Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN17_LEIMU

TriTrypDb:

LmxM.10.0110

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0097361	CIA complex	3	12
GO:0140535	intracellular protein-containing complex	2	12

Expansion

Sequence features

E9AN17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN17

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.475
CLV_NRD_NRD_1	27	29	PF00675	0.557
CLV_PCSK_KEX2_1	115	117	PF00082	0.405
CLV_PCSK_KEX2_1	27	29	PF00082	0.408
CLV_PCSK_KEX2_1	275	277	PF00082	0.438
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.446
CLV_PCSK_SKI1_1	294	298	PF00082	0.438
CLV_Separin_Metazoa	245	249	PF03568	0.581
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DOC_CDC14_PxL_1	8	16	PF14671	0.518
DOC_CYCLIN_RxL_1	291	300	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.565
DOC_MAPK_RevD_3	12	28	PF00069	0.564
DOC_PP1_RVXF_1	136	143	PF00149	0.496
DOC_PP1_RVXF_1	89	96	PF00149	0.465
DOC_PP2B_LxvP_1	14	17	PF13499	0.421
DOC_PP2B_LxvP_1	240	243	PF13499	0.525
DOC_PP4_FxxP_1	186	189	PF00568	0.541
DOC_USP7_MATH_1	143	147	PF00917	0.469
DOC_USP7_MATH_1	292	296	PF00917	0.396
DOC_USP7_MATH_1	310	314	PF00917	0.354
DOC_USP7_MATH_1	52	56	PF00917	0.455
DOC_WW_Pin1_4	93	98	PF00397	0.455
LIG_14-3-3_CanoR_1	248	256	PF00244	0.584
LIG_14-3-3_CanoR_1	91	96	PF00244	0.478
LIG_APCC_ABBA_1	187	192	PF00400	0.560
LIG_APCC_ABBA_1	321	326	PF00400	0.476
LIG_BRCT_BRCA1_1	269	273	PF00533	0.361
LIG_BRCT_BRCA1_1	347	351	PF00533	0.496
LIG_BRCT_BRCA1_2	269	275	PF00533	0.400
LIG_Clathr_ClatBox_1	296	300	PF01394	0.426
LIG_CtBP_PxDLS_1	243	247	PF00389	0.575
LIG_deltaCOP1_diTrp_1	37	44	PF00928	0.456
LIG_FHA_1	108	114	PF00498	0.455
LIG_FHA_1	154	160	PF00498	0.455
LIG_FHA_1	173	179	PF00498	0.494
LIG_FHA_1	204	210	PF00498	0.445
LIG_FHA_1	27	33	PF00498	0.514
LIG_FHA_1	365	371	PF00498	0.560
LIG_FHA_1	45	51	PF00498	0.407
LIG_FHA_2	371	377	PF00498	0.541
LIG_LIR_Gen_1	217	227	PF02991	0.528
LIG_LIR_Gen_1	315	324	PF02991	0.425
LIG_LIR_Gen_1	74	82	PF02991	0.345
LIG_LIR_LC3C_4	194	199	PF02991	0.560
LIG_LIR_Nem_3	217	222	PF02991	0.486
LIG_LIR_Nem_3	315	321	PF02991	0.422
LIG_LIR_Nem_3	74	79	PF02991	0.311
LIG_MYND_1	13	17	PF01753	0.555
LIG_PDZ_Class_3	385	390	PF00595	0.245
LIG_Pex14_2	297	301	PF04695	0.426
LIG_PTAP_UEV_1	45	50	PF05743	0.490
LIG_SH2_STAP1	203	207	PF00017	0.466
LIG_SH2_STAT5	101	104	PF00017	0.496
LIG_SH3_1	43	49	PF00018	0.490
LIG_SH3_3	43	49	PF00018	0.530
LIG_SUMO_SIM_anti_2	266	273	PF11976	0.452
LIG_SUMO_SIM_par_1	12	19	PF11976	0.524
LIG_SUMO_SIM_par_1	194	200	PF11976	0.498
MOD_CK1_1	103	109	PF00069	0.541
MOD_CK1_1	350	356	PF00069	0.518
MOD_CK1_1	55	61	PF00069	0.555
MOD_CK2_1	77	83	PF00069	0.394
MOD_GlcNHglycan	150	153	PF01048	0.336
MOD_GlcNHglycan	18	21	PF01048	0.570
MOD_GlcNHglycan	288	291	PF01048	0.459
MOD_GlcNHglycan	312	315	PF01048	0.332
MOD_GlcNHglycan	385	388	PF01048	0.461
MOD_GlcNHglycan	54	57	PF01048	0.259
MOD_GlcNHglycan	67	70	PF01048	0.464
MOD_GlcNHglycan	97	100	PF01048	0.266
MOD_GSK3_1	103	110	PF00069	0.430
MOD_GSK3_1	143	150	PF00069	0.460
MOD_GSK3_1	228	235	PF00069	0.475
MOD_GSK3_1	263	270	PF00069	0.324
MOD_GSK3_1	310	317	PF00069	0.426
MOD_GSK3_1	52	59	PF00069	0.469
MOD_GSK3_1	74	81	PF00069	0.406
MOD_GSK3_1	91	98	PF00069	0.373
MOD_N-GLC_2	71	73	PF02516	0.500
MOD_NEK2_1	107	112	PF00069	0.459
MOD_NEK2_1	147	152	PF00069	0.489
MOD_NEK2_1	197	202	PF00069	0.471
MOD_NEK2_1	246	251	PF00069	0.578
MOD_NEK2_1	261	266	PF00069	0.437
MOD_NEK2_1	370	375	PF00069	0.466
MOD_NEK2_2	203	208	PF00069	0.455
MOD_NEK2_2	292	297	PF00069	0.380
MOD_NEK2_2	56	61	PF00069	0.455
MOD_OFUCOSY	73	78	PF10250	0.483
MOD_PIKK_1	350	356	PF00454	0.548
MOD_PKA_2	247	253	PF00069	0.581
MOD_PKA_2	26	32	PF00069	0.458
MOD_PKA_2	286	292	PF00069	0.471
MOD_Plk_1	153	159	PF00069	0.483
MOD_Plk_1	203	209	PF00069	0.466
MOD_Plk_1	228	234	PF00069	0.396
MOD_Plk_1	267	273	PF00069	0.345
MOD_Plk_1	292	298	PF00069	0.382
MOD_Plk_1	314	320	PF00069	0.454
MOD_Plk_1	375	381	PF00069	0.485
MOD_Plk_1	56	62	PF00069	0.480
MOD_Plk_4	109	115	PF00069	0.461
MOD_Plk_4	143	149	PF00069	0.521
MOD_Plk_4	228	234	PF00069	0.350
MOD_Plk_4	267	273	PF00069	0.333
MOD_Plk_4	375	381	PF00069	0.468
MOD_ProDKin_1	93	99	PF00069	0.455
MOD_SUMO_rev_2	131	140	PF00179	0.466
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.550
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.469
TRG_ER_diArg_1	114	116	PF00400	0.459
TRG_ER_diArg_1	26	28	PF00400	0.471
TRG_ER_FFAT_2	96	106	PF00635	0.560
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	75%
A0A0N1ILE6	Leptomonas seymouri	73%	97%
A0A0S4JE56	Bodo saltans	40%	94%
A0A0S4JL38	Bodo saltans	28%	73%
A0A0S4JQ93	Bodo saltans	26%	70%
A0A1X0NQ54	Trypanosomatidae	53%	96%
A0A1X0NVZ7	Trypanosomatidae	23%	75%
A0A3Q8IGC4	Leishmania donovani	24%	75%
A0A3R7M365	Trypanosoma rangeli	50%	93%
A0A3R7N6M9	Trypanosoma rangeli	24%	75%
A0A3R7NRU0	Trypanosoma rangeli	24%	88%
A0A3S7WQZ2	Leishmania donovani	95%	99%
A1CQL6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	32%	86%
A1D3I2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	31%	84%
A2QPW4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	95%
A3LVM1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	100%
A4H5Z3	Leishmania braziliensis	91%	100%
A4HDT7	Leishmania braziliensis	22%	100%
A4HUB8	Leishmania infantum	95%	99%
A4I135	Leishmania infantum	23%	75%
A4R7U3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	87%
A4REK3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
A5DHD2	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	100%
A5DXE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	23%	100%
A5E2R6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	28%	94%
A6RT32	Botryotinia fuckeliana (strain B05.10)	29%	89%
A6ZYM0	Saccharomyces cerevisiae (strain YJM789)	28%	100%
A7EZJ5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	26%	86%
A7RWD2	Nematostella vectensis	35%	100%
A7TLU2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	28%	100%
A8IZG4	Chlamydomonas reinhardtii	38%	100%
A8PWQ8	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	31%	100%
A9VDW7	Monosiga brevicollis	31%	77%
B0LSW3	Felis catus	24%	95%
B0XAF3	Culex quinquefasciatus	32%	100%
B0XQ15	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	31%	85%
B3MC74	Drosophila ananassae	34%	100%
B3NQR5	Drosophila erecta	33%	100%
B3RNR8	Trichoplax adhaerens	32%	100%
B4GDM7	Drosophila persimilis	33%	100%
B4HRQ6	Drosophila sechellia	33%	100%
B4JW81	Drosophila grimshawi	31%	100%
B4KTK4	Drosophila mojavensis	32%	100%
B4LJT7	Drosophila virilis	32%	100%
B4MY77	Drosophila willistoni	33%	100%
B4P7Q3	Drosophila yakuba	31%	100%
B4QFZ8	Drosophila simulans	33%	100%
B5X212	Salmo salar	35%	100%
B5X3Z6	Salmo salar	24%	95%
B5X9P2	Salmo salar	35%	100%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	84%
B6H7A3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	29%	86%
B7QKS1	Ixodes scapularis	36%	100%
B8MWR8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	31%	89%
B9WHJ2	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	27%	100%
C4JPW9	Uncinocarpus reesii (strain UAMH 1704)	26%	85%
C4Q0P6	Schistosoma mansoni	27%	94%
C7Z6H2	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	25%	87%
C9ZVH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	92%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	75%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	75%
O60907	Homo sapiens	22%	68%
O76071	Homo sapiens	34%	100%
O80990	Arabidopsis thaliana	34%	100%
O94319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P0CS30	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	89%
P0CS31	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	89%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	90%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	90%
P16520	Homo sapiens	23%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	76%
P43033	Bos taurus	24%	95%
P43034	Homo sapiens	24%	95%
P63004	Rattus norvegicus	24%	95%
P63005	Mus musculus	24%	95%
Q00664	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	88%
Q04491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q05583	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q0CCS0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	34%	92%
Q0USG2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	88%
Q17GR9	Aedes aegypti	32%	100%
Q1DR81	Coccidioides immitis (strain RS)	30%	82%
Q1DZQ0	Coccidioides immitis (strain RS)	23%	100%
Q28DW0	Xenopus tropicalis	32%	100%
Q292E8	Drosophila pseudoobscura pseudoobscura	33%	100%
Q2GP45	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	86%
Q2UPI0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	89%
Q32PJ6	Bos taurus	35%	100%
Q3Y8L7	Chlamydomonas reinhardtii	27%	87%
Q4ICM0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	85%
Q4P5F5	Ustilago maydis (strain 521 / FGSC 9021)	30%	86%
Q4QAA4	Leishmania major	23%	100%
Q4QHK9	Leishmania major	95%	100%
Q4R8H1	Macaca fascicularis	22%	69%
Q4RJN5	Tetraodon nigroviridis	25%	95%
Q4WTL0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	85%
Q55DA2	Dictyostelium discoideum	30%	100%
Q58D20	Bos taurus	26%	80%
Q5AG86	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
Q5B563	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5BDJ5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	87%
Q5DFU0	Schistosoma japonicum	30%	100%
Q5IS43	Pan troglodytes	24%	95%
Q5M7T1	Rattus norvegicus	35%	100%
Q5REG7	Pongo abelii	24%	95%
Q5RFF8	Pongo abelii	25%	80%
Q6BIR9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	99%
Q6CBI8	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%
Q6CMA2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6FJ73	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	21%	86%
Q6GPC6	Xenopus laevis	21%	75%
Q6NZH4	Xenopus tropicalis	24%	95%
Q6P0D9	Danio rerio	36%	100%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q75C26	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q7K1Y4	Drosophila melanogaster	32%	100%
Q7PS24	Anopheles gambiae	31%	100%
Q7SZM9	Xenopus laevis	21%	75%
Q7T394	Danio rerio	25%	95%
Q7ZVF0	Danio rerio	27%	94%
Q7ZXK9	Xenopus laevis	25%	82%
Q803D2	Danio rerio	25%	95%
Q8BHJ5	Mus musculus	22%	76%
Q8HXX0	Macaca fascicularis	24%	95%
Q8I0F4	Dictyostelium discoideum	25%	93%
Q8VEJ4	Mus musculus	27%	80%
Q90ZL4	Xenopus laevis	24%	95%
Q99KN2	Mus musculus	35%	100%
Q9BQ87	Homo sapiens	23%	75%
Q9BZK7	Homo sapiens	22%	76%
Q9D0I6	Mus musculus	24%	82%
Q9FLX9	Arabidopsis thaliana	23%	82%
Q9GL51	Sus scrofa	24%	95%
Q9NVX2	Homo sapiens	26%	80%
Q9P5P0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	83%
Q9PTR5	Gallus gallus	24%	95%
Q9QXE7	Mus musculus	23%	74%
Q9VPR4	Drosophila melanogaster	24%	80%
Q9XW12	Caenorhabditis elegans	28%	100%
V5BE41	Trypanosoma cruzi	50%	92%
V5BEB2	Trypanosoma cruzi	25%	72%