Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial

Species:

Leishmania mexicana

UniProt:

E9AN20_LEIMU

TriTrypDb:

LmxM.10.0140

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043227	membrane-bounded organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9AN20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN20

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016072	rRNA metabolic process	7	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0009451	RNA modification	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003676	nucleic acid binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004386	helicase activity	2	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140640	catalytic activity, acting on a nucleic acid	2	17
GO:0140657	ATP-dependent activity	1	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0003724	RNA helicase activity	3	5
GO:0008186	ATP-dependent activity, acting on RNA	2	5
GO:0016787	hydrolase activity	2	10
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0003723	RNA binding	4	3
GO:0003743	translation initiation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.590
CLV_C14_Caspase3-7	199	203	PF00656	0.614
CLV_C14_Caspase3-7	20	24	PF00656	0.641
CLV_C14_Caspase3-7	31	35	PF00656	0.568
CLV_C14_Caspase3-7	683	687	PF00656	0.375
CLV_NRD_NRD_1	142	144	PF00675	0.592
CLV_NRD_NRD_1	402	404	PF00675	0.288
CLV_NRD_NRD_1	489	491	PF00675	0.456
CLV_NRD_NRD_1	558	560	PF00675	0.276
CLV_NRD_NRD_1	581	583	PF00675	0.233
CLV_NRD_NRD_1	675	677	PF00675	0.403
CLV_NRD_NRD_1	713	715	PF00675	0.586
CLV_PCSK_FUR_1	711	715	PF00082	0.592
CLV_PCSK_KEX2_1	142	144	PF00082	0.592
CLV_PCSK_KEX2_1	402	404	PF00082	0.276
CLV_PCSK_KEX2_1	540	542	PF00082	0.212
CLV_PCSK_KEX2_1	558	560	PF00082	0.212
CLV_PCSK_KEX2_1	583	585	PF00082	0.220
CLV_PCSK_KEX2_1	607	609	PF00082	0.254
CLV_PCSK_KEX2_1	713	715	PF00082	0.591
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.212
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.240
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.210
CLV_PCSK_PC7_1	398	404	PF00082	0.206
CLV_PCSK_SKI1_1	171	175	PF00082	0.556
CLV_PCSK_SKI1_1	320	324	PF00082	0.223
CLV_PCSK_SKI1_1	452	456	PF00082	0.307
CLV_PCSK_SKI1_1	513	517	PF00082	0.470
DEG_APCC_DBOX_1	451	459	PF00400	0.410
DEG_APCC_DBOX_1	512	520	PF00400	0.352
DEG_APCC_KENBOX_2	465	469	PF00400	0.463
DEG_Kelch_Keap1_1	343	348	PF01344	0.367
DEG_SCF_FBW7_1	649	654	PF00400	0.346
DEG_SPOP_SBC_1	341	345	PF00917	0.423
DOC_ANK_TNKS_1	141	148	PF00023	0.530
DOC_CKS1_1	411	416	PF01111	0.454
DOC_CKS1_1	648	653	PF01111	0.334
DOC_CKS1_1	691	696	PF01111	0.586
DOC_MAPK_gen_1	283	290	PF00069	0.388
DOC_MAPK_gen_1	402	411	PF00069	0.471
DOC_MAPK_gen_1	490	498	PF00069	0.405
DOC_MAPK_gen_1	540	546	PF00069	0.437
DOC_MAPK_HePTP_8	488	500	PF00069	0.331
DOC_MAPK_MEF2A_6	304	312	PF00069	0.378
DOC_MAPK_MEF2A_6	491	500	PF00069	0.434
DOC_PP2B_LxvP_1	565	568	PF13499	0.412
DOC_PP4_FxxP_1	648	651	PF00568	0.345
DOC_USP7_MATH_1	17	21	PF00917	0.603
DOC_USP7_MATH_1	292	296	PF00917	0.452
DOC_USP7_MATH_1	302	306	PF00917	0.466
DOC_USP7_MATH_1	342	346	PF00917	0.505
DOC_USP7_MATH_1	518	522	PF00917	0.410
DOC_USP7_MATH_1	8	12	PF00917	0.640
DOC_USP7_MATH_1	84	88	PF00917	0.540
DOC_USP7_MATH_1	90	94	PF00917	0.573
DOC_USP7_MATH_2	19	25	PF00917	0.531
DOC_WW_Pin1_4	15	20	PF00397	0.526
DOC_WW_Pin1_4	164	169	PF00397	0.525
DOC_WW_Pin1_4	236	241	PF00397	0.538
DOC_WW_Pin1_4	410	415	PF00397	0.454
DOC_WW_Pin1_4	445	450	PF00397	0.454
DOC_WW_Pin1_4	491	496	PF00397	0.427
DOC_WW_Pin1_4	647	652	PF00397	0.332
DOC_WW_Pin1_4	690	695	PF00397	0.636
DOC_WW_Pin1_4	93	98	PF00397	0.648
LIG_14-3-3_CanoR_1	362	366	PF00244	0.476
LIG_14-3-3_CanoR_1	641	651	PF00244	0.452
LIG_Actin_WH2_2	351	369	PF00022	0.411
LIG_APCC_ABBA_1	37	42	PF00400	0.548
LIG_BRCT_BRCA1_1	644	648	PF00533	0.331
LIG_Clathr_ClatBox_1	442	446	PF01394	0.406
LIG_CtBP_PxDLS_1	335	339	PF00389	0.391
LIG_eIF4E_1	63	69	PF01652	0.590
LIG_FHA_1	224	230	PF00498	0.475
LIG_FHA_1	25	31	PF00498	0.583
LIG_FHA_1	416	422	PF00498	0.450
LIG_FHA_1	437	443	PF00498	0.407
LIG_FHA_1	495	501	PF00498	0.446
LIG_FHA_1	604	610	PF00498	0.475
LIG_FHA_1	691	697	PF00498	0.587
LIG_FHA_1	83	89	PF00498	0.571
LIG_FHA_2	107	113	PF00498	0.538
LIG_FHA_2	16	22	PF00498	0.524
LIG_FHA_2	501	507	PF00498	0.477
LIG_FHA_2	551	557	PF00498	0.446
LIG_FHA_2	648	654	PF00498	0.464
LIG_Integrin_isoDGR_2	450	452	PF01839	0.210
LIG_LIR_Apic_2	23	29	PF02991	0.648
LIG_LIR_Apic_2	645	651	PF02991	0.338
LIG_LIR_Apic_2	688	694	PF02991	0.590
LIG_LIR_Nem_3	34	40	PF02991	0.597
LIG_PCNA_yPIPBox_3	311	325	PF02747	0.410
LIG_Rb_LxCxE_1	199	218	PF01857	0.520
LIG_Rb_LxCxE_1	475	494	PF01857	0.338
LIG_Rb_pABgroove_1	527	535	PF01858	0.341
LIG_RPA_C_Fungi	137	149	PF08784	0.505
LIG_SH2_CRK	372	376	PF00017	0.314
LIG_SH2_CRK	386	390	PF00017	0.314
LIG_SH2_CRK	492	496	PF00017	0.363
LIG_SH2_CRK	620	624	PF00017	0.257
LIG_SH2_NCK_1	620	624	PF00017	0.259
LIG_SH2_SRC	63	66	PF00017	0.485
LIG_SH2_STAP1	372	376	PF00017	0.209
LIG_SH2_STAT5	26	29	PF00017	0.615
LIG_SH2_STAT5	547	550	PF00017	0.271
LIG_SH3_3	149	155	PF00018	0.583
LIG_SH3_3	330	336	PF00018	0.225
LIG_SH3_3	347	353	PF00018	0.295
LIG_SH3_3	408	414	PF00018	0.333
LIG_SUMO_SIM_anti_2	497	503	PF11976	0.404
LIG_SUMO_SIM_par_1	27	34	PF11976	0.548
LIG_SUMO_SIM_par_1	354	360	PF11976	0.389
LIG_SUMO_SIM_par_1	432	437	PF11976	0.372
LIG_SUMO_SIM_par_1	441	446	PF11976	0.437
LIG_SUMO_SIM_par_1	494	499	PF11976	0.414
LIG_SUMO_SIM_par_1	597	603	PF11976	0.203
LIG_TRAF2_1	196	199	PF00917	0.563
LIG_TRAF2_1	314	317	PF00917	0.230
LIG_TRAF2_1	503	506	PF00917	0.506
LIG_TRAF2_1	553	556	PF00917	0.252
MOD_CDK_SPxxK_3	164	171	PF00069	0.528
MOD_CDK_SPxxK_3	445	452	PF00069	0.230
MOD_CDK_SPxxK_3	690	697	PF00069	0.554
MOD_CK1_1	11	17	PF00069	0.642
MOD_CK1_1	167	173	PF00069	0.597
MOD_CK1_1	24	30	PF00069	0.509
MOD_CK1_1	265	271	PF00069	0.473
MOD_CK1_1	295	301	PF00069	0.321
MOD_CK1_1	343	349	PF00069	0.248
MOD_CK1_1	484	490	PF00069	0.379
MOD_CK1_1	494	500	PF00069	0.369
MOD_CK1_1	566	572	PF00069	0.314
MOD_CK1_1	690	696	PF00069	0.588
MOD_CK1_1	93	99	PF00069	0.578
MOD_CK2_1	107	113	PF00069	0.770
MOD_CK2_1	15	21	PF00069	0.526
MOD_CK2_1	193	199	PF00069	0.603
MOD_CK2_1	342	348	PF00069	0.181
MOD_CK2_1	500	506	PF00069	0.471
MOD_CK2_1	550	556	PF00069	0.281
MOD_Cter_Amidation	711	714	PF01082	0.626
MOD_GlcNHglycan	10	14	PF01048	0.640
MOD_GlcNHglycan	120	123	PF01048	0.678
MOD_GlcNHglycan	177	180	PF01048	0.748
MOD_GlcNHglycan	264	267	PF01048	0.437
MOD_GlcNHglycan	274	277	PF01048	0.298
MOD_GlcNHglycan	294	297	PF01048	0.324
MOD_GlcNHglycan	330	333	PF01048	0.230
MOD_GlcNHglycan	345	348	PF01048	0.296
MOD_GlcNHglycan	398	401	PF01048	0.183
MOD_GlcNHglycan	42	45	PF01048	0.639
MOD_GlcNHglycan	452	455	PF01048	0.425
MOD_GlcNHglycan	56	59	PF01048	0.530
MOD_GlcNHglycan	565	568	PF01048	0.331
MOD_GlcNHglycan	576	579	PF01048	0.376
MOD_GlcNHglycan	723	726	PF01048	0.573
MOD_GlcNHglycan	92	95	PF01048	0.782
MOD_GSK3_1	102	109	PF00069	0.541
MOD_GSK3_1	11	18	PF00069	0.549
MOD_GSK3_1	160	167	PF00069	0.592
MOD_GSK3_1	190	197	PF00069	0.670
MOD_GSK3_1	217	224	PF00069	0.615
MOD_GSK3_1	268	275	PF00069	0.359
MOD_GSK3_1	336	343	PF00069	0.246
MOD_GSK3_1	357	364	PF00069	0.311
MOD_GSK3_1	472	479	PF00069	0.359
MOD_GSK3_1	496	503	PF00069	0.439
MOD_GSK3_1	563	570	PF00069	0.328
MOD_GSK3_1	574	581	PF00069	0.314
MOD_GSK3_1	599	606	PF00069	0.354
MOD_GSK3_1	647	654	PF00069	0.335
MOD_N-GLC_1	292	297	PF02516	0.189
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	138	143	PF00069	0.617
MOD_NEK2_1	181	186	PF00069	0.566
MOD_NEK2_1	221	226	PF00069	0.567
MOD_NEK2_1	262	267	PF00069	0.418
MOD_NEK2_1	272	277	PF00069	0.217
MOD_NEK2_1	371	376	PF00069	0.315
MOD_NEK2_1	496	501	PF00069	0.423
MOD_PIKK_1	104	110	PF00454	0.510
MOD_PIKK_1	631	637	PF00454	0.230
MOD_PKA_2	190	196	PF00069	0.584
MOD_PKA_2	268	274	PF00069	0.445
MOD_PKA_2	361	367	PF00069	0.320
MOD_PKA_2	550	556	PF00069	0.349
MOD_PKA_2	631	637	PF00069	0.292
MOD_PKA_2	8	14	PF00069	0.533
MOD_Plk_1	22	28	PF00069	0.696
MOD_Plk_1	687	693	PF00069	0.569
MOD_Plk_4	268	274	PF00069	0.388
MOD_Plk_4	361	367	PF00069	0.340
MOD_Plk_4	484	490	PF00069	0.443
MOD_Plk_4	496	502	PF00069	0.344
MOD_Plk_4	534	540	PF00069	0.291
MOD_Plk_4	567	573	PF00069	0.342
MOD_Plk_4	644	650	PF00069	0.378
MOD_Plk_4	687	693	PF00069	0.466
MOD_ProDKin_1	15	21	PF00069	0.526
MOD_ProDKin_1	164	170	PF00069	0.526
MOD_ProDKin_1	236	242	PF00069	0.540
MOD_ProDKin_1	410	416	PF00069	0.292
MOD_ProDKin_1	445	451	PF00069	0.292
MOD_ProDKin_1	491	497	PF00069	0.425
MOD_ProDKin_1	647	653	PF00069	0.330
MOD_ProDKin_1	690	696	PF00069	0.638
MOD_ProDKin_1	93	99	PF00069	0.648
MOD_SUMO_rev_2	729	735	PF00179	0.537
TRG_DiLeu_BaEn_1	378	383	PF01217	0.291
TRG_DiLeu_BaEn_4	316	322	PF01217	0.203
TRG_ENDOCYTIC_2	372	375	PF00928	0.330
TRG_ENDOCYTIC_2	386	389	PF00928	0.318
TRG_ER_diArg_1	282	285	PF00400	0.255
TRG_ER_diArg_1	401	403	PF00400	0.325
TRG_ER_diArg_1	557	559	PF00400	0.230
TRG_ER_diArg_1	579	582	PF00400	0.229
TRG_ER_diArg_1	710	713	PF00400	0.604
TRG_ER_diLys_1	732	736	PF00400	0.471
TRG_NES_CRM1_1	621	631	PF08389	0.225
TRG_NLS_MonoExtC_3	402	408	PF00514	0.225
TRG_NLS_MonoExtN_4	402	407	PF00514	0.225
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I458	Leptomonas seymouri	23%	100%
A0A0N1I5R1	Leptomonas seymouri	60%	93%
A0A0S4JSZ9	Bodo saltans	24%	100%
A0A1X0NRS9	Trypanosomatidae	34%	94%
A0A3Q8ID91	Leishmania donovani	27%	100%
A0A3Q8IQY6	Leishmania donovani	25%	100%
A0A3S5H5X3	Leishmania donovani	23%	100%
A0A3S5H6T7	Leishmania donovani	23%	100%
A0A3S7WR01	Leishmania donovani	89%	94%
A0A3S7X579	Leishmania donovani	24%	100%
A1CHL3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	21%	92%
A1DG51	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A4H4Y0	Leishmania braziliensis	23%	100%
A4H5Z5	Leishmania braziliensis	68%	98%
A4HGR1	Leishmania braziliensis	27%	100%
A4HK38	Leishmania braziliensis	25%	100%
A4HP82	Leishmania braziliensis	24%	100%
A4HTF8	Leishmania infantum	25%	100%
A4HUC1	Leishmania infantum	89%	94%
A4HWB0	Leishmania infantum	24%	100%
A4HZF8	Leishmania infantum	22%	100%
A4I3T6	Leishmania infantum	27%	100%
A4I7M5	Leishmania infantum	25%	100%
A4IDI7	Leishmania infantum	25%	100%
D0A3C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A4H6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AM86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AT30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
P0CQ74	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CQ75	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
Q4Q1G8	Leishmania major	23%	100%
Q4Q1K8	Leishmania major	24%	100%
Q4Q5M6	Leishmania major	26%	100%
Q4Q858	Leishmania major	28%	100%
Q4QHK6	Leishmania major	89%	100%
Q4QIG1	Leishmania major	26%	100%
Q4QIQ9	Leishmania major	23%	100%
Q8RXK6	Arabidopsis thaliana	22%	100%
V5BII0	Trypanosoma cruzi	35%	100%