Alpha-1,2-Mannosidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMZ2_LEIMU

TriTrypDb:

LmxM.09.1400

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AMZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMZ2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004559	alpha-mannosidase activity	6	7
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	8	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0015923	mannosidase activity	5	7
GO:0015924	mannosyl-oligosaccharide mannosidase activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.190
CLV_NRD_NRD_1	10	12	PF00675	0.359
CLV_NRD_NRD_1	235	237	PF00675	0.521
CLV_NRD_NRD_1	287	289	PF00675	0.443
CLV_NRD_NRD_1	394	396	PF00675	0.429
CLV_NRD_NRD_1	469	471	PF00675	0.566
CLV_NRD_NRD_1	481	483	PF00675	0.463
CLV_PCSK_KEX2_1	287	289	PF00082	0.428
CLV_PCSK_KEX2_1	481	483	PF00082	0.499
CLV_PCSK_KEX2_1	9	11	PF00082	0.364
CLV_PCSK_SKI1_1	135	139	PF00082	0.531
CLV_PCSK_SKI1_1	161	165	PF00082	0.471
CLV_PCSK_SKI1_1	184	188	PF00082	0.554
CLV_PCSK_SKI1_1	276	280	PF00082	0.457
CLV_PCSK_SKI1_1	313	317	PF00082	0.443
CLV_PCSK_SKI1_1	62	66	PF00082	0.665
CLV_PCSK_SKI1_1	70	74	PF00082	0.695
DEG_APCC_DBOX_1	12	20	PF00400	0.543
DEG_APCC_DBOX_1	183	191	PF00400	0.356
DEG_Nend_UBRbox_2	1	3	PF02207	0.540
DEG_SCF_FBW7_1	194	199	PF00400	0.366
DOC_CKS1_1	337	342	PF01111	0.232
DOC_CKS1_1	531	536	PF01111	0.376
DOC_MAPK_gen_1	395	403	PF00069	0.233
DOC_MAPK_gen_1	481	492	PF00069	0.263
DOC_MAPK_gen_1	9	18	PF00069	0.543
DOC_MAPK_MEF2A_6	276	283	PF00069	0.258
DOC_MAPK_MEF2A_6	485	494	PF00069	0.243
DOC_MAPK_NFAT4_5	276	284	PF00069	0.232
DOC_PP1_RVXF_1	19	26	PF00149	0.451
DOC_PP1_RVXF_1	68	75	PF00149	0.340
DOC_USP7_MATH_1	147	151	PF00917	0.432
DOC_USP7_MATH_1	163	167	PF00917	0.252
DOC_USP7_MATH_1	200	204	PF00917	0.383
DOC_USP7_MATH_1	224	228	PF00917	0.325
DOC_USP7_MATH_1	238	242	PF00917	0.349
DOC_USP7_MATH_1	262	266	PF00917	0.368
DOC_USP7_MATH_1	301	305	PF00917	0.243
DOC_USP7_MATH_1	415	419	PF00917	0.190
DOC_USP7_MATH_1	54	58	PF00917	0.399
DOC_USP7_MATH_1	64	68	PF00917	0.370
DOC_WW_Pin1_4	190	195	PF00397	0.354
DOC_WW_Pin1_4	196	201	PF00397	0.385
DOC_WW_Pin1_4	220	225	PF00397	0.339
DOC_WW_Pin1_4	336	341	PF00397	0.232
DOC_WW_Pin1_4	518	523	PF00397	0.280
DOC_WW_Pin1_4	530	535	PF00397	0.358
LIG_14-3-3_CanoR_1	236	245	PF00244	0.373
LIG_14-3-3_CanoR_1	313	322	PF00244	0.232
LIG_14-3-3_CanoR_1	368	375	PF00244	0.232
LIG_14-3-3_CanoR_1	395	403	PF00244	0.223
LIG_14-3-3_CanoR_1	425	429	PF00244	0.232
LIG_14-3-3_CanoR_1	470	478	PF00244	0.299
LIG_APCC_ABBA_1	386	391	PF00400	0.228
LIG_deltaCOP1_diTrp_1	71	78	PF00928	0.381
LIG_EH1_1	494	502	PF00400	0.289
LIG_eIF4E_1	451	457	PF01652	0.190
LIG_FHA_1	105	111	PF00498	0.381
LIG_FHA_1	193	199	PF00498	0.345
LIG_FHA_1	223	229	PF00498	0.340
LIG_FHA_1	273	279	PF00498	0.223
LIG_FHA_1	310	316	PF00498	0.232
LIG_FHA_1	487	493	PF00498	0.397
LIG_FHA_1	509	515	PF00498	0.320
LIG_FHA_1	522	528	PF00498	0.340
LIG_FHA_1	63	69	PF00498	0.386
LIG_FHA_1	95	101	PF00498	0.361
LIG_FHA_2	411	417	PF00498	0.279
LIG_FHA_2	443	449	PF00498	0.360
LIG_GBD_Chelix_1	31	39	PF00786	0.233
LIG_IRF3_LxIS_1	31	38	PF10401	0.193
LIG_LIR_Apic_2	239	245	PF02991	0.375
LIG_LIR_Gen_1	2	12	PF02991	0.599
LIG_LIR_Gen_1	20	30	PF02991	0.427
LIG_LIR_Gen_1	203	212	PF02991	0.345
LIG_LIR_Gen_1	229	238	PF02991	0.433
LIG_LIR_Gen_1	265	274	PF02991	0.330
LIG_LIR_Gen_1	426	436	PF02991	0.243
LIG_LIR_Gen_1	489	497	PF02991	0.253
LIG_LIR_Nem_3	20	25	PF02991	0.432
LIG_LIR_Nem_3	203	208	PF02991	0.338
LIG_LIR_Nem_3	229	235	PF02991	0.398
LIG_LIR_Nem_3	265	271	PF02991	0.350
LIG_LIR_Nem_3	383	389	PF02991	0.234
LIG_LIR_Nem_3	426	431	PF02991	0.270
LIG_LIR_Nem_3	437	443	PF02991	0.207
LIG_LIR_Nem_3	489	494	PF02991	0.249
LIG_NRBOX	452	458	PF00104	0.190
LIG_PCNA_PIPBox_1	303	312	PF02747	0.228
LIG_SH2_CRK	232	236	PF00017	0.294
LIG_SH2_CRK	268	272	PF00017	0.311
LIG_SH2_NCK_1	389	393	PF00017	0.232
LIG_SH2_NCK_1	412	416	PF00017	0.243
LIG_SH2_PTP2	33	36	PF00017	0.268
LIG_SH2_SRC	389	392	PF00017	0.232
LIG_SH2_STAP1	268	272	PF00017	0.311
LIG_SH2_STAP1	298	302	PF00017	0.232
LIG_SH2_STAP1	311	315	PF00017	0.232
LIG_SH2_STAT5	22	25	PF00017	0.349
LIG_SH2_STAT5	311	314	PF00017	0.243
LIG_SH2_STAT5	33	36	PF00017	0.349
LIG_SH2_STAT5	402	405	PF00017	0.232
LIG_SH2_STAT5	412	415	PF00017	0.232
LIG_SH2_STAT5	428	431	PF00017	0.232
LIG_SH2_STAT5	95	98	PF00017	0.288
LIG_SH3_3	334	340	PF00018	0.232
LIG_SH3_3	358	364	PF00018	0.243
LIG_SH3_3	525	531	PF00018	0.300
LIG_SH3_3	69	75	PF00018	0.390
LIG_SH3_3	76	82	PF00018	0.389
LIG_SH3_CIN85_PxpxPR_1	336	341	PF14604	0.243
LIG_Sin3_3	331	338	PF02671	0.243
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.264
LIG_SUMO_SIM_anti_2	455	460	PF11976	0.221
LIG_SUMO_SIM_par_1	119	124	PF11976	0.254
LIG_SUMO_SIM_par_1	33	38	PF11976	0.246
LIG_TYR_ITIM	31	36	PF00017	0.241
LIG_TYR_ITSM	424	431	PF00017	0.190
LIG_WRC_WIRS_1	436	441	PF05994	0.232
MOD_CDK_SPK_2	336	341	PF00069	0.232
MOD_CK1_1	150	156	PF00069	0.340
MOD_CK1_1	203	209	PF00069	0.341
MOD_CK1_1	214	220	PF00069	0.389
MOD_CK1_1	222	228	PF00069	0.425
MOD_CK1_1	418	424	PF00069	0.235
MOD_CK1_1	505	511	PF00069	0.358
MOD_CK1_1	521	527	PF00069	0.285
MOD_CK2_1	220	226	PF00069	0.330
MOD_CK2_1	326	332	PF00069	0.306
MOD_CK2_1	435	441	PF00069	0.232
MOD_CK2_1	54	60	PF00069	0.403
MOD_Cter_Amidation	285	288	PF01082	0.428
MOD_Cter_Amidation	393	396	PF01082	0.428
MOD_GlcNHglycan	145	148	PF01048	0.546
MOD_GlcNHglycan	149	152	PF01048	0.652
MOD_GlcNHglycan	165	168	PF01048	0.575
MOD_GlcNHglycan	205	208	PF01048	0.527
MOD_GlcNHglycan	264	267	PF01048	0.577
MOD_GlcNHglycan	365	368	PF01048	0.409
MOD_GlcNHglycan	398	401	PF01048	0.451
MOD_GlcNHglycan	405	408	PF01048	0.417
MOD_GlcNHglycan	419	423	PF01048	0.432
MOD_GlcNHglycan	475	478	PF01048	0.540
MOD_GlcNHglycan	56	59	PF01048	0.608
MOD_GSK3_1	121	128	PF00069	0.293
MOD_GSK3_1	143	150	PF00069	0.349
MOD_GSK3_1	188	195	PF00069	0.367
MOD_GSK3_1	196	203	PF00069	0.430
MOD_GSK3_1	220	227	PF00069	0.358
MOD_GSK3_1	309	316	PF00069	0.232
MOD_GSK3_1	322	329	PF00069	0.232
MOD_GSK3_1	363	370	PF00069	0.232
MOD_GSK3_1	420	427	PF00069	0.233
MOD_GSK3_1	469	476	PF00069	0.358
MOD_GSK3_1	514	521	PF00069	0.277
MOD_GSK3_1	526	533	PF00069	0.296
MOD_GSK3_1	94	101	PF00069	0.435
MOD_N-GLC_1	322	327	PF02516	0.432
MOD_NEK2_1	255	260	PF00069	0.532
MOD_NEK2_1	309	314	PF00069	0.232
MOD_NEK2_1	322	327	PF00069	0.232
MOD_NEK2_1	35	40	PF00069	0.258
MOD_NEK2_1	381	386	PF00069	0.232
MOD_NEK2_1	424	429	PF00069	0.270
MOD_NEK2_1	435	440	PF00069	0.207
MOD_NEK2_1	442	447	PF00069	0.192
MOD_NEK2_1	514	519	PF00069	0.284
MOD_NEK2_2	231	236	PF00069	0.313
MOD_NEK2_2	420	425	PF00069	0.224
MOD_PIKK_1	2	8	PF00454	0.566
MOD_PKA_1	236	242	PF00069	0.338
MOD_PKA_1	287	293	PF00069	0.228
MOD_PKA_2	214	220	PF00069	0.314
MOD_PKA_2	287	293	PF00069	0.228
MOD_PKA_2	362	368	PF00069	0.243
MOD_PKA_2	424	430	PF00069	0.223
MOD_PKA_2	469	475	PF00069	0.361
MOD_PKA_2	502	508	PF00069	0.360
MOD_Plk_1	141	147	PF00069	0.283
MOD_Plk_1	322	328	PF00069	0.232
MOD_Plk_4	238	244	PF00069	0.369
MOD_Plk_4	301	307	PF00069	0.232
MOD_Plk_4	435	441	PF00069	0.232
MOD_Plk_4	515	521	PF00069	0.302
MOD_ProDKin_1	190	196	PF00069	0.353
MOD_ProDKin_1	220	226	PF00069	0.342
MOD_ProDKin_1	336	342	PF00069	0.232
MOD_ProDKin_1	518	524	PF00069	0.281
MOD_ProDKin_1	530	536	PF00069	0.367
MOD_SUMO_for_1	173	176	PF00179	0.288
MOD_SUMO_rev_2	57	64	PF00179	0.374
TRG_DiLeu_BaEn_1	182	187	PF01217	0.288
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.257
TRG_ENDOCYTIC_2	22	25	PF00928	0.251
TRG_ENDOCYTIC_2	232	235	PF00928	0.288
TRG_ENDOCYTIC_2	268	271	PF00928	0.320
TRG_ENDOCYTIC_2	33	36	PF00928	0.251
TRG_ENDOCYTIC_2	428	431	PF00928	0.243
TRG_ER_diArg_1	480	482	PF00400	0.298
TRG_ER_diArg_1	9	11	PF00400	0.564
TRG_NES_CRM1_1	448	462	PF08389	0.232
TRG_NLS_MonoExtN_4	392	399	PF00514	0.228
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A3	Leptomonas seymouri	51%	97%
A0A3Q8I8J9	Leishmania donovani	88%	82%
A4H5W7	Leishmania braziliensis	75%	100%
A4HU62	Leishmania infantum	88%	100%
Q4QHN5	Leishmania major	88%	100%