Protein sleepless

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein sleepless

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN31_LEIMU

TriTrypDb:

LmxM.10.0219

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AN31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.581
CLV_PCSK_SKI1_1	120	124	PF00082	0.656
CLV_PCSK_SKI1_1	5	9	PF00082	0.673
DOC_CKS1_1	123	128	PF01111	0.457
DOC_PP2B_PxIxI_1	196	202	PF00149	0.222
DOC_USP7_MATH_1	214	218	PF00917	0.673
DOC_USP7_MATH_1	260	264	PF00917	0.701
DOC_USP7_MATH_1	273	277	PF00917	0.575
DOC_USP7_MATH_1	39	43	PF00917	0.382
DOC_WW_Pin1_4	122	127	PF00397	0.448
DOC_WW_Pin1_4	164	169	PF00397	0.461
DOC_WW_Pin1_4	212	217	PF00397	0.692
LIG_14-3-3_CanoR_1	131	138	PF00244	0.448
LIG_14-3-3_CanoR_1	144	148	PF00244	0.363
LIG_14-3-3_CanoR_1	183	190	PF00244	0.557
LIG_14-3-3_CanoR_1	5	10	PF00244	0.528
LIG_FHA_1	107	113	PF00498	0.494
LIG_FHA_1	15	21	PF00498	0.667
LIG_FHA_1	185	191	PF00498	0.451
LIG_FHA_1	200	206	PF00498	0.411
LIG_FHA_1	59	65	PF00498	0.414
LIG_FHA_2	39	45	PF00498	0.291
LIG_LIR_Gen_1	220	226	PF02991	0.713
LIG_LIR_Nem_3	146	151	PF02991	0.400
LIG_LIR_Nem_3	90	96	PF02991	0.397
LIG_PTAP_UEV_1	167	172	PF05743	0.571
LIG_SH2_CRK	97	101	PF00017	0.375
LIG_SH2_GRB2like	45	48	PF00017	0.279
LIG_SH2_NCK_1	173	177	PF00017	0.386
LIG_SH2_NCK_1	45	49	PF00017	0.416
LIG_SH2_STAP1	45	49	PF00017	0.433
LIG_SH2_STAP1	97	101	PF00017	0.388
LIG_SH3_2	126	131	PF14604	0.466
LIG_SH3_3	123	129	PF00018	0.453
LIG_SH3_3	165	171	PF00018	0.553
LIG_SH3_3	33	39	PF00018	0.460
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.543
LIG_SUMO_SIM_par_1	17	24	PF11976	0.678
LIG_TRAF2_1	237	240	PF00917	0.680
MOD_CDK_SPxxK_3	212	219	PF00069	0.693
MOD_CK1_1	150	156	PF00069	0.439
MOD_CK1_1	164	170	PF00069	0.319
MOD_CK1_1	217	223	PF00069	0.682
MOD_CK1_1	80	86	PF00069	0.451
MOD_CK2_1	234	240	PF00069	0.653
MOD_GlcNHglycan	168	171	PF01048	0.664
MOD_GlcNHglycan	23	26	PF01048	0.701
MOD_GlcNHglycan	275	278	PF01048	0.401
MOD_GSK3_1	106	113	PF00069	0.287
MOD_GSK3_1	143	150	PF00069	0.426
MOD_GSK3_1	162	169	PF00069	0.451
MOD_GSK3_1	184	191	PF00069	0.491
MOD_GSK3_1	214	221	PF00069	0.656
MOD_GSK3_1	230	237	PF00069	0.636
MOD_GSK3_1	39	46	PF00069	0.376
MOD_N-GLC_1	156	161	PF02516	0.723
MOD_NEK2_1	184	189	PF00069	0.481
MOD_NEK2_1	20	25	PF00069	0.605
MOD_NEK2_1	218	223	PF00069	0.634
MOD_NEK2_2	143	148	PF00069	0.453
MOD_NEK2_2	58	63	PF00069	0.272
MOD_OFUCOSY	155	160	PF10250	0.640
MOD_OFUCOSY	203	209	PF10250	0.222
MOD_PIKK_1	162	168	PF00454	0.445
MOD_PIKK_1	171	177	PF00454	0.523
MOD_PKA_1	5	11	PF00069	0.448
MOD_PKA_2	130	136	PF00069	0.459
MOD_PKA_2	143	149	PF00069	0.365
MOD_PKA_2	229	235	PF00069	0.676
MOD_PKB_1	228	236	PF00069	0.591
MOD_Plk_1	80	86	PF00069	0.378
MOD_Plk_4	14	20	PF00069	0.563
MOD_Plk_4	143	149	PF00069	0.355
MOD_Plk_4	218	224	PF00069	0.751
MOD_Plk_4	5	11	PF00069	0.571
MOD_ProDKin_1	122	128	PF00069	0.449
MOD_ProDKin_1	164	170	PF00069	0.466
MOD_ProDKin_1	212	218	PF00069	0.690
MOD_SUMO_rev_2	276	282	PF00179	0.601
TRG_ENDOCYTIC_2	222	225	PF00928	0.772
TRG_ENDOCYTIC_2	97	100	PF00928	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT1	Leptomonas seymouri	54%	90%
A0A3S7WR08	Leishmania donovani	81%	100%
A4H604	Leishmania braziliensis	61%	100%
A4HUD1	Leishmania infantum	81%	100%
Q4QHJ5	Leishmania major	81%	100%