Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMZ0_LEIMU

TriTrypDb:

LmxM.09.1380

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.722
CLV_NRD_NRD_1	110	112	PF00675	0.533
CLV_NRD_NRD_1	28	30	PF00675	0.645
CLV_NRD_NRD_1	382	384	PF00675	0.564
CLV_PCSK_KEX2_1	110	112	PF00082	0.473
CLV_PCSK_KEX2_1	28	30	PF00082	0.647
CLV_PCSK_KEX2_1	382	384	PF00082	0.507
CLV_PCSK_SKI1_1	110	114	PF00082	0.445
CLV_PCSK_SKI1_1	323	327	PF00082	0.511
CLV_PCSK_SKI1_1	352	356	PF00082	0.490
CLV_PCSK_SKI1_1	429	433	PF00082	0.629
CLV_PCSK_SKI1_1	463	467	PF00082	0.452
CLV_PCSK_SKI1_1	545	549	PF00082	0.509
DEG_APCC_DBOX_1	322	330	PF00400	0.531
DEG_APCC_DBOX_1	351	359	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DEG_SCF_FBW7_1	519	526	PF00400	0.582
DEG_SPOP_SBC_1	371	375	PF00917	0.520
DEG_SPOP_SBC_1	44	48	PF00917	0.657
DEG_SPOP_SBC_1	49	53	PF00917	0.583
DEG_SPOP_SBC_1	63	67	PF00917	0.409
DOC_CYCLIN_RxL_1	423	435	PF00134	0.607
DOC_CYCLIN_RxL_1	460	469	PF00134	0.534
DOC_MAPK_MEF2A_6	352	361	PF00069	0.505
DOC_MAPK_MEF2A_6	408	415	PF00069	0.532
DOC_MAPK_NFAT4_5	352	360	PF00069	0.547
DOC_PP1_RVXF_1	427	433	PF00149	0.534
DOC_PP2B_LxvP_1	303	306	PF13499	0.572
DOC_PP4_FxxP_1	325	328	PF00568	0.569
DOC_USP7_MATH_1	285	289	PF00917	0.741
DOC_USP7_MATH_1	364	368	PF00917	0.571
DOC_USP7_MATH_1	45	49	PF00917	0.738
DOC_USP7_MATH_1	50	54	PF00917	0.642
DOC_USP7_MATH_1	61	65	PF00917	0.613
DOC_WW_Pin1_4	101	106	PF00397	0.638
DOC_WW_Pin1_4	275	280	PF00397	0.624
DOC_WW_Pin1_4	281	286	PF00397	0.681
DOC_WW_Pin1_4	432	437	PF00397	0.693
DOC_WW_Pin1_4	519	524	PF00397	0.550
LIG_14-3-3_CanoR_1	210	219	PF00244	0.620
LIG_14-3-3_CanoR_1	28	32	PF00244	0.641
LIG_14-3-3_CanoR_1	356	362	PF00244	0.490
LIG_14-3-3_CanoR_1	382	391	PF00244	0.509
LIG_14-3-3_CanoR_1	568	573	PF00244	0.492
LIG_14-3-3_CanoR_1	74	80	PF00244	0.589
LIG_Actin_WH2_2	113	130	PF00022	0.504
LIG_APCC_ABBA_1	547	552	PF00400	0.392
LIG_BRCT_BRCA1_1	321	325	PF00533	0.570
LIG_BRCT_BRCA1_1	411	415	PF00533	0.529
LIG_BRCT_BRCA1_1	65	69	PF00533	0.604
LIG_CaM_NSCaTE_8	453	460	PF13499	0.545
LIG_Clathr_ClatBox_1	395	399	PF01394	0.396
LIG_Clathr_ClatBox_1	465	469	PF01394	0.405
LIG_CtBP_PxDLS_1	232	236	PF00389	0.510
LIG_EH1_1	424	432	PF00400	0.595
LIG_FHA_1	122	128	PF00498	0.540
LIG_FHA_1	13	19	PF00498	0.605
LIG_FHA_1	139	145	PF00498	0.645
LIG_FHA_1	262	268	PF00498	0.540
LIG_FHA_2	329	335	PF00498	0.490
LIG_FHA_2	508	514	PF00498	0.539
LIG_GBD_Chelix_1	266	274	PF00786	0.527
LIG_LIR_Apic_2	322	328	PF02991	0.576
LIG_LIR_Apic_2	392	397	PF02991	0.446
LIG_LIR_Gen_1	116	123	PF02991	0.548
LIG_LIR_Gen_1	491	496	PF02991	0.579
LIG_LIR_Nem_3	116	120	PF02991	0.544
LIG_LIR_Nem_3	307	313	PF02991	0.469
LIG_LIR_Nem_3	450	456	PF02991	0.486
LIG_LIR_Nem_3	459	465	PF02991	0.342
LIG_LIR_Nem_3	573	579	PF02991	0.488
LIG_LIR_Nem_3	81	85	PF02991	0.529
LIG_NRBOX	246	252	PF00104	0.491
LIG_PCNA_yPIPBox_3	241	251	PF02747	0.596
LIG_SH2_CRK	462	466	PF00017	0.425
LIG_SH2_NCK_1	341	345	PF00017	0.602
LIG_SH2_SRC	85	88	PF00017	0.643
LIG_SH2_STAP1	391	395	PF00017	0.463
LIG_SH2_STAP1	458	462	PF00017	0.547
LIG_SH2_STAP1	492	496	PF00017	0.572
LIG_SH2_STAT3	363	366	PF00017	0.565
LIG_SH2_STAT3	458	461	PF00017	0.541
LIG_SH2_STAT5	311	314	PF00017	0.444
LIG_SH2_STAT5	550	553	PF00017	0.419
LIG_SH2_STAT5	85	88	PF00017	0.643
LIG_SH3_1	276	282	PF00018	0.606
LIG_SH3_3	219	225	PF00018	0.550
LIG_SH3_3	227	233	PF00018	0.535
LIG_SH3_3	276	282	PF00018	0.662
LIG_SH3_5	306	310	PF00018	0.474
LIG_Sin3_3	192	199	PF02671	0.259
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.574
LIG_SUMO_SIM_par_1	463	469	PF11976	0.456
LIG_TRAF2_1	284	287	PF00917	0.452
LIG_TRAF2_1	571	574	PF00917	0.397
LIG_TYR_ITIM	308	313	PF00017	0.477
LIG_UBA3_1	395	400	PF00899	0.465
LIG_UBA3_1	464	470	PF00899	0.505
LIG_UBA3_1	507	515	PF00899	0.542
MOD_CDK_SPxK_1	519	525	PF00069	0.589
MOD_CK1_1	138	144	PF00069	0.612
MOD_CK1_1	181	187	PF00069	0.682
MOD_CK1_1	234	240	PF00069	0.676
MOD_CK1_1	319	325	PF00069	0.492
MOD_CK1_1	373	379	PF00069	0.635
MOD_CK1_1	435	441	PF00069	0.676
MOD_CK1_1	48	54	PF00069	0.694
MOD_CK1_1	483	489	PF00069	0.611
MOD_CK1_1	64	70	PF00069	0.680
MOD_CK1_1	75	81	PF00069	0.657
MOD_CK2_1	144	150	PF00069	0.592
MOD_CK2_1	281	287	PF00069	0.680
MOD_CK2_1	328	334	PF00069	0.465
MOD_CK2_1	507	513	PF00069	0.527
MOD_CK2_1	568	574	PF00069	0.398
MOD_CK2_1	75	81	PF00069	0.600
MOD_GlcNHglycan	165	168	PF01048	0.751
MOD_GlcNHglycan	180	183	PF01048	0.620
MOD_GlcNHglycan	186	189	PF01048	0.493
MOD_GlcNHglycan	192	195	PF01048	0.471
MOD_GlcNHglycan	197	200	PF01048	0.467
MOD_GlcNHglycan	212	215	PF01048	0.534
MOD_GlcNHglycan	247	250	PF01048	0.578
MOD_GlcNHglycan	259	262	PF01048	0.342
MOD_GlcNHglycan	287	291	PF01048	0.665
MOD_GlcNHglycan	298	301	PF01048	0.398
MOD_GlcNHglycan	342	345	PF01048	0.559
MOD_GlcNHglycan	366	369	PF01048	0.579
MOD_GlcNHglycan	403	406	PF01048	0.503
MOD_GlcNHglycan	439	443	PF01048	0.632
MOD_GlcNHglycan	458	461	PF01048	0.456
MOD_GlcNHglycan	47	50	PF01048	0.708
MOD_GlcNHglycan	485	488	PF01048	0.597
MOD_GlcNHglycan	541	545	PF01048	0.612
MOD_GlcNHglycan	56	59	PF01048	0.621
MOD_GSK3_1	134	141	PF00069	0.552
MOD_GSK3_1	180	187	PF00069	0.664
MOD_GSK3_1	257	264	PF00069	0.279
MOD_GSK3_1	27	34	PF00069	0.558
MOD_GSK3_1	281	288	PF00069	0.655
MOD_GSK3_1	315	322	PF00069	0.550
MOD_GSK3_1	369	376	PF00069	0.715
MOD_GSK3_1	431	438	PF00069	0.578
MOD_GSK3_1	44	51	PF00069	0.683
MOD_GSK3_1	479	486	PF00069	0.612
MOD_GSK3_1	503	510	PF00069	0.435
MOD_GSK3_1	519	526	PF00069	0.410
MOD_GSK3_1	61	68	PF00069	0.676
MOD_N-GLC_1	2	7	PF02516	0.660
MOD_N-GLC_1	479	484	PF02516	0.590
MOD_NEK2_1	10	15	PF00069	0.537
MOD_NEK2_1	119	124	PF00069	0.543
MOD_NEK2_1	144	149	PF00069	0.645
MOD_NEK2_1	18	23	PF00069	0.451
MOD_NEK2_1	195	200	PF00069	0.460
MOD_NEK2_1	2	7	PF00069	0.636
MOD_NEK2_1	357	362	PF00069	0.526
MOD_NEK2_1	398	403	PF00069	0.474
MOD_NEK2_1	411	416	PF00069	0.396
MOD_NEK2_1	431	436	PF00069	0.455
MOD_NEK2_1	507	512	PF00069	0.505
MOD_NEK2_1	540	545	PF00069	0.649
MOD_NEK2_1	69	74	PF00069	0.629
MOD_PIKK_1	18	24	PF00454	0.549
MOD_PIKK_1	181	187	PF00454	0.561
MOD_PIKK_1	31	37	PF00454	0.590
MOD_PK_1	568	574	PF00069	0.488
MOD_PKA_2	27	33	PF00069	0.638
MOD_Plk_1	2	8	PF00069	0.586
MOD_Plk_1	398	404	PF00069	0.533
MOD_Plk_4	218	224	PF00069	0.579
MOD_Plk_4	231	237	PF00069	0.694
MOD_Plk_4	357	363	PF00069	0.512
MOD_Plk_4	503	509	PF00069	0.496
MOD_Plk_4	65	71	PF00069	0.506
MOD_ProDKin_1	101	107	PF00069	0.631
MOD_ProDKin_1	275	281	PF00069	0.637
MOD_ProDKin_1	432	438	PF00069	0.700
MOD_ProDKin_1	519	525	PF00069	0.550
MOD_SUMO_rev_2	94	103	PF00179	0.381
TRG_DiLeu_BaEn_1	513	518	PF01217	0.489
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.557
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.489
TRG_ENDOCYTIC_2	310	313	PF00928	0.478
TRG_ENDOCYTIC_2	462	465	PF00928	0.424
TRG_ENDOCYTIC_2	492	495	PF00928	0.475
TRG_ER_diArg_1	382	384	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L4	Leptomonas seymouri	56%	96%
A0A1X0NHU3	Trypanosomatidae	27%	100%
A0A3Q8I8N5	Leishmania donovani	91%	100%
A0A3R7NSE1	Trypanosoma rangeli	30%	100%
A4H5W5	Leishmania braziliensis	82%	100%
A4HU60	Leishmania infantum	91%	100%
Q4QHN7	Leishmania major	90%	100%
V5BMK0	Trypanosoma cruzi	28%	100%