Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AN07_LEIMU

TriTrypDb:

LmxM.09.1540

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AN07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.508
CLV_C14_Caspase3-7	39	43	PF00656	0.693
CLV_C14_Caspase3-7	525	529	PF00656	0.662
CLV_NRD_NRD_1	235	237	PF00675	0.535
CLV_NRD_NRD_1	532	534	PF00675	0.739
CLV_NRD_NRD_1	75	77	PF00675	0.456
CLV_NRD_NRD_1	84	86	PF00675	0.459
CLV_PCSK_KEX2_1	234	236	PF00082	0.567
CLV_PCSK_KEX2_1	45	47	PF00082	0.603
CLV_PCSK_KEX2_1	532	534	PF00082	0.739
CLV_PCSK_KEX2_1	61	63	PF00082	0.589
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.603
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.341
CLV_PCSK_SKI1_1	10	14	PF00082	0.529
CLV_PCSK_SKI1_1	204	208	PF00082	0.613
CLV_PCSK_SKI1_1	215	219	PF00082	0.532
CLV_PCSK_SKI1_1	521	525	PF00082	0.666
CLV_PCSK_SKI1_1	593	597	PF00082	0.627
DEG_APCC_DBOX_1	203	211	PF00400	0.574
DEG_APCC_DBOX_1	214	222	PF00400	0.517
DEG_APCC_DBOX_1	542	550	PF00400	0.529
DEG_APCC_KENBOX_2	475	479	PF00400	0.322
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DOC_MAPK_gen_1	588	596	PF00069	0.486
DOC_MAPK_gen_1	83	92	PF00069	0.569
DOC_MAPK_MEF2A_6	409	417	PF00069	0.470
DOC_USP7_MATH_1	11	15	PF00917	0.530
DOC_USP7_MATH_1	56	60	PF00917	0.605
DOC_USP7_UBL2_3	48	52	PF12436	0.598
DOC_WW_Pin1_4	174	179	PF00397	0.461
LIG_14-3-3_CanoR_1	10	20	PF00244	0.597
LIG_14-3-3_CanoR_1	103	110	PF00244	0.558
LIG_14-3-3_CanoR_1	162	169	PF00244	0.699
LIG_14-3-3_CanoR_1	2	7	PF00244	0.660
LIG_14-3-3_CanoR_1	317	323	PF00244	0.550
LIG_14-3-3_CanoR_1	498	502	PF00244	0.529
LIG_14-3-3_CanoR_1	543	547	PF00244	0.727
LIG_14-3-3_CanoR_1	555	563	PF00244	0.467
LIG_14-3-3_CterR_2	604	607	PF00244	0.704
LIG_BRCT_BRCA1_1	373	377	PF00533	0.528
LIG_CaM_IQ_9	396	411	PF13499	0.598
LIG_FHA_1	155	161	PF00498	0.561
LIG_FHA_1	412	418	PF00498	0.566
LIG_FHA_2	142	148	PF00498	0.619
LIG_FHA_2	156	162	PF00498	0.622
LIG_FHA_2	189	195	PF00498	0.571
LIG_FHA_2	228	234	PF00498	0.645
LIG_FHA_2	258	264	PF00498	0.581
LIG_Integrin_RGD_1	433	435	PF01839	0.531
LIG_LIR_Gen_1	3	12	PF02991	0.629
LIG_LIR_Nem_3	3	9	PF02991	0.639
LIG_NRBOX	188	194	PF00104	0.613
LIG_NRBOX	447	453	PF00104	0.417
LIG_NRBOX	77	83	PF00104	0.508
LIG_SH2_GRB2like	422	425	PF00017	0.491
LIG_SH2_SRC	6	9	PF00017	0.653
LIG_SH2_STAP1	16	20	PF00017	0.565
LIG_SH2_STAP1	301	305	PF00017	0.573
LIG_SH2_STAP1	345	349	PF00017	0.449
LIG_SH2_STAT5	398	401	PF00017	0.458
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.461
LIG_SUMO_SIM_par_1	219	224	PF11976	0.620
LIG_SUMO_SIM_par_1	413	419	PF11976	0.568
LIG_SUMO_SIM_par_1	522	528	PF11976	0.711
LIG_TRAF2_1	364	367	PF00917	0.593
LIG_TRAF2_1	391	394	PF00917	0.572
LIG_TRAF2_1	580	583	PF00917	0.525
LIG_TRAF2_1	95	98	PF00917	0.548
MOD_CK1_1	141	147	PF00069	0.730
MOD_CK1_1	174	180	PF00069	0.551
MOD_CK1_1	188	194	PF00069	0.510
MOD_CK1_1	257	263	PF00069	0.579
MOD_CK1_1	467	473	PF00069	0.610
MOD_CK2_1	11	17	PF00069	0.609
MOD_CK2_1	141	147	PF00069	0.646
MOD_CK2_1	155	161	PF00069	0.636
MOD_CK2_1	188	194	PF00069	0.495
MOD_CK2_1	227	233	PF00069	0.522
MOD_CK2_1	257	263	PF00069	0.531
MOD_CK2_1	33	39	PF00069	0.657
MOD_CK2_1	361	367	PF00069	0.526
MOD_CK2_1	388	394	PF00069	0.528
MOD_CK2_1	462	468	PF00069	0.475
MOD_CK2_1	577	583	PF00069	0.511
MOD_CK2_1	92	98	PF00069	0.568
MOD_GlcNHglycan	173	176	PF01048	0.669
MOD_GlcNHglycan	178	181	PF01048	0.652
MOD_GlcNHglycan	208	213	PF01048	0.526
MOD_GlcNHglycan	308	311	PF01048	0.630
MOD_GlcNHglycan	363	366	PF01048	0.449
MOD_GSK3_1	137	144	PF00069	0.648
MOD_GSK3_1	308	315	PF00069	0.512
MOD_GSK3_1	367	374	PF00069	0.592
MOD_GSK3_1	388	395	PF00069	0.525
MOD_GSK3_1	577	584	PF00069	0.599
MOD_GSK3_1	92	99	PF00069	0.565
MOD_N-GLC_1	148	153	PF02516	0.536
MOD_N-GLC_1	243	248	PF02516	0.575
MOD_N-GLC_1	312	317	PF02516	0.570
MOD_N-GLC_1	367	372	PF02516	0.570
MOD_N-GLC_1	477	482	PF02516	0.608
MOD_NEK2_1	221	226	PF00069	0.499
MOD_NEK2_1	30	35	PF00069	0.734
MOD_NEK2_1	308	313	PF00069	0.615
MOD_NEK2_1	371	376	PF00069	0.570
MOD_NEK2_1	462	467	PF00069	0.461
MOD_NEK2_1	497	502	PF00069	0.606
MOD_NEK2_1	511	516	PF00069	0.484
MOD_NEK2_1	563	568	PF00069	0.625
MOD_NEK2_1	577	582	PF00069	0.420
MOD_NEK2_1	96	101	PF00069	0.643
MOD_PIKK_1	11	17	PF00454	0.604
MOD_PIKK_1	115	121	PF00454	0.616
MOD_PIKK_1	161	167	PF00454	0.612
MOD_PIKK_1	371	377	PF00454	0.474
MOD_PKA_2	102	108	PF00069	0.591
MOD_PKA_2	138	144	PF00069	0.718
MOD_PKA_2	161	167	PF00069	0.698
MOD_PKA_2	254	260	PF00069	0.583
MOD_PKA_2	30	36	PF00069	0.647
MOD_PKA_2	497	503	PF00069	0.532
MOD_PKA_2	542	548	PF00069	0.713
MOD_PKB_1	484	492	PF00069	0.489
MOD_Plk_1	155	161	PF00069	0.665
MOD_Plk_1	16	22	PF00069	0.631
MOD_Plk_1	208	214	PF00069	0.544
MOD_Plk_1	243	249	PF00069	0.575
MOD_Plk_1	367	373	PF00069	0.573
MOD_Plk_1	392	398	PF00069	0.530
MOD_Plk_1	477	483	PF00069	0.602
MOD_Plk_1	577	583	PF00069	0.629
MOD_Plk_2-3	367	373	PF00069	0.576
MOD_Plk_2-3	416	422	PF00069	0.467
MOD_Plk_2-3	522	528	PF00069	0.711
MOD_Plk_4	188	194	PF00069	0.526
MOD_Plk_4	367	373	PF00069	0.576
MOD_Plk_4	477	483	PF00069	0.624
MOD_Plk_4	486	492	PF00069	0.546
MOD_ProDKin_1	174	180	PF00069	0.459
MOD_SUMO_rev_2	17	25	PF00179	0.353
MOD_SUMO_rev_2	188	197	PF00179	0.555
MOD_SUMO_rev_2	437	446	PF00179	0.594
MOD_SUMO_rev_2	565	575	PF00179	0.452
TRG_DiLeu_BaEn_1	276	281	PF01217	0.365
TRG_DiLeu_BaEn_1	367	372	PF01217	0.570
TRG_DiLeu_BaEn_1	447	452	PF01217	0.602
TRG_DiLeu_BaEn_1	477	482	PF01217	0.423
TRG_DiLeu_BaEn_2	372	378	PF01217	0.576
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.611
TRG_ENDOCYTIC_2	6	9	PF00928	0.640
TRG_ER_diArg_1	133	136	PF00400	0.628
TRG_ER_diArg_1	234	236	PF00400	0.631
TRG_ER_diArg_1	483	486	PF00400	0.498
TRG_NES_CRM1_1	464	479	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGV3	Leptomonas seymouri	55%	92%
A0A1X0NJR6	Trypanosomatidae	42%	81%
A0A3Q8IH29	Leishmania donovani	89%	100%
A0A422NZK3	Trypanosoma rangeli	41%	80%
A4H5Y1	Leishmania braziliensis	82%	100%
A4HU77	Leishmania infantum	89%	100%
D0A9Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
Q4QHM1	Leishmania major	90%	100%
V5BI13	Trypanosoma cruzi	39%	81%