Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMY7_LEIMU

TriTrypDb:

LmxM.09.1350

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AMY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.534
CLV_NRD_NRD_1	46	48	PF00675	0.374
CLV_PCSK_FUR_1	112	116	PF00082	0.482
CLV_PCSK_KEX2_1	114	116	PF00082	0.534
CLV_PCSK_KEX2_1	46	48	PF00082	0.374
CLV_PCSK_SKI1_1	114	118	PF00082	0.440
CLV_PCSK_SKI1_1	171	175	PF00082	0.435
CLV_PCSK_SKI1_1	187	191	PF00082	0.454
DEG_MDM2_SWIB_1	78	85	PF02201	0.500
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DEG_SPOP_SBC_1	4	8	PF00917	0.580
DOC_CKS1_1	116	121	PF01111	0.434
DOC_PP4_FxxP_1	116	119	PF00568	0.316
DOC_PP4_FxxP_1	38	41	PF00568	0.507
DOC_USP7_MATH_1	4	8	PF00917	0.580
DOC_USP7_MATH_1	99	103	PF00917	0.504
DOC_WW_Pin1_4	115	120	PF00397	0.429
DOC_WW_Pin1_4	23	28	PF00397	0.560
LIG_14-3-3_CanoR_1	114	119	PF00244	0.577
LIG_14-3-3_CanoR_1	20	29	PF00244	0.605
LIG_14-3-3_CanoR_1	92	97	PF00244	0.517
LIG_APCC_Cbox_1	162	168	PF00515	0.420
LIG_FHA_1	115	121	PF00498	0.556
LIG_FHA_1	24	30	PF00498	0.558
LIG_FHA_1	4	10	PF00498	0.479
LIG_FHA_2	34	40	PF00498	0.399
LIG_FHA_2	6	12	PF00498	0.589
LIG_LIR_Apic_2	36	41	PF02991	0.377
LIG_LIR_Apic_2	95	99	PF02991	0.463
LIG_LIR_Gen_1	138	147	PF02991	0.258
LIG_LIR_Nem_3	138	142	PF02991	0.328
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.604
LIG_Pex14_2	78	82	PF04695	0.504
LIG_SH2_GRB2like	55	58	PF00017	0.286
LIG_SH2_STAP1	137	141	PF00017	0.507
LIG_SH2_STAP1	55	59	PF00017	0.408
LIG_SH2_STAP1	65	69	PF00017	0.436
LIG_SH2_STAT3	137	140	PF00017	0.267
LIG_SH2_STAT5	44	47	PF00017	0.370
LIG_SH2_STAT5	65	68	PF00017	0.452
LIG_SH3_3	26	32	PF00018	0.521
MOD_CK1_1	19	25	PF00069	0.684
MOD_CK1_1	7	13	PF00069	0.590
MOD_CK2_1	156	162	PF00069	0.473
MOD_CK2_1	19	25	PF00069	0.637
MOD_CK2_1	5	11	PF00069	0.588
MOD_GlcNHglycan	144	148	PF01048	0.545
MOD_GSK3_1	114	121	PF00069	0.482
MOD_GSK3_1	19	26	PF00069	0.539
MOD_GSK3_1	3	10	PF00069	0.582
MOD_GSK3_1	88	95	PF00069	0.489
MOD_NEK2_1	126	131	PF00069	0.379
MOD_PKA_1	114	120	PF00069	0.564
MOD_PKA_2	114	120	PF00069	0.584
MOD_PKA_2	150	156	PF00069	0.415
MOD_PKA_2	19	25	PF00069	0.613
MOD_PKB_1	112	120	PF00069	0.466
MOD_Plk_1	33	39	PF00069	0.414
MOD_Plk_4	99	105	PF00069	0.475
MOD_ProDKin_1	115	121	PF00069	0.422
MOD_ProDKin_1	23	29	PF00069	0.551
MOD_SUMO_for_1	189	192	PF00179	0.470
MOD_SUMO_rev_2	175	182	PF00179	0.516
TRG_ER_diArg_1	112	115	PF00400	0.534
TRG_ER_diArg_1	45	47	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T5	Leptomonas seymouri	66%	96%
A0A1X0NJH0	Trypanosomatidae	35%	100%
A0A3Q8IH21	Leishmania donovani	90%	100%
A0A3R7KP70	Trypanosoma rangeli	39%	100%
A4H5W3	Leishmania braziliensis	78%	100%
A4HU58	Leishmania infantum	90%	100%
D0A9N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QHP0	Leishmania major	91%	100%
V5BI27	Trypanosoma cruzi	38%	100%