Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AN14_LEIMU

TriTrypDb:

LmxM.10.0080

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.391
CLV_NRD_NRD_1	137	139	PF00675	0.430
CLV_NRD_NRD_1	142	144	PF00675	0.375
CLV_NRD_NRD_1	219	221	PF00675	0.384
CLV_PCSK_KEX2_1	137	139	PF00082	0.430
CLV_PCSK_KEX2_1	142	144	PF00082	0.403
CLV_PCSK_KEX2_1	219	221	PF00082	0.384
CLV_PCSK_PC7_1	138	144	PF00082	0.366
CLV_PCSK_SKI1_1	241	245	PF00082	0.383
CLV_PCSK_SKI1_1	63	67	PF00082	0.357
DEG_APCC_DBOX_1	60	68	PF00400	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.518
DEG_SPOP_SBC_1	328	332	PF00917	0.321
DOC_CYCLIN_yClb5_NLxxxL_5	187	196	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.343
DOC_MAPK_gen_1	219	229	PF00069	0.407
DOC_MAPK_gen_1	61	69	PF00069	0.402
DOC_USP7_MATH_1	71	75	PF00917	0.443
DOC_USP7_MATH_1	90	94	PF00917	0.312
DOC_WW_Pin1_4	36	41	PF00397	0.557
LIG_14-3-3_CanoR_1	118	124	PF00244	0.399
LIG_14-3-3_CanoR_1	142	150	PF00244	0.333
LIG_14-3-3_CanoR_1	171	175	PF00244	0.515
LIG_14-3-3_CanoR_1	220	229	PF00244	0.408
LIG_14-3-3_CanoR_1	241	247	PF00244	0.372
LIG_14-3-3_CanoR_1	282	286	PF00244	0.376
LIG_14-3-3_CanoR_1	327	337	PF00244	0.332
LIG_14-3-3_CanoR_1	63	68	PF00244	0.360
LIG_14-3-3_CanoR_1	72	77	PF00244	0.415
LIG_BRCT_BRCA1_1	74	78	PF00533	0.428
LIG_Clathr_ClatBox_1	64	68	PF01394	0.356
LIG_FHA_1	15	21	PF00498	0.579
LIG_FHA_1	173	179	PF00498	0.468
LIG_FHA_1	203	209	PF00498	0.314
LIG_FHA_1	64	70	PF00498	0.357
LIG_FHA_2	243	249	PF00498	0.369
LIG_FHA_2	310	316	PF00498	0.543
LIG_Integrin_isoDGR_2	33	35	PF01839	0.367
LIG_LIR_Apic_2	19	25	PF02991	0.358
LIG_LIR_Gen_1	269	279	PF02991	0.355
LIG_LIR_Gen_1	292	303	PF02991	0.383
LIG_LIR_Gen_1	48	55	PF02991	0.353
LIG_LIR_Gen_1	75	82	PF02991	0.385
LIG_LIR_Nem_3	269	275	PF02991	0.355
LIG_LIR_Nem_3	292	298	PF02991	0.368
LIG_LIR_Nem_3	48	53	PF02991	0.332
LIG_LIR_Nem_3	75	81	PF02991	0.388
LIG_LIR_Nem_3	9	15	PF02991	0.429
LIG_PDZ_Class_1	338	343	PF00595	0.341
LIG_RPA_C_Fungi	215	227	PF08784	0.359
LIG_SH2_CRK	12	16	PF00017	0.420
LIG_SH2_CRK	22	26	PF00017	0.356
LIG_SH2_STAP1	250	254	PF00017	0.362
LIG_SH2_STAP1	338	342	PF00017	0.329
LIG_SH2_STAT3	164	167	PF00017	0.382
LIG_SH2_STAT5	124	127	PF00017	0.451
LIG_SH2_STAT5	250	253	PF00017	0.329
LIG_SH2_STAT5	272	275	PF00017	0.342
LIG_SH2_STAT5	97	100	PF00017	0.392
LIG_SH3_3	257	263	PF00018	0.415
LIG_SUMO_SIM_par_1	197	205	PF11976	0.312
LIG_SUMO_SIM_par_1	87	94	PF11976	0.390
LIG_WRC_WIRS_1	243	248	PF05994	0.362
LIG_WRC_WIRS_1	50	55	PF05994	0.529
MOD_CK1_1	145	151	PF00069	0.325
MOD_CK1_1	173	179	PF00069	0.401
MOD_CK1_1	183	189	PF00069	0.296
MOD_CK1_1	202	208	PF00069	0.362
MOD_CK1_1	289	295	PF00069	0.358
MOD_CK1_1	309	315	PF00069	0.279
MOD_CK1_1	331	337	PF00069	0.332
MOD_CK1_1	36	42	PF00069	0.504
MOD_CK1_1	74	80	PF00069	0.426
MOD_CK2_1	242	248	PF00069	0.365
MOD_CK2_1	90	96	PF00069	0.392
MOD_GlcNHglycan	107	110	PF01048	0.425
MOD_GlcNHglycan	144	147	PF01048	0.291
MOD_GlcNHglycan	188	191	PF01048	0.592
MOD_GlcNHglycan	229	232	PF01048	0.294
MOD_GlcNHglycan	259	263	PF01048	0.527
MOD_GlcNHglycan	268	271	PF01048	0.377
MOD_GlcNHglycan	308	311	PF01048	0.382
MOD_GlcNHglycan	320	323	PF01048	0.438
MOD_GlcNHglycan	333	336	PF01048	0.325
MOD_GlcNHglycan	68	72	PF01048	0.393
MOD_GSK3_1	105	112	PF00069	0.487
MOD_GSK3_1	129	136	PF00069	0.480
MOD_GSK3_1	145	152	PF00069	0.306
MOD_GSK3_1	172	179	PF00069	0.345
MOD_GSK3_1	182	189	PF00069	0.404
MOD_GSK3_1	274	281	PF00069	0.413
MOD_GSK3_1	29	36	PF00069	0.485
MOD_GSK3_1	298	305	PF00069	0.401
MOD_GSK3_1	314	321	PF00069	0.373
MOD_GSK3_1	327	334	PF00069	0.332
MOD_GSK3_1	45	52	PF00069	0.280
MOD_GSK3_1	63	70	PF00069	0.354
MOD_GSK3_1	96	103	PF00069	0.500
MOD_LATS_1	140	146	PF00433	0.349
MOD_NEK2_1	149	154	PF00069	0.367
MOD_NEK2_1	227	232	PF00069	0.299
MOD_NEK2_1	298	303	PF00069	0.505
MOD_NEK2_1	314	319	PF00069	0.273
MOD_NEK2_1	67	72	PF00069	0.535
MOD_NEK2_1	8	13	PF00069	0.481
MOD_NEK2_1	81	86	PF00069	0.329
MOD_NEK2_2	119	124	PF00069	0.350
MOD_OFUCOSY	44	49	PF10250	0.246
MOD_PK_1	72	78	PF00069	0.441
MOD_PKA_1	142	148	PF00069	0.332
MOD_PKA_2	117	123	PF00069	0.527
MOD_PKA_2	142	148	PF00069	0.408
MOD_PKA_2	170	176	PF00069	0.554
MOD_PKA_2	221	227	PF00069	0.408
MOD_PKA_2	281	287	PF00069	0.376
MOD_PKA_2	29	35	PF00069	0.378
MOD_PKA_2	71	77	PF00069	0.457
MOD_PKB_1	61	69	PF00069	0.364
MOD_Plk_1	183	189	PF00069	0.411
MOD_Plk_1	202	208	PF00069	0.362
MOD_Plk_1	248	254	PF00069	0.376
MOD_Plk_1	314	320	PF00069	0.271
MOD_Plk_4	119	125	PF00069	0.353
MOD_Plk_4	145	151	PF00069	0.368
MOD_Plk_4	183	189	PF00069	0.411
MOD_Plk_4	268	274	PF00069	0.367
MOD_Plk_4	281	287	PF00069	0.339
MOD_Plk_4	309	315	PF00069	0.398
MOD_Plk_4	74	80	PF00069	0.367
MOD_ProDKin_1	36	42	PF00069	0.543
MOD_SUMO_for_1	275	278	PF00179	0.351
TRG_DiLeu_BaEn_2	202	208	PF01217	0.243
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.381
TRG_ENDOCYTIC_2	12	15	PF00928	0.428
TRG_ENDOCYTIC_2	272	275	PF00928	0.342
TRG_ER_diArg_1	141	143	PF00400	0.438
TRG_ER_diArg_1	219	222	PF00400	0.430
TRG_ER_diArg_1	61	64	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ49	Leptomonas seymouri	46%	100%
A0A3S7WQY3	Leishmania donovani	93%	100%
A4H5Z0	Leishmania braziliensis	82%	100%
A4HUB5	Leishmania infantum	94%	100%
Q4QHL2	Leishmania major	93%	100%