Gryzun domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gryzun, putative trafficking through Golgi, putative

Species:

Leishmania mexicana

UniProt:

E9AN10_LEIMU

TriTrypDb:

LmxM.10.0040

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.508
CLV_C14_Caspase3-7	304	308	PF00656	0.503
CLV_MEL_PAP_1	831	837	PF00089	0.282
CLV_NRD_NRD_1	206	208	PF00675	0.422
CLV_NRD_NRD_1	237	239	PF00675	0.549
CLV_NRD_NRD_1	371	373	PF00675	0.293
CLV_NRD_NRD_1	73	75	PF00675	0.393
CLV_NRD_NRD_1	77	79	PF00675	0.551
CLV_NRD_NRD_1	883	885	PF00675	0.477
CLV_PCSK_KEX2_1	371	373	PF00082	0.293
CLV_PCSK_KEX2_1	73	75	PF00082	0.393
CLV_PCSK_KEX2_1	749	751	PF00082	0.485
CLV_PCSK_KEX2_1	883	885	PF00082	0.434
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.485
CLV_PCSK_PC7_1	745	751	PF00082	0.480
CLV_PCSK_SKI1_1	124	128	PF00082	0.482
CLV_PCSK_SKI1_1	269	273	PF00082	0.477
CLV_PCSK_SKI1_1	30	34	PF00082	0.491
CLV_PCSK_SKI1_1	434	438	PF00082	0.341
CLV_PCSK_SKI1_1	457	461	PF00082	0.385
CLV_PCSK_SKI1_1	513	517	PF00082	0.520
CLV_PCSK_SKI1_1	519	523	PF00082	0.526
CLV_PCSK_SKI1_1	528	532	PF00082	0.351
CLV_PCSK_SKI1_1	694	698	PF00082	0.632
CLV_PCSK_SKI1_1	723	727	PF00082	0.427
CLV_PCSK_SKI1_1	750	754	PF00082	0.435
CLV_PCSK_SKI1_1	79	83	PF00082	0.540
CLV_PCSK_SKI1_1	805	809	PF00082	0.369
CLV_PCSK_SKI1_1	812	816	PF00082	0.457
CLV_PCSK_SKI1_1	897	901	PF00082	0.478
DEG_APCC_DBOX_1	896	904	PF00400	0.485
DEG_MDM2_SWIB_1	97	105	PF02201	0.301
DEG_Nend_UBRbox_4	1	3	PF02207	0.427
DEG_SCF_FBW7_1	840	847	PF00400	0.377
DEG_SPOP_SBC_1	505	509	PF00917	0.452
DEG_SPOP_SBC_1	682	686	PF00917	0.590
DOC_CKS1_1	841	846	PF01111	0.523
DOC_CKS1_1	899	904	PF01111	0.436
DOC_CYCLIN_yClb3_PxF_3	128	136	PF00134	0.383
DOC_CYCLIN_yClb5_NLxxxL_5	27	33	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.490
DOC_MAPK_gen_1	238	244	PF00069	0.513
DOC_MAPK_gen_1	525	533	PF00069	0.533
DOC_PP1_RVXF_1	582	589	PF00149	0.483
DOC_PP1_RVXF_1	803	809	PF00149	0.484
DOC_PP1_RVXF_1	96	102	PF00149	0.302
DOC_PP2B_LxvP_1	393	396	PF13499	0.467
DOC_PP2B_LxvP_1	90	93	PF13499	0.307
DOC_PP2B_LxvP_1	908	911	PF13499	0.424
DOC_PP4_FxxP_1	631	634	PF00568	0.494
DOC_PP4_FxxP_1	704	707	PF00568	0.627
DOC_PP4_FxxP_1	807	810	PF00568	0.554
DOC_SPAK_OSR1_1	912	916	PF12202	0.418
DOC_USP7_MATH_1	285	289	PF00917	0.434
DOC_USP7_MATH_1	320	324	PF00917	0.426
DOC_USP7_MATH_1	463	467	PF00917	0.334
DOC_USP7_MATH_1	504	508	PF00917	0.506
DOC_USP7_MATH_1	511	515	PF00917	0.710
DOC_USP7_MATH_1	55	59	PF00917	0.425
DOC_USP7_MATH_1	613	617	PF00917	0.393
DOC_USP7_MATH_1	663	667	PF00917	0.584
DOC_USP7_MATH_1	678	682	PF00917	0.650
DOC_USP7_MATH_1	683	687	PF00917	0.594
DOC_USP7_MATH_1	927	931	PF00917	0.614
DOC_WW_Pin1_4	336	341	PF00397	0.571
DOC_WW_Pin1_4	342	347	PF00397	0.527
DOC_WW_Pin1_4	451	456	PF00397	0.462
DOC_WW_Pin1_4	703	708	PF00397	0.625
DOC_WW_Pin1_4	840	845	PF00397	0.483
DOC_WW_Pin1_4	898	903	PF00397	0.584
LIG_14-3-3_CanoR_1	347	354	PF00244	0.383
LIG_14-3-3_CanoR_1	416	422	PF00244	0.346
LIG_14-3-3_CanoR_1	434	439	PF00244	0.298
LIG_14-3-3_CanoR_1	745	752	PF00244	0.529
LIG_14-3-3_CanoR_1	816	824	PF00244	0.441
LIG_14-3-3_CanoR_1	834	842	PF00244	0.421
LIG_14-3-3_CanoR_1	883	887	PF00244	0.410
LIG_14-3-3_CanoR_1	922	932	PF00244	0.510
LIG_BIR_III_4	359	363	PF00653	0.520
LIG_BRCT_BRCA1_1	477	481	PF00533	0.395
LIG_BRCT_BRCA1_1	57	61	PF00533	0.426
LIG_BRCT_BRCA1_1	627	631	PF00533	0.451
LIG_BRCT_BRCA1_1	716	720	PF00533	0.477
LIG_BRCT_BRCA1_1	740	744	PF00533	0.477
LIG_BRCT_BRCA1_1	872	876	PF00533	0.308
LIG_deltaCOP1_diTrp_1	332	341	PF00928	0.447
LIG_eIF4E_1	692	698	PF01652	0.627
LIG_EVH1_2	536	540	PF00568	0.446
LIG_FHA_1	186	192	PF00498	0.461
LIG_FHA_1	207	213	PF00498	0.477
LIG_FHA_1	275	281	PF00498	0.365
LIG_FHA_1	310	316	PF00498	0.456
LIG_FHA_1	347	353	PF00498	0.419
LIG_FHA_1	422	428	PF00498	0.285
LIG_FHA_1	485	491	PF00498	0.392
LIG_FHA_1	650	656	PF00498	0.548
LIG_FHA_1	735	741	PF00498	0.546
LIG_FHA_1	823	829	PF00498	0.446
LIG_FHA_1	894	900	PF00498	0.404
LIG_FHA_1	918	924	PF00498	0.567
LIG_FHA_2	290	296	PF00498	0.445
LIG_FHA_2	724	730	PF00498	0.550
LIG_GBD_Chelix_1	189	197	PF00786	0.443
LIG_IRF3_LxIS_1	848	854	PF10401	0.289
LIG_LIR_Apic_2	628	634	PF02991	0.508
LIG_LIR_Apic_2	843	848	PF02991	0.410
LIG_LIR_Gen_1	161	171	PF02991	0.384
LIG_LIR_Gen_1	293	301	PF02991	0.401
LIG_LIR_Gen_1	339	348	PF02991	0.569
LIG_LIR_Gen_1	815	826	PF02991	0.446
LIG_LIR_Nem_3	125	130	PF02991	0.397
LIG_LIR_Nem_3	161	167	PF02991	0.355
LIG_LIR_Nem_3	198	204	PF02991	0.329
LIG_LIR_Nem_3	293	299	PF02991	0.402
LIG_LIR_Nem_3	339	344	PF02991	0.550
LIG_LIR_Nem_3	4	10	PF02991	0.595
LIG_LIR_Nem_3	641	647	PF02991	0.432
LIG_LIR_Nem_3	686	692	PF02991	0.593
LIG_LIR_Nem_3	815	821	PF02991	0.521
LIG_LIR_Nem_3	836	842	PF02991	0.476
LIG_LYPXL_yS_3	839	842	PF13949	0.529
LIG_MLH1_MIPbox_1	716	720	PF16413	0.387
LIG_NRBOX	28	34	PF00104	0.470
LIG_Pex14_1	144	148	PF04695	0.344
LIG_Pex14_2	142	146	PF04695	0.405
LIG_Pex14_2	799	803	PF04695	0.482
LIG_Pex14_2	97	101	PF04695	0.303
LIG_PTB_Apo_2	797	804	PF02174	0.438
LIG_REV1ctd_RIR_1	718	727	PF16727	0.600
LIG_SH2_CRK	573	577	PF00017	0.356
LIG_SH2_CRK	644	648	PF00017	0.497
LIG_SH2_CRK	845	849	PF00017	0.441
LIG_SH2_NCK_1	606	610	PF00017	0.384
LIG_SH2_SRC	164	167	PF00017	0.368
LIG_SH2_STAP1	422	426	PF00017	0.393
LIG_SH2_STAP1	692	696	PF00017	0.630
LIG_SH2_STAT3	938	941	PF00017	0.464
LIG_SH2_STAT5	103	106	PF00017	0.343
LIG_SH2_STAT5	204	207	PF00017	0.383
LIG_SH2_STAT5	220	223	PF00017	0.255
LIG_SH2_STAT5	296	299	PF00017	0.402
LIG_SH2_STAT5	402	405	PF00017	0.470
LIG_SH2_STAT5	719	722	PF00017	0.552
LIG_SH2_STAT5	827	830	PF00017	0.439
LIG_SH2_STAT5	898	901	PF00017	0.421
LIG_SH2_STAT5	931	934	PF00017	0.504
LIG_SH3_2	452	457	PF14604	0.499
LIG_SH3_3	125	131	PF00018	0.382
LIG_SH3_3	3	9	PF00018	0.533
LIG_SH3_3	449	455	PF00018	0.500
LIG_SH3_3	468	474	PF00018	0.478
LIG_SH3_3	530	536	PF00018	0.413
LIG_SH3_3	539	545	PF00018	0.390
LIG_SH3_3	574	580	PF00018	0.418
LIG_SH3_3	654	660	PF00018	0.397
LIG_SH3_3	818	824	PF00018	0.598
LIG_SH3_3	896	902	PF00018	0.453
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.357
LIG_SUMO_SIM_anti_2	763	769	PF11976	0.430
LIG_SUMO_SIM_par_1	188	194	PF11976	0.370
LIG_SUMO_SIM_par_1	417	425	PF11976	0.394
LIG_SUMO_SIM_par_1	434	440	PF11976	0.271
LIG_SUMO_SIM_par_1	736	743	PF11976	0.404
LIG_SUMO_SIM_par_1	847	852	PF11976	0.566
LIG_TRAF2_1	17	20	PF00917	0.521
LIG_TRAF2_1	364	367	PF00917	0.541
LIG_TRFH_1	127	131	PF08558	0.406
LIG_TRFH_1	898	902	PF08558	0.394
LIG_UBA3_1	116	124	PF00899	0.413
LIG_WRC_WIRS_1	130	135	PF05994	0.381
LIG_WRC_WIRS_1	767	772	PF05994	0.403
MOD_CDC14_SPxK_1	454	457	PF00782	0.507
MOD_CDK_SPK_2	342	347	PF00069	0.475
MOD_CDK_SPxK_1	451	457	PF00069	0.493
MOD_CDK_SPxK_1	898	904	PF00069	0.386
MOD_CK1_1	158	164	PF00069	0.381
MOD_CK1_1	339	345	PF00069	0.575
MOD_CK1_1	439	445	PF00069	0.467
MOD_CK1_1	681	687	PF00069	0.576
MOD_CK2_1	14	20	PF00069	0.626
MOD_CK2_1	156	162	PF00069	0.450
MOD_CK2_1	234	240	PF00069	0.522
MOD_CK2_1	285	291	PF00069	0.462
MOD_CK2_1	543	549	PF00069	0.433
MOD_CK2_1	587	593	PF00069	0.495
MOD_CK2_1	723	729	PF00069	0.524
MOD_CK2_1	844	850	PF00069	0.400
MOD_CK2_1	923	929	PF00069	0.426
MOD_GlcNHglycan	110	113	PF01048	0.377
MOD_GlcNHglycan	117	120	PF01048	0.344
MOD_GlcNHglycan	268	272	PF01048	0.481
MOD_GlcNHglycan	341	344	PF01048	0.615
MOD_GlcNHglycan	39	42	PF01048	0.531
MOD_GlcNHglycan	413	416	PF01048	0.399
MOD_GlcNHglycan	424	427	PF01048	0.442
MOD_GlcNHglycan	439	442	PF01048	0.336
MOD_GlcNHglycan	461	464	PF01048	0.432
MOD_GlcNHglycan	477	480	PF01048	0.427
MOD_GlcNHglycan	513	516	PF01048	0.678
MOD_GlcNHglycan	522	525	PF01048	0.552
MOD_GlcNHglycan	589	592	PF01048	0.474
MOD_GlcNHglycan	627	630	PF01048	0.509
MOD_GlcNHglycan	835	838	PF01048	0.396
MOD_GlcNHglycan	925	928	PF01048	0.431
MOD_GSK3_1	10	17	PF00069	0.623
MOD_GSK3_1	263	270	PF00069	0.453
MOD_GSK3_1	28	35	PF00069	0.636
MOD_GSK3_1	285	292	PF00069	0.444
MOD_GSK3_1	321	328	PF00069	0.632
MOD_GSK3_1	342	349	PF00069	0.522
MOD_GSK3_1	37	44	PF00069	0.323
MOD_GSK3_1	417	424	PF00069	0.466
MOD_GSK3_1	459	466	PF00069	0.397
MOD_GSK3_1	511	518	PF00069	0.671
MOD_GSK3_1	520	527	PF00069	0.470
MOD_GSK3_1	531	538	PF00069	0.341
MOD_GSK3_1	645	652	PF00069	0.420
MOD_GSK3_1	678	685	PF00069	0.623
MOD_GSK3_1	703	710	PF00069	0.602
MOD_GSK3_1	719	726	PF00069	0.512
MOD_GSK3_1	734	741	PF00069	0.522
MOD_GSK3_1	812	819	PF00069	0.482
MOD_GSK3_1	840	847	PF00069	0.474
MOD_GSK3_1	878	885	PF00069	0.516
MOD_GSK3_1	923	930	PF00069	0.452
MOD_N-GLC_1	107	112	PF02516	0.404
MOD_N-GLC_1	336	341	PF02516	0.480
MOD_NEK2_1	137	142	PF00069	0.395
MOD_NEK2_1	148	153	PF00069	0.479
MOD_NEK2_1	191	196	PF00069	0.444
MOD_NEK2_1	267	272	PF00069	0.401
MOD_NEK2_1	32	37	PF00069	0.617
MOD_NEK2_1	421	426	PF00069	0.407
MOD_NEK2_1	436	441	PF00069	0.319
MOD_NEK2_1	459	464	PF00069	0.385
MOD_NEK2_1	481	486	PF00069	0.361
MOD_NEK2_1	531	536	PF00069	0.393
MOD_NEK2_1	61	66	PF00069	0.462
MOD_NEK2_1	619	624	PF00069	0.327
MOD_NEK2_1	734	739	PF00069	0.430
MOD_NEK2_1	740	745	PF00069	0.486
MOD_NEK2_1	851	856	PF00069	0.517
MOD_NEK2_2	178	183	PF00069	0.541
MOD_NEK2_2	285	290	PF00069	0.317
MOD_NEK2_2	613	618	PF00069	0.393
MOD_NEK2_2	649	654	PF00069	0.474
MOD_OFUCOSY	458	465	PF10250	0.396
MOD_OFUCOSY	558	564	PF10250	0.444
MOD_PIKK_1	446	452	PF00454	0.464
MOD_PIKK_1	463	469	PF00454	0.299
MOD_PKA_2	206	212	PF00069	0.473
MOD_PKA_2	274	280	PF00069	0.328
MOD_PKA_2	289	295	PF00069	0.488
MOD_PKA_2	346	352	PF00069	0.422
MOD_PKA_2	744	750	PF00069	0.540
MOD_PKA_2	833	839	PF00069	0.281
MOD_PKA_2	882	888	PF00069	0.512
MOD_Plk_1	267	273	PF00069	0.482
MOD_Plk_1	61	67	PF00069	0.476
MOD_Plk_1	613	619	PF00069	0.382
MOD_Plk_1	663	669	PF00069	0.587
MOD_Plk_1	692	698	PF00069	0.588
MOD_Plk_1	714	720	PF00069	0.406
MOD_Plk_1	851	857	PF00069	0.390
MOD_Plk_1	927	933	PF00069	0.474
MOD_Plk_2-3	543	549	PF00069	0.486
MOD_Plk_2-3	870	876	PF00069	0.377
MOD_Plk_4	122	128	PF00069	0.445
MOD_Plk_4	137	143	PF00069	0.236
MOD_Plk_4	185	191	PF00069	0.488
MOD_Plk_4	322	328	PF00069	0.565
MOD_Plk_4	496	502	PF00069	0.351
MOD_Plk_4	535	541	PF00069	0.573
MOD_Plk_4	543	549	PF00069	0.593
MOD_Plk_4	55	61	PF00069	0.361
MOD_Plk_4	663	669	PF00069	0.596
MOD_Plk_4	692	698	PF00069	0.561
MOD_Plk_4	714	720	PF00069	0.397
MOD_Plk_4	783	789	PF00069	0.449
MOD_Plk_4	822	828	PF00069	0.396
MOD_Plk_4	927	933	PF00069	0.521
MOD_ProDKin_1	336	342	PF00069	0.565
MOD_ProDKin_1	451	457	PF00069	0.463
MOD_ProDKin_1	703	709	PF00069	0.624
MOD_ProDKin_1	840	846	PF00069	0.484
MOD_ProDKin_1	898	904	PF00069	0.592
MOD_SUMO_for_1	182	185	PF00179	0.473
MOD_SUMO_rev_2	71	81	PF00179	0.537
TRG_DiLeu_BaEn_1	543	548	PF01217	0.484
TRG_DiLeu_BaEn_1	615	620	PF01217	0.411
TRG_DiLeu_BaEn_2	294	300	PF01217	0.373
TRG_DiLeu_BaEn_2	773	779	PF01217	0.419
TRG_DiLeu_BaEn_3	165	171	PF01217	0.224
TRG_DiLeu_BaEn_4	774	780	PF01217	0.463
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.441
TRG_DiLeu_LyEn_5	615	620	PF01217	0.321
TRG_ENDOCYTIC_2	103	106	PF00928	0.355
TRG_ENDOCYTIC_2	164	167	PF00928	0.434
TRG_ENDOCYTIC_2	296	299	PF00928	0.402
TRG_ENDOCYTIC_2	573	576	PF00928	0.477
TRG_ENDOCYTIC_2	644	647	PF00928	0.440
TRG_ENDOCYTIC_2	818	821	PF00928	0.533
TRG_ENDOCYTIC_2	839	842	PF00928	0.529
TRG_ER_diArg_1	272	275	PF00400	0.414
TRG_ER_diArg_1	371	373	PF00400	0.580
TRG_ER_diArg_1	72	74	PF00400	0.390
TRG_NES_CRM1_1	374	387	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA1	Leptomonas seymouri	55%	100%
A0A1X0NQK5	Trypanosomatidae	23%	87%
A0A3S7WQY9	Leishmania donovani	91%	100%
A0A422N156	Trypanosoma rangeli	24%	87%
A4H5Y6	Leishmania braziliensis	79%	100%
A4HUB1	Leishmania infantum	91%	100%
Q4QHL6	Leishmania major	91%	100%
V5BE46	Trypanosoma cruzi	23%	100%