SRP40_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SRP40, C-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AN16_LEIMU

TriTrypDb:

LmxM.10.0100

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AN16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.695
CLV_NRD_NRD_1	156	158	PF00675	0.583
CLV_NRD_NRD_1	169	171	PF00675	0.697
CLV_NRD_NRD_1	182	184	PF00675	0.430
CLV_NRD_NRD_1	24	26	PF00675	0.656
CLV_NRD_NRD_1	92	94	PF00675	0.726
CLV_PCSK_KEX2_1	145	147	PF00082	0.626
CLV_PCSK_KEX2_1	169	171	PF00082	0.697
CLV_PCSK_KEX2_1	182	184	PF00082	0.430
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.626
CLV_PCSK_SKI1_1	118	122	PF00082	0.600
CLV_PCSK_SKI1_1	77	81	PF00082	0.778
CLV_Separin_Metazoa	216	220	PF03568	0.430
DEG_SPOP_SBC_1	79	83	PF00917	0.829
DOC_MAPK_gen_1	113	121	PF00069	0.504
DOC_MAPK_gen_1	203	211	PF00069	0.498
DOC_MAPK_MEF2A_6	113	121	PF00069	0.504
DOC_PP1_RVXF_1	189	195	PF00149	0.376
DOC_USP7_MATH_1	138	142	PF00917	0.745
DOC_USP7_MATH_1	79	83	PF00917	0.814
DOC_USP7_UBL2_3	114	118	PF12436	0.737
DOC_USP7_UBL2_3	223	227	PF12436	0.385
DOC_USP7_UBL2_3	229	233	PF12436	0.389
DOC_WW_Pin1_4	113	118	PF00397	0.642
DOC_WW_Pin1_4	168	173	PF00397	0.753
DOC_WW_Pin1_4	34	39	PF00397	0.647
DOC_WW_Pin1_4	54	59	PF00397	0.613
DOC_WW_Pin1_4	80	85	PF00397	0.752
DOC_WW_Pin1_4	92	97	PF00397	0.716
LIG_14-3-3_CanoR_1	146	151	PF00244	0.525
LIG_14-3-3_CanoR_1	52	58	PF00244	0.665
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_CtBP_PxDLS_1	240	246	PF00389	0.424
LIG_FHA_2	160	166	PF00498	0.768
LIG_LIR_Nem_3	178	184	PF02991	0.692
LIG_MYND_1	84	88	PF01753	0.513
LIG_SH2_STAT3	51	54	PF00017	0.706
LIG_SH2_STAT5	12	15	PF00017	0.569
LIG_SH3_3	104	110	PF00018	0.711
LIG_SxIP_EBH_1	80	93	PF03271	0.807
LIG_TRAF2_1	43	46	PF00917	0.584
LIG_TRAF2_1	67	70	PF00917	0.536
LIG_WW_3	154	158	PF00397	0.499
MOD_CDK_SPK_2	113	118	PF00069	0.699
MOD_CDK_SPxxK_3	34	41	PF00069	0.659
MOD_CK1_1	75	81	PF00069	0.796
MOD_CK1_1	82	88	PF00069	0.641
MOD_CK2_1	127	133	PF00069	0.725
MOD_CK2_1	146	152	PF00069	0.583
MOD_CK2_1	157	163	PF00069	0.664
MOD_CK2_1	250	256	PF00069	0.594
MOD_CK2_1	40	46	PF00069	0.604
MOD_CK2_1	63	69	PF00069	0.530
MOD_CK2_1	99	105	PF00069	0.717
MOD_Cter_Amidation	143	146	PF01082	0.704
MOD_Cter_Amidation	39	42	PF01082	0.711
MOD_GlcNHglycan	141	144	PF01048	0.815
MOD_GlcNHglycan	58	61	PF01048	0.508
MOD_GSK3_1	157	164	PF00069	0.579
MOD_GSK3_1	75	82	PF00069	0.814
MOD_GSK3_1	99	106	PF00069	0.769
MOD_N-GLC_1	127	132	PF02516	0.554
MOD_N-GLC_1	139	144	PF02516	0.704
MOD_N-GLC_1	62	67	PF02516	0.704
MOD_NEK2_1	217	222	PF00069	0.440
MOD_PIKK_1	72	78	PF00454	0.653
MOD_PKA_1	157	163	PF00069	0.510
MOD_PKA_2	72	78	PF00069	0.750
MOD_Plk_1	103	109	PF00069	0.709
MOD_Plk_1	241	247	PF00069	0.430
MOD_Plk_2-3	99	105	PF00069	0.717
MOD_Plk_4	82	88	PF00069	0.516
MOD_ProDKin_1	113	119	PF00069	0.639
MOD_ProDKin_1	168	174	PF00069	0.746
MOD_ProDKin_1	34	40	PF00069	0.640
MOD_ProDKin_1	54	60	PF00069	0.617
MOD_ProDKin_1	80	86	PF00069	0.751
MOD_ProDKin_1	92	98	PF00069	0.717
TRG_ER_diArg_1	181	183	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.720
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8F0	Bodo saltans	42%	100%
A0A1X0NQ23	Trypanosomatidae	52%	100%
A0A3S5H6F2	Leishmania donovani	89%	100%
A4H5Z2	Leishmania braziliensis	75%	98%
A4HUB7	Leishmania infantum	89%	100%
Q4QHL0	Leishmania major	89%	100%