Thymine dioxygenase JBP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

J-binding protein

Species:

Leishmania mexicana

UniProt:

E9AN00_LEIMU

TriTrypDb:

LmxM.09.1480

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AN00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN00

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	1
GO:0006283	transcription-coupled nucleotide-excision repair	7	1
GO:0006289	nucleotide-excision repair	6	1
GO:0006304	DNA modification	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005506	iron ion binding	6	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0008198	ferrous iron binding	7	1
GO:0016491	oxidoreductase activity	2	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	7
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.547
CLV_C14_Caspase3-7	55	59	PF00656	0.402
CLV_NRD_NRD_1	122	124	PF00675	0.283
CLV_NRD_NRD_1	277	279	PF00675	0.438
CLV_NRD_NRD_1	366	368	PF00675	0.295
CLV_NRD_NRD_1	447	449	PF00675	0.450
CLV_NRD_NRD_1	544	546	PF00675	0.344
CLV_NRD_NRD_1	547	549	PF00675	0.348
CLV_NRD_NRD_1	556	558	PF00675	0.348
CLV_NRD_NRD_1	720	722	PF00675	0.429

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A0	Leptomonas seymouri	65%	99%
A0A0S4JFS0	Bodo saltans	42%	95%
A0A1X0NHV5	Trypanosomatidae	47%	99%
A0A3Q8IAX2	Leishmania donovani	92%	100%
A0A422NZF9	Trypanosoma rangeli	46%	99%
A4H5X5	Leishmania braziliensis	83%	100%
A4HU70	Leishmania infantum	92%	100%
D0A9Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
P86937	Trypanosoma brucei brucei	45%	97%
P86938	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	45%	97%

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