Mu-transpos_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN19_LEIMU

TriTrypDb:

LmxM.10.0130

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.698
CLV_C14_Caspase3-7	410	414	PF00656	0.554
CLV_C14_Caspase3-7	530	534	PF00656	0.467
CLV_NRD_NRD_1	184	186	PF00675	0.529
CLV_NRD_NRD_1	209	211	PF00675	0.511
CLV_NRD_NRD_1	240	242	PF00675	0.518
CLV_NRD_NRD_1	449	451	PF00675	0.639
CLV_NRD_NRD_1	503	505	PF00675	0.627
CLV_NRD_NRD_1	90	92	PF00675	0.491
CLV_PCSK_KEX2_1	183	185	PF00082	0.591
CLV_PCSK_KEX2_1	208	210	PF00082	0.526
CLV_PCSK_KEX2_1	503	505	PF00082	0.749
CLV_PCSK_KEX2_1	622	624	PF00082	0.587
CLV_PCSK_KEX2_1	90	92	PF00082	0.558
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.627
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.749
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.587
CLV_PCSK_PC7_1	86	92	PF00082	0.575
CLV_PCSK_SKI1_1	11	15	PF00082	0.414
CLV_PCSK_SKI1_1	185	189	PF00082	0.603
CLV_PCSK_SKI1_1	210	214	PF00082	0.570
CLV_PCSK_SKI1_1	340	344	PF00082	0.486
CLV_PCSK_SKI1_1	437	441	PF00082	0.653
CLV_PCSK_SKI1_1	442	446	PF00082	0.652
CLV_PCSK_SKI1_1	485	489	PF00082	0.693
DEG_SPOP_SBC_1	603	607	PF00917	0.472
DOC_MAPK_gen_1	127	134	PF00069	0.491
DOC_MAPK_gen_1	183	189	PF00069	0.460
DOC_MAPK_gen_1	225	234	PF00069	0.572
DOC_MAPK_MEF2A_6	127	134	PF00069	0.440
DOC_MAPK_MEF2A_6	167	175	PF00069	0.475
DOC_MAPK_RevD_3	171	185	PF00069	0.492
DOC_PP4_FxxP_1	559	562	PF00568	0.599
DOC_SPAK_OSR1_1	9	13	PF12202	0.402
DOC_USP7_MATH_1	259	263	PF00917	0.415
DOC_USP7_MATH_1	468	472	PF00917	0.566
DOC_USP7_MATH_1	544	548	PF00917	0.724
DOC_USP7_MATH_1	554	558	PF00917	0.701
DOC_USP7_MATH_1	562	566	PF00917	0.672
DOC_USP7_MATH_1	598	602	PF00917	0.691
DOC_USP7_MATH_1	603	607	PF00917	0.663
DOC_USP7_MATH_1	611	615	PF00917	0.609
DOC_USP7_MATH_1	705	709	PF00917	0.674
DOC_USP7_MATH_2	694	700	PF00917	0.773
DOC_USP7_UBL2_3	349	353	PF12436	0.640
DOC_USP7_UBL2_3	438	442	PF12436	0.596
DOC_WW_Pin1_4	353	358	PF00397	0.579
DOC_WW_Pin1_4	36	41	PF00397	0.481
DOC_WW_Pin1_4	480	485	PF00397	0.711
DOC_WW_Pin1_4	514	519	PF00397	0.719
DOC_WW_Pin1_4	584	589	PF00397	0.743
DOC_WW_Pin1_4	659	664	PF00397	0.669
DOC_WW_Pin1_4	690	695	PF00397	0.717
LIG_14-3-3_CanoR_1	561	567	PF00244	0.675
LIG_14-3-3_CanoR_1	713	721	PF00244	0.761
LIG_Actin_WH2_2	322	339	PF00022	0.522
LIG_ActinCP_TwfCPI_2	559	567	PF01115	0.496
LIG_APCC_ABBA_1	132	137	PF00400	0.455
LIG_BIR_III_2	570	574	PF00653	0.591
LIG_Clathr_ClatBox_1	174	178	PF01394	0.466
LIG_EVH1_2	140	144	PF00568	0.494
LIG_FHA_1	219	225	PF00498	0.530
LIG_FHA_1	3	9	PF00498	0.487
LIG_FHA_1	318	324	PF00498	0.428
LIG_FHA_1	462	468	PF00498	0.716
LIG_FHA_1	517	523	PF00498	0.775
LIG_FHA_1	649	655	PF00498	0.767
LIG_FHA_1	99	105	PF00498	0.587
LIG_FHA_2	177	183	PF00498	0.530
LIG_FHA_2	224	230	PF00498	0.586
LIG_FHA_2	275	281	PF00498	0.586
LIG_FHA_2	481	487	PF00498	0.731
LIG_FHA_2	493	499	PF00498	0.734
LIG_FHA_2	702	708	PF00498	0.800
LIG_FHA_2	94	100	PF00498	0.402
LIG_IBAR_NPY_1	719	721	PF08397	0.661
LIG_LIR_Apic_2	557	562	PF02991	0.608
LIG_LIR_Gen_1	625	636	PF02991	0.697
LIG_LIR_Gen_1	642	650	PF02991	0.469
LIG_LIR_Nem_3	116	122	PF02991	0.497
LIG_LIR_Nem_3	143	147	PF02991	0.494
LIG_LIR_Nem_3	574	580	PF02991	0.743
LIG_LIR_Nem_3	642	648	PF02991	0.606
LIG_LIR_Nem_3	718	724	PF02991	0.722
LIG_NRBOX	176	182	PF00104	0.563
LIG_SH2_CRK	721	725	PF00017	0.741
LIG_SH2_NCK_1	645	649	PF00017	0.575
LIG_SH2_PTP2	236	239	PF00017	0.334
LIG_SH2_PTP2	76	79	PF00017	0.270
LIG_SH2_STAP1	26	30	PF00017	0.424
LIG_SH2_STAT3	42	45	PF00017	0.541
LIG_SH2_STAT5	236	239	PF00017	0.566
LIG_SH2_STAT5	254	257	PF00017	0.374
LIG_SH2_STAT5	26	29	PF00017	0.489
LIG_SH2_STAT5	42	45	PF00017	0.436
LIG_SH2_STAT5	666	669	PF00017	0.755
LIG_SH2_STAT5	721	724	PF00017	0.694
LIG_SH2_STAT5	76	79	PF00017	0.448
LIG_SH2_STAT5	84	87	PF00017	0.465
LIG_SH3_1	523	529	PF00018	0.654
LIG_SH3_2	518	523	PF14604	0.586
LIG_SH3_3	150	156	PF00018	0.662
LIG_SH3_3	515	521	PF00018	0.686
LIG_SH3_3	523	529	PF00018	0.647
LIG_SH3_3	592	598	PF00018	0.723
LIG_SUMO_SIM_par_1	11	16	PF11976	0.471
LIG_TRAF2_1	197	200	PF00917	0.654
LIG_TRAF2_1	288	291	PF00917	0.533
LIG_TRFH_1	594	598	PF08558	0.738
LIG_TYR_ITIM	234	239	PF00017	0.544
LIG_WRC_WIRS_1	654	659	PF05994	0.731
LIG_WW_1	663	666	PF00397	0.470
MOD_CDK_SPK_2	480	485	PF00069	0.724
MOD_CDK_SPxK_1	514	520	PF00069	0.543
MOD_CDK_SPxxK_3	353	360	PF00069	0.593
MOD_CK1_1	109	115	PF00069	0.504
MOD_CK1_1	274	280	PF00069	0.649
MOD_CK1_1	471	477	PF00069	0.715
MOD_CK1_1	557	563	PF00069	0.772
MOD_CK1_1	584	590	PF00069	0.660
MOD_CK1_1	669	675	PF00069	0.645
MOD_CK2_1	176	182	PF00069	0.470
MOD_CK2_1	194	200	PF00069	0.507
MOD_CK2_1	223	229	PF00069	0.586
MOD_CK2_1	258	264	PF00069	0.497
MOD_CK2_1	274	280	PF00069	0.582
MOD_CK2_1	285	291	PF00069	0.412
MOD_CK2_1	469	475	PF00069	0.619
MOD_CK2_1	50	56	PF00069	0.506
MOD_CK2_1	690	696	PF00069	0.774
MOD_CK2_1	701	707	PF00069	0.620
MOD_GlcNHglycan	109	112	PF01048	0.445
MOD_GlcNHglycan	261	264	PF01048	0.425
MOD_GlcNHglycan	272	276	PF01048	0.667
MOD_GlcNHglycan	45	48	PF01048	0.447
MOD_GlcNHglycan	478	481	PF01048	0.761
MOD_GlcNHglycan	529	532	PF01048	0.677
MOD_GlcNHglycan	537	540	PF01048	0.628
MOD_GlcNHglycan	613	616	PF01048	0.719
MOD_GlcNHglycan	636	639	PF01048	0.466
MOD_GlcNHglycan	677	680	PF01048	0.703
MOD_GlcNHglycan	685	688	PF01048	0.676
MOD_GSK3_1	109	116	PF00069	0.547
MOD_GSK3_1	270	277	PF00069	0.611
MOD_GSK3_1	32	39	PF00069	0.513
MOD_GSK3_1	341	348	PF00069	0.445
MOD_GSK3_1	403	410	PF00069	0.654
MOD_GSK3_1	466	473	PF00069	0.668
MOD_GSK3_1	476	483	PF00069	0.634
MOD_GSK3_1	557	564	PF00069	0.791
MOD_GSK3_1	598	605	PF00069	0.648
MOD_GSK3_1	690	697	PF00069	0.637
MOD_GSK3_1	701	708	PF00069	0.586
MOD_GSK3_1	722	729	PF00069	0.680
MOD_N-GLC_1	285	290	PF02516	0.546
MOD_N-GLC_1	35	40	PF02516	0.587
MOD_N-GLC_1	714	719	PF02516	0.783
MOD_N-GLC_2	421	423	PF02516	0.474
MOD_NEK2_1	121	126	PF00069	0.511
MOD_NEK2_1	258	263	PF00069	0.543
MOD_NEK2_1	336	341	PF00069	0.489
MOD_NEK2_1	460	465	PF00069	0.712
MOD_NEK2_1	499	504	PF00069	0.737
MOD_NEK2_1	581	586	PF00069	0.714
MOD_NEK2_2	562	567	PF00069	0.494
MOD_PIKK_1	98	104	PF00454	0.501
MOD_PKA_2	2	8	PF00069	0.561
MOD_PKA_2	469	475	PF00069	0.734
MOD_PKA_2	560	566	PF00069	0.748
MOD_PKA_2	669	675	PF00069	0.735
MOD_Plk_1	285	291	PF00069	0.553
MOD_Plk_1	632	638	PF00069	0.697
MOD_Plk_1	98	104	PF00069	0.554
MOD_Plk_4	113	119	PF00069	0.520
MOD_Plk_4	176	182	PF00069	0.474
MOD_Plk_4	24	30	PF00069	0.532
MOD_Plk_4	274	280	PF00069	0.673
MOD_Plk_4	576	582	PF00069	0.752
MOD_ProDKin_1	353	359	PF00069	0.572
MOD_ProDKin_1	36	42	PF00069	0.474
MOD_ProDKin_1	480	486	PF00069	0.710
MOD_ProDKin_1	514	520	PF00069	0.719
MOD_ProDKin_1	584	590	PF00069	0.746
MOD_ProDKin_1	659	665	PF00069	0.670
MOD_ProDKin_1	690	696	PF00069	0.717
MOD_SUMO_for_1	187	190	PF00179	0.669
MOD_SUMO_rev_2	197	204	PF00179	0.627
MOD_SUMO_rev_2	405	410	PF00179	0.670
TRG_DiLeu_BaEn_4	301	307	PF01217	0.497
TRG_ENDOCYTIC_2	236	239	PF00928	0.587
TRG_ENDOCYTIC_2	26	29	PF00928	0.524
TRG_ENDOCYTIC_2	628	631	PF00928	0.709
TRG_ENDOCYTIC_2	645	648	PF00928	0.527
TRG_ENDOCYTIC_2	721	724	PF00928	0.745
TRG_ENDOCYTIC_2	76	79	PF00928	0.511
TRG_ER_diArg_1	183	185	PF00400	0.522
TRG_ER_diArg_1	89	91	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD89	Leptomonas seymouri	62%	97%
A0A0S4J8X4	Bodo saltans	23%	91%
A0A1X0NRK9	Trypanosomatidae	38%	100%
A0A3Q8I7M1	Leishmania donovani	88%	99%
A0A422NRU0	Trypanosoma rangeli	39%	100%
A4H5Z4	Leishmania braziliensis	65%	100%
A4HUC0	Leishmania infantum	88%	100%
C9ZVH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
Q4QHK7	Leishmania major	86%	100%
V5B9H5	Trypanosoma cruzi	36%	100%