Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN30_LEIMU

TriTrypDb:

LmxM.10.0218

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.608
CLV_C14_Caspase3-7	116	120	PF00656	0.584
CLV_C14_Caspase3-7	209	213	PF00656	0.665
CLV_C14_Caspase3-7	345	349	PF00656	0.590
CLV_C14_Caspase3-7	368	372	PF00656	0.509
CLV_NRD_NRD_1	12	14	PF00675	0.565
CLV_NRD_NRD_1	297	299	PF00675	0.539
CLV_NRD_NRD_1	532	534	PF00675	0.460
CLV_NRD_NRD_1	550	552	PF00675	0.519
CLV_NRD_NRD_1	666	668	PF00675	0.509
CLV_PCSK_KEX2_1	12	14	PF00082	0.565
CLV_PCSK_KEX2_1	297	299	PF00082	0.539
CLV_PCSK_KEX2_1	532	534	PF00082	0.460
CLV_PCSK_KEX2_1	550	552	PF00082	0.519
CLV_PCSK_KEX2_1	665	667	PF00082	0.502
CLV_PCSK_PC7_1	661	667	PF00082	0.486
CLV_PCSK_SKI1_1	588	592	PF00082	0.454
CLV_PCSK_SKI1_1	65	69	PF00082	0.614
DEG_APCC_DBOX_1	154	162	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_ANK_TNKS_1	12	19	PF00023	0.568
DOC_CYCLIN_RxL_1	547	555	PF00134	0.509
DOC_MAPK_gen_1	155	164	PF00069	0.584
DOC_MAPK_gen_1	297	306	PF00069	0.592
DOC_MAPK_gen_1	532	539	PF00069	0.455
DOC_MAPK_MEF2A_6	246	253	PF00069	0.503
DOC_MAPK_MEF2A_6	300	308	PF00069	0.590
DOC_MAPK_MEF2A_6	532	539	PF00069	0.455
DOC_PP1_RVXF_1	628	634	PF00149	0.551
DOC_PP2B_LxvP_1	195	198	PF13499	0.613
DOC_PP4_MxPP_1	711	714	PF00568	0.536
DOC_USP7_MATH_1	153	157	PF00917	0.683
DOC_USP7_MATH_1	205	209	PF00917	0.646
DOC_USP7_MATH_1	290	294	PF00917	0.565
DOC_USP7_MATH_1	376	380	PF00917	0.472
DOC_USP7_MATH_1	384	388	PF00917	0.485
DOC_USP7_MATH_1	423	427	PF00917	0.628
DOC_USP7_MATH_1	460	464	PF00917	0.534
DOC_USP7_MATH_1	508	512	PF00917	0.660
DOC_USP7_MATH_1	540	544	PF00917	0.523
DOC_USP7_MATH_1	598	602	PF00917	0.543
DOC_USP7_MATH_1	642	646	PF00917	0.502
DOC_USP7_MATH_1	677	681	PF00917	0.487
DOC_USP7_MATH_1	684	688	PF00917	0.702
DOC_USP7_MATH_1	73	77	PF00917	0.632
DOC_USP7_MATH_2	99	105	PF00917	0.632
DOC_WW_Pin1_4	136	141	PF00397	0.595
DOC_WW_Pin1_4	34	39	PF00397	0.591
DOC_WW_Pin1_4	519	524	PF00397	0.480
DOC_WW_Pin1_4	566	571	PF00397	0.579
DOC_WW_Pin1_4	66	71	PF00397	0.662
DOC_WW_Pin1_4	92	97	PF00397	0.622
LIG_14-3-3_CanoR_1	190	195	PF00244	0.632
LIG_14-3-3_CanoR_1	261	265	PF00244	0.437
LIG_14-3-3_CanoR_1	298	308	PF00244	0.498
LIG_14-3-3_CanoR_1	3	7	PF00244	0.753
LIG_14-3-3_CanoR_1	359	366	PF00244	0.625
LIG_14-3-3_CanoR_1	444	449	PF00244	0.511
LIG_14-3-3_CanoR_1	495	499	PF00244	0.588
LIG_14-3-3_CanoR_1	542	547	PF00244	0.374
LIG_BIR_III_4	512	516	PF00653	0.545
LIG_BRCT_BRCA1_1	262	266	PF00533	0.607
LIG_deltaCOP1_diTrp_1	42	47	PF00928	0.576
LIG_eIF4E_1	451	457	PF01652	0.680
LIG_EVH1_1	195	199	PF00568	0.492
LIG_FHA_1	179	185	PF00498	0.496
LIG_FHA_1	2	8	PF00498	0.620
LIG_FHA_1	222	228	PF00498	0.537
LIG_FHA_1	394	400	PF00498	0.518
LIG_FHA_1	494	500	PF00498	0.425
LIG_FHA_1	703	709	PF00498	0.343
LIG_FHA_2	207	213	PF00498	0.672
LIG_FHA_2	366	372	PF00498	0.489
LIG_FHA_2	410	416	PF00498	0.551
LIG_FHA_2	686	692	PF00498	0.483
LIG_FHA_2	9	15	PF00498	0.765
LIG_LIR_Gen_1	124	134	PF02991	0.530
LIG_LIR_Gen_1	156	166	PF02991	0.424
LIG_LIR_Gen_1	347	357	PF02991	0.526
LIG_LIR_Nem_3	124	129	PF02991	0.529
LIG_LIR_Nem_3	156	162	PF02991	0.418
LIG_LIR_Nem_3	287	291	PF02991	0.496
LIG_LIR_Nem_3	347	353	PF02991	0.513
LIG_LIR_Nem_3	698	704	PF02991	0.436
LIG_NRBOX	157	163	PF00104	0.521
LIG_SH2_CRK	301	305	PF00017	0.636
LIG_SH2_CRK	350	354	PF00017	0.405
LIG_SH2_NCK_1	115	119	PF00017	0.629
LIG_SH2_NCK_1	639	643	PF00017	0.496
LIG_SH2_SRC	332	335	PF00017	0.529
LIG_SH2_STAT5	301	304	PF00017	0.513
LIG_SH2_STAT5	32	35	PF00017	0.609
LIG_SH2_STAT5	332	335	PF00017	0.573
LIG_SH2_STAT5	451	454	PF00017	0.487
LIG_SH2_STAT5	529	532	PF00017	0.507
LIG_SH2_STAT5	6	9	PF00017	0.720
LIG_SH2_STAT5	60	63	PF00017	0.558
LIG_SH3_1	93	99	PF00018	0.633
LIG_SH3_3	191	197	PF00018	0.584
LIG_SH3_3	199	205	PF00018	0.596
LIG_SH3_3	21	27	PF00018	0.505
LIG_SH3_3	426	432	PF00018	0.610
LIG_SH3_3	45	51	PF00018	0.540
LIG_SH3_3	58	64	PF00018	0.488
LIG_SH3_3	67	73	PF00018	0.559
LIG_SH3_3	93	99	PF00018	0.689
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.586
LIG_SUMO_SIM_anti_2	226	231	PF11976	0.436
LIG_SUMO_SIM_par_1	180	186	PF11976	0.424
LIG_SUMO_SIM_par_1	409	416	PF11976	0.575
LIG_TRAF2_1	617	620	PF00917	0.516
LIG_TRFH_1	6	10	PF08558	0.612
MOD_CDK_SPxxK_3	136	143	PF00069	0.587
MOD_CK1_1	144	150	PF00069	0.496
MOD_CK1_1	400	406	PF00069	0.604
MOD_CK1_1	76	82	PF00069	0.543
MOD_CK1_1	95	101	PF00069	0.572
MOD_CK2_1	290	296	PF00069	0.606
MOD_CK2_1	409	415	PF00069	0.559
MOD_CK2_1	684	690	PF00069	0.436
MOD_CK2_1	95	101	PF00069	0.577
MOD_CMANNOS	44	47	PF00535	0.578
MOD_Cter_Amidation	548	551	PF01082	0.555
MOD_GlcNHglycan	121	124	PF01048	0.516
MOD_GlcNHglycan	174	177	PF01048	0.589
MOD_GlcNHglycan	292	295	PF01048	0.579
MOD_GlcNHglycan	337	340	PF01048	0.563
MOD_GlcNHglycan	382	385	PF01048	0.615
MOD_GlcNHglycan	398	402	PF01048	0.528
MOD_GlcNHglycan	404	407	PF01048	0.574
MOD_GlcNHglycan	446	449	PF01048	0.637
MOD_GlcNHglycan	570	573	PF01048	0.537
MOD_GlcNHglycan	613	616	PF01048	0.530
MOD_GlcNHglycan	644	647	PF01048	0.607
MOD_GlcNHglycan	75	79	PF01048	0.590
MOD_GSK3_1	280	287	PF00069	0.595
MOD_GSK3_1	302	309	PF00069	0.622
MOD_GSK3_1	376	383	PF00069	0.389
MOD_GSK3_1	393	400	PF00069	0.590
MOD_GSK3_1	494	501	PF00069	0.500
MOD_GSK3_1	515	522	PF00069	0.513
MOD_GSK3_1	702	709	PF00069	0.456
MOD_LATS_1	188	194	PF00433	0.476
MOD_N-GLC_1	540	545	PF02516	0.673
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	177	182	PF00069	0.517
MOD_NEK2_1	313	318	PF00069	0.510
MOD_NEK2_1	33	38	PF00069	0.555
MOD_NEK2_1	498	503	PF00069	0.572
MOD_OFUCOSY	595	602	PF10250	0.560
MOD_PIKK_1	384	390	PF00454	0.504
MOD_PIKK_1	540	546	PF00454	0.669
MOD_PKA_2	189	195	PF00069	0.574
MOD_PKA_2	2	8	PF00069	0.660
MOD_PKA_2	205	211	PF00069	0.716
MOD_PKA_2	260	266	PF00069	0.437
MOD_PKA_2	299	305	PF00069	0.489
MOD_PKA_2	358	364	PF00069	0.513
MOD_PKA_2	494	500	PF00069	0.590
MOD_PKA_2	608	614	PF00069	0.430
MOD_PKA_2	660	666	PF00069	0.434
MOD_PKB_1	204	212	PF00069	0.586
MOD_Plk_1	309	315	PF00069	0.506
MOD_Plk_1	706	712	PF00069	0.495
MOD_Plk_4	101	107	PF00069	0.544
MOD_Plk_4	141	147	PF00069	0.669
MOD_Plk_4	190	196	PF00069	0.527
MOD_Plk_4	2	8	PF00069	0.732
MOD_Plk_4	233	239	PF00069	0.515
MOD_Plk_4	284	290	PF00069	0.493
MOD_Plk_4	494	500	PF00069	0.546
MOD_Plk_4	542	548	PF00069	0.364
MOD_Plk_4	707	713	PF00069	0.511
MOD_ProDKin_1	136	142	PF00069	0.590
MOD_ProDKin_1	34	40	PF00069	0.593
MOD_ProDKin_1	519	525	PF00069	0.480
MOD_ProDKin_1	566	572	PF00069	0.574
MOD_ProDKin_1	66	72	PF00069	0.666
MOD_ProDKin_1	92	98	PF00069	0.622
MOD_SUMO_rev_2	139	145	PF00179	0.530
TRG_ENDOCYTIC_2	301	304	PF00928	0.633
TRG_ENDOCYTIC_2	350	353	PF00928	0.399
TRG_ER_diArg_1	154	157	PF00400	0.557
TRG_ER_diArg_1	203	206	PF00400	0.603
TRG_ER_diArg_1	216	219	PF00400	0.539
TRG_ER_diArg_1	297	300	PF00400	0.542
TRG_ER_diArg_1	443	446	PF00400	0.507
TRG_ER_diArg_1	550	552	PF00400	0.710
TRG_ER_diArg_1	665	667	PF00400	0.602
TRG_NES_CRM1_1	258	273	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	550	555	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	669	674	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE3	Leptomonas seymouri	38%	100%
A0A3S7WR11	Leishmania donovani	87%	100%
A4H603	Leishmania braziliensis	70%	99%
A4HUD0	Leishmania infantum	87%	100%
Q4QHJ6	Leishmania major	85%	100%