Putative nucleoside phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AN23_LEIMU

TriTrypDb:

LmxM.10.0170

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AN23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN23

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009134	nucleoside diphosphate catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004382	GDP phosphatase activity	7	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017110	nucleoside diphosphate phosphatase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.256
CLV_NRD_NRD_1	154	156	PF00675	0.545
CLV_PCSK_KEX2_1	132	134	PF00082	0.563
CLV_PCSK_KEX2_1	154	156	PF00082	0.545
CLV_PCSK_KEX2_1	468	470	PF00082	0.289
CLV_PCSK_KEX2_1	507	509	PF00082	0.265
CLV_PCSK_KEX2_1	76	78	PF00082	0.559
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.543
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.289
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.265
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.408
CLV_PCSK_SKI1_1	406	410	PF00082	0.457
CLV_PCSK_SKI1_1	504	508	PF00082	0.464
CLV_PCSK_SKI1_1	530	534	PF00082	0.378
CLV_PCSK_SKI1_1	97	101	PF00082	0.651
DEG_APCC_DBOX_1	132	140	PF00400	0.482
DEG_APCC_DBOX_1	78	86	PF00400	0.496
DEG_SPOP_SBC_1	429	433	PF00917	0.289
DOC_MAPK_gen_1	528	537	PF00069	0.338
DOC_MAPK_gen_1	587	594	PF00069	0.447
DOC_MAPK_gen_1	76	85	PF00069	0.636
DOC_PP1_RVXF_1	404	411	PF00149	0.277
DOC_PP2B_LxvP_1	477	480	PF13499	0.156
DOC_PP4_MxPP_1	473	476	PF00568	0.277
DOC_PP4_MxPP_1	550	553	PF00568	0.289
DOC_USP7_MATH_1	219	223	PF00917	0.310
DOC_USP7_MATH_1	30	34	PF00917	0.578
DOC_USP7_MATH_1	345	349	PF00917	0.338
DOC_USP7_MATH_1	456	460	PF00917	0.287
DOC_USP7_MATH_1	574	578	PF00917	0.421
DOC_USP7_MATH_1	583	587	PF00917	0.334
DOC_USP7_UBL2_3	185	189	PF12436	0.289
DOC_USP7_UBL2_3	415	419	PF12436	0.363
DOC_USP7_UBL2_3	589	593	PF12436	0.460
LIG_14-3-3_CanoR_1	125	130	PF00244	0.649
LIG_14-3-3_CanoR_1	154	162	PF00244	0.491
LIG_14-3-3_CanoR_1	373	380	PF00244	0.323
LIG_14-3-3_CanoR_1	530	536	PF00244	0.156
LIG_14-3-3_CanoR_1	92	100	PF00244	0.589
LIG_BIR_III_4	455	459	PF00653	0.156
LIG_BRCT_BRCA1_1	111	115	PF00533	0.489
LIG_BRCT_BRCA1_1	190	194	PF00533	0.262
LIG_BRCT_BRCA1_1	564	568	PF00533	0.338
LIG_deltaCOP1_diTrp_1	253	259	PF00928	0.338
LIG_EVH1_1	474	478	PF00568	0.156
LIG_FHA_1	121	127	PF00498	0.669
LIG_FHA_1	279	285	PF00498	0.262
LIG_FHA_1	291	297	PF00498	0.262
LIG_FHA_1	347	353	PF00498	0.270
LIG_FHA_1	358	364	PF00498	0.283
LIG_FHA_1	403	409	PF00498	0.391
LIG_FHA_1	532	538	PF00498	0.156
LIG_FHA_1	556	562	PF00498	0.286
LIG_FHA_2	132	138	PF00498	0.350
LIG_FHA_2	17	23	PF00498	0.584
LIG_FHA_2	272	278	PF00498	0.378
LIG_FHA_2	615	621	PF00498	0.164
LIG_LIR_Gen_1	187	196	PF02991	0.321
LIG_LIR_Gen_1	253	262	PF02991	0.431
LIG_LIR_Gen_1	368	378	PF02991	0.183
LIG_LIR_Gen_1	565	574	PF02991	0.262
LIG_LIR_Gen_1	628	637	PF02991	0.318
LIG_LIR_Nem_3	145	151	PF02991	0.670
LIG_LIR_Nem_3	187	193	PF02991	0.300
LIG_LIR_Nem_3	231	236	PF02991	0.465
LIG_LIR_Nem_3	253	259	PF02991	0.421
LIG_LIR_Nem_3	395	399	PF02991	0.338
LIG_LIR_Nem_3	488	493	PF02991	0.297
LIG_LIR_Nem_3	565	571	PF02991	0.262
LIG_LIR_Nem_3	630	636	PF02991	0.296
LIG_MYND_1	472	476	PF01753	0.156
LIG_PDZ_Class_1	671	676	PF00595	0.234
LIG_Pex14_2	564	568	PF04695	0.461
LIG_PTB_Apo_2	302	309	PF02174	0.289
LIG_SH2_CRK	190	194	PF00017	0.286
LIG_SH2_CRK	634	638	PF00017	0.387
LIG_SH2_NCK_1	190	194	PF00017	0.286
LIG_SH2_NCK_1	645	649	PF00017	0.325
LIG_SH2_SRC	392	395	PF00017	0.262
LIG_SH2_SRC	497	500	PF00017	0.357
LIG_SH2_SRC	636	639	PF00017	0.357
LIG_SH2_STAP1	190	194	PF00017	0.286
LIG_SH2_STAP1	380	384	PF00017	0.289
LIG_SH2_STAP1	562	566	PF00017	0.283
LIG_SH2_STAP1	629	633	PF00017	0.373
LIG_SH2_STAP1	634	638	PF00017	0.364
LIG_SH2_STAP1	662	666	PF00017	0.302
LIG_SH2_STAT5	334	337	PF00017	0.298
LIG_SH2_STAT5	636	639	PF00017	0.316
LIG_SH3_1	469	475	PF00018	0.283
LIG_SH3_3	360	366	PF00018	0.286
LIG_SH3_3	469	475	PF00018	0.376
LIG_SH3_3	476	482	PF00018	0.258
LIG_SH3_3	508	514	PF00018	0.369
LIG_SH3_3	546	552	PF00018	0.263
LIG_SH3_3	589	595	PF00018	0.325
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.480
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.358
LIG_SUMO_SIM_anti_2	569	574	PF11976	0.229
LIG_SUMO_SIM_anti_2	80	87	PF11976	0.426
LIG_SUMO_SIM_par_1	348	354	PF11976	0.354
LIG_SUMO_SIM_par_1	84	89	PF11976	0.619
LIG_TRAF2_1	128	131	PF00917	0.520
LIG_TRAF2_1	321	324	PF00917	0.338
LIG_UBA3_1	166	175	PF00899	0.603
LIG_UBA3_1	286	291	PF00899	0.338
LIG_UBA3_1	567	576	PF00899	0.259
LIG_WW_2	475	478	PF00397	0.211
MOD_CK1_1	138	144	PF00069	0.360
MOD_CK1_1	222	228	PF00069	0.289
MOD_CK1_1	427	433	PF00069	0.433
MOD_CK1_1	606	612	PF00069	0.184
MOD_CK1_1	95	101	PF00069	0.565
MOD_CK2_1	125	131	PF00069	0.680
MOD_CK2_1	16	22	PF00069	0.429
MOD_CK2_1	271	277	PF00069	0.378
MOD_CK2_1	49	55	PF00069	0.399
MOD_CK2_1	614	620	PF00069	0.204
MOD_GlcNHglycan	190	193	PF01048	0.300
MOD_GlcNHglycan	380	383	PF01048	0.385
MOD_GlcNHglycan	457	461	PF01048	0.343
MOD_GlcNHglycan	605	608	PF01048	0.211
MOD_GlcNHglycan	61	64	PF01048	0.551
MOD_GlcNHglycan	94	97	PF01048	0.659
MOD_GSK3_1	131	138	PF00069	0.604
MOD_GSK3_1	184	191	PF00069	0.368
MOD_GSK3_1	421	428	PF00069	0.395
MOD_GSK3_1	45	52	PF00069	0.470
MOD_GSK3_1	531	538	PF00069	0.156
MOD_GSK3_1	664	671	PF00069	0.330
MOD_N-GLC_1	120	125	PF02516	0.628
MOD_N-GLC_1	555	560	PF02516	0.393
MOD_N-GLC_1	574	579	PF02516	0.143
MOD_NEK2_1	142	147	PF00069	0.569
MOD_NEK2_1	170	175	PF00069	0.619
MOD_NEK2_1	278	283	PF00069	0.277
MOD_NEK2_1	378	383	PF00069	0.266
MOD_NEK2_1	531	536	PF00069	0.156
MOD_NEK2_1	608	613	PF00069	0.325
MOD_NEK2_1	632	637	PF00069	0.285
MOD_NEK2_1	668	673	PF00069	0.284
MOD_NEK2_2	385	390	PF00069	0.168
MOD_NEK2_2	621	626	PF00069	0.389
MOD_PIKK_1	357	363	PF00454	0.262
MOD_PIKK_1	413	419	PF00454	0.325
MOD_PK_1	109	115	PF00069	0.395
MOD_PK_1	443	449	PF00069	0.205
MOD_PKA_1	154	160	PF00069	0.473
MOD_PKA_2	153	159	PF00069	0.529
MOD_PKA_2	170	176	PF00069	0.560
MOD_PKA_2	378	384	PF00069	0.334
MOD_PKB_1	90	98	PF00069	0.544
MOD_Plk_1	109	115	PF00069	0.650
MOD_Plk_1	574	580	PF00069	0.338
MOD_Plk_4	109	115	PF00069	0.493
MOD_Plk_4	135	141	PF00069	0.589
MOD_Plk_4	443	449	PF00069	0.205
MOD_Plk_4	574	580	PF00069	0.431
MOD_Plk_4	632	638	PF00069	0.263
MOD_Plk_4	668	674	PF00069	0.305
MOD_Plk_4	81	87	PF00069	0.364
MOD_SUMO_for_1	44	47	PF00179	0.555
MOD_SUMO_for_1	625	628	PF00179	0.373
MOD_SUMO_rev_2	128	134	PF00179	0.348
MOD_SUMO_rev_2	55	62	PF00179	0.444
MOD_SUMO_rev_2	586	595	PF00179	0.325
TRG_DiLeu_BaEn_3	80	86	PF01217	0.498
TRG_DiLeu_BaEn_4	231	237	PF01217	0.289
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.338
TRG_ENDOCYTIC_2	190	193	PF00928	0.286
TRG_ENDOCYTIC_2	629	632	PF00928	0.373
TRG_ENDOCYTIC_2	634	637	PF00928	0.374
TRG_ENDOCYTIC_2	638	641	PF00928	0.375
TRG_ER_diArg_1	153	155	PF00400	0.682
TRG_NES_CRM1_1	105	119	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E8	Leptomonas seymouri	47%	99%
A0A0S4IR76	Bodo saltans	30%	100%
A0A1X0NQR7	Trypanosomatidae	34%	100%
A0A3R7NV38	Trypanosoma rangeli	32%	100%
A0A3S7WR18	Leishmania donovani	86%	100%
A4H5Z8	Leishmania braziliensis	67%	100%
A4HUC4	Leishmania infantum	87%	100%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
P40009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q4QHK3	Leishmania major	85%	99%
Q8TGG8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	100%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%