J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMZ6_LEIMU

TriTrypDb:

LmxM.09.1440

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.630
CLV_NRD_NRD_1	151	153	PF00675	0.471
CLV_NRD_NRD_1	258	260	PF00675	0.670
CLV_NRD_NRD_1	268	270	PF00675	0.548
CLV_NRD_NRD_1	360	362	PF00675	0.631
CLV_NRD_NRD_1	380	382	PF00675	0.490
CLV_NRD_NRD_1	40	42	PF00675	0.513
CLV_NRD_NRD_1	5	7	PF00675	0.592
CLV_PCSK_KEX2_1	103	105	PF00082	0.630
CLV_PCSK_KEX2_1	151	153	PF00082	0.488
CLV_PCSK_KEX2_1	258	260	PF00082	0.611
CLV_PCSK_KEX2_1	268	270	PF00082	0.675
CLV_PCSK_KEX2_1	380	382	PF00082	0.636
CLV_PCSK_KEX2_1	5	7	PF00082	0.556
CLV_PCSK_KEX2_1	60	62	PF00082	0.272
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.289
CLV_PCSK_SKI1_1	103	107	PF00082	0.656
CLV_PCSK_SKI1_1	260	264	PF00082	0.609
DEG_SPOP_SBC_1	78	82	PF00917	0.422
DOC_CYCLIN_RxL_1	99	109	PF00134	0.534
DOC_MAPK_gen_1	41	49	PF00069	0.454
DOC_MAPK_gen_1	5	11	PF00069	0.533
DOC_PP4_FxxP_1	168	171	PF00568	0.497
DOC_USP7_MATH_1	117	121	PF00917	0.792
DOC_USP7_MATH_1	15	19	PF00917	0.505
DOC_USP7_MATH_1	186	190	PF00917	0.760
DOC_USP7_MATH_1	71	75	PF00917	0.349
DOC_USP7_MATH_1	78	82	PF00917	0.349
DOC_WW_Pin1_4	281	286	PF00397	0.540
DOC_WW_Pin1_4	328	333	PF00397	0.661
LIG_14-3-3_CanoR_1	14	20	PF00244	0.521
LIG_14-3-3_CanoR_1	249	256	PF00244	0.558
LIG_14-3-3_CanoR_1	29	35	PF00244	0.427
LIG_14-3-3_CanoR_1	355	363	PF00244	0.617
LIG_14-3-3_CanoR_1	84	92	PF00244	0.404
LIG_APCC_ABBA_1	219	224	PF00400	0.390
LIG_BRCT_BRCA1_1	21	25	PF00533	0.515
LIG_BRCT_BRCA1_1	226	230	PF00533	0.394
LIG_EH_1	310	314	PF12763	0.598
LIG_FHA_2	207	213	PF00498	0.463
LIG_FHA_2	34	40	PF00498	0.419
LIG_FHA_2	52	58	PF00498	0.314
LIG_LIR_Apic_2	166	171	PF02991	0.661
LIG_LIR_Apic_2	173	178	PF02991	0.665
LIG_LIR_Apic_2	321	326	PF02991	0.632
LIG_LIR_Gen_1	227	235	PF02991	0.387
LIG_LIR_Gen_1	291	301	PF02991	0.575
LIG_LIR_Nem_3	227	231	PF02991	0.386
LIG_LIR_Nem_3	287	293	PF02991	0.542
LIG_LIR_Nem_3	331	336	PF02991	0.773
LIG_Pex14_1	7	11	PF04695	0.496
LIG_SH2_CRK	323	327	PF00017	0.751
LIG_SH2_CRK	44	48	PF00017	0.271
LIG_SH2_CRK	92	96	PF00017	0.271
LIG_SH2_NCK_1	323	327	PF00017	0.612
LIG_SH2_SRC	222	225	PF00017	0.410
LIG_SH2_STAP1	143	147	PF00017	0.422
LIG_SH2_STAT3	124	127	PF00017	0.615
LIG_TRAF2_1	125	128	PF00917	0.456
LIG_TRAF2_1	305	308	PF00917	0.620
LIG_WW_3	176	180	PF00397	0.687
MOD_CK1_1	118	124	PF00069	0.683
MOD_CK1_1	189	195	PF00069	0.729
MOD_CK1_1	204	210	PF00069	0.597
MOD_CK1_1	364	370	PF00069	0.532
MOD_CK1_1	403	409	PF00069	0.595
MOD_CK1_1	74	80	PF00069	0.404
MOD_CK2_1	122	128	PF00069	0.482
MOD_CK2_1	206	212	PF00069	0.585
MOD_CK2_1	281	287	PF00069	0.595
MOD_CK2_1	302	308	PF00069	0.620
MOD_Cter_Amidation	101	104	PF01082	0.472
MOD_Cter_Amidation	200	203	PF01082	0.640
MOD_GlcNHglycan	128	131	PF01048	0.547
MOD_GlcNHglycan	182	185	PF01048	0.784
MOD_GlcNHglycan	189	192	PF01048	0.570
MOD_GlcNHglycan	238	241	PF01048	0.543
MOD_GlcNHglycan	25	28	PF01048	0.633
MOD_GlcNHglycan	326	329	PF01048	0.550
MOD_GlcNHglycan	339	342	PF01048	0.559
MOD_GlcNHglycan	391	394	PF01048	0.738
MOD_GlcNHglycan	397	400	PF01048	0.740
MOD_GlcNHglycan	405	408	PF01048	0.755
MOD_GlcNHglycan	51	54	PF01048	0.358
MOD_GlcNHglycan	76	79	PF01048	0.363
MOD_GSK3_1	106	113	PF00069	0.515
MOD_GSK3_1	115	122	PF00069	0.665
MOD_GSK3_1	15	22	PF00069	0.544
MOD_GSK3_1	186	193	PF00069	0.629
MOD_GSK3_1	201	208	PF00069	0.549
MOD_GSK3_1	324	331	PF00069	0.554
MOD_GSK3_1	357	364	PF00069	0.702
MOD_GSK3_1	49	56	PF00069	0.335
MOD_GSK3_1	73	80	PF00069	0.358
MOD_N-GLC_1	118	123	PF02516	0.683
MOD_N-GLC_1	180	185	PF02516	0.782
MOD_N-GLC_1	357	362	PF02516	0.715
MOD_N-GLC_1	74	79	PF02516	0.360
MOD_NEK2_1	106	111	PF00069	0.716
MOD_NEK2_1	23	28	PF00069	0.581
MOD_NEK2_2	91	96	PF00069	0.349
MOD_PKA_1	202	208	PF00069	0.524
MOD_PKA_1	361	367	PF00069	0.768
MOD_PKA_2	186	192	PF00069	0.690
MOD_PKA_2	248	254	PF00069	0.444
MOD_PKA_2	83	89	PF00069	0.404
MOD_PKB_1	185	193	PF00069	0.665
MOD_Plk_2-3	224	230	PF00069	0.399
MOD_Plk_2-3	303	309	PF00069	0.676
MOD_Plk_4	19	25	PF00069	0.446
MOD_ProDKin_1	281	287	PF00069	0.541
MOD_ProDKin_1	328	334	PF00069	0.661
MOD_SUMO_rev_2	189	198	PF00179	0.501
TRG_ENDOCYTIC_2	135	138	PF00928	0.494
TRG_ENDOCYTIC_2	143	146	PF00928	0.392
TRG_ENDOCYTIC_2	293	296	PF00928	0.668
TRG_ENDOCYTIC_2	346	349	PF00928	0.578
TRG_ENDOCYTIC_2	44	47	PF00928	0.285
TRG_ENDOCYTIC_2	62	65	PF00928	0.271
TRG_ENDOCYTIC_2	92	95	PF00928	0.319
TRG_ER_diArg_1	103	105	PF00400	0.635
TRG_ER_diArg_1	150	152	PF00400	0.467
TRG_ER_diArg_1	268	271	PF00400	0.616
TRG_ER_diArg_1	380	382	PF00400	0.644
TRG_ER_diArg_1	4	6	PF00400	0.569
TRG_NLS_Bipartite_1	41	63	PF00514	0.335
TRG_NLS_MonoExtC_3	58	64	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I106	Leptomonas seymouri	56%	97%
A0A1X0NII8	Trypanosomatidae	39%	100%
A0A3Q8IC04	Leishmania donovani	90%	100%
A0A3R7KNF9	Trypanosoma rangeli	39%	100%
A4H5X1	Leishmania braziliensis	78%	100%
A4HU66	Leishmania infantum	90%	100%
D0A9P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QHN1	Leishmania major	92%	100%
V5BMJ5	Trypanosoma cruzi	37%	100%