Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania mexicana

UniProt:

E9AN24_LEIMU

TriTrypDb:

LmxM.10.0180

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AN24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.534
CLV_PCSK_SKI1_1	151	155	PF00082	0.610
DEG_APCC_DBOX_1	53	61	PF00400	0.549
DOC_CDC14_PxL_1	144	152	PF14671	0.585
DOC_CYCLIN_RxL_1	148	156	PF00134	0.645
DOC_MAPK_gen_1	100	109	PF00069	0.387
DOC_MAPK_gen_1	191	199	PF00069	0.559
DOC_MAPK_MEF2A_6	191	199	PF00069	0.582
DOC_MAPK_MEF2A_6	206	213	PF00069	0.598
DOC_PP2B_LxvP_1	145	148	PF13499	0.541
DOC_USP7_MATH_1	177	181	PF00917	0.561
DOC_WW_Pin1_4	69	74	PF00397	0.663
LIG_14-3-3_CanoR_1	106	110	PF00244	0.381
LIG_14-3-3_CanoR_1	151	156	PF00244	0.647
LIG_14-3-3_CanoR_1	67	75	PF00244	0.653
LIG_Actin_WH2_2	77	94	PF00022	0.448
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	37	41	PF00533	0.702
LIG_CSL_BTD_1	115	118	PF09270	0.422
LIG_FHA_1	17	23	PF00498	0.653
LIG_FHA_2	223	229	PF00498	0.628
LIG_LIR_Gen_1	198	205	PF02991	0.579
LIG_LIR_Gen_1	207	214	PF02991	0.570
LIG_LIR_Gen_1	87	94	PF02991	0.317
LIG_LIR_Nem_3	115	119	PF02991	0.395
LIG_LIR_Nem_3	120	124	PF02991	0.367
LIG_LIR_Nem_3	190	196	PF02991	0.589
LIG_LIR_Nem_3	198	202	PF02991	0.448
LIG_LIR_Nem_3	207	213	PF02991	0.351
LIG_LIR_Nem_3	87	91	PF02991	0.317
LIG_MAD2	151	159	PF02301	0.678
LIG_PCNA_yPIPBox_3	103	117	PF02747	0.448
LIG_Pex14_2	37	41	PF04695	0.710
LIG_PTB_Apo_2	155	162	PF02174	0.657
LIG_PTB_Phospho_1	155	161	PF10480	0.683
LIG_SH2_CRK	88	92	PF00017	0.317
LIG_SH2_NCK_1	43	47	PF00017	0.558
LIG_SH2_SRC	174	177	PF00017	0.665
LIG_SH2_STAT5	161	164	PF00017	0.687
LIG_SH2_STAT5	174	177	PF00017	0.605
LIG_SH2_STAT5	36	39	PF00017	0.647
LIG_SH2_STAT5	43	46	PF00017	0.628
LIG_SH2_STAT5	88	91	PF00017	0.336
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.568
LIG_SUMO_SIM_par_1	151	156	PF11976	0.561
LIG_SxIP_EBH_1	168	179	PF03271	0.515
LIG_TRAF2_1	126	129	PF00917	0.336
LIG_WRC_WIRS_1	196	201	PF05994	0.564
MOD_CDK_SPK_2	69	74	PF00069	0.663
MOD_CK1_1	87	93	PF00069	0.448
MOD_CK1_1	96	102	PF00069	0.299
MOD_CK2_1	222	228	PF00069	0.618
MOD_CK2_1	99	105	PF00069	0.332
MOD_GlcNHglycan	182	186	PF01048	0.677
MOD_GSK3_1	177	184	PF00069	0.596
MOD_GSK3_1	31	38	PF00069	0.569
MOD_GSK3_1	69	76	PF00069	0.664
MOD_GSK3_1	90	97	PF00069	0.422
MOD_N-GLC_1	41	46	PF02516	0.696
MOD_N-GLC_1	84	89	PF02516	0.317
MOD_NEK2_1	3	8	PF00069	0.691
MOD_NEK2_1	35	40	PF00069	0.586
MOD_NEK2_1	84	89	PF00069	0.317
MOD_NEK2_2	31	36	PF00069	0.670
MOD_PKA_2	66	72	PF00069	0.581
MOD_PKA_2	73	79	PF00069	0.630
MOD_PKA_2	99	105	PF00069	0.336
MOD_PKB_1	149	157	PF00069	0.675
MOD_Plk_1	84	90	PF00069	0.324
MOD_Plk_1	94	100	PF00069	0.332
MOD_Plk_4	10	16	PF00069	0.660
MOD_Plk_4	112	118	PF00069	0.448
MOD_Plk_4	170	176	PF00069	0.613
MOD_Plk_4	31	37	PF00069	0.607
MOD_ProDKin_1	69	75	PF00069	0.662
TRG_ENDOCYTIC_2	193	196	PF00928	0.537
TRG_ENDOCYTIC_2	205	208	PF00928	0.393
TRG_ENDOCYTIC_2	43	46	PF00928	0.565
TRG_ENDOCYTIC_2	88	91	PF00928	0.302
TRG_ER_diArg_1	148	151	PF00400	0.668
TRG_ER_diArg_1	223	226	PF00400	0.616
TRG_NES_CRM1_1	123	133	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B1	Leptomonas seymouri	59%	100%
A0A0S4J897	Bodo saltans	45%	83%
A0A1X0NQ44	Trypanosomatidae	54%	100%
A0A3S7WQZ4	Leishmania donovani	90%	100%
A0A422NRS7	Trypanosoma rangeli	53%	100%
A4H5Z9	Leishmania braziliensis	84%	100%
A4HUC5	Leishmania infantum	91%	100%
C9ZVG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D3ZXS4	Rattus norvegicus	26%	71%
Q4QHK2	Leishmania major	89%	100%
V5BIH6	Trypanosoma cruzi	53%	100%