_FxxP_1	16	19	PF00568	0.536
DOC_USP7_MATH_1	244	248	PF00917	0.633
DOC_USP7_MATH_1	84	88	PF00917	0.712
DOC_USP7_MATH_1	9	13	PF00917	0.574
DOC_WW_Pin1_4	154	159	PF00397	0.252
LIG_14-3-3_CanoR_1	197	205	PF00244	0.470
LIG_14-3-3_CanoR_1	4	8	PF00244	0.685
LIG_Actin_WH2_2	206	222	PF00022	0.514
LIG_BRCT_BRCA1_1	156	160	PF00533	0.279
LIG_FHA_1	150	156	PF00498	0.321
LIG_FHA_1	219	225	PF00498	0.600
LIG_FHA_2	197	203	PF00498	0.499
LIG_LIR_Gen_1	115	126	PF02991	0.306
LIG_LIR_Gen_1	29	40	PF02991	0.563
LIG_LIR_Gen_1	5	15	PF02991	0.580
LIG_LIR_Nem_3	115	121	PF02991	0.299
LIG_LIR_Nem_3	138	144	PF02991	0.258
LIG_LIR_Nem_3	157	163	PF02991	0.279
LIG_LIR_Nem_3	176	181	PF02991	0.360
LIG_LIR_Nem_3	29	35	PF02991	0.573
LIG_LIR_Nem_3	5	10	PF02991	0.637
LIG_LYPXL_yS_3	141	144	PF13949	0.258
LIG_Pex14_1	132	136	PF04695	0.296
LIG_Pex14_1	68	72	PF04695	0.488
LIG_PTB_Apo_2	172	179	PF02174	0.370
LIG_PTB_Phospho_1	172	178	PF10480	0.297
LIG_SH2_CRK	178	182	PF00017	0.392
LIG_SH2_NCK_1	72	76	PF00017	0.603
LIG_SH2_SRC	154	157	PF00017	0.297
LIG_SH2_SRC	72	75	PF00017	0.505
LIG_SH2_STAP1	72	76	PF00017	0.603
LIG_SH2_STAT5	125	128	PF00017	0.303
LIG_SH2_STAT5	154	157	PF00017	0.297
LIG_SH3_3	96	102	PF00018	0.674
LIG_TRAF2_1	200	203	PF00917	0.455
LIG_TRAF2_1	223	226	PF00917	0.563
LIG_ULM_U2AF65_1	182	187	PF00076	0.469
LIG_WRC_WIRS_1	113	118	PF05994	0.324
MOD_CDK_SPxxK_3	154	161	PF00069	0.252
MOD_CK1_1	233	239	PF00069	0.673
MOD_CK1_1	5	11	PF00069	0.678
MOD_CK1_1	86	92	PF00069	0.726
MOD_CK1_1	93	99	PF00069	0.749
MOD_CK2_1	161	167	PF00069	0.279
MOD_CK2_1	196	202	PF00069	0.450
MOD_CK2_1	92	98	PF00069	0.709
MOD_GlcNHglycan	11	14	PF01048	0.674
MOD_GlcNHglycan	235	238	PF01048	0.593
MOD_GlcNHglycan	7	10	PF01048	0.679
MOD_GlcNHglycan	92	95	PF01048	0.652
MOD_GSK3_1	142	149	PF00069	0.322
MOD_GSK3_1	5	12	PF00069	0.636
MOD_GSK3_1	84	91	PF00069	0.740
MOD_NEK2_1	35	40	PF00069	0.503
MOD_NEK2_1	61	66	PF00069	0.393
MOD_NEK2_1	90	95	PF00069	0.486
MOD_PIKK_1	19	25	PF00454	0.618
MOD_PKA_2	181	187	PF00069	0.479
MOD_PKA_2	196	202	PF00069	0.447
MOD_PKA_2	215	221	PF00069	0.558
MOD_PKA_2	3	9	PF00069	0.673
MOD_ProDKin_1	154	160	PF00069	0.252
TRG_DiLeu_BaEn_2	122	128	PF01217	0.410
TRG_DiLeu_BaEn_2	56	62	PF01217	0.412
TRG_ENDOCYTIC_2	125	128	PF00928	0.279
TRG_ENDOCYTIC_2	141	144	PF00928	0.258
TRG_ENDOCYTIC_2	178	181	PF00928	0.376
TRG_ENDOCYTIC_2	72	75	PF00928	0.597
TRG_ER_diArg_1	189	191	PF00400	0.534
TRG_ER_diArg_1	51	54	PF00400	0.432
TRG_NLS_Bipartite_1	165	186	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W5	Leptomonas seymouri	71%	95%
A0A0S4IXY6	Bodo saltans	41%	100%
A0A1X0NQ34	Trypanosomatidae	59%	98%
A0A3S7WR02	Leishmania donovani	90%	98%
A4H608	Leishmania braziliensis	78%	100%
A4HUD5	Leishmania infantum	90%	98%
C9ZVG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	80%
Q4QHJ1	Leishmania major	86%	99%
V5BIH1	Trypanosoma cruzi	60%	100%