Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN22_LEIMU

TriTrypDb:

LmxM.10.0160

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.647
CLV_C14_Caspase3-7	425	429	PF00656	0.521
CLV_C14_Caspase3-7	494	498	PF00656	0.566
CLV_NRD_NRD_1	139	141	PF00675	0.500
CLV_NRD_NRD_1	147	149	PF00675	0.481
CLV_NRD_NRD_1	281	283	PF00675	0.492
CLV_NRD_NRD_1	71	73	PF00675	0.445
CLV_NRD_NRD_1	82	84	PF00675	0.366
CLV_NRD_NRD_1	90	92	PF00675	0.314
CLV_PCSK_KEX2_1	139	141	PF00082	0.527
CLV_PCSK_KEX2_1	281	283	PF00082	0.492
CLV_PCSK_KEX2_1	289	291	PF00082	0.469
CLV_PCSK_KEX2_1	71	73	PF00082	0.445
CLV_PCSK_KEX2_1	82	84	PF00082	0.366
CLV_PCSK_KEX2_1	88	90	PF00082	0.332
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.488
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.477
CLV_PCSK_PC7_1	285	291	PF00082	0.422
CLV_PCSK_SKI1_1	124	128	PF00082	0.461
CLV_PCSK_SKI1_1	480	484	PF00082	0.589
DEG_APCC_DBOX_1	51	59	PF00400	0.425
DEG_SPOP_SBC_1	181	185	PF00917	0.475
DEG_SPOP_SBC_1	209	213	PF00917	0.480
DEG_SPOP_SBC_1	228	232	PF00917	0.660
DEG_SPOP_SBC_1	401	405	PF00917	0.600
DOC_CYCLIN_RxL_1	121	132	PF00134	0.365
DOC_PP4_FxxP_1	369	372	PF00568	0.496
DOC_USP7_MATH_1	181	185	PF00917	0.587
DOC_USP7_MATH_1	189	193	PF00917	0.526
DOC_USP7_MATH_1	202	206	PF00917	0.650
DOC_USP7_MATH_1	209	213	PF00917	0.664
DOC_USP7_MATH_1	228	232	PF00917	0.552
DOC_USP7_MATH_1	257	261	PF00917	0.433
DOC_USP7_MATH_1	357	361	PF00917	0.650
DOC_USP7_MATH_1	399	403	PF00917	0.544
DOC_USP7_MATH_1	418	422	PF00917	0.787
DOC_USP7_MATH_1	449	453	PF00917	0.719
DOC_USP7_MATH_1	481	485	PF00917	0.698
DOC_USP7_MATH_1	490	494	PF00917	0.738
DOC_USP7_MATH_1	7	11	PF00917	0.566
DOC_WW_Pin1_4	193	198	PF00397	0.550
DOC_WW_Pin1_4	346	351	PF00397	0.616
DOC_WW_Pin1_4	363	368	PF00397	0.459
DOC_WW_Pin1_4	442	447	PF00397	0.810
LIG_14-3-3_CanoR_1	113	122	PF00244	0.433
LIG_14-3-3_CanoR_1	361	369	PF00244	0.664
LIG_14-3-3_CanoR_1	441	446	PF00244	0.608
LIG_14-3-3_CanoR_1	480	490	PF00244	0.581
LIG_AP2alpha_2	387	389	PF02296	0.612
LIG_BIR_III_2	428	432	PF00653	0.489
LIG_BRCT_BRCA1_1	211	215	PF00533	0.549
LIG_BRCT_BRCA1_1	331	335	PF00533	0.656
LIG_BRCT_BRCA1_1	365	369	PF00533	0.493
LIG_FHA_1	114	120	PF00498	0.430
LIG_FHA_1	157	163	PF00498	0.520
LIG_FHA_1	194	200	PF00498	0.656
LIG_FHA_1	235	241	PF00498	0.665
LIG_FHA_1	243	249	PF00498	0.567
LIG_FHA_1	261	267	PF00498	0.309
LIG_FHA_1	295	301	PF00498	0.510
LIG_FHA_1	347	353	PF00498	0.708
LIG_FHA_1	44	50	PF00498	0.519
LIG_FHA_1	471	477	PF00498	0.597
LIG_FHA_2	234	240	PF00498	0.598
LIG_FHA_2	481	487	PF00498	0.581
LIG_FHA_2	55	61	PF00498	0.494
LIG_GBD_Chelix_1	133	141	PF00786	0.443
LIG_GBD_Chelix_1	76	84	PF00786	0.412
LIG_LIR_Apic_2	366	372	PF02991	0.492
LIG_LIR_Gen_1	387	396	PF02991	0.465
LIG_LIR_Nem_3	212	218	PF02991	0.547
LIG_LIR_Nem_3	387	392	PF02991	0.460
LIG_MYND_1	197	201	PF01753	0.461
LIG_PCNA_yPIPBox_3	71	80	PF02747	0.525
LIG_Pex14_2	335	339	PF04695	0.438
LIG_RPA_C_Fungi	78	90	PF08784	0.423
LIG_SH2_STAP1	16	20	PF00017	0.522
LIG_SH2_STAT5	250	253	PF00017	0.512
LIG_SH2_STAT5	272	275	PF00017	0.513
LIG_SH3_3	194	200	PF00018	0.616
LIG_SH3_3	382	388	PF00018	0.582
LIG_SH3_3	428	434	PF00018	0.515
LIG_SH3_3	473	479	PF00018	0.786
LIG_Sin3_3	389	396	PF02671	0.470
LIG_SUMO_SIM_par_1	389	395	PF11976	0.469
LIG_TRAF2_1	106	109	PF00917	0.444
LIG_TRAF2_1	154	157	PF00917	0.449
LIG_TRAF2_1	57	60	PF00917	0.492
LIG_UBA3_1	80	88	PF00899	0.437
LIG_WW_1	13	16	PF00397	0.554
MOD_CDK_SPxxK_3	346	353	PF00069	0.641
MOD_CK1_1	205	211	PF00069	0.638
MOD_CK1_1	224	230	PF00069	0.518
MOD_CK1_1	260	266	PF00069	0.435
MOD_CK1_1	341	347	PF00069	0.548
MOD_CK1_1	402	408	PF00069	0.748
MOD_CK1_1	421	427	PF00069	0.789
MOD_CK1_1	460	466	PF00069	0.589
MOD_CK1_1	484	490	PF00069	0.668
MOD_CK1_1	491	497	PF00069	0.705
MOD_CK1_1	54	60	PF00069	0.438
MOD_CK2_1	115	121	PF00069	0.372
MOD_CK2_1	264	270	PF00069	0.608
MOD_CK2_1	449	455	PF00069	0.667
MOD_CK2_1	480	486	PF00069	0.580
MOD_CK2_1	54	60	PF00069	0.488
MOD_GlcNHglycan	184	187	PF01048	0.630
MOD_GlcNHglycan	191	194	PF01048	0.629
MOD_GlcNHglycan	205	208	PF01048	0.668
MOD_GlcNHglycan	226	229	PF01048	0.579
MOD_GlcNHglycan	341	344	PF01048	0.573
MOD_GlcNHglycan	355	358	PF01048	0.636
MOD_GlcNHglycan	363	366	PF01048	0.731
MOD_GlcNHglycan	394	397	PF01048	0.687
MOD_GlcNHglycan	416	419	PF01048	0.672
MOD_GlcNHglycan	420	423	PF01048	0.484
MOD_GlcNHglycan	449	452	PF01048	0.558
MOD_GlcNHglycan	483	486	PF01048	0.552
MOD_GlcNHglycan	490	493	PF01048	0.593
MOD_GlcNHglycan	9	12	PF01048	0.637
MOD_GSK3_1	187	194	PF00069	0.645
MOD_GSK3_1	203	210	PF00069	0.776
MOD_GSK3_1	220	227	PF00069	0.539
MOD_GSK3_1	228	235	PF00069	0.590
MOD_GSK3_1	260	267	PF00069	0.473
MOD_GSK3_1	338	345	PF00069	0.552
MOD_GSK3_1	353	360	PF00069	0.636
MOD_GSK3_1	363	370	PF00069	0.678
MOD_GSK3_1	414	421	PF00069	0.761
MOD_GSK3_1	456	463	PF00069	0.625
MOD_GSK3_1	480	487	PF00069	0.685
MOD_LATS_1	219	225	PF00433	0.666
MOD_N-GLC_1	113	118	PF02516	0.518
MOD_N-GLC_1	330	335	PF02516	0.467
MOD_N-GLC_1	447	452	PF02516	0.503
MOD_N-GLC_1	5	10	PF02516	0.473
MOD_NEK2_1	112	117	PF00069	0.456
MOD_NEK2_1	203	208	PF00069	0.683
MOD_NEK2_1	330	335	PF00069	0.587
MOD_NEK2_1	339	344	PF00069	0.538
MOD_NEK2_1	391	396	PF00069	0.576
MOD_NEK2_1	44	49	PF00069	0.438
MOD_NEK2_1	447	452	PF00069	0.747
MOD_NEK2_1	470	475	PF00069	0.632
MOD_NEK2_1	51	56	PF00069	0.446
MOD_NEK2_1	84	89	PF00069	0.491
MOD_NEK2_2	257	262	PF00069	0.436
MOD_PIKK_1	104	110	PF00454	0.484
MOD_PIKK_1	113	119	PF00454	0.483
MOD_PIKK_1	187	193	PF00454	0.553
MOD_PIKK_1	294	300	PF00454	0.512
MOD_PIKK_1	367	373	PF00454	0.521
MOD_PKA_1	89	95	PF00069	0.375
MOD_PKA_2	112	118	PF00069	0.434
MOD_PKA_2	220	226	PF00069	0.657
MOD_PKA_2	440	446	PF00069	0.612
MOD_PKA_2	51	57	PF00069	0.497
MOD_PKA_2	89	95	PF00069	0.375
MOD_Plk_1	330	336	PF00069	0.578
MOD_Plk_1	454	460	PF00069	0.792
MOD_Plk_1	485	491	PF00069	0.697
MOD_Plk_1	5	11	PF00069	0.465
MOD_Plk_4	210	216	PF00069	0.529
MOD_Plk_4	44	50	PF00069	0.420
MOD_ProDKin_1	193	199	PF00069	0.553
MOD_ProDKin_1	346	352	PF00069	0.620
MOD_ProDKin_1	363	369	PF00069	0.463
MOD_ProDKin_1	442	448	PF00069	0.811
MOD_SUMO_for_1	126	129	PF00179	0.504
MOD_SUMO_rev_2	104	112	PF00179	0.457
TRG_ENDOCYTIC_2	66	69	PF00928	0.488
TRG_ER_diArg_1	139	141	PF00400	0.440
TRG_ER_diArg_1	281	283	PF00400	0.533
TRG_ER_diArg_1	49	52	PF00400	0.428
TRG_ER_diArg_1	81	83	PF00400	0.414
TRG_ER_diArg_1	89	91	PF00400	0.409
TRG_NES_CRM1_1	117	132	PF08389	0.319
TRG_NLS_Bipartite_1	71	92	PF00514	0.473
TRG_NLS_MonoCore_2	87	92	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X5	Leptomonas seymouri	56%	66%
A0A0S4JC19	Bodo saltans	27%	100%
A0A3R7MLU6	Trypanosoma rangeli	31%	100%
A0A3S7WR07	Leishmania donovani	89%	99%
A4H5Z7	Leishmania braziliensis	75%	100%
A4HUC3	Leishmania infantum	88%	99%
Q4QHK4	Leishmania major	88%	100%