Dehydrogenase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dehydrogenase-like protein

Species:

Leishmania mexicana

UniProt:

E9AN15_LEIMU

TriTrypDb:

LmxM.10.0090

Length:

412

Annotations

LeishMANIAdb annotations

Homologous to other Eukarytotic short-chain dehydrogenases.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AN15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	299	301	PF00675	0.431
CLV_NRD_NRD_1	385	387	PF00675	0.512
CLV_NRD_NRD_1	41	43	PF00675	0.281
CLV_NRD_NRD_1	62	64	PF00675	0.576
CLV_NRD_NRD_1	85	87	PF00675	0.620
CLV_PCSK_FUR_1	383	387	PF00082	0.507
CLV_PCSK_KEX2_1	211	213	PF00082	0.509
CLV_PCSK_KEX2_1	299	301	PF00082	0.431
CLV_PCSK_KEX2_1	385	387	PF00082	0.512
CLV_PCSK_KEX2_1	41	43	PF00082	0.281
CLV_PCSK_KEX2_1	62	64	PF00082	0.576
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.477
CLV_PCSK_PC7_1	295	301	PF00082	0.419
CLV_PCSK_SKI1_1	262	266	PF00082	0.638
CLV_PCSK_SKI1_1	287	291	PF00082	0.448
CLV_PCSK_SKI1_1	329	333	PF00082	0.614
CLV_PCSK_SKI1_1	385	389	PF00082	0.507
CLV_PCSK_SKI1_1	42	46	PF00082	0.338
CLV_PCSK_SKI1_1	93	97	PF00082	0.619
DEG_Nend_Nbox_1	1	3	PF02207	0.441
DOC_CYCLIN_RxL_1	281	294	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.281
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.306
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.346
DOC_MAPK_FxFP_2	336	339	PF00069	0.379
DOC_MAPK_gen_1	208	218	PF00069	0.310
DOC_MAPK_gen_1	62	70	PF00069	0.372
DOC_MAPK_MEF2A_6	134	141	PF00069	0.277
DOC_MAPK_MEF2A_6	164	172	PF00069	0.224
DOC_MAPK_MEF2A_6	211	220	PF00069	0.277
DOC_MAPK_MEF2A_6	63	72	PF00069	0.377
DOC_PP1_RVXF_1	162	168	PF00149	0.260
DOC_PP4_FxxP_1	336	339	PF00568	0.337
DOC_USP7_MATH_1	102	106	PF00917	0.354
DOC_USP7_MATH_1	158	162	PF00917	0.250
DOC_USP7_MATH_1	77	81	PF00917	0.435
DOC_USP7_UBL2_3	398	402	PF12436	0.380
DOC_WW_Pin1_4	200	205	PF00397	0.195
DOC_WW_Pin1_4	273	278	PF00397	0.416
DOC_WW_Pin1_4	369	374	PF00397	0.309
DOC_WW_Pin1_4	78	83	PF00397	0.422
DOC_WW_Pin1_4	96	101	PF00397	0.420
LIG_14-3-3_CanoR_1	20	29	PF00244	0.305
LIG_14-3-3_CanoR_1	71	76	PF00244	0.448
LIG_14-3-3_CanoR_1	86	95	PF00244	0.417
LIG_Actin_WH2_2	121	136	PF00022	0.281
LIG_Actin_WH2_2	319	335	PF00022	0.383
LIG_Actin_WH2_2	6	22	PF00022	0.277
LIG_BRCT_BRCA1_1	218	222	PF00533	0.281
LIG_BRCT_BRCA1_1	356	360	PF00533	0.310
LIG_Clathr_ClatBox_1	250	254	PF01394	0.331
LIG_eIF4E_1	283	289	PF01652	0.260
LIG_FHA_1	187	193	PF00498	0.290
LIG_FHA_1	227	233	PF00498	0.244
LIG_FHA_1	292	298	PF00498	0.247
LIG_FHA_1	398	404	PF00498	0.350
LIG_FHA_2	116	122	PF00498	0.277
LIG_FHA_2	13	19	PF00498	0.329
LIG_FHA_2	188	194	PF00498	0.164
LIG_FHA_2	261	267	PF00498	0.370
LIG_HP1_1	113	117	PF01393	0.211
LIG_LIR_Apic_2	334	339	PF02991	0.355
LIG_LIR_Nem_3	366	370	PF02991	0.358
LIG_NRBOX	284	290	PF00104	0.297
LIG_PCNA_yPIPBox_3	282	295	PF02747	0.297
LIG_PCNA_yPIPBox_3	381	390	PF02747	0.309
LIG_Pex14_2	323	327	PF04695	0.433
LIG_REV1ctd_RIR_1	56	67	PF16727	0.511
LIG_SH2_CRK	348	352	PF00017	0.297
LIG_SH2_CRK	367	371	PF00017	0.355
LIG_SH2_STAP1	214	218	PF00017	0.281
LIG_SH2_STAP1	293	297	PF00017	0.247
LIG_SH2_STAP1	361	365	PF00017	0.326
LIG_SH2_STAT5	293	296	PF00017	0.291
LIG_SH2_STAT5	348	351	PF00017	0.296
LIG_SH2_STAT5	391	394	PF00017	0.310
LIG_SH2_STAT5	53	56	PF00017	0.329
LIG_SH2_STAT5	8	11	PF00017	0.443
LIG_SH3_3	254	260	PF00018	0.348
LIG_SH3_3	271	277	PF00018	0.412
LIG_SH3_3	32	38	PF00018	0.291
LIG_SH3_4	398	405	PF00018	0.372
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.286
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.164
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.303
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.249
LIG_SUMO_SIM_par_1	112	118	PF11976	0.236
LIG_SUMO_SIM_par_1	372	378	PF11976	0.342
LIG_TYR_ITIM	346	351	PF00017	0.297
LIG_TYR_ITIM	389	394	PF00017	0.316
MOD_CK1_1	203	209	PF00069	0.264
MOD_CK1_1	239	245	PF00069	0.277
MOD_CK1_1	397	403	PF00069	0.370
MOD_CK2_1	115	121	PF00069	0.277
MOD_CK2_1	12	18	PF00069	0.329
MOD_CK2_1	77	83	PF00069	0.496
MOD_GlcNHglycan	104	107	PF01048	0.507
MOD_GlcNHglycan	238	241	PF01048	0.486
MOD_GlcNHglycan	356	359	PF01048	0.522
MOD_GlcNHglycan	65	68	PF01048	0.589
MOD_GlcNHglycan	88	91	PF01048	0.698
MOD_GSK3_1	273	280	PF00069	0.372
MOD_GSK3_1	303	310	PF00069	0.345
MOD_N-GLC_1	281	286	PF02516	0.520
MOD_NEK2_1	186	191	PF00069	0.164
MOD_NEK2_1	331	336	PF00069	0.430
MOD_NEK2_1	394	399	PF00069	0.453
MOD_NEK2_1	85	90	PF00069	0.422
MOD_NEK2_2	307	312	PF00069	0.228
MOD_PKA_1	86	92	PF00069	0.418
MOD_PKA_2	301	307	PF00069	0.355
MOD_PKA_2	85	91	PF00069	0.406
MOD_Plk_1	281	287	PF00069	0.317
MOD_Plk_4	246	252	PF00069	0.277
MOD_Plk_4	356	362	PF00069	0.301
MOD_ProDKin_1	200	206	PF00069	0.195
MOD_ProDKin_1	273	279	PF00069	0.408
MOD_ProDKin_1	369	375	PF00069	0.303
MOD_ProDKin_1	78	84	PF00069	0.420
MOD_ProDKin_1	96	102	PF00069	0.421
TRG_DiLeu_BaEn_1	366	371	PF01217	0.356
TRG_ENDOCYTIC_2	214	217	PF00928	0.281
TRG_ENDOCYTIC_2	348	351	PF00928	0.296
TRG_ENDOCYTIC_2	367	370	PF00928	0.361
TRG_ENDOCYTIC_2	391	394	PF00928	0.310
TRG_ER_diArg_1	299	302	PF00400	0.243
TRG_ER_diArg_1	383	386	PF00400	0.278
TRG_ER_diArg_1	62	64	PF00400	0.376
TRG_NES_CRM1_1	382	395	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P0	Leptomonas seymouri	66%	100%
A0A0N0P2S5	Leptomonas seymouri	29%	92%
A0A0N0P2S7	Leptomonas seymouri	26%	80%
A0A0S4IP03	Bodo saltans	26%	100%
A0A0S4IWT0	Bodo saltans	27%	88%
A0A0S4IZG2	Bodo saltans	28%	91%
A0A0S4J1I6	Bodo saltans	26%	94%
A0A0S4JBQ4	Bodo saltans	36%	100%
A0A0U5CNP2	Aspergillus calidoustus	27%	100%
A0A1J0HSL5	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	25%	100%
A0A1V0QS34	Hericium erinaceus	28%	100%
A0A1X0NVT8	Trypanosomatidae	30%	83%
A0A1X0P5Q9	Trypanosomatidae	26%	90%
A0A1X0P5W3	Trypanosomatidae	27%	92%
A0A2H3CZZ2	Armillaria gallica	29%	100%
A0A3Q8ID46	Leishmania donovani	27%	81%
A0A3Q8IM89	Leishmania donovani	25%	94%
A0A3R7N7S2	Trypanosoma rangeli	29%	96%
A0A3S7WQY1	Leishmania donovani	94%	100%
A0A422N2B6	Trypanosoma rangeli	28%	86%
A2RVM0	Arabidopsis thaliana	27%	100%
A4H5Z1	Leishmania braziliensis	82%	100%
A4HDP3	Leishmania braziliensis	25%	100%
A4HMN7	Leishmania braziliensis	25%	100%
A4HUB6	Leishmania infantum	94%	100%
B2X050	Capsicum annuum	25%	100%
C8VI80	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
E9AH89	Leishmania infantum	27%	81%
E9AHV6	Leishmania infantum	25%	94%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	81%
F4JJR8	Arabidopsis thaliana	27%	100%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P59837	Bos taurus	33%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0V6Q2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	100%
Q17QU7	Bos taurus	32%	100%
Q17QW3	Bos taurus	33%	100%
Q42850	Hordeum vulgare	28%	100%
Q4QAE9	Leishmania major	27%	81%
Q4QHL1	Leishmania major	92%	100%
Q5SS80	Mus musculus	32%	100%
Q6RVV4	Pisum sativum	28%	100%
Q6UX07	Homo sapiens	31%	100%
Q803A8	Danio rerio	29%	100%
Q8BYK4	Mus musculus	34%	100%
Q8CEE7	Mus musculus	31%	100%
Q8NBN7	Homo sapiens	32%	100%
Q8VBZ0	Mus musculus	31%	100%
Q91WL8	Mus musculus	26%	100%
Q949M3	Brassica napus	23%	100%
Q96NR8	Homo sapiens	34%	100%
Q9ERI6	Mus musculus	32%	100%
Q9HBH5	Homo sapiens	33%	100%
V5BAF4	Trypanosoma cruzi	29%	87%
V5BJC7	Trypanosoma cruzi	24%	93%
V5BNY6	Trypanosoma cruzi	31%	96%