C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN21_LEIMU

TriTrypDb:

LmxM.10.0150

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	260	265	PF00400	0.553
DEG_SPOP_SBC_1	268	272	PF00917	0.656
DOC_CDC14_PxL_1	181	189	PF14671	0.609
DOC_CKS1_1	166	171	PF01111	0.649
DOC_CKS1_1	263	268	PF01111	0.562
DOC_PP2B_LxvP_1	154	157	PF13499	0.610
DOC_USP7_MATH_1	25	29	PF00917	0.635
DOC_USP7_MATH_1	267	271	PF00917	0.658
DOC_USP7_MATH_1	286	290	PF00917	0.487
DOC_USP7_MATH_1	84	88	PF00917	0.647
DOC_WW_Pin1_4	165	170	PF00397	0.621
DOC_WW_Pin1_4	172	177	PF00397	0.617
DOC_WW_Pin1_4	187	192	PF00397	0.654
DOC_WW_Pin1_4	207	212	PF00397	0.433
DOC_WW_Pin1_4	222	227	PF00397	0.592
DOC_WW_Pin1_4	258	263	PF00397	0.567
DOC_WW_Pin1_4	269	274	PF00397	0.597
DOC_WW_Pin1_4	318	323	PF00397	0.572
DOC_WW_Pin1_4	326	331	PF00397	0.602
DOC_WW_Pin1_4	345	350	PF00397	0.648
LIG_14-3-3_CanoR_1	280	284	PF00244	0.625
LIG_14-3-3_CanoR_1	310	318	PF00244	0.653
LIG_BRCT_BRCA1_1	22	26	PF00533	0.669
LIG_BRCT_BRCA1_1	52	56	PF00533	0.621
LIG_EVH1_1	154	158	PF00568	0.605
LIG_EVH1_2	196	200	PF00568	0.540
LIG_FHA_1	16	22	PF00498	0.699
LIG_FHA_1	240	246	PF00498	0.562
LIG_FHA_1	34	40	PF00498	0.506
LIG_FHA_1	346	352	PF00498	0.613
LIG_FHA_1	44	50	PF00498	0.557
LIG_FHA_2	25	31	PF00498	0.689
LIG_FHA_2	32	38	PF00498	0.646
LIG_LIR_Apic_2	261	267	PF02991	0.553
LIG_LIR_Gen_1	53	62	PF02991	0.691
LIG_LIR_Nem_3	53	59	PF02991	0.584
LIG_NRBOX	74	80	PF00104	0.481
LIG_PCNA_yPIPBox_3	72	83	PF02747	0.551
LIG_PROFILIN_1	155	161	PF00235	0.593
LIG_SH2_CRK	121	125	PF00017	0.655
LIG_SH2_CRK	166	170	PF00017	0.593
LIG_SH2_CRK	181	185	PF00017	0.441
LIG_SH2_CRK	264	268	PF00017	0.565
LIG_SH2_CRK	281	285	PF00017	0.567
LIG_SH2_GRB2like	177	180	PF00017	0.641
LIG_SH2_NCK_1	125	129	PF00017	0.660
LIG_SH2_NCK_1	148	152	PF00017	0.654
LIG_SH2_NCK_1	166	170	PF00017	0.669
LIG_SH2_NCK_1	264	268	PF00017	0.565
LIG_SH2_NCK_1	281	285	PF00017	0.567
LIG_SH2_PTP2	231	234	PF00017	0.609
LIG_SH2_SRC	231	234	PF00017	0.550
LIG_SH2_STAP1	148	152	PF00017	0.630
LIG_SH2_STAP1	177	181	PF00017	0.628
LIG_SH2_STAP1	338	342	PF00017	0.618
LIG_SH2_STAT5	125	128	PF00017	0.654
LIG_SH2_STAT5	17	20	PF00017	0.674
LIG_SH2_STAT5	231	234	PF00017	0.609
LIG_SH2_STAT5	264	267	PF00017	0.558
LIG_SH2_STAT5	320	323	PF00017	0.478
LIG_SH2_STAT5	331	334	PF00017	0.688
LIG_SH3_1	114	120	PF00018	0.481
LIG_SH3_3	114	120	PF00018	0.646
LIG_SH3_3	152	158	PF00018	0.660
LIG_SH3_3	170	176	PF00018	0.491
LIG_SH3_3	192	198	PF00018	0.739
LIG_SH3_3	230	236	PF00018	0.552
LIG_SH3_3	257	263	PF00018	0.540
LIG_SH3_3	271	277	PF00018	0.568
LIG_SH3_3	319	325	PF00018	0.640
LIG_SH3_3	360	366	PF00018	0.689
LIG_SUMO_SIM_anti_2	86	98	PF11976	0.533
LIG_TRAF2_1	220	223	PF00917	0.616
LIG_TRAF2_1	238	241	PF00917	0.600
LIG_TRAF2_1	61	64	PF00917	0.612
LIG_TRFH_1	252	256	PF08558	0.509
LIG_TRFH_1	281	285	PF08558	0.567
LIG_UBA3_1	253	259	PF00899	0.523
LIG_WW_1	163	166	PF00397	0.567
LIG_WW_1	355	358	PF00397	0.553
MOD_CDK_SPxxK_3	187	194	PF00069	0.656
MOD_CDK_SPxxK_3	273	280	PF00069	0.624
MOD_CK1_1	147	153	PF00069	0.668
MOD_CK1_1	167	173	PF00069	0.732
MOD_CK1_1	218	224	PF00069	0.684
MOD_CK1_1	258	264	PF00069	0.571
MOD_CK1_1	33	39	PF00069	0.537
MOD_CK2_1	16	22	PF00069	0.669
MOD_CK2_1	196	202	PF00069	0.579
MOD_CK2_1	310	316	PF00069	0.687
MOD_GlcNHglycan	149	152	PF01048	0.684
MOD_GlcNHglycan	18	21	PF01048	0.736
MOD_GlcNHglycan	181	184	PF01048	0.652
MOD_GlcNHglycan	22	25	PF01048	0.765
MOD_GSK3_1	12	19	PF00069	0.649
MOD_GSK3_1	146	153	PF00069	0.664
MOD_GSK3_1	186	193	PF00069	0.772
MOD_GSK3_1	20	27	PF00069	0.776
MOD_GSK3_1	203	210	PF00069	0.558
MOD_GSK3_1	218	225	PF00069	0.631
MOD_GSK3_1	258	265	PF00069	0.548
MOD_GSK3_1	269	276	PF00069	0.571
MOD_GSK3_1	286	293	PF00069	0.683
MOD_GSK3_1	305	312	PF00069	0.669
MOD_GSK3_1	326	333	PF00069	0.636
MOD_GSK3_1	341	348	PF00069	0.680
MOD_N-GLC_1	144	149	PF02516	0.624
MOD_NEK2_1	215	220	PF00069	0.704
MOD_NEK2_1	245	250	PF00069	0.567
MOD_NEK2_1	299	304	PF00069	0.581
MOD_NEK2_1	332	337	PF00069	0.632
MOD_NEK2_2	51	56	PF00069	0.619
MOD_PIKK_1	218	224	PF00454	0.624
MOD_PK_1	310	316	PF00069	0.613
MOD_PKA_2	245	251	PF00069	0.553
MOD_PKA_2	279	285	PF00069	0.629
MOD_PKA_2	309	315	PF00069	0.657
MOD_Plk_1	144	150	PF00069	0.627
MOD_Plk_2-3	98	104	PF00069	0.622
MOD_Plk_4	210	216	PF00069	0.660
MOD_Plk_4	239	245	PF00069	0.567
MOD_Plk_4	300	306	PF00069	0.679
MOD_Plk_4	51	57	PF00069	0.655
MOD_ProDKin_1	165	171	PF00069	0.619
MOD_ProDKin_1	172	178	PF00069	0.618
MOD_ProDKin_1	187	193	PF00069	0.653
MOD_ProDKin_1	207	213	PF00069	0.437
MOD_ProDKin_1	222	228	PF00069	0.590
MOD_ProDKin_1	258	264	PF00069	0.569
MOD_ProDKin_1	269	275	PF00069	0.595
MOD_ProDKin_1	318	324	PF00069	0.571
MOD_ProDKin_1	326	332	PF00069	0.604
MOD_ProDKin_1	345	351	PF00069	0.646
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.538
TRG_ENDOCYTIC_2	125	128	PF00928	0.664
TRG_ENDOCYTIC_2	181	184	PF00928	0.630
TRG_ENDOCYTIC_2	320	323	PF00928	0.642
TRG_ER_diArg_1	111	114	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	58%	100%
A0A3Q8IAY2	Leishmania donovani	91%	99%
A4H5Z6	Leishmania braziliensis	80%	100%
A4HUC2	Leishmania infantum	92%	100%
Q4QHK5	Leishmania major	91%	100%
V5BE36	Trypanosoma cruzi	38%	100%