Thymidylate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thymidylate kinase-like protein

Species:

Leishmania mexicana

UniProt:

E9AN12_LEIMU

TriTrypDb:

LmxM.10.0060

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AN12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN12

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006220	pyrimidine nucleotide metabolic process	5	5
GO:0006221	pyrimidine nucleotide biosynthetic process	6	5
GO:0006227	dUDP biosynthetic process	8	1
GO:0006233	dTDP biosynthetic process	8	5
GO:0006235	dTTP biosynthetic process	8	1
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006753	nucleoside phosphate metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0009058	biosynthetic process	2	5
GO:0009117	nucleotide metabolic process	5	5
GO:0009132	nucleoside diphosphate metabolic process	5	5
GO:0009133	nucleoside diphosphate biosynthetic process	6	5
GO:0009138	pyrimidine nucleoside diphosphate metabolic process	6	5
GO:0009139	pyrimidine nucleoside diphosphate biosynthetic process	7	5
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009147	pyrimidine nucleoside triphosphate metabolic process	6	1
GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	5
GO:0009186	deoxyribonucleoside diphosphate metabolic process	6	5
GO:0009189	deoxyribonucleoside diphosphate biosynthetic process	7	5
GO:0009196	pyrimidine deoxyribonucleoside diphosphate metabolic process	7	5
GO:0009197	pyrimidine deoxyribonucleoside diphosphate biosynthetic process	8	5
GO:0009211	pyrimidine deoxyribonucleoside triphosphate metabolic process	7	1
GO:0009212	pyrimidine deoxyribonucleoside triphosphate biosynthetic process	8	1
GO:0009219	pyrimidine deoxyribonucleotide metabolic process	6	5
GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	7	5
GO:0009262	deoxyribonucleotide metabolic process	4	5
GO:0009263	deoxyribonucleotide biosynthetic process	5	5
GO:0009265	2'-deoxyribonucleotide biosynthetic process	6	5
GO:0009394	2'-deoxyribonucleotide metabolic process	5	5
GO:0018130	heterocycle biosynthetic process	4	5
GO:0019438	aromatic compound biosynthetic process	4	5
GO:0019637	organophosphate metabolic process	3	5
GO:0019692	deoxyribose phosphate metabolic process	4	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034654	nucleobase-containing compound biosynthetic process	4	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0044281	small molecule metabolic process	2	5
GO:0046072	dTDP metabolic process	7	5
GO:0046075	dTTP metabolic process	7	1
GO:0046077	dUDP metabolic process	7	1
GO:0046385	deoxyribose phosphate biosynthetic process	5	5
GO:0046483	heterocycle metabolic process	3	5
GO:0055086	nucleobase-containing small molecule metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0072527	pyrimidine-containing compound metabolic process	4	5
GO:0072528	pyrimidine-containing compound biosynthetic process	5	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901135	carbohydrate derivative metabolic process	3	5
GO:1901137	carbohydrate derivative biosynthetic process	4	5
GO:1901293	nucleoside phosphate biosynthetic process	5	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901362	organic cyclic compound biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004798	thymidylate kinase activity	6	10
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	10
GO:0019205	nucleobase-containing compound kinase activity	5	10
GO:0050145	nucleoside monophosphate kinase activity	5	10
GO:0004550	nucleoside diphosphate kinase activity	5	1
GO:0009041	uridylate kinase activity	6	1
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.294
CLV_NRD_NRD_1	119	121	PF00675	0.432
CLV_NRD_NRD_1	159	161	PF00675	0.393
CLV_NRD_NRD_1	223	225	PF00675	0.342
CLV_NRD_NRD_1	288	290	PF00675	0.275
CLV_NRD_NRD_1	292	294	PF00675	0.390
CLV_NRD_NRD_1	335	337	PF00675	0.527
CLV_PCSK_KEX2_1	159	161	PF00082	0.428
CLV_PCSK_KEX2_1	223	225	PF00082	0.367
CLV_PCSK_KEX2_1	288	290	PF00082	0.275
CLV_PCSK_KEX2_1	335	337	PF00082	0.531
CLV_PCSK_SKI1_1	185	189	PF00082	0.319
CLV_PCSK_SKI1_1	250	254	PF00082	0.425
CLV_PCSK_SKI1_1	335	339	PF00082	0.448
DEG_APCC_DBOX_1	60	68	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.397
DEG_SCF_FBW7_1	97	104	PF00400	0.483
DEG_SPOP_SBC_1	130	134	PF00917	0.466
DOC_CKS1_1	98	103	PF01111	0.482
DOC_CYCLIN_RxL_1	182	189	PF00134	0.163
DOC_MAPK_gen_1	223	230	PF00069	0.339
DOC_MAPK_MEF2A_6	269	278	PF00069	0.353
DOC_PP1_RVXF_1	214	221	PF00149	0.418
DOC_PP2B_LxvP_1	265	268	PF13499	0.259
DOC_PP2B_LxvP_1	276	279	PF13499	0.290
DOC_USP7_MATH_1	113	117	PF00917	0.566
DOC_USP7_MATH_1	123	127	PF00917	0.342
DOC_USP7_MATH_1	131	135	PF00917	0.512
DOC_USP7_MATH_1	22	26	PF00917	0.468
DOC_WW_Pin1_4	103	108	PF00397	0.600
DOC_WW_Pin1_4	97	102	PF00397	0.504
LIG_14-3-3_CanoR_1	223	229	PF00244	0.370
LIG_14-3-3_CanoR_1	269	274	PF00244	0.397
LIG_14-3-3_CanoR_1	309	315	PF00244	0.308
LIG_APCC_ABBAyCdc20_2	2	8	PF00400	0.364
LIG_BRCT_BRCA1_1	169	173	PF00533	0.265
LIG_Clathr_ClatBox_1	29	33	PF01394	0.236
LIG_Dynein_DLC8_1	148	154	PF01221	0.287
LIG_FHA_1	152	158	PF00498	0.306
LIG_FHA_1	269	275	PF00498	0.406
LIG_FHA_1	345	351	PF00498	0.521
LIG_FHA_1	94	100	PF00498	0.459
LIG_FHA_2	336	342	PF00498	0.443
LIG_FHA_2	77	83	PF00498	0.527
LIG_KLC1_Yacidic_2	28	33	PF13176	0.430
LIG_LIR_Apic_2	54	58	PF02991	0.361
LIG_LIR_Gen_1	23	34	PF02991	0.519
LIG_LIR_Gen_1	256	267	PF02991	0.325
LIG_LIR_Gen_1	272	283	PF02991	0.248
LIG_LIR_Gen_1	84	95	PF02991	0.481
LIG_LIR_Nem_3	125	130	PF02991	0.415
LIG_LIR_Nem_3	23	29	PF02991	0.495
LIG_LIR_Nem_3	256	262	PF02991	0.327
LIG_LIR_Nem_3	263	267	PF02991	0.301
LIG_LIR_Nem_3	272	278	PF02991	0.284
LIG_LIR_Nem_3	70	74	PF02991	0.397
LIG_LIR_Nem_3	84	90	PF02991	0.302
LIG_PCNA_TLS_4	121	128	PF02747	0.307
LIG_Pex14_1	46	50	PF04695	0.498
LIG_SH2_CRK	180	184	PF00017	0.310
LIG_SH2_CRK	55	59	PF00017	0.366
LIG_SH2_NCK_1	55	59	PF00017	0.366
LIG_SH2_PTP2	31	34	PF00017	0.494
LIG_SH2_SRC	31	34	PF00017	0.480
LIG_SH2_SRC	55	58	PF00017	0.356
LIG_SH2_STAP1	234	238	PF00017	0.386
LIG_SH2_STAP1	26	30	PF00017	0.436
LIG_SH2_STAP1	87	91	PF00017	0.424
LIG_SH2_STAT5	234	237	PF00017	0.295
LIG_SH2_STAT5	275	278	PF00017	0.263
LIG_SH2_STAT5	31	34	PF00017	0.455
LIG_SH2_STAT5	74	77	PF00017	0.463
LIG_SH3_3	95	101	PF00018	0.465
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.476
LIG_SUMO_SIM_par_1	138	143	PF11976	0.403
LIG_SUMO_SIM_par_1	95	100	PF11976	0.366
LIG_TRAF2_1	246	249	PF00917	0.325
LIG_TRAF2_1	338	341	PF00917	0.502
LIG_TYR_ITIM	273	278	PF00017	0.305
LIG_TYR_ITIM	29	34	PF00017	0.496
LIG_WRC_WIRS_1	124	129	PF05994	0.373
LIG_WRC_WIRS_1	202	207	PF05994	0.416
MOD_CK1_1	126	132	PF00069	0.497
MOD_CK1_1	133	139	PF00069	0.481
MOD_CK1_1	345	351	PF00069	0.518
MOD_CK2_1	132	138	PF00069	0.553
MOD_CK2_1	191	197	PF00069	0.370
MOD_CK2_1	22	28	PF00069	0.364
MOD_CK2_1	252	258	PF00069	0.338
MOD_CK2_1	335	341	PF00069	0.515
MOD_Cter_Amidation	189	192	PF01082	0.330
MOD_Cter_Amidation	333	336	PF01082	0.473
MOD_GlcNHglycan	10	13	PF01048	0.545
MOD_GlcNHglycan	117	120	PF01048	0.463
MOD_GlcNHglycan	135	138	PF01048	0.401
MOD_GlcNHglycan	188	191	PF01048	0.331
MOD_GlcNHglycan	36	39	PF01048	0.486
MOD_GSK3_1	126	133	PF00069	0.486
MOD_GSK3_1	201	208	PF00069	0.310
MOD_GSK3_1	4	11	PF00069	0.479
MOD_GSK3_1	41	48	PF00069	0.500
MOD_GSK3_1	76	83	PF00069	0.435
MOD_GSK3_1	93	100	PF00069	0.402
MOD_NEK2_1	205	210	PF00069	0.306
MOD_NEK2_1	67	72	PF00069	0.566
MOD_NEK2_2	123	128	PF00069	0.492
MOD_PIKK_1	149	155	PF00454	0.308
MOD_PIKK_1	32	38	PF00454	0.292
MOD_PK_1	191	197	PF00069	0.409
MOD_PK_1	224	230	PF00069	0.350
MOD_PK_1	269	275	PF00069	0.200
MOD_PKA_1	191	197	PF00069	0.409
MOD_PKA_1	223	229	PF00069	0.428
MOD_PKA_1	335	341	PF00069	0.538
MOD_PKA_2	223	229	PF00069	0.369
MOD_PKA_2	268	274	PF00069	0.473
MOD_PKA_2	310	316	PF00069	0.296
MOD_PKA_2	335	341	PF00069	0.420
MOD_Plk_1	76	82	PF00069	0.320
MOD_Plk_2-3	167	173	PF00069	0.265
MOD_Plk_4	123	129	PF00069	0.482
MOD_Plk_4	224	230	PF00069	0.424
MOD_Plk_4	269	275	PF00069	0.393
MOD_Plk_4	67	73	PF00069	0.538
MOD_Plk_4	93	99	PF00069	0.421
MOD_ProDKin_1	97	103	PF00069	0.523
MOD_SUMO_rev_2	62	70	PF00179	0.613
TRG_DiLeu_BaEn_1	93	98	PF01217	0.410
TRG_DiLeu_BaEn_2	12	18	PF01217	0.227
TRG_DiLeu_BaEn_3	248	254	PF01217	0.325
TRG_ENDOCYTIC_2	180	183	PF00928	0.308
TRG_ENDOCYTIC_2	26	29	PF00928	0.518
TRG_ENDOCYTIC_2	275	278	PF00928	0.289
TRG_ENDOCYTIC_2	31	34	PF00928	0.494
TRG_ENDOCYTIC_2	87	90	PF00928	0.395
TRG_ER_diArg_1	158	160	PF00400	0.431
TRG_ER_diArg_1	222	224	PF00400	0.386
TRG_ER_diArg_1	287	289	PF00400	0.275
TRG_ER_diArg_1	335	337	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS08	Leptomonas seymouri	63%	100%
A0A0S4KK84	Bodo saltans	37%	95%
A0A1X0NRS1	Trypanosomatidae	47%	100%
A0A3Q8I8L2	Leishmania donovani	93%	100%
A0A3R7KQ58	Trypanosoma rangeli	52%	100%
A0A3R7LZ67	Trypanosoma rangeli	26%	90%
A4H5Y8	Leishmania braziliensis	84%	100%
A4HUB3	Leishmania infantum	93%	100%
C9ZVH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4QHL4	Leishmania major	93%	100%
V5AU19	Trypanosoma cruzi	50%	100%
V5BR99	Trypanosoma cruzi	29%	89%