F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMZ1_LEIMU

TriTrypDb:

LmxM.09.1390

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AMZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.711
CLV_C14_Caspase3-7	124	128	PF00656	0.751
CLV_C14_Caspase3-7	8	12	PF00656	0.637
CLV_NRD_NRD_1	189	191	PF00675	0.431
CLV_NRD_NRD_1	200	202	PF00675	0.422
CLV_NRD_NRD_1	482	484	PF00675	0.635
CLV_PCSK_KEX2_1	200	202	PF00082	0.484
CLV_PCSK_KEX2_1	482	484	PF00082	0.609
CLV_PCSK_KEX2_1	498	500	PF00082	0.524
CLV_PCSK_KEX2_1	5	7	PF00082	0.520
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.610
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.527
CLV_PCSK_SKI1_1	207	211	PF00082	0.448
CLV_PCSK_SKI1_1	265	269	PF00082	0.691
CLV_PCSK_SKI1_1	342	346	PF00082	0.601
CLV_PCSK_SKI1_1	382	386	PF00082	0.521
CLV_PCSK_SKI1_1	40	44	PF00082	0.519
CLV_PCSK_SKI1_1	551	555	PF00082	0.483
DEG_SPOP_SBC_1	73	77	PF00917	0.792
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.259
DOC_MAPK_gen_1	187	195	PF00069	0.598
DOC_MAPK_HePTP_8	584	596	PF00069	0.616
DOC_MAPK_MEF2A_6	40	49	PF00069	0.584
DOC_MAPK_MEF2A_6	587	596	PF00069	0.587
DOC_MAPK_RevD_3	469	483	PF00069	0.229
DOC_PP1_RVXF_1	233	240	PF00149	0.593
DOC_PP1_RVXF_1	310	317	PF00149	0.482
DOC_USP7_MATH_1	267	271	PF00917	0.446
DOC_USP7_MATH_1	298	302	PF00917	0.665
DOC_USP7_MATH_1	360	364	PF00917	0.485
DOC_USP7_MATH_2	357	363	PF00917	0.444
DOC_WW_Pin1_4	41	46	PF00397	0.709
LIG_14-3-3_CanoR_1	265	274	PF00244	0.442
LIG_14-3-3_CanoR_1	35	43	PF00244	0.594
LIG_14-3-3_CanoR_1	382	387	PF00244	0.322
LIG_14-3-3_CanoR_1	499	504	PF00244	0.404
LIG_14-3-3_CanoR_1	6	11	PF00244	0.691
LIG_14-3-3_CanoR_1	66	74	PF00244	0.762
LIG_AP2alpha_2	447	449	PF02296	0.424
LIG_APCC_ABBA_1	149	154	PF00400	0.661
LIG_APCC_ABBA_1	413	418	PF00400	0.301
LIG_BRCT_BRCA1_1	422	426	PF00533	0.328
LIG_BRCT_BRCA1_1	87	91	PF00533	0.716
LIG_Clathr_ClatBox_1	150	154	PF01394	0.678
LIG_Clathr_ClatBox_1	414	418	PF01394	0.353
LIG_deltaCOP1_diTrp_1	527	536	PF00928	0.391
LIG_EH1_1	196	204	PF00400	0.661
LIG_FHA_1	204	210	PF00498	0.699
LIG_FHA_1	275	281	PF00498	0.373
LIG_FHA_1	289	295	PF00498	0.306
LIG_FHA_1	308	314	PF00498	0.611
LIG_FHA_1	347	353	PF00498	0.387
LIG_FHA_1	42	48	PF00498	0.771
LIG_FHA_1	5	11	PF00498	0.721
LIG_FHA_1	503	509	PF00498	0.372
LIG_FHA_1	569	575	PF00498	0.338
LIG_FHA_1	597	603	PF00498	0.335
LIG_FHA_1	607	613	PF00498	0.343
LIG_FHA_1	641	647	PF00498	0.378
LIG_FHA_1	74	80	PF00498	0.803
LIG_FHA_2	106	112	PF00498	0.676
LIG_FHA_2	155	161	PF00498	0.662
LIG_FHA_2	208	214	PF00498	0.613
LIG_FHA_2	284	290	PF00498	0.454
LIG_FHA_2	383	389	PF00498	0.351
LIG_FHA_2	487	493	PF00498	0.455
LIG_FHA_2	6	12	PF00498	0.617
LIG_GBD_Chelix_1	284	292	PF00786	0.453
LIG_LIR_Apic_2	490	496	PF02991	0.378
LIG_LIR_Gen_1	277	287	PF02991	0.357
LIG_LIR_Gen_1	368	376	PF02991	0.317
LIG_LIR_Gen_1	440	449	PF02991	0.284
LIG_LIR_Gen_1	501	508	PF02991	0.440
LIG_LIR_Gen_1	552	562	PF02991	0.433
LIG_LIR_Gen_1	643	651	PF02991	0.447
LIG_LIR_Nem_3	277	282	PF02991	0.447
LIG_LIR_Nem_3	368	372	PF02991	0.318
LIG_LIR_Nem_3	378	384	PF02991	0.321
LIG_LIR_Nem_3	440	445	PF02991	0.436
LIG_LIR_Nem_3	501	506	PF02991	0.437
LIG_LIR_Nem_3	559	564	PF02991	0.327
LIG_LIR_Nem_3	643	647	PF02991	0.447
LIG_Pex14_1	536	540	PF04695	0.405
LIG_REV1ctd_RIR_1	1	10	PF16727	0.752
LIG_SH2_CRK	174	178	PF00017	0.721
LIG_SH2_CRK	442	446	PF00017	0.259
LIG_SH2_CRK	476	480	PF00017	0.399
LIG_SH2_CRK	564	568	PF00017	0.370
LIG_SH2_GRB2like	174	177	PF00017	0.622
LIG_SH2_PTP2	540	543	PF00017	0.354
LIG_SH2_SRC	229	232	PF00017	0.629
LIG_SH2_STAP1	174	178	PF00017	0.649
LIG_SH2_STAP1	421	425	PF00017	0.382
LIG_SH2_STAP1	442	446	PF00017	0.442
LIG_SH2_STAT5	152	155	PF00017	0.595
LIG_SH2_STAT5	183	186	PF00017	0.686
LIG_SH2_STAT5	214	217	PF00017	0.651
LIG_SH2_STAT5	229	232	PF00017	0.585
LIG_SH2_STAT5	259	262	PF00017	0.432
LIG_SH2_STAT5	396	399	PF00017	0.372
LIG_SH2_STAT5	416	419	PF00017	0.178
LIG_SH2_STAT5	540	543	PF00017	0.340
LIG_SH2_STAT5	624	627	PF00017	0.389
LIG_SH2_STAT5	650	653	PF00017	0.335
LIG_SH3_3	190	196	PF00018	0.540
LIG_SH3_3	290	296	PF00018	0.354
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.420
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.314
LIG_SUMO_SIM_par_1	160	166	PF11976	0.497
LIG_SUMO_SIM_par_1	280	286	PF11976	0.363
LIG_SUMO_SIM_par_1	348	353	PF11976	0.413
LIG_SUMO_SIM_par_1	382	388	PF11976	0.432
LIG_SUMO_SIM_par_1	467	472	PF11976	0.317
LIG_TRFH_1	369	373	PF08558	0.419
LIG_TYR_ITIM	15	20	PF00017	0.772
LIG_TYR_ITIM	562	567	PF00017	0.430
LIG_UBA3_1	580	587	PF00899	0.581
LIG_Vh1_VBS_1	585	603	PF01044	0.396
LIG_WRC_WIRS_1	276	281	PF05994	0.479
LIG_WRC_WIRS_1	366	371	PF05994	0.538
MOD_CK1_1	105	111	PF00069	0.543
MOD_CK1_1	301	307	PF00069	0.595
MOD_CK1_1	504	510	PF00069	0.429
MOD_CK1_1	57	63	PF00069	0.706
MOD_CK1_1	9	15	PF00069	0.616
MOD_CK2_1	207	213	PF00069	0.515
MOD_CK2_1	283	289	PF00069	0.400
MOD_CK2_1	382	388	PF00069	0.476
MOD_CK2_1	649	655	PF00069	0.479
MOD_GlcNHglycan	141	144	PF01048	0.526
MOD_GlcNHglycan	330	333	PF01048	0.389
MOD_GlcNHglycan	354	357	PF01048	0.599
MOD_GlcNHglycan	400	403	PF01048	0.479
MOD_GlcNHglycan	422	425	PF01048	0.441
MOD_GlcNHglycan	429	432	PF01048	0.422
MOD_GlcNHglycan	455	458	PF01048	0.575
MOD_GlcNHglycan	462	465	PF01048	0.585
MOD_GlcNHglycan	511	514	PF01048	0.642
MOD_GlcNHglycan	551	554	PF01048	0.295
MOD_GlcNHglycan	612	615	PF01048	0.375
MOD_GlcNHglycan	630	633	PF01048	0.398
MOD_GlcNHglycan	86	90	PF01048	0.671
MOD_GSK3_1	135	142	PF00069	0.627
MOD_GSK3_1	203	210	PF00069	0.638
MOD_GSK3_1	263	270	PF00069	0.570
MOD_GSK3_1	298	305	PF00069	0.632
MOD_GSK3_1	346	353	PF00069	0.551
MOD_GSK3_1	449	456	PF00069	0.493
MOD_GSK3_1	494	501	PF00069	0.442
MOD_GSK3_1	5	12	PF00069	0.507
MOD_GSK3_1	504	511	PF00069	0.422
MOD_GSK3_1	606	613	PF00069	0.432
MOD_GSK3_1	62	69	PF00069	0.628
MOD_GSK3_1	645	652	PF00069	0.422
MOD_GSK3_1	85	92	PF00069	0.659
MOD_LATS_1	83	89	PF00433	0.734
MOD_N-GLC_1	427	432	PF02516	0.411
MOD_N-GLC_1	460	465	PF02516	0.589
MOD_NEK2_1	263	268	PF00069	0.562
MOD_NEK2_1	274	279	PF00069	0.368
MOD_NEK2_1	288	293	PF00069	0.277
MOD_NEK2_1	321	326	PF00069	0.333
MOD_NEK2_1	333	338	PF00069	0.377
MOD_NEK2_1	352	357	PF00069	0.593
MOD_NEK2_1	4	9	PF00069	0.707
MOD_NEK2_1	417	422	PF00069	0.299
MOD_NEK2_1	449	454	PF00069	0.627
MOD_NEK2_1	475	480	PF00069	0.386
MOD_NEK2_1	508	513	PF00069	0.503
MOD_NEK2_1	543	548	PF00069	0.508
MOD_NEK2_1	56	61	PF00069	0.694
MOD_NEK2_1	610	615	PF00069	0.410
MOD_NEK2_1	645	650	PF00069	0.387
MOD_NEK2_1	91	96	PF00069	0.584
MOD_PIKK_1	469	475	PF00454	0.541
MOD_PKA_1	498	504	PF00069	0.425
MOD_PKA_1	5	11	PF00069	0.497
MOD_PKA_2	121	127	PF00069	0.521
MOD_PKA_2	498	504	PF00069	0.505
MOD_PKA_2	5	11	PF00069	0.478
MOD_PKA_2	508	514	PF00069	0.522
MOD_PKA_2	515	521	PF00069	0.624
MOD_PKA_2	67	73	PF00069	0.762
MOD_PKB_1	380	388	PF00069	0.396
MOD_PKB_1	66	74	PF00069	0.495
MOD_Plk_1	288	294	PF00069	0.386
MOD_Plk_1	350	356	PF00069	0.530
MOD_Plk_1	417	423	PF00069	0.403
MOD_Plk_1	427	433	PF00069	0.435
MOD_Plk_1	57	63	PF00069	0.554
MOD_Plk_1	89	95	PF00069	0.685
MOD_Plk_2-3	346	352	PF00069	0.530
MOD_Plk_4	275	281	PF00069	0.390
MOD_Plk_4	283	289	PF00069	0.324
MOD_Plk_4	321	327	PF00069	0.409
MOD_Plk_4	606	612	PF00069	0.438
MOD_Plk_4	620	626	PF00069	0.482
MOD_Plk_4	640	646	PF00069	0.150
MOD_ProDKin_1	41	47	PF00069	0.651
MOD_SUMO_for_1	219	222	PF00179	0.606
TRG_ENDOCYTIC_2	17	20	PF00928	0.777
TRG_ENDOCYTIC_2	174	177	PF00928	0.555
TRG_ENDOCYTIC_2	442	445	PF00928	0.311
TRG_ENDOCYTIC_2	476	479	PF00928	0.407
TRG_ENDOCYTIC_2	540	543	PF00928	0.424
TRG_ENDOCYTIC_2	564	567	PF00928	0.343
TRG_ER_diArg_1	113	116	PF00400	0.694
TRG_ER_diArg_1	184	187	PF00400	0.522
TRG_ER_diArg_1	199	201	PF00400	0.553
TRG_ER_diArg_1	22	25	PF00400	0.756
TRG_NES_CRM1_1	144	154	PF08389	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M8	Leptomonas seymouri	64%	100%
A0A1X0NIN6	Trypanosomatidae	44%	100%
A0A3Q8I8N7	Leishmania donovani	90%	99%
A0A3R7N0K0	Trypanosoma rangeli	42%	100%
A4H5W6	Leishmania braziliensis	79%	100%
A4HU61	Leishmania infantum	90%	99%
D0A9P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QHN6	Leishmania major	88%	100%
V5BI21	Trypanosoma cruzi	42%	91%