Thymine dioxygenase JBP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

J-binding protein

Species:

Leishmania mexicana

UniProt:

E9AN00_LEIMU

TriTrypDb:

LmxM.09.1480

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AN00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AN00

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006304	DNA modification	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0070580	base J metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0006281	DNA repair	5	1
GO:0006283	transcription-coupled nucleotide-excision repair	7	1
GO:0006289	nucleotide-excision repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	7
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050341	thymine dioxygenase activity	5	7
GO:0051213	dioxygenase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005506	iron ion binding	6	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0008198	ferrous iron binding	7	1
GO:0046914	transition metal ion binding	5	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.547
CLV_C14_Caspase3-7	55	59	PF00656	0.402
CLV_NRD_NRD_1	122	124	PF00675	0.283
CLV_NRD_NRD_1	277	279	PF00675	0.438
CLV_NRD_NRD_1	366	368	PF00675	0.295
CLV_NRD_NRD_1	447	449	PF00675	0.450
CLV_NRD_NRD_1	544	546	PF00675	0.344
CLV_NRD_NRD_1	547	549	PF00675	0.348
CLV_NRD_NRD_1	556	558	PF00675	0.348
CLV_NRD_NRD_1	720	722	PF00675	0.429
CLV_PCSK_KEX2_1	254	256	PF00082	0.378
CLV_PCSK_KEX2_1	276	278	PF00082	0.462
CLV_PCSK_KEX2_1	366	368	PF00082	0.295
CLV_PCSK_KEX2_1	543	545	PF00082	0.351
CLV_PCSK_KEX2_1	556	558	PF00082	0.340
CLV_PCSK_KEX2_1	567	569	PF00082	0.606
CLV_PCSK_KEX2_1	720	722	PF00082	0.429
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.378
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.372
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.708
CLV_PCSK_SKI1_1	254	258	PF00082	0.371
CLV_PCSK_SKI1_1	263	267	PF00082	0.375
CLV_PCSK_SKI1_1	449	453	PF00082	0.411
CLV_PCSK_SKI1_1	532	536	PF00082	0.348
CLV_PCSK_SKI1_1	6	10	PF00082	0.539
CLV_PCSK_SKI1_1	601	605	PF00082	0.539
CLV_PCSK_SKI1_1	69	73	PF00082	0.384
CLV_PCSK_SKI1_1	74	78	PF00082	0.372
DEG_APCC_DBOX_1	614	622	PF00400	0.257
DEG_APCC_DBOX_1	89	97	PF00400	0.571
DEG_APCC_KENBOX_2	297	301	PF00400	0.577
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DEG_SCF_FBW7_1	170	177	PF00400	0.483
DOC_CYCLIN_RxL_1	207	218	PF00134	0.556
DOC_CYCLIN_RxL_1	424	437	PF00134	0.356
DOC_CYCLIN_RxL_1	666	676	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.431
DOC_MAPK_FxFP_2	13	16	PF00069	0.590
DOC_MAPK_gen_1	424	433	PF00069	0.408
DOC_MAPK_gen_1	57	66	PF00069	0.417
DOC_MAPK_gen_1	6	12	PF00069	0.520
DOC_MAPK_MEF2A_6	60	68	PF00069	0.409
DOC_MAPK_MEF2A_6	615	623	PF00069	0.534
DOC_PP2B_LxvP_1	507	510	PF13499	0.344
DOC_PP2B_LxvP_1	639	642	PF13499	0.370
DOC_PP2B_LxvP_1	671	674	PF13499	0.552
DOC_PP4_FxxP_1	13	16	PF00568	0.488
DOC_PP4_FxxP_1	318	321	PF00568	0.449
DOC_PP4_FxxP_1	353	356	PF00568	0.508
DOC_USP7_MATH_1	215	219	PF00917	0.347
DOC_USP7_MATH_1	290	294	PF00917	0.594
DOC_USP7_MATH_1	34	38	PF00917	0.381
DOC_USP7_MATH_1	343	347	PF00917	0.534
DOC_USP7_MATH_1	512	516	PF00917	0.158
DOC_USP7_MATH_1	687	691	PF00917	0.450
DOC_USP7_MATH_1	724	728	PF00917	0.368
DOC_USP7_MATH_2	117	123	PF00917	0.483
DOC_USP7_UBL2_3	518	522	PF12436	0.348
DOC_USP7_UBL2_3	601	605	PF12436	0.574
DOC_WW_Pin1_4	113	118	PF00397	0.410
DOC_WW_Pin1_4	170	175	PF00397	0.483
DOC_WW_Pin1_4	20	25	PF00397	0.546
DOC_WW_Pin1_4	286	291	PF00397	0.625
DOC_WW_Pin1_4	305	310	PF00397	0.282
DOC_WW_Pin1_4	313	318	PF00397	0.400
DOC_WW_Pin1_4	796	801	PF00397	0.385
DOC_WW_Pin1_4	806	811	PF00397	0.440
DOC_WW_Pin1_4	99	104	PF00397	0.451
LIG_14-3-3_CanoR_1	123	128	PF00244	0.483
LIG_14-3-3_CanoR_1	183	192	PF00244	0.556
LIG_14-3-3_CanoR_1	255	262	PF00244	0.362
LIG_14-3-3_CanoR_1	646	655	PF00244	0.453
LIG_14-3-3_CanoR_1	740	746	PF00244	0.389
LIG_14-3-3_CanoR_1	90	94	PF00244	0.429
LIG_Actin_WH2_2	632	648	PF00022	0.313
LIG_BIR_III_2	162	166	PF00653	0.500
LIG_BRCT_BRCA1_1	234	238	PF00533	0.496
LIG_BRCT_BRCA1_1	36	40	PF00533	0.420
LIG_BRCT_BRCA1_1	460	464	PF00533	0.450
LIG_BRCT_BRCA1_1	94	98	PF00533	0.438
LIG_CSL_BTD_1	318	321	PF09270	0.473
LIG_deltaCOP1_diTrp_1	132	139	PF00928	0.483
LIG_deltaCOP1_diTrp_1	251	260	PF00928	0.389
LIG_EH1_1	218	226	PF00400	0.506
LIG_FHA_1	175	181	PF00498	0.483
LIG_FHA_1	287	293	PF00498	0.604
LIG_FHA_1	395	401	PF00498	0.158
LIG_FHA_1	437	443	PF00498	0.379
LIG_FHA_1	602	608	PF00498	0.475
LIG_FHA_1	802	808	PF00498	0.498
LIG_FHA_2	15	21	PF00498	0.574
LIG_FHA_2	240	246	PF00498	0.400
LIG_FHA_2	396	402	PF00498	0.348
LIG_FHA_2	53	59	PF00498	0.398
LIG_FHA_2	776	782	PF00498	0.406
LIG_LIR_Apic_2	11	16	PF02991	0.482
LIG_LIR_Apic_2	316	321	PF02991	0.473
LIG_LIR_Apic_2	350	356	PF02991	0.515
LIG_LIR_Gen_1	173	180	PF02991	0.483
LIG_LIR_Gen_1	196	205	PF02991	0.483
LIG_LIR_Gen_1	435	446	PF02991	0.351
LIG_LIR_Gen_1	648	659	PF02991	0.408
LIG_LIR_Gen_1	694	705	PF02991	0.479
LIG_LIR_Gen_1	752	761	PF02991	0.370
LIG_LIR_Nem_3	132	138	PF02991	0.457
LIG_LIR_Nem_3	146	152	PF02991	0.407
LIG_LIR_Nem_3	173	178	PF02991	0.483
LIG_LIR_Nem_3	196	202	PF02991	0.483
LIG_LIR_Nem_3	206	212	PF02991	0.483
LIG_LIR_Nem_3	251	256	PF02991	0.411
LIG_LIR_Nem_3	271	275	PF02991	0.292
LIG_LIR_Nem_3	461	466	PF02991	0.450
LIG_LIR_Nem_3	648	654	PF02991	0.411
LIG_LIR_Nem_3	694	700	PF02991	0.495
LIG_LIR_Nem_3	752	756	PF02991	0.378
LIG_MAD2	620	628	PF02301	0.422
LIG_MLH1_MIPbox_1	460	464	PF16413	0.450
LIG_Pex14_1	135	139	PF04695	0.483
LIG_PTB_Apo_2	404	411	PF02174	0.372
LIG_PTB_Apo_2	571	578	PF02174	0.463
LIG_SH2_CRK	199	203	PF00017	0.483
LIG_SH2_CRK	41	45	PF00017	0.428
LIG_SH2_CRK	697	701	PF00017	0.249
LIG_SH2_CRK	753	757	PF00017	0.386
LIG_SH2_GRB2like	405	408	PF00017	0.372
LIG_SH2_GRB2like	41	44	PF00017	0.395
LIG_SH2_NCK_1	199	203	PF00017	0.483
LIG_SH2_NCK_1	753	757	PF00017	0.386
LIG_SH2_SRC	31	34	PF00017	0.459
LIG_SH2_SRC	405	408	PF00017	0.450
LIG_SH2_SRC	41	44	PF00017	0.395
LIG_SH2_STAP1	129	133	PF00017	0.527
LIG_SH2_STAP1	199	203	PF00017	0.483
LIG_SH2_STAP1	31	35	PF00017	0.456
LIG_SH2_STAP1	495	499	PF00017	0.301
LIG_SH2_STAP1	697	701	PF00017	0.249
LIG_SH2_STAP1	75	79	PF00017	0.503
LIG_SH2_STAP1	753	757	PF00017	0.376
LIG_SH2_STAT5	110	113	PF00017	0.483
LIG_SH2_STAT5	144	147	PF00017	0.441
LIG_SH2_STAT5	405	408	PF00017	0.348
LIG_SH2_STAT5	533	536	PF00017	0.348
LIG_SH2_STAT5	718	721	PF00017	0.394
LIG_SH2_STAT5	743	746	PF00017	0.377
LIG_SH3_1	306	312	PF00018	0.471
LIG_SH3_3	306	312	PF00018	0.471
LIG_SH3_3	620	626	PF00018	0.390
LIG_SH3_3	804	810	PF00018	0.516
LIG_SH3_5	140	144	PF00018	0.483
LIG_SUMO_SIM_par_1	116	122	PF11976	0.483
LIG_SUMO_SIM_par_1	176	182	PF11976	0.483
LIG_SUMO_SIM_par_1	621	627	PF11976	0.487
LIG_TRAF2_1	23	26	PF00917	0.536
LIG_TRAF2_1	485	488	PF00917	0.348
LIG_TRAF2_1	538	541	PF00917	0.450
LIG_UBA3_1	419	424	PF00899	0.450
LIG_UBA3_1	441	449	PF00899	0.450
LIG_UBA3_1	474	480	PF00899	0.352
LIG_WRC_WIRS_1	216	221	PF05994	0.347
MOD_CK1_1	102	108	PF00069	0.409
MOD_CK1_1	122	128	PF00069	0.320
MOD_CK1_1	14	20	PF00069	0.393
MOD_CK1_1	176	182	PF00069	0.483
MOD_CK1_1	561	567	PF00069	0.468
MOD_CK1_1	768	774	PF00069	0.426
MOD_CK1_1	78	84	PF00069	0.529
MOD_CK1_1	92	98	PF00069	0.261
MOD_CK2_1	113	119	PF00069	0.470
MOD_CK2_1	14	20	PF00069	0.564
MOD_CK2_1	237	243	PF00069	0.389
MOD_CK2_1	268	274	PF00069	0.429
MOD_CK2_1	27	33	PF00069	0.439
MOD_CK2_1	395	401	PF00069	0.348
MOD_CK2_1	646	652	PF00069	0.284
MOD_CK2_1	775	781	PF00069	0.416
MOD_GlcNHglycan	104	107	PF01048	0.413
MOD_GlcNHglycan	248	251	PF01048	0.564
MOD_GlcNHglycan	331	334	PF01048	0.275
MOD_GlcNHglycan	377	380	PF01048	0.614
MOD_GlcNHglycan	415	418	PF01048	0.450
MOD_GlcNHglycan	460	463	PF01048	0.450
MOD_GlcNHglycan	52	55	PF01048	0.345
MOD_GlcNHglycan	561	564	PF01048	0.593
MOD_GlcNHglycan	726	729	PF01048	0.343
MOD_GlcNHglycan	85	88	PF01048	0.500
MOD_GSK3_1	119	126	PF00069	0.483
MOD_GSK3_1	14	21	PF00069	0.644
MOD_GSK3_1	170	177	PF00069	0.483
MOD_GSK3_1	179	186	PF00069	0.483
MOD_GSK3_1	279	286	PF00069	0.521
MOD_GSK3_1	339	346	PF00069	0.455
MOD_GSK3_1	377	384	PF00069	0.574
MOD_GSK3_1	405	412	PF00069	0.450
MOD_GSK3_1	432	439	PF00069	0.227
MOD_GSK3_1	454	461	PF00069	0.408
MOD_GSK3_1	641	648	PF00069	0.564
MOD_GSK3_1	687	694	PF00069	0.511
MOD_GSK3_1	74	81	PF00069	0.504
MOD_GSK3_1	781	788	PF00069	0.497
MOD_GSK3_1	796	803	PF00069	0.313
MOD_GSK3_1	88	95	PF00069	0.436
MOD_LATS_1	599	605	PF00433	0.557
MOD_N-GLC_1	299	304	PF02516	0.592
MOD_N-GLC_1	454	459	PF02516	0.348
MOD_N-GLC_1	573	578	PF02516	0.453
MOD_N-GLC_1	801	806	PF02516	0.492
MOD_NEK2_1	279	284	PF00069	0.569
MOD_NEK2_1	389	394	PF00069	0.577
MOD_NEK2_1	395	400	PF00069	0.370
MOD_NEK2_1	50	55	PF00069	0.358
MOD_NEK2_1	528	533	PF00069	0.348
MOD_NEK2_1	654	659	PF00069	0.323
MOD_NEK2_1	688	693	PF00069	0.293
MOD_NEK2_1	801	806	PF00069	0.492
MOD_NEK2_1	83	88	PF00069	0.416
MOD_NEK2_2	490	495	PF00069	0.450
MOD_NEK2_2	512	517	PF00069	0.158
MOD_PIKK_1	675	681	PF00454	0.256
MOD_PKA_1	123	129	PF00069	0.483
MOD_PKA_1	254	260	PF00069	0.369
MOD_PKA_2	122	128	PF00069	0.483
MOD_PKA_2	18	24	PF00069	0.577
MOD_PKA_2	254	260	PF00069	0.369
MOD_PKA_2	645	651	PF00069	0.460
MOD_PKA_2	89	95	PF00069	0.476
MOD_PKB_1	183	191	PF00069	0.483
MOD_Plk_1	244	250	PF00069	0.495
MOD_Plk_1	284	290	PF00069	0.534
MOD_Plk_1	436	442	PF00069	0.372
MOD_Plk_1	573	579	PF00069	0.445
MOD_Plk_1	801	807	PF00069	0.493
MOD_Plk_2-3	268	274	PF00069	0.429
MOD_Plk_2-3	52	58	PF00069	0.392
MOD_Plk_2-3	578	584	PF00069	0.541
MOD_Plk_4	43	49	PF00069	0.317
MOD_Plk_4	781	787	PF00069	0.382
MOD_ProDKin_1	113	119	PF00069	0.410
MOD_ProDKin_1	170	176	PF00069	0.483
MOD_ProDKin_1	20	26	PF00069	0.544
MOD_ProDKin_1	286	292	PF00069	0.619
MOD_ProDKin_1	305	311	PF00069	0.276
MOD_ProDKin_1	313	319	PF00069	0.396
MOD_ProDKin_1	796	802	PF00069	0.386
MOD_ProDKin_1	806	812	PF00069	0.461
MOD_ProDKin_1	99	105	PF00069	0.447
MOD_SUMO_for_1	485	488	PF00179	0.450
MOD_SUMO_rev_2	116	122	PF00179	0.483
MOD_SUMO_rev_2	2	8	PF00179	0.581
MOD_SUMO_rev_2	247	256	PF00179	0.448
MOD_SUMO_rev_2	368	372	PF00179	0.586
MOD_SUMO_rev_2	630	639	PF00179	0.633
TRG_DiLeu_BaEn_1	650	655	PF01217	0.401
TRG_DiLeu_BaEn_1	781	786	PF01217	0.501
TRG_DiLeu_BaEn_2	446	452	PF01217	0.450
TRG_ENDOCYTIC_2	149	152	PF00928	0.449
TRG_ENDOCYTIC_2	199	202	PF00928	0.441
TRG_ENDOCYTIC_2	41	44	PF00928	0.419
TRG_ENDOCYTIC_2	697	700	PF00928	0.251
TRG_ENDOCYTIC_2	742	745	PF00928	0.382
TRG_ENDOCYTIC_2	753	756	PF00928	0.393
TRG_ER_diArg_1	275	278	PF00400	0.453
TRG_ER_diArg_1	365	367	PF00400	0.290
TRG_ER_diArg_1	544	546	PF00400	0.348
TRG_ER_diArg_1	719	721	PF00400	0.429
TRG_NLS_MonoExtC_3	5	11	PF00514	0.532
TRG_NLS_MonoExtN_4	3	10	PF00514	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A0	Leptomonas seymouri	65%	99%
A0A0S4JFS0	Bodo saltans	42%	95%
A0A1X0NHV5	Trypanosomatidae	47%	99%
A0A3Q8IAX2	Leishmania donovani	92%	100%
A0A422NZF9	Trypanosoma rangeli	46%	99%
A4H5X5	Leishmania braziliensis	83%	100%
A4HU70	Leishmania infantum	92%	100%
D0A9Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
P86937	Trypanosoma brucei brucei	45%	97%
P86938	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	45%	97%
Q4DBW3	Trypanosoma cruzi (strain CL Brener)	49%	98%
Q4DLX9	Trypanosoma cruzi (strain CL Brener)	49%	98%
Q4QHM7	Leishmania major	92%	100%
Q9U6M1	Leishmania tarentolae	88%	98%
Q9U6M2	Crithidia fasciculata	63%	100%
V5DE87	Trypanosoma cruzi	49%	98%