PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9AN18_LEIMU

TriTrypDb:

LmxM.10.0120

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AN18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.311
CLV_NRD_NRD_1	339	341	PF00675	0.588
CLV_NRD_NRD_1	358	360	PF00675	0.710
CLV_NRD_NRD_1	88	90	PF00675	0.689
CLV_PCSK_FUR_1	18	22	PF00082	0.426
CLV_PCSK_FUR_1	337	341	PF00082	0.589
CLV_PCSK_KEX2_1	20	22	PF00082	0.559
CLV_PCSK_KEX2_1	336	338	PF00082	0.559
CLV_PCSK_KEX2_1	339	341	PF00082	0.578
CLV_PCSK_KEX2_1	357	359	PF00082	0.471
CLV_PCSK_KEX2_1	88	90	PF00082	0.689
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.582
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.639
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.646
CLV_PCSK_PC7_1	353	359	PF00082	0.642
CLV_PCSK_SKI1_1	236	240	PF00082	0.569
CLV_PCSK_SKI1_1	292	296	PF00082	0.395
CLV_PCSK_SKI1_1	89	93	PF00082	0.688
DEG_Nend_UBRbox_3	1	3	PF02207	0.530
DEG_SCF_FBW7_1	69	75	PF00400	0.579
DOC_CKS1_1	69	74	PF01111	0.664
DOC_CYCLIN_RxL_1	86	95	PF00134	0.693
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.371
DOC_MAPK_gen_1	133	141	PF00069	0.579
DOC_MAPK_gen_1	240	250	PF00069	0.387
DOC_MAPK_MEF2A_6	150	159	PF00069	0.531
DOC_MAPK_MEF2A_6	182	191	PF00069	0.537
DOC_PP2B_LxvP_1	276	279	PF13499	0.424
DOC_PP2B_LxvP_1	29	32	PF13499	0.574
DOC_PP4_FxxP_1	166	169	PF00568	0.405
DOC_USP7_MATH_1	234	238	PF00917	0.537
DOC_USP7_MATH_1	24	28	PF00917	0.590
DOC_USP7_MATH_1	32	36	PF00917	0.649
DOC_USP7_MATH_1	45	49	PF00917	0.652
DOC_USP7_UBL2_3	134	138	PF12436	0.603
DOC_USP7_UBL2_3	236	240	PF12436	0.470
DOC_WW_Pin1_4	100	105	PF00397	0.685
DOC_WW_Pin1_4	215	220	PF00397	0.744
DOC_WW_Pin1_4	227	232	PF00397	0.765
DOC_WW_Pin1_4	41	46	PF00397	0.667
DOC_WW_Pin1_4	48	53	PF00397	0.640
DOC_WW_Pin1_4	68	73	PF00397	0.402
DOC_WW_Pin1_4	92	97	PF00397	0.654
LIG_14-3-3_CanoR_1	125	131	PF00244	0.659
LIG_14-3-3_CanoR_1	160	168	PF00244	0.517
LIG_14-3-3_CanoR_1	243	250	PF00244	0.458
LIG_14-3-3_CanoR_1	291	297	PF00244	0.311
LIG_14-3-3_CanoR_1	88	92	PF00244	0.539
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.691
LIG_BRCT_BRCA1_1	34	38	PF00533	0.569
LIG_Clathr_ClatBox_1	174	178	PF01394	0.557
LIG_FHA_1	154	160	PF00498	0.530
LIG_FHA_1	163	169	PF00498	0.508
LIG_FHA_1	179	185	PF00498	0.591
LIG_FHA_1	308	314	PF00498	0.424
LIG_FHA_1	69	75	PF00498	0.593
LIG_FHA_2	219	225	PF00498	0.821
LIG_IBAR_NPY_1	23	25	PF08397	0.533
LIG_LIR_Apic_2	163	169	PF02991	0.420
LIG_LIR_Gen_1	170	177	PF02991	0.572
LIG_LIR_Gen_1	300	309	PF02991	0.355
LIG_LIR_Gen_1	35	46	PF02991	0.607
LIG_LIR_Gen_1	63	74	PF02991	0.649
LIG_LIR_Nem_3	197	202	PF02991	0.582
LIG_LIR_Nem_3	300	306	PF02991	0.300
LIG_LIR_Nem_3	63	69	PF02991	0.583
LIG_Pex14_2	60	64	PF04695	0.530
LIG_SH2_CRK	66	70	PF00017	0.581
LIG_SH2_GRB2like	66	69	PF00017	0.715
LIG_SH2_NCK_1	66	70	PF00017	0.539
LIG_SH2_STAP1	172	176	PF00017	0.577
LIG_SH2_STAP1	25	29	PF00017	0.606
LIG_SH2_STAP1	298	302	PF00017	0.424
LIG_SH2_STAT3	73	76	PF00017	0.571
LIG_SH2_STAT5	140	143	PF00017	0.472
LIG_SH2_STAT5	266	269	PF00017	0.424
LIG_SH2_STAT5	298	301	PF00017	0.303
LIG_SH2_STAT5	303	306	PF00017	0.284
LIG_SH2_STAT5	73	76	PF00017	0.665
LIG_SH3_3	125	131	PF00018	0.594
LIG_SH3_3	143	149	PF00018	0.511
LIG_SH3_3	182	188	PF00018	0.475
LIG_SH3_3	66	72	PF00018	0.651
LIG_SUMO_SIM_par_1	187	192	PF11976	0.567
LIG_SUMO_SIM_par_1	277	283	PF11976	0.427
LIG_TRAF2_1	176	179	PF00917	0.609
LIG_TRAF2_1	221	224	PF00917	0.816
MOD_CDK_SPK_2	215	220	PF00069	0.588
MOD_CK1_1	105	111	PF00069	0.660
MOD_CK1_1	126	132	PF00069	0.691
MOD_CK1_1	162	168	PF00069	0.537
MOD_CK1_1	211	217	PF00069	0.722
MOD_CK1_1	218	224	PF00069	0.731
MOD_CK1_1	44	50	PF00069	0.705
MOD_CK1_1	67	73	PF00069	0.623
MOD_CK1_1	77	83	PF00069	0.613
MOD_CK2_1	218	224	PF00069	0.798
MOD_CK2_1	243	249	PF00069	0.419
MOD_Cter_Amidation	337	340	PF01082	0.698
MOD_Cter_Amidation	344	347	PF01082	0.668
MOD_GlcNHglycan	11	14	PF01048	0.656
MOD_GlcNHglycan	202	205	PF01048	0.481
MOD_GlcNHglycan	222	227	PF01048	0.590
MOD_GlcNHglycan	245	248	PF01048	0.420
MOD_GSK3_1	102	109	PF00069	0.708
MOD_GSK3_1	211	218	PF00069	0.708
MOD_GSK3_1	274	281	PF00069	0.489
MOD_GSK3_1	292	299	PF00069	0.207
MOD_GSK3_1	37	44	PF00069	0.667
MOD_GSK3_1	5	12	PF00069	0.658
MOD_GSK3_1	60	67	PF00069	0.589
MOD_GSK3_1	68	75	PF00069	0.538
MOD_N-GLC_1	67	72	PF02516	0.708
MOD_NEK2_1	124	129	PF00069	0.710
MOD_NEK2_1	14	19	PF00069	0.550
MOD_NEK2_1	208	213	PF00069	0.603
MOD_NEK2_1	64	69	PF00069	0.597
MOD_NEK2_1	74	79	PF00069	0.694
MOD_PIKK_1	72	78	PF00454	0.628
MOD_PKA_1	292	298	PF00069	0.366
MOD_PKA_2	124	130	PF00069	0.664
MOD_PKA_2	159	165	PF00069	0.507
MOD_PKA_2	296	302	PF00069	0.424
MOD_PKA_2	327	333	PF00069	0.589
MOD_PKA_2	87	93	PF00069	0.541
MOD_Plk_1	153	159	PF00069	0.498
MOD_Plk_1	162	168	PF00069	0.471
MOD_Plk_1	307	313	PF00069	0.424
MOD_Plk_1	32	38	PF00069	0.636
MOD_Plk_4	162	168	PF00069	0.507
MOD_Plk_4	170	176	PF00069	0.565
MOD_Plk_4	234	240	PF00069	0.578
MOD_Plk_4	37	43	PF00069	0.655
MOD_Plk_4	60	66	PF00069	0.603
MOD_ProDKin_1	100	106	PF00069	0.687
MOD_ProDKin_1	215	221	PF00069	0.748
MOD_ProDKin_1	227	233	PF00069	0.763
MOD_ProDKin_1	41	47	PF00069	0.666
MOD_ProDKin_1	48	54	PF00069	0.637
MOD_ProDKin_1	68	74	PF00069	0.403
MOD_ProDKin_1	92	98	PF00069	0.656
MOD_SUMO_for_1	206	209	PF00179	0.630
MOD_SUMO_for_1	219	222	PF00179	0.743
TRG_ENDOCYTIC_2	172	175	PF00928	0.562
TRG_ENDOCYTIC_2	303	306	PF00928	0.311
TRG_ENDOCYTIC_2	66	69	PF00928	0.668
TRG_ER_diArg_1	337	340	PF00400	0.586
TRG_ER_diArg_1	87	89	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	61%	95%
A0A0S4JEW1	Bodo saltans	28%	100%
A0A1X0NQL8	Trypanosomatidae	30%	91%
A0A3Q8IC14	Leishmania donovani	93%	100%
A0A3Q8ILM8	Leishmania donovani	32%	100%
A0A3R7KIC4	Trypanosoma rangeli	31%	92%
A4HUB9	Leishmania infantum	93%	100%
E9AI38	Leishmania braziliensis	83%	100%
E9AUD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q051	Leishmania major	32%	100%
Q4QHK8	Leishmania major	94%	100%
V5DA19	Trypanosoma cruzi	32%	92%