PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN26_LEIMU

TriTrypDb:

LmxM.10.0190

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.559
CLV_NRD_NRD_1	208	210	PF00675	0.680
CLV_NRD_NRD_1	279	281	PF00675	0.653
CLV_PCSK_KEX2_1	208	210	PF00082	0.593
CLV_PCSK_SKI1_1	212	216	PF00082	0.513
CLV_PCSK_SKI1_1	403	407	PF00082	0.778
CLV_PCSK_SKI1_1	425	429	PF00082	0.836
CLV_PCSK_SKI1_1	536	540	PF00082	0.498
CLV_PCSK_SKI1_1	628	632	PF00082	0.471
CLV_PCSK_SKI1_1	647	651	PF00082	0.303
CLV_PCSK_SKI1_1	97	101	PF00082	0.646
DEG_APCC_DBOX_1	155	163	PF00400	0.841
DEG_APCC_DBOX_1	285	293	PF00400	0.691
DEG_APCC_DBOX_1	627	635	PF00400	0.471
DEG_COP1_1	367	378	PF00400	0.534
DEG_Kelch_actinfilin_1	113	117	PF01344	0.567
DEG_SCF_FBW7_1	317	322	PF00400	0.537
DEG_SPOP_SBC_1	133	137	PF00917	0.831
DEG_SPOP_SBC_1	517	521	PF00917	0.626
DOC_CYCLIN_yClb5_NLxxxL_5	5	14	PF00134	0.648
DOC_CYCLIN_yCln2_LP_2	296	299	PF00134	0.668
DOC_MAPK_DCC_7	481	490	PF00069	0.538
DOC_MAPK_DCC_7	592	601	PF00069	0.355
DOC_MAPK_MEF2A_6	481	490	PF00069	0.538
DOC_MAPK_MEF2A_6	609	616	PF00069	0.433
DOC_MAPK_MEF2A_6	635	643	PF00069	0.425
DOC_PP2B_LxvP_1	198	201	PF13499	0.504
DOC_PP2B_LxvP_1	296	299	PF13499	0.566
DOC_PP2B_LxvP_1	444	447	PF13499	0.615
DOC_USP7_MATH_1	133	137	PF00917	0.762
DOC_USP7_MATH_1	166	170	PF00917	0.852
DOC_USP7_MATH_1	181	185	PF00917	0.603
DOC_USP7_MATH_1	261	265	PF00917	0.604
DOC_USP7_MATH_1	319	323	PF00917	0.537
DOC_USP7_MATH_1	344	348	PF00917	0.732
DOC_USP7_MATH_1	386	390	PF00917	0.825
DOC_USP7_MATH_1	394	398	PF00917	0.719
DOC_USP7_MATH_1	423	427	PF00917	0.681
DOC_USP7_MATH_1	504	508	PF00917	0.677
DOC_USP7_MATH_1	511	515	PF00917	0.698
DOC_USP7_MATH_1	544	548	PF00917	0.766
DOC_USP7_MATH_1	56	60	PF00917	0.641
DOC_USP7_MATH_1	620	624	PF00917	0.452
DOC_USP7_UBL2_3	33	37	PF12436	0.683
DOC_WW_Pin1_4	137	142	PF00397	0.748
DOC_WW_Pin1_4	162	167	PF00397	0.839
DOC_WW_Pin1_4	168	173	PF00397	0.732
DOC_WW_Pin1_4	174	179	PF00397	0.647
DOC_WW_Pin1_4	182	187	PF00397	0.572
DOC_WW_Pin1_4	256	261	PF00397	0.635
DOC_WW_Pin1_4	262	267	PF00397	0.630
DOC_WW_Pin1_4	315	320	PF00397	0.693
DOC_WW_Pin1_4	349	354	PF00397	0.812
DOC_WW_Pin1_4	357	362	PF00397	0.747
DOC_WW_Pin1_4	367	372	PF00397	0.553
DOC_WW_Pin1_4	380	385	PF00397	0.622
DOC_WW_Pin1_4	560	565	PF00397	0.477
DOC_WW_Pin1_4	594	599	PF00397	0.452
DOC_WW_Pin1_4	73	78	PF00397	0.822
DOC_WW_Pin1_4	87	92	PF00397	0.567
LIG_14-3-3_CanoR_1	387	395	PF00244	0.596
LIG_14-3-3_CanoR_1	466	473	PF00244	0.587
LIG_14-3-3_CanoR_1	635	639	PF00244	0.565
LIG_14-3-3_CanoR_1	647	656	PF00244	0.377
LIG_14-3-3_CanoR_1	71	77	PF00244	0.757
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BIR_III_4	412	416	PF00653	0.550
LIG_BIR_III_4	474	478	PF00653	0.680
LIG_BIR_III_4	64	68	PF00653	0.745
LIG_BRCT_BRCA1_1	75	79	PF00533	0.541
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.731
LIG_EVH1_1	159	163	PF00568	0.831
LIG_EVH1_1	444	448	PF00568	0.618
LIG_FHA_1	16	22	PF00498	0.411
LIG_FHA_1	174	180	PF00498	0.744
LIG_FHA_1	437	443	PF00498	0.554
LIG_FHA_1	517	523	PF00498	0.527
LIG_FHA_1	648	654	PF00498	0.394
LIG_FHA_2	451	457	PF00498	0.777
LIG_GBD_Chelix_1	289	297	PF00786	0.706
LIG_Integrin_RGD_1	189	191	PF01839	0.531
LIG_Integrin_RGD_1	365	367	PF01839	0.759
LIG_Integrin_RGD_1	609	611	PF01839	0.433
LIG_LIR_Apic_2	342	346	PF02991	0.727
LIG_LIR_Gen_1	537	548	PF02991	0.701
LIG_LIR_Nem_3	537	543	PF02991	0.707
LIG_LIR_Nem_3	652	658	PF02991	0.414
LIG_MYND_1	160	164	PF01753	0.828
LIG_MYND_1	371	375	PF01753	0.522
LIG_PCNA_yPIPBox_3	229	243	PF02747	0.673
LIG_PDZ_Class_2	655	660	PF00595	0.480
LIG_Pex14_1	95	99	PF04695	0.724
LIG_SH2_CRK	343	347	PF00017	0.731
LIG_SH2_CRK	540	544	PF00017	0.704
LIG_SH2_NCK_1	343	347	PF00017	0.731
LIG_SH2_STAP1	17	21	PF00017	0.628
LIG_SH2_STAT5	17	20	PF00017	0.492
LIG_SH2_STAT5	248	251	PF00017	0.535
LIG_SH3_2	354	359	PF14604	0.561
LIG_SH3_3	157	163	PF00018	0.826
LIG_SH3_3	297	303	PF00018	0.691
LIG_SH3_3	351	357	PF00018	0.572
LIG_SH3_3	365	371	PF00018	0.680
LIG_SH3_3	376	382	PF00018	0.781
LIG_SH3_3	439	445	PF00018	0.756
LIG_SH3_3	457	463	PF00018	0.729
LIG_SH3_3	476	482	PF00018	0.529
LIG_SH3_CIN85_PxpxPR_1	382	387	PF14604	0.533
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.660
LIG_TRAF2_1	649	652	PF00917	0.548
LIG_TRAF2_2	353	358	PF00917	0.768
LIG_WRC_WIRS_1	96	101	PF05994	0.723
LIG_WW_2	160	163	PF00397	0.827
LIG_WW_2	460	463	PF00397	0.753
LIG_WW_3	171	175	PF00397	0.608
MOD_CDC14_SPxK_1	171	174	PF00782	0.602
MOD_CDK_SPK_2	560	565	PF00069	0.468
MOD_CDK_SPxK_1	168	174	PF00069	0.610
MOD_CDK_SPxxK_3	182	189	PF00069	0.770
MOD_CDK_SPxxK_3	380	387	PF00069	0.538
MOD_CK1_1	135	141	PF00069	0.846
MOD_CK1_1	264	270	PF00069	0.557
MOD_CK1_1	336	342	PF00069	0.639
MOD_CK1_1	401	407	PF00069	0.742
MOD_CK1_1	426	432	PF00069	0.839
MOD_CK1_1	435	441	PF00069	0.699
MOD_CK1_1	542	548	PF00069	0.765
MOD_CK1_1	550	556	PF00069	0.655
MOD_CK1_1	85	91	PF00069	0.727
MOD_CK2_1	16	22	PF00069	0.703
MOD_CK2_1	181	187	PF00069	0.659
MOD_CK2_1	450	456	PF00069	0.778
MOD_CK2_1	490	496	PF00069	0.810
MOD_CK2_1	550	556	PF00069	0.702
MOD_Cter_Amidation	206	209	PF01082	0.592
MOD_GlcNHglycan	1	4	PF01048	0.776
MOD_GlcNHglycan	11	14	PF01048	0.562
MOD_GlcNHglycan	137	140	PF01048	0.641
MOD_GlcNHglycan	304	307	PF01048	0.739
MOD_GlcNHglycan	333	336	PF01048	0.803
MOD_GlcNHglycan	338	341	PF01048	0.501
MOD_GlcNHglycan	347	350	PF01048	0.699
MOD_GlcNHglycan	375	378	PF01048	0.675
MOD_GlcNHglycan	396	399	PF01048	0.733
MOD_GlcNHglycan	400	403	PF01048	0.680
MOD_GlcNHglycan	412	416	PF01048	0.581
MOD_GlcNHglycan	434	437	PF01048	0.770
MOD_GlcNHglycan	448	451	PF01048	0.609
MOD_GlcNHglycan	512	516	PF01048	0.632
MOD_GlcNHglycan	536	539	PF01048	0.524
MOD_GSK3_1	133	140	PF00069	0.769
MOD_GSK3_1	162	169	PF00069	0.780
MOD_GSK3_1	249	256	PF00069	0.535
MOD_GSK3_1	261	268	PF00069	0.574
MOD_GSK3_1	298	305	PF00069	0.619
MOD_GSK3_1	315	322	PF00069	0.712
MOD_GSK3_1	345	352	PF00069	0.810
MOD_GSK3_1	394	401	PF00069	0.759
MOD_GSK3_1	41	48	PF00069	0.516
MOD_GSK3_1	425	432	PF00069	0.665
MOD_GSK3_1	436	443	PF00069	0.706
MOD_GSK3_1	446	453	PF00069	0.798
MOD_GSK3_1	513	520	PF00069	0.605
MOD_GSK3_1	539	546	PF00069	0.642
MOD_GSK3_1	547	554	PF00069	0.616
MOD_GSK3_1	67	74	PF00069	0.757
MOD_GSK3_1	78	85	PF00069	0.681
MOD_N-GLC_1	320	325	PF02516	0.538
MOD_N-GLC_1	387	392	PF02516	0.616
MOD_N-GLC_1	525	530	PF02516	0.630
MOD_N-GLC_1	71	76	PF02516	0.546
MOD_N-GLC_2	532	534	PF02516	0.712
MOD_NEK2_1	132	137	PF00069	0.563
MOD_NEK2_1	249	254	PF00069	0.538
MOD_NEK2_1	333	338	PF00069	0.731
MOD_NEK2_1	539	544	PF00069	0.661
MOD_PIKK_1	634	640	PF00454	0.629
MOD_PIKK_1	647	653	PF00454	0.402
MOD_PK_1	592	598	PF00069	0.530
MOD_PKA_2	173	179	PF00069	0.730
MOD_PKA_2	239	245	PF00069	0.619
MOD_PKA_2	386	392	PF00069	0.552
MOD_PKA_2	429	435	PF00069	0.846
MOD_PKA_2	499	505	PF00069	0.842
MOD_PKA_2	634	640	PF00069	0.583
MOD_Plk_1	144	150	PF00069	0.770
MOD_Plk_1	320	326	PF00069	0.536
MOD_Plk_1	387	393	PF00069	0.558
MOD_ProDKin_1	137	143	PF00069	0.751
MOD_ProDKin_1	162	168	PF00069	0.839
MOD_ProDKin_1	174	180	PF00069	0.644
MOD_ProDKin_1	182	188	PF00069	0.647
MOD_ProDKin_1	256	262	PF00069	0.635
MOD_ProDKin_1	315	321	PF00069	0.695
MOD_ProDKin_1	349	355	PF00069	0.814
MOD_ProDKin_1	357	363	PF00069	0.746
MOD_ProDKin_1	367	373	PF00069	0.555
MOD_ProDKin_1	380	386	PF00069	0.618
MOD_ProDKin_1	560	566	PF00069	0.471
MOD_ProDKin_1	594	600	PF00069	0.452
MOD_ProDKin_1	73	79	PF00069	0.827
MOD_ProDKin_1	87	93	PF00069	0.561
MOD_SUMO_rev_2	28	34	PF00179	0.677
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.722
TRG_ENDOCYTIC_2	540	543	PF00928	0.709
TRG_ER_diArg_1	208	211	PF00400	0.533
TRG_ER_diArg_1	243	246	PF00400	0.671
TRG_ER_diArg_1	285	288	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQZ0	Leishmania donovani	82%	99%
A4H600	Leishmania braziliensis	58%	98%
A4HUC6	Leishmania infantum	82%	99%
Q4QHK0	Leishmania major	81%	100%