MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN27_LEIMU

TriTrypDb:

LmxM.10.0195

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	36	38	PF00675	0.454
CLV_PCSK_KEX2_1	36	38	PF00082	0.454
CLV_PCSK_SKI1_1	6	10	PF00082	0.700
DEG_SPOP_SBC_1	81	85	PF00917	0.672
DOC_ANK_TNKS_1	161	168	PF00023	0.440
DOC_ANK_TNKS_1	36	43	PF00023	0.520
DOC_CDC14_PxL_1	190	198	PF14671	0.593
DOC_MAPK_gen_1	4	16	PF00069	0.591
DOC_MAPK_MEF2A_6	198	206	PF00069	0.415
DOC_USP7_MATH_1	54	58	PF00917	0.723
DOC_USP7_MATH_1	80	84	PF00917	0.600
DOC_USP7_UBL2_3	5	9	PF12436	0.612
DOC_WW_Pin1_4	36	41	PF00397	0.616
DOC_WW_Pin1_4	60	65	PF00397	0.716
LIG_14-3-3_CanoR_1	58	64	PF00244	0.725
LIG_14-3-3_CanoR_1	97	103	PF00244	0.448
LIG_BIR_III_4	45	49	PF00653	0.632
LIG_FHA_1	205	211	PF00498	0.713
LIG_LIR_Gen_1	166	176	PF02991	0.341
LIG_LIR_Nem_3	166	172	PF02991	0.341
LIG_LYPXL_S_1	192	196	PF13949	0.629
LIG_LYPXL_yS_3	193	196	PF13949	0.639
LIG_Pex14_1	177	181	PF04695	0.409
LIG_SH2_CRK	100	104	PF00017	0.406
LIG_SH2_CRK	38	42	PF00017	0.647
LIG_SH2_GRB2like	181	184	PF00017	0.482
LIG_SH2_NCK_1	100	104	PF00017	0.440
LIG_SH2_NCK_1	169	173	PF00017	0.338
LIG_SH2_NCK_1	38	42	PF00017	0.632
LIG_SH2_STAT3	154	157	PF00017	0.332
LIG_SH2_STAT5	100	103	PF00017	0.417
LIG_SH2_STAT5	146	149	PF00017	0.289
LIG_SH2_STAT5	169	172	PF00017	0.301
LIG_SH2_STAT5	22	25	PF00017	0.502
LIG_SH2_STAT5	38	41	PF00017	0.510
LIG_SH3_3	7	13	PF00018	0.670
MOD_CDK_SPxxK_3	60	67	PF00069	0.497
MOD_CK1_1	59	65	PF00069	0.767
MOD_DYRK1A_RPxSP_1	60	64	PF00069	0.699
MOD_GlcNHglycan	126	129	PF01048	0.398
MOD_GlcNHglycan	140	143	PF01048	0.359
MOD_GlcNHglycan	149	152	PF01048	0.290
MOD_GlcNHglycan	154	157	PF01048	0.237
MOD_GlcNHglycan	74	77	PF01048	0.730
MOD_GSK3_1	138	145	PF00069	0.376
MOD_GSK3_1	54	61	PF00069	0.790
MOD_GSK3_1	81	88	PF00069	0.593
MOD_N-GLC_1	182	187	PF02516	0.511
MOD_NEK2_1	124	129	PF00069	0.555
MOD_NEK2_1	147	152	PF00069	0.222
MOD_PKA_2	59	65	PF00069	0.660
MOD_Plk_4	142	148	PF00069	0.240
MOD_Plk_4	18	24	PF00069	0.444
MOD_ProDKin_1	36	42	PF00069	0.626
MOD_ProDKin_1	60	66	PF00069	0.717
TRG_ENDOCYTIC_2	169	172	PF00928	0.325
TRG_ENDOCYTIC_2	193	196	PF00928	0.615
TRG_ER_diArg_1	35	37	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I749	Leptomonas seymouri	59%	86%
A0A0S4J1U4	Bodo saltans	32%	100%
A0A1X0NQ66	Trypanosomatidae	44%	100%
A0A3R7KKB6	Trypanosoma rangeli	47%	100%
A0A3S5H6F3	Leishmania donovani	87%	100%
A0A422NAN4	Trypanosoma rangeli	35%	100%
A4HUC7	Leishmania infantum	86%	100%
C9ZJK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZKJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	69%
C9ZVG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AI39	Leishmania braziliensis	75%	100%
Q4QHJ9	Leishmania major	88%	100%
V5BCY8	Trypanosoma cruzi	33%	100%