SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMZ3_LEIMU

TriTrypDb:

LmxM.09.1410

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.628
CLV_NRD_NRD_1	164	166	PF00675	0.617
CLV_NRD_NRD_1	174	176	PF00675	0.578
CLV_NRD_NRD_1	188	190	PF00675	0.399
CLV_NRD_NRD_1	341	343	PF00675	0.333
CLV_NRD_NRD_1	530	532	PF00675	0.579
CLV_NRD_NRD_1	78	80	PF00675	0.589
CLV_PCSK_KEX2_1	164	166	PF00082	0.612
CLV_PCSK_KEX2_1	174	176	PF00082	0.553
CLV_PCSK_KEX2_1	188	190	PF00082	0.405
CLV_PCSK_KEX2_1	341	343	PF00082	0.333
CLV_PCSK_KEX2_1	439	441	PF00082	0.577
CLV_PCSK_KEX2_1	530	532	PF00082	0.599
CLV_PCSK_KEX2_1	78	80	PF00082	0.604
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.648
CLV_PCSK_SKI1_1	128	132	PF00082	0.435
CLV_PCSK_SKI1_1	175	179	PF00082	0.546
CLV_PCSK_SKI1_1	18	22	PF00082	0.538
DEG_SPOP_SBC_1	462	466	PF00917	0.648
DOC_CYCLIN_RxL_1	185	196	PF00134	0.616
DOC_MAPK_DCC_7	341	350	PF00069	0.538
DOC_MAPK_HePTP_8	125	137	PF00069	0.403
DOC_MAPK_HePTP_8	338	350	PF00069	0.562
DOC_MAPK_MEF2A_6	128	137	PF00069	0.392
DOC_MAPK_MEF2A_6	341	350	PF00069	0.510
DOC_PP1_RVXF_1	488	495	PF00149	0.276
DOC_PP2B_LxvP_1	296	299	PF13499	0.513
DOC_USP7_MATH_1	113	117	PF00917	0.489
DOC_USP7_MATH_1	206	210	PF00917	0.551
DOC_USP7_MATH_1	303	307	PF00917	0.359
DOC_USP7_MATH_1	462	466	PF00917	0.727
DOC_WW_Pin1_4	139	144	PF00397	0.523
DOC_WW_Pin1_4	150	155	PF00397	0.546
DOC_WW_Pin1_4	234	239	PF00397	0.647
DOC_WW_Pin1_4	33	38	PF00397	0.663
DOC_WW_Pin1_4	408	413	PF00397	0.548
DOC_WW_Pin1_4	458	463	PF00397	0.759
DOC_WW_Pin1_4	476	481	PF00397	0.699
LIG_14-3-3_CanoR_1	174	178	PF00244	0.638
LIG_14-3-3_CanoR_1	195	201	PF00244	0.586
LIG_14-3-3_CanoR_1	26	30	PF00244	0.547
LIG_14-3-3_CanoR_1	282	292	PF00244	0.541
LIG_Actin_WH2_2	10	28	PF00022	0.316
LIG_APCC_ABBA_1	350	355	PF00400	0.440
LIG_APCC_ABBAyCdc20_2	401	407	PF00400	0.576
LIG_BIR_III_2	160	164	PF00653	0.626
LIG_BRCT_BRCA1_1	471	475	PF00533	0.796
LIG_CtBP_PxDLS_1	388	394	PF00389	0.562
LIG_deltaCOP1_diTrp_1	491	500	PF00928	0.403
LIG_EH1_1	286	294	PF00400	0.534
LIG_FHA_1	132	138	PF00498	0.386
LIG_FHA_1	194	200	PF00498	0.515
LIG_FHA_1	235	241	PF00498	0.521
LIG_FHA_1	284	290	PF00498	0.490
LIG_FHA_1	48	54	PF00498	0.469
LIG_FHA_2	385	391	PF00498	0.458
LIG_LIR_Gen_1	61	68	PF02991	0.279
LIG_LIR_Nem_3	61	67	PF02991	0.283
LIG_Pex14_1	494	498	PF04695	0.392
LIG_SH2_CRK	300	304	PF00017	0.356
LIG_SH2_CRK	64	68	PF00017	0.286
LIG_SH2_GRB2like	32	35	PF00017	0.718
LIG_SH2_GRB2like	561	564	PF00017	0.508
LIG_SH2_STAP1	64	68	PF00017	0.286
LIG_SH2_STAT5	138	141	PF00017	0.415
LIG_SH2_STAT5	244	247	PF00017	0.636
LIG_SH2_STAT5	300	303	PF00017	0.361
LIG_SH3_2	151	156	PF14604	0.335
LIG_SH3_3	145	151	PF00018	0.498
LIG_SH3_3	160	166	PF00018	0.503
LIG_SH3_3	340	346	PF00018	0.580
LIG_SH3_3	406	412	PF00018	0.737
LIG_SH3_3	474	480	PF00018	0.669
LIG_SH3_3	537	543	PF00018	0.622
LIG_SH3_3	563	569	PF00018	0.562
LIG_TRAF2_1	387	390	PF00917	0.496
LIG_TYR_ITIM	62	67	PF00017	0.286
MOD_CDC14_SPxK_1	153	156	PF00782	0.518
MOD_CDK_SPxK_1	150	156	PF00069	0.544
MOD_CK1_1	109	115	PF00069	0.567
MOD_CK1_1	116	122	PF00069	0.558
MOD_CK1_1	250	256	PF00069	0.620
MOD_CK1_1	33	39	PF00069	0.683
MOD_CK1_1	463	469	PF00069	0.693
MOD_CK1_1	66	72	PF00069	0.547
MOD_CK2_1	303	309	PF00069	0.619
MOD_CK2_1	384	390	PF00069	0.303
MOD_GlcNHglycan	111	114	PF01048	0.549
MOD_GlcNHglycan	115	118	PF01048	0.619
MOD_GlcNHglycan	249	252	PF01048	0.592
MOD_GlcNHglycan	320	324	PF01048	0.443
MOD_GlcNHglycan	372	376	PF01048	0.382
MOD_GlcNHglycan	423	426	PF01048	0.725
MOD_GlcNHglycan	471	474	PF01048	0.586
MOD_GSK3_1	109	116	PF00069	0.530
MOD_GSK3_1	377	384	PF00069	0.375
MOD_GSK3_1	408	415	PF00069	0.678
MOD_GSK3_1	43	50	PF00069	0.516
MOD_GSK3_1	458	465	PF00069	0.736
MOD_GSK3_1	467	474	PF00069	0.565
MOD_GSK3_1	7	14	PF00069	0.550
MOD_N-GLC_1	33	38	PF02516	0.721
MOD_N-GLC_1	357	362	PF02516	0.351
MOD_NEK2_1	131	136	PF00069	0.397
MOD_NEK2_1	137	142	PF00069	0.415
MOD_NEK2_1	173	178	PF00069	0.617
MOD_NEK2_1	25	30	PF00069	0.620
MOD_NEK2_1	330	335	PF00069	0.307
MOD_NEK2_1	357	362	PF00069	0.363
MOD_NEK2_1	513	518	PF00069	0.652
MOD_PIKK_1	11	17	PF00454	0.565
MOD_PIKK_1	250	256	PF00454	0.582
MOD_PIKK_1	71	77	PF00454	0.534
MOD_PIKK_1	83	89	PF00454	0.592
MOD_PK_1	63	69	PF00069	0.487
MOD_PKA_2	109	115	PF00069	0.580
MOD_PKA_2	173	179	PF00069	0.637
MOD_PKA_2	194	200	PF00069	0.544
MOD_PKA_2	247	253	PF00069	0.561
MOD_PKA_2	25	31	PF00069	0.530
MOD_PKA_2	256	262	PF00069	0.558
MOD_PKA_2	421	427	PF00069	0.552
MOD_PKA_2	559	565	PF00069	0.396
MOD_PKA_2	7	13	PF00069	0.654
MOD_PKA_2	71	77	PF00069	0.487
MOD_PKB_1	469	477	PF00069	0.503
MOD_Plk_1	319	325	PF00069	0.459
MOD_Plk_4	236	242	PF00069	0.565
MOD_Plk_4	346	352	PF00069	0.447
MOD_Plk_4	63	69	PF00069	0.541
MOD_ProDKin_1	139	145	PF00069	0.522
MOD_ProDKin_1	150	156	PF00069	0.546
MOD_ProDKin_1	234	240	PF00069	0.642
MOD_ProDKin_1	33	39	PF00069	0.663
MOD_ProDKin_1	408	414	PF00069	0.551
MOD_ProDKin_1	458	464	PF00069	0.761
MOD_ProDKin_1	476	482	PF00069	0.688
MOD_SUMO_rev_2	14	23	PF00179	0.498
TRG_ENDOCYTIC_2	395	398	PF00928	0.535
TRG_ENDOCYTIC_2	442	445	PF00928	0.617
TRG_ENDOCYTIC_2	64	67	PF00928	0.293
TRG_ER_diArg_1	163	165	PF00400	0.622
TRG_ER_diArg_1	173	175	PF00400	0.578
TRG_ER_diArg_1	187	189	PF00400	0.424
TRG_ER_diArg_1	340	342	PF00400	0.334
TRG_ER_diArg_1	420	423	PF00400	0.726
TRG_ER_diArg_1	519	522	PF00400	0.522
TRG_ER_diArg_1	529	531	PF00400	0.512
TRG_ER_diArg_1	558	561	PF00400	0.487
TRG_ER_diArg_1	77	79	PF00400	0.619
TRG_NLS_MonoExtC_3	530	535	PF00514	0.599
TRG_NLS_MonoExtN_4	530	535	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB06	Leptomonas seymouri	60%	99%
A0A0S4JCA3	Bodo saltans	28%	91%
A0A1X0NHU4	Trypanosomatidae	38%	100%
A0A3S7WQW9	Leishmania donovani	91%	100%
A0A422NZM7	Trypanosoma rangeli	39%	100%
A4H5W8	Leishmania braziliensis	80%	100%
A4HU63	Leishmania infantum	91%	100%
D0A9P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
Q4QHN4	Leishmania major	91%	100%
V5AY09	Trypanosoma cruzi	38%	100%