Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AN32_LEIMU

TriTrypDb:

LmxM.10.0220

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

E9AN32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.525
CLV_NRD_NRD_1	19	21	PF00675	0.514
CLV_NRD_NRD_1	327	329	PF00675	0.549
CLV_NRD_NRD_1	42	44	PF00675	0.457
CLV_NRD_NRD_1	60	62	PF00675	0.436
CLV_NRD_NRD_1	68	70	PF00675	0.371
CLV_PCSK_FUR_1	58	62	PF00082	0.359
CLV_PCSK_KEX2_1	19	21	PF00082	0.519
CLV_PCSK_KEX2_1	49	51	PF00082	0.331
CLV_PCSK_KEX2_1	60	62	PF00082	0.435
CLV_PCSK_KEX2_1	68	70	PF00082	0.373
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.331
CLV_PCSK_SKI1_1	232	236	PF00082	0.453
CLV_PCSK_SKI1_1	45	49	PF00082	0.411
DEG_MDM2_SWIB_1	267	275	PF02201	0.514
DOC_MAPK_gen_1	279	288	PF00069	0.440
DOC_MAPK_MEF2A_6	281	290	PF00069	0.440
DOC_MAPK_RevD_3	316	329	PF00069	0.225
DOC_PP1_RVXF_1	279	286	PF00149	0.440
DOC_USP7_MATH_1	173	177	PF00917	0.266
DOC_USP7_MATH_1	234	238	PF00917	0.198
DOC_USP7_MATH_1	3	7	PF00917	0.657
DOC_USP7_MATH_1	316	320	PF00917	0.394
DOC_USP7_MATH_1	414	418	PF00917	0.232
DOC_USP7_UBL2_3	136	140	PF12436	0.182
DOC_USP7_UBL2_3	45	49	PF12436	0.718
DOC_WW_Pin1_4	412	417	PF00397	0.275
LIG_14-3-3_CanoR_1	331	336	PF00244	0.346
LIG_14-3-3_CanoR_1	61	67	PF00244	0.535
LIG_14-3-3_CanoR_1	8	12	PF00244	0.686
LIG_BRCT_BRCA1_1	177	181	PF00533	0.185
LIG_BRCT_BRCA1_1	209	213	PF00533	0.271
LIG_BRCT_BRCA1_1	263	267	PF00533	0.185
LIG_BRCT_BRCA1_1	307	311	PF00533	0.238
LIG_BRCT_BRCA1_1	383	387	PF00533	0.379
LIG_BRCT_BRCA1_1	390	394	PF00533	0.387
LIG_BRCT_BRCA1_2	263	269	PF00533	0.185
LIG_FHA_1	270	276	PF00498	0.601
LIG_FHA_1	278	284	PF00498	0.577
LIG_FHA_1	399	405	PF00498	0.414
LIG_FHA_1	459	465	PF00498	0.296
LIG_FHA_2	12	18	PF00498	0.692
LIG_FHA_2	96	102	PF00498	0.567
LIG_Integrin_isoDGR_2	407	409	PF01839	0.405
LIG_LIR_Apic_2	339	344	PF02991	0.251
LIG_LIR_Gen_1	178	188	PF02991	0.385
LIG_LIR_Gen_1	207	216	PF02991	0.339
LIG_LIR_Gen_1	217	225	PF02991	0.376
LIG_LIR_Gen_1	420	430	PF02991	0.316
LIG_LIR_LC3C_4	217	222	PF02991	0.373
LIG_LIR_Nem_3	178	184	PF02991	0.371
LIG_LIR_Nem_3	207	212	PF02991	0.356
LIG_LIR_Nem_3	217	221	PF02991	0.404
LIG_LIR_Nem_3	264	270	PF02991	0.185
LIG_LIR_Nem_3	294	300	PF02991	0.304
LIG_LIR_Nem_3	308	314	PF02991	0.251
LIG_LIR_Nem_3	424	430	PF02991	0.308
LIG_LIR_Nem_3	440	444	PF02991	0.252
LIG_LIR_Nem_3	448	453	PF02991	0.279
LIG_MLH1_MIPbox_1	209	213	PF16413	0.212
LIG_Pex14_1	307	311	PF04695	0.298
LIG_Pex14_2	204	208	PF04695	0.313
LIG_Pex14_2	267	271	PF04695	0.492
LIG_REV1ctd_RIR_1	265	273	PF16727	0.320
LIG_SH2_CRK	112	116	PF00017	0.373
LIG_SH2_CRK	341	345	PF00017	0.276
LIG_SH2_CRK	427	431	PF00017	0.364
LIG_SH2_PTP2	287	290	PF00017	0.266
LIG_SH2_STAP1	164	168	PF00017	0.223
LIG_SH2_STAP1	209	213	PF00017	0.245
LIG_SH2_STAP1	389	393	PF00017	0.450
LIG_SH2_STAT3	164	167	PF00017	0.240
LIG_SH2_STAT3	376	379	PF00017	0.432
LIG_SH2_STAT5	112	115	PF00017	0.373
LIG_SH2_STAT5	287	290	PF00017	0.281
LIG_SH2_STAT5	304	307	PF00017	0.217
LIG_SH2_STAT5	380	383	PF00017	0.510
LIG_SH3_3	6	12	PF00018	0.603
LIG_SUMO_SIM_par_1	400	405	PF11976	0.394
LIG_TRAF2_1	36	39	PF00917	0.502
LIG_TYR_ITIM	110	115	PF00017	0.373
LIG_WRC_WIRS_1	181	186	PF05994	0.317
LIG_WRC_WIRS_1	205	210	PF05994	0.373
LIG_WRC_WIRS_1	225	230	PF05994	0.175
LIG_WRC_WIRS_1	332	337	PF05994	0.316
MOD_CK1_1	207	213	PF00069	0.417
MOD_CK1_1	214	220	PF00069	0.329
MOD_CK1_1	274	280	PF00069	0.610
MOD_CK1_1	291	297	PF00069	0.351
MOD_CK1_1	337	343	PF00069	0.349
MOD_CK1_1	417	423	PF00069	0.227
MOD_CK1_1	442	448	PF00069	0.231
MOD_CK2_1	33	39	PF00069	0.593
MOD_CK2_1	442	448	PF00069	0.314
MOD_CK2_1	75	81	PF00069	0.765
MOD_CK2_1	95	101	PF00069	0.700
MOD_Cter_Amidation	137	140	PF01082	0.508
MOD_GlcNHglycan	115	118	PF01048	0.245
MOD_GlcNHglycan	136	139	PF01048	0.617
MOD_GlcNHglycan	177	180	PF01048	0.424
MOD_GlcNHglycan	188	191	PF01048	0.379
MOD_GlcNHglycan	236	239	PF01048	0.537
MOD_GlcNHglycan	276	279	PF01048	0.435
MOD_GlcNHglycan	416	419	PF01048	0.527
MOD_GlcNHglycan	431	434	PF01048	0.580
MOD_GlcNHglycan	440	444	PF01048	0.545
MOD_GlcNHglycan	9	12	PF01048	0.533
MOD_GSK3_1	173	180	PF00069	0.311
MOD_GSK3_1	200	207	PF00069	0.477
MOD_GSK3_1	3	10	PF00069	0.742
MOD_GSK3_1	327	334	PF00069	0.282
MOD_GSK3_1	388	395	PF00069	0.357
MOD_GSK3_1	398	405	PF00069	0.388
MOD_GSK3_1	414	421	PF00069	0.334
MOD_GSK3_1	91	98	PF00069	0.733
MOD_LATS_1	31	37	PF00433	0.539
MOD_NEK2_1	122	127	PF00069	0.358
MOD_NEK2_1	175	180	PF00069	0.383
MOD_NEK2_1	200	205	PF00069	0.465
MOD_NEK2_1	211	216	PF00069	0.294
MOD_NEK2_1	224	229	PF00069	0.280
MOD_NEK2_1	246	251	PF00069	0.252
MOD_NEK2_1	296	301	PF00069	0.427
MOD_NEK2_1	336	341	PF00069	0.384
MOD_NEK2_1	357	362	PF00069	0.406
MOD_NEK2_1	402	407	PF00069	0.407
MOD_PIKK_1	375	381	PF00454	0.425
MOD_PIKK_1	95	101	PF00454	0.575
MOD_PKA_2	327	333	PF00069	0.335
MOD_PKA_2	7	13	PF00069	0.680
MOD_Plk_1	160	166	PF00069	0.247
MOD_Plk_1	31	37	PF00069	0.634
MOD_Plk_1	314	320	PF00069	0.325
MOD_Plk_4	110	116	PF00069	0.327
MOD_Plk_4	200	206	PF00069	0.460
MOD_Plk_4	207	213	PF00069	0.340
MOD_Plk_4	246	252	PF00069	0.316
MOD_Plk_4	291	297	PF00069	0.375
MOD_Plk_4	302	308	PF00069	0.311
MOD_Plk_4	316	322	PF00069	0.266
MOD_Plk_4	331	337	PF00069	0.382
MOD_Plk_4	357	363	PF00069	0.338
MOD_ProDKin_1	412	418	PF00069	0.275
MOD_SUMO_rev_2	89	98	PF00179	0.652
TRG_DiLeu_BaEn_1	448	453	PF01217	0.373
TRG_ENDOCYTIC_2	112	115	PF00928	0.373
TRG_ENDOCYTIC_2	209	212	PF00928	0.310
TRG_ENDOCYTIC_2	225	228	PF00928	0.299
TRG_ENDOCYTIC_2	287	290	PF00928	0.431
TRG_ENDOCYTIC_2	427	430	PF00928	0.316
TRG_ER_diArg_1	18	20	PF00400	0.703
TRG_ER_diArg_1	68	70	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	60%	93%
A0A0N1PC74	Leptomonas seymouri	28%	94%
A0A0N1PCA2	Leptomonas seymouri	28%	100%
A0A0S4IH58	Bodo saltans	22%	80%
A0A0S4JGE7	Bodo saltans	21%	76%
A0A3Q8I8Q6	Leishmania donovani	87%	97%
A0A3S7WR28	Leishmania donovani	27%	100%
A0A3S7X1E1	Leishmania donovani	28%	91%
A4H605	Leishmania braziliensis	76%	100%
A4H606	Leishmania braziliensis	24%	99%
A4HGF8	Leishmania braziliensis	27%	100%
A4HUD2	Leishmania infantum	87%	97%
A4HUD3	Leishmania infantum	27%	100%
A4I3I9	Leishmania infantum	28%	91%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	91%
Q4Q8F3	Leishmania major	27%	100%
Q4QHJ3	Leishmania major	27%	96%
Q4QHJ4	Leishmania major	87%	100%