C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN21_LEIMU

TriTrypDb:

LmxM.10.0150

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AN21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN21

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	260	265	PF00400	0.553
DEG_SPOP_SBC_1	268	272	PF00917	0.656
DOC_CDC14_PxL_1	181	189	PF14671	0.609
DOC_CKS1_1	166	171	PF01111	0.649
DOC_CKS1_1	263	268	PF01111	0.562
DOC_PP2B_LxvP_1	154	157	PF13499	0.610
DOC_USP7_MATH_1	25	29	PF00917	0.635
DOC_USP7_MATH_1	267	271	PF00917	0.658
DOC_USP7_MATH_1	286	290	PF00917	0.487
DOC_USP7_MATH_1	84	88	PF00917	0.647

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	58%	100%
A0A3Q8IAY2	Leishmania donovani	91%	99%
A4H5Z6	Leishmania braziliensis	80%	100%
A4HUC2	Leishmania infantum	92%	100%
Q4QHK5	Leishmania major	91%	100%
V5BE36	Trypanosoma cruzi	38%	100%

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