MMS19 nucleotide excision repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dos2-interacting transcription regulator of RNA-Pol-II, putative

Species:

Leishmania mexicana

UniProt:

E9AN11_LEIMU

TriTrypDb:

LmxM.10.0050

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0097361	CIA complex	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0140535	intracellular protein-containing complex	2	8

Expansion

Sequence features

E9AN11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN11

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006790	sulfur compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0016226	iron-sulfur cluster assembly	4	8
GO:0019538	protein metabolic process	3	8
GO:0022607	cellular component assembly	4	8
GO:0031163	metallo-sulfur cluster assembly	5	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051604	protein maturation	4	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.286
CLV_C14_Caspase3-7	692	696	PF00656	0.603
CLV_MEL_PAP_1	279	285	PF00089	0.498
CLV_NRD_NRD_1	554	556	PF00675	0.379
CLV_NRD_NRD_1	645	647	PF00675	0.340
CLV_NRD_NRD_1	796	798	PF00675	0.325
CLV_NRD_NRD_1	903	905	PF00675	0.371
CLV_NRD_NRD_1	95	97	PF00675	0.447
CLV_PCSK_KEX2_1	192	194	PF00082	0.451
CLV_PCSK_KEX2_1	554	556	PF00082	0.499
CLV_PCSK_KEX2_1	645	647	PF00082	0.340
CLV_PCSK_KEX2_1	902	904	PF00082	0.367
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.486
CLV_PCSK_PC1ET2_1	902	904	PF00082	0.367
CLV_PCSK_PC7_1	188	194	PF00082	0.451
CLV_PCSK_SKI1_1	152	156	PF00082	0.477
CLV_PCSK_SKI1_1	271	275	PF00082	0.514
CLV_PCSK_SKI1_1	34	38	PF00082	0.486
CLV_PCSK_SKI1_1	502	506	PF00082	0.265
CLV_PCSK_SKI1_1	554	558	PF00082	0.317
CLV_PCSK_SKI1_1	797	801	PF00082	0.431
CLV_PCSK_SKI1_1	812	816	PF00082	0.232
CLV_PCSK_SKI1_1	830	834	PF00082	0.231
CLV_PCSK_SKI1_1	866	870	PF00082	0.424
DEG_APCC_DBOX_1	615	623	PF00400	0.535
DEG_APCC_DBOX_1	811	819	PF00400	0.515
DEG_APCC_DBOX_1	865	873	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.399
DEG_SPOP_SBC_1	635	639	PF00917	0.441
DOC_CDC14_PxL_1	734	742	PF14671	0.523
DOC_CKS1_1	5	10	PF01111	0.378
DOC_CKS1_1	78	83	PF01111	0.252
DOC_CYCLIN_RxL_1	268	278	PF00134	0.314
DOC_CYCLIN_RxL_1	808	819	PF00134	0.526
DOC_CYCLIN_RxL_1	853	863	PF00134	0.516
DOC_MAPK_gen_1	192	199	PF00069	0.277
DOC_MAPK_gen_1	885	893	PF00069	0.537
DOC_MAPK_JIP1_4	747	753	PF00069	0.546
DOC_MAPK_MEF2A_6	192	199	PF00069	0.284
DOC_MAPK_MEF2A_6	220	228	PF00069	0.259
DOC_MAPK_MEF2A_6	30	37	PF00069	0.277
DOC_MAPK_MEF2A_6	675	684	PF00069	0.580
DOC_MAPK_MEF2A_6	747	755	PF00069	0.555
DOC_MAPK_NFAT4_5	192	200	PF00069	0.286
DOC_MAPK_NFAT4_5	30	38	PF00069	0.252
DOC_PP1_RVXF_1	32	38	PF00149	0.277
DOC_PP1_RVXF_1	810	817	PF00149	0.505
DOC_PP1_RVXF_1	828	835	PF00149	0.586
DOC_PP2B_LxvP_1	203	206	PF13499	0.277
DOC_PP4_FxxP_1	174	177	PF00568	0.245
DOC_USP7_MATH_1	147	151	PF00917	0.277
DOC_USP7_MATH_1	213	217	PF00917	0.273
DOC_USP7_MATH_1	315	319	PF00917	0.299
DOC_USP7_MATH_1	365	369	PF00917	0.495
DOC_USP7_MATH_1	446	450	PF00917	0.628
DOC_USP7_MATH_1	464	468	PF00917	0.437
DOC_USP7_MATH_1	511	515	PF00917	0.520
DOC_USP7_MATH_1	53	57	PF00917	0.242
DOC_USP7_MATH_1	600	604	PF00917	0.606
DOC_USP7_MATH_1	611	615	PF00917	0.574
DOC_USP7_MATH_1	768	772	PF00917	0.526
DOC_USP7_MATH_1	92	96	PF00917	0.252
DOC_WW_Pin1_4	211	216	PF00397	0.245
DOC_WW_Pin1_4	391	396	PF00397	0.565
DOC_WW_Pin1_4	4	9	PF00397	0.390
DOC_WW_Pin1_4	572	577	PF00397	0.483
DOC_WW_Pin1_4	77	82	PF00397	0.252
LIG_14-3-3_CanoR_1	854	859	PF00244	0.502
LIG_14-3-3_CanoR_1	866	872	PF00244	0.527
LIG_Actin_WH2_2	605	622	PF00022	0.430
LIG_APCC_ABBA_1	197	202	PF00400	0.277
LIG_APCC_ABBA_1	519	524	PF00400	0.524
LIG_APCC_ABBAyCdc20_2	830	836	PF00400	0.522
LIG_BRCT_BRCA1_1	103	107	PF00533	0.277
LIG_BRCT_BRCA1_1	166	170	PF00533	0.245
LIG_BRCT_BRCA1_1	339	343	PF00533	0.320
LIG_BRCT_BRCA1_1	574	578	PF00533	0.461
LIG_BRCT_BRCA1_1	830	834	PF00533	0.550
LIG_Clathr_ClatBox_1	137	141	PF01394	0.246
LIG_Clathr_ClatBox_1	815	819	PF01394	0.474
LIG_CSL_BTD_1	441	444	PF09270	0.558
LIG_eIF4E_1	234	240	PF01652	0.252
LIG_eIF4E_1	855	861	PF01652	0.423
LIG_FHA_1	109	115	PF00498	0.286
LIG_FHA_1	137	143	PF00498	0.264
LIG_FHA_1	268	274	PF00498	0.325
LIG_FHA_1	320	326	PF00498	0.299
LIG_FHA_1	392	398	PF00498	0.582
LIG_FHA_1	461	467	PF00498	0.548
LIG_FHA_1	564	570	PF00498	0.574
LIG_FHA_1	651	657	PF00498	0.526
LIG_FHA_1	663	669	PF00498	0.616
LIG_FHA_1	81	87	PF00498	0.277
LIG_FHA_2	155	161	PF00498	0.323
LIG_FHA_2	181	187	PF00498	0.245
LIG_FHA_2	227	233	PF00498	0.277
LIG_FHA_2	289	295	PF00498	0.327
LIG_FHA_2	379	385	PF00498	0.527
LIG_FHA_2	527	533	PF00498	0.515
LIG_FHA_2	635	641	PF00498	0.519
LIG_FHA_2	802	808	PF00498	0.470
LIG_GBD_Chelix_1	338	346	PF00786	0.285
LIG_GBD_Chelix_1	542	550	PF00786	0.228
LIG_LIR_Gen_1	153	163	PF02991	0.270
LIG_LIR_Gen_1	340	350	PF02991	0.501
LIG_LIR_Gen_1	418	428	PF02991	0.519
LIG_LIR_Gen_1	454	464	PF02991	0.467
LIG_LIR_Gen_1	476	485	PF02991	0.526
LIG_LIR_Gen_1	710	720	PF02991	0.551
LIG_LIR_Gen_1	732	741	PF02991	0.565
LIG_LIR_Gen_1	83	93	PF02991	0.320
LIG_LIR_Nem_3	153	158	PF02991	0.256
LIG_LIR_Nem_3	160	166	PF02991	0.233
LIG_LIR_Nem_3	167	173	PF02991	0.224
LIG_LIR_Nem_3	229	234	PF02991	0.286
LIG_LIR_Nem_3	340	346	PF02991	0.454
LIG_LIR_Nem_3	454	460	PF02991	0.486
LIG_LIR_Nem_3	476	480	PF02991	0.650
LIG_LIR_Nem_3	71	77	PF02991	0.246
LIG_LIR_Nem_3	710	716	PF02991	0.558
LIG_LIR_Nem_3	732	737	PF02991	0.556
LIG_LIR_Nem_3	80	85	PF02991	0.244
LIG_LIR_Nem_3	852	858	PF02991	0.507
LIG_LIR_Nem_3	915	919	PF02991	0.530
LIG_MLH1_MIPbox_1	166	170	PF16413	0.245
LIG_NRBOX	119	125	PF00104	0.245
LIG_NRBOX	223	229	PF00104	0.277
LIG_NRBOX	488	494	PF00104	0.542
LIG_NRBOX	514	520	PF00104	0.516
LIG_NRBOX	750	756	PF00104	0.561
LIG_NRBOX	788	794	PF00104	0.520
LIG_PCNA_yPIPBox_3	786	798	PF02747	0.499
LIG_Pex14_2	170	174	PF04695	0.245
LIG_Pex14_2	522	526	PF04695	0.650
LIG_PTAP_UEV_1	495	500	PF05743	0.519
LIG_PTB_Apo_2	655	662	PF02174	0.504
LIG_REV1ctd_RIR_1	37	47	PF16727	0.245
LIG_SH2_CRK	855	859	PF00017	0.433
LIG_SH2_NCK_1	477	481	PF00017	0.528
LIG_SH2_PTP2	85	88	PF00017	0.252
LIG_SH2_STAT3	234	237	PF00017	0.277
LIG_SH2_STAT5	162	165	PF00017	0.280
LIG_SH2_STAT5	169	172	PF00017	0.286
LIG_SH2_STAT5	341	344	PF00017	0.339
LIG_SH2_STAT5	736	739	PF00017	0.519
LIG_SH2_STAT5	85	88	PF00017	0.252
LIG_SH3_3	438	444	PF00018	0.546
LIG_SH3_3	477	483	PF00018	0.436
LIG_SH3_3	493	499	PF00018	0.664
LIG_SH3_3	75	81	PF00018	0.286
LIG_SH3_5	81	85	PF00018	0.183
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.307
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.289
LIG_SUMO_SIM_anti_2	55	63	PF11976	0.240
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.475
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.442
LIG_SUMO_SIM_anti_2	791	796	PF11976	0.445
LIG_SUMO_SIM_anti_2	888	894	PF11976	0.519
LIG_SUMO_SIM_par_1	122	128	PF11976	0.271
LIG_SUMO_SIM_par_1	134	139	PF11976	0.286
LIG_SUMO_SIM_par_1	888	894	PF11976	0.502
LIG_TRAF2_1	45	48	PF00917	0.362
LIG_TRAF2_1	729	732	PF00917	0.521
LIG_TRAF2_1	876	879	PF00917	0.568
LIG_TYR_ITIM	853	858	PF00017	0.429
LIG_TYR_ITSM	81	88	PF00017	0.252
LIG_UBA3_1	102	110	PF00899	0.272
LIG_UBA3_1	792	798	PF00899	0.491
LIG_WRC_WIRS_1	102	107	PF05994	0.286
LIG_WRC_WIRS_1	137	142	PF05994	0.264
LIG_WRC_WIRS_1	257	262	PF05994	0.363
LIG_WRC_WIRS_1	708	713	PF05994	0.662
MOD_CDK_SPxK_1	4	10	PF00069	0.386
MOD_CK1_1	165	171	PF00069	0.245
MOD_CK1_1	214	220	PF00069	0.249
MOD_CK1_1	265	271	PF00069	0.371
MOD_CK1_1	288	294	PF00069	0.312
MOD_CK1_1	587	593	PF00069	0.620
MOD_CK1_1	614	620	PF00069	0.573
MOD_CK1_1	801	807	PF00069	0.630
MOD_CK2_1	128	134	PF00069	0.253
MOD_CK2_1	147	153	PF00069	0.245
MOD_CK2_1	288	294	PF00069	0.367
MOD_CK2_1	378	384	PF00069	0.541
MOD_CK2_1	385	391	PF00069	0.596
MOD_CK2_1	526	532	PF00069	0.570
MOD_CK2_1	801	807	PF00069	0.529
MOD_CK2_1	873	879	PF00069	0.531
MOD_GlcNHglycan	310	313	PF01048	0.505
MOD_GlcNHglycan	317	320	PF01048	0.511
MOD_GlcNHglycan	367	370	PF01048	0.308
MOD_GlcNHglycan	435	438	PF01048	0.304
MOD_GlcNHglycan	496	499	PF01048	0.375
MOD_GlcNHglycan	589	592	PF01048	0.316
MOD_GlcNHglycan	598	601	PF01048	0.291
MOD_GlcNHglycan	613	616	PF01048	0.333
MOD_GlcNHglycan	695	698	PF01048	0.439
MOD_GlcNHglycan	770	773	PF01048	0.389
MOD_GlcNHglycan	800	803	PF01048	0.433
MOD_GlcNHglycan	908	911	PF01048	0.306
MOD_GSK3_1	101	108	PF00069	0.286
MOD_GSK3_1	207	214	PF00069	0.383
MOD_GSK3_1	281	288	PF00069	0.304
MOD_GSK3_1	315	322	PF00069	0.308
MOD_GSK3_1	337	344	PF00069	0.369
MOD_GSK3_1	386	393	PF00069	0.596
MOD_GSK3_1	460	467	PF00069	0.538
MOD_GSK3_1	580	587	PF00069	0.486
MOD_GSK3_1	596	603	PF00069	0.484
MOD_GSK3_1	667	674	PF00069	0.626
MOD_GSK3_1	797	804	PF00069	0.552
MOD_GSK3_1	867	874	PF00069	0.491
MOD_N-GLC_1	265	270	PF02516	0.563
MOD_N-GLC_1	587	592	PF02516	0.340
MOD_N-GLC_1	834	839	PF02516	0.325
MOD_N-GLC_2	333	335	PF02516	0.308
MOD_N-GLC_2	820	822	PF02516	0.229
MOD_NEK2_1	114	119	PF00069	0.236
MOD_NEK2_1	145	150	PF00069	0.212
MOD_NEK2_1	17	22	PF00069	0.247
MOD_NEK2_1	207	212	PF00069	0.274
MOD_NEK2_1	337	342	PF00069	0.352
MOD_NEK2_1	433	438	PF00069	0.524
MOD_NEK2_1	510	515	PF00069	0.500
MOD_NEK2_1	526	531	PF00069	0.609
MOD_NEK2_1	584	589	PF00069	0.490
MOD_NEK2_1	707	712	PF00069	0.598
MOD_NEK2_1	739	744	PF00069	0.548
MOD_NEK2_1	828	833	PF00069	0.542
MOD_NEK2_1	834	839	PF00069	0.538
MOD_NEK2_1	860	865	PF00069	0.503
MOD_NEK2_1	871	876	PF00069	0.500
MOD_NEK2_1	891	896	PF00069	0.548
MOD_NEK2_2	849	854	PF00069	0.615
MOD_OFUCOSY	272	277	PF10250	0.492
MOD_PIKK_1	172	178	PF00454	0.232
MOD_PIKK_1	233	239	PF00454	0.277
MOD_PIKK_1	288	294	PF00454	0.337
MOD_PIKK_1	402	408	PF00454	0.514
MOD_PIKK_1	662	668	PF00454	0.560
MOD_PIKK_1	739	745	PF00454	0.527
MOD_PIKK_1	873	879	PF00454	0.560
MOD_PK_1	285	291	PF00069	0.267
MOD_PKA_1	797	803	PF00069	0.548
MOD_PKA_2	148	154	PF00069	0.269
MOD_PKA_2	262	268	PF00069	0.378
MOD_PKA_2	281	287	PF00069	0.405
MOD_PKA_2	386	392	PF00069	0.674
MOD_PKA_2	563	569	PF00069	0.608
MOD_PKA_2	746	752	PF00069	0.515
MOD_PKB_1	904	912	PF00069	0.558
MOD_Plk_1	108	114	PF00069	0.286
MOD_Plk_1	265	271	PF00069	0.361
MOD_Plk_1	418	424	PF00069	0.473
MOD_Plk_1	834	840	PF00069	0.540
MOD_Plk_2-3	128	134	PF00069	0.245
MOD_Plk_4	101	107	PF00069	0.270
MOD_Plk_4	154	160	PF00069	0.272
MOD_Plk_4	165	171	PF00069	0.229
MOD_Plk_4	242	248	PF00069	0.208
MOD_Plk_4	319	325	PF00069	0.266
MOD_Plk_4	337	343	PF00069	0.313
MOD_Plk_4	451	457	PF00069	0.457
MOD_Plk_4	580	586	PF00069	0.413
MOD_Plk_4	602	608	PF00069	0.534
MOD_Plk_4	707	713	PF00069	0.563
MOD_Plk_4	746	752	PF00069	0.647
MOD_Plk_4	867	873	PF00069	0.493
MOD_ProDKin_1	211	217	PF00069	0.245
MOD_ProDKin_1	391	397	PF00069	0.558
MOD_ProDKin_1	4	10	PF00069	0.386
MOD_ProDKin_1	572	578	PF00069	0.478
MOD_ProDKin_1	77	83	PF00069	0.252
MOD_SUMO_for_1	250	253	PF00179	0.286
MOD_SUMO_rev_2	874	881	PF00179	0.559
TRG_DiLeu_BaEn_1	580	585	PF01217	0.508
TRG_DiLeu_BaEn_3	72	78	PF01217	0.246
TRG_DiLeu_BaEn_4	878	884	PF01217	0.550
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.371
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.518
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.535
TRG_ENDOCYTIC_2	169	172	PF00928	0.245
TRG_ENDOCYTIC_2	200	203	PF00928	0.277
TRG_ENDOCYTIC_2	320	323	PF00928	0.267
TRG_ENDOCYTIC_2	477	480	PF00928	0.529
TRG_ENDOCYTIC_2	713	716	PF00928	0.562
TRG_ENDOCYTIC_2	736	739	PF00928	0.516
TRG_ENDOCYTIC_2	85	88	PF00928	0.351
TRG_ENDOCYTIC_2	855	858	PF00928	0.431
TRG_ER_diArg_1	553	555	PF00400	0.475
TRG_ER_diArg_1	644	646	PF00400	0.547
TRG_ER_diArg_1	903	906	PF00400	0.607
TRG_ER_FFAT_1	572	583	PF00635	0.430
TRG_NES_CRM1_1	222	237	PF08389	0.183
TRG_NLS_MonoExtC_3	901	906	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU9	Leptomonas seymouri	52%	95%
A0A1X0NRK4	Trypanosomatidae	26%	97%
A0A3S7WQY6	Leishmania donovani	89%	100%
A4H5Y7	Leishmania braziliensis	78%	100%
A4HUB2	Leishmania infantum	89%	100%
Q4QHL5	Leishmania major	89%	100%